The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Prediction of the Depressive Effects of Interferon Alfa Therapy by the Patient's Initial Affective State
Open accessAbstract
To the Editor: The study by Leon et al. (Dec.3 issue) 1 comparing three antithrombotic-drug regimens -aspirin alone, aspirin and warfarin, and aspirin and ticlopidineafter coronary stenting showed a lower rate of stent thrombosis with aspirin and ticlopidine, although there were more hemorrhagic complications than with aspirin alone.By contrast, there were no significant differences in the incidence of neutropenia or thrombocytopenia among the three regimens (overall incidence, 0.3 percent).Despite the absence of severe hematologic dyscrasias in the study, the authors refer to reports of the risk of serious hematologic complications, such as thrombotic thrombocytopenic purpura, among patients who received ticlopidine after coronary stent placement.However, they did not mention the risk of aplastic anemia, a life-threatening condition that may be induced by ticlopidine.Recently, Yeh et al. reviewed the cases of ticlopidine-induced aplastic anemia published in the English literature, 2 and four other cases have been reported 3,4 (including one case reported by us).Ten of 23 patients died (43 percent): 7 because of infection (candidal and gram-negative sepsis) and 1 from massive gastrointestinal bleeding.The only factor significantly correlated with survival was the patients' age.Other factors, such as sex, duration of ticlopidine use, and the presence of agranulocytosis at onset, had no prognostic value. 2 Although the pathogenesis of marrow toxicity related to this drug is still unclear, both direct toxicity and immunologic effects have been proposed. 2The therapeutic use of hematopoietic growth factors has been suggested, 4 but this treatment seems to have little effect on survival. 2,3n summary, although it is an infrequent event, ticlopi-dine-induced marrow aplasia is possible, and patients and doctors should be aware of it.However, aplastic anemia, like other hematologic dyscrasias induced by ticlopidine, appears after 2 weeks of treatment, 2-4 whereas stent thrombosis generally occurs within the first 14 days after coronary stenting (a mean of 0.7 day in the study by Leon et al.). 1 So, we agree with the suggestion made by Leon et al.to shorten the duration of ticlopidine therapy after stenting to two weeks.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The patients who developed psychological symptoms of depression scored higher on a depression scale before immunotherapy was started51 and had an enhanced pituitary–adrenal response following the first injection of IFN-α52, indicating that vulnerability to immunotherapy-induced depression involves both psychological and physiological risk factors.”
From From inflammation to sickness and depression: when the immune system subjugates the brain (2008) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
Kirkwood, J. M., Strawderman, M. H., Ernstoff, M. S., Smith, T. J., Borden, E. C., & Blum, R. H. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.1.7 · Cited by 2,089
Cole, B. F., Gelber, R. D., Kirkwood, J. M., Goldhirsch, A., Barylak, E., & Borden, E. C. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.10.2666 · Cited by 204
A perspective on the clinical effectiveness and tolerance of interferon-alpha.
Borden, E. C., & Parkinson, D. (1998) · PubMed · Cited by 94
Research works printed but not linked: 1
- Borden EC, 1998, Semin Oncol, 25, 3
Cited by
Sorted by citations
Items 101–169 of 169
Almeida, A. G.-D., Quarantini, L. C., Sampaio, A. S., Lyra, A. C., Parise, C. L., Paraná, R., de Oliveira, I. R., Koenen, K. C., Miranda-Scippa, Â. M. D. A., & Guindalini, C. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.001 · Cited by 23
Psychoneuroimmunology of Depressive Disorder: Mechanisms and Clinical Implications
Capuron, L., Miller, A. H., & Irwin, M. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50030-7 · Cited by 22
Self-citationPsychological stress, cytokines and the inflammatory response system
Maes, M. H. J. (1999) · Current Opinion in Psychiatry · doi:10.1097/00001504-199911000-00019 · Cited by 21
Drugs acting on the immune system
Vial, T., Descotes, J., Screaton, G. R., Behrend, M., & Ludwig, C. (2003) · Side effects of drugs annual · doi:10.1016/s0378-6080(03)80044-2 · Cited by 21
Cooper, C. M., Godlewska, B., Sharpley, A. L., Barnes, E., Cowen, P. J., & Harmer, C. J. (2018) · Psychological Medicine · doi:10.1017/s0033291717002379 · Cited by 20
Mahajan, S. L., Avasthi, A., Grover, S., & Chawla, Y. K. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.05.008 · Cited by 20
Psychiatric Implications of Hepatitis-C Infection
Giunta, B. N., Somboonwit, C., Nikolic, W. V., Rrapo, E., Tan, J. R., Shapshak, P., & Fernandez, F. (2007) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v19.i2-3.20 · Cited by 18
Comanagement of Depression and HCV Treatment
Loftis, J. M., & Hauser, P. (2003) · Psychiatric Annals · doi:10.3928/0048-5713-20030601-08 · Cited by 17
Inflammatory Exposure and Depression in Older Adults With Insomnia
Irwin, M. R., Boyle, C. C., Cho, H. J., Piber, D., Sadeghi, N., Castillo, D., Smith, M. T., Eisenberger, N. I., & Olmstead, R. (2025) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.1327 · Cited by 19
Measuring sickness behavior in the context of pancreatic cancer
Tobias, K. G., Rosenfeld, B. D., Pessin, H., & BREITBART, W. S. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.01.002 · Cited by 16
Sarkar, S., Sarkar, R., Berg, T., & Schaefer, M. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.141770 · Cited by 16
Psychosis Induced by Interferon-α
García–Parés, G., Domenech, C., & Gil, M. (2002) · Psychosomatics · doi:10.1176/appi.psy.43.5.428 · Cited by 15
A French prospective observational study of the treatment of chronic hepatitis C in drug abusers
Chossegros, P., Melin, P., Hézode, C., Bourlière, M., Pol, S., Fhima, A., Filoche, B., TREPO, C. G., Couzigou, P., Ouzan, D., et al. (2008) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2008.07.004 · Cited by 14
Schizophrenia and Co-occurring General Medical Illness
Hendrick, D. C., Torrey, W. C., & Green, A. I. (2005) · Psychiatric Annals · doi:10.3928/00485713-20050101-09 · Cited by 14
Gene expression profiles associated with depression in patients with chronic hepatitis C ( CH ‐C)
Birerdinc, A., Afendy, A., Stepanova, M., Younossi, I. M., Baranova, A. V., & Younossi, Z. M. (2012) · Brain and Behavior · doi:10.1002/brb3.72 · Cited by 13
Osinusi, A. O., Rasimas, J. J., Bishop, R. J., Proschan, M. A., McLaughlin, M. E., Murphy, A., Cortez, K. J., Polis, M. A., Masur, H., Rosenstein, D. L., et al. (2010) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181c7a29d · Cited by 13
Cytokines and Sickness Behavior
Dantzer, R. (2003) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4615-0323-1_7 · Cited by 13
Inflammation, sickness behaviour and depression
Dantzer, R., Castanon, N., Lestage, J., Moreau, M. M., & Capuron, L. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544293.013 · Cited by 12
Self-citationOrrù, M. G., Baita, A., Sitzia, R., Costa, A., Muntoni, E., Landau, S., Chessa, L., Farci, M. G., Carpiniello, B., & Pariante, C. M. (2005) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00006394 · Cited by 11
Vignau, J., Costisella, O., Canva, V., Imbenotte, M., Duhamel, A., & Lhermitte, M. (2008) · L Encéphale · doi:10.1016/j.encep.2007.09.007 · Cited by 11
Manifestations psychiatriques au cours du traitement de l’hépatite chronique C
Castéra, L., Constant, A., Henry, C., & Couzigou, P. (2005) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(05)80714-6 · Cited by 10
More on the Depressive Effects of Interferon Alfa
Rosenstein, D. L., Lerner, D. M., & Cai, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909093411116 · Cited by 11
Neuropsychiatric Complications Associated With Interferon-Alpha-2b Treatment of Malignant Melanoma
Okereke, O. I. (2002) · Psychosomatics · doi:10.1176/appi.psy.43.3.237 · Cited by 10
Huang, Y., Hu, J., Hu, F., Chang, C., Chang, H.-Y., Kao, J., Yang, S.-S., & Chen, D. (2012) · Antiviral Therapy · doi:10.3851/imp2441 · Cited by 9
Almeida, A. G.-D., Quarantini, L. C., Tartaglioni, A. G., Lyra, A. C., Parise, C. L., Paraná, R., de Oliveira, I. R., Miranda‐Scippa, Â., & Guindalini, C. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.12.007 · Cited by 9
Polyunsaturated fatty acids moderate the effect of poor sleep on depression risk
Lotrich, F. E., Sears, B., & McNamara, R. K. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.10.004 · Cited by 9
Management of psychiatric adverse events with immunotherapy with interferon-alfa
Gool, A. R. V., Kruit, W. H. J., Cornelissen, J. J., Berk, L., Eggermont, A. M. M., & Bannink, M. (1999) · Acta Neuropsychiatrica · doi:10.1017/s0924270800035857 · Cited by 9
Hanna, T. P., Baetz, T. D., Xu, J., Miao, Q., Earle, C. C., Peng, Y., Booth, C. M., Petrella, T. M., McKay, D. R., Nguyen, P., et al. (2017) · Current Oncology · doi:10.3747/co.24.3685 · Cited by 8
Jakiche, A., Paredez, E. C., Tannan, P. K., GEPPERT, C. M. A., Sontag, V., Qualls, C., Blair, D. A., & Dettmer, E. L. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01425.x · Cited by 8
Drugs acting on the immune system
Vial, T., & Descotes, J. (2000) · Side effects of drugs annual · doi:10.1016/s0378-6080(00)80043-4 · Cited by 8
Traitements complémentaires de l’hépatite chronique virale C
Thévenot, T., Martino, V. D., Lunel, F., Vanlemmens, C., Becker, M.-C., Bronowicki, J., Bresson‐Hadni, S., & Miguet, J. (2006) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(06)73154-2 · Cited by 8
Cytokine Regulation in Major Depression
Kronfol, Z. (2003) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4615-0323-1_12 · Cited by 7
Neuroimmune Mediators: Are Cytokines Mediators of Depression?
de Beaurepaire, R., Swiergiel, A. H., & Dunn, A. J. (2005) · Wiley eBooks · doi:10.1002/9783527619672.ch22 · Cited by 7
From Psychoneuroimmunology to Immunopsychiatry: An Historical Perspective
Kelley, K. W. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108539623.003 · Cited by 6
Neuropsychiatric Changes in HIV/Hepatitis C Coinfected Patients Undergoing Interferon Therapy
Corcoran, C. P. (2003) · Journal of the Association of Nurses in AIDS Care · doi:10.1177/1055329003255589 · Cited by 6
Intérêts et limites de l’approche biologique pour l’étude des comportements agressifs
Combalbert, N., Bret-Dibat, J. L., & Favard, A.-M. (2002) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/s0003-4487(02)00228-7 · Cited by 5
The Inflammatory Hypothesis of Depression
Soskin, D. P., Cassiello-Robbins, C. F., Isacoff, O. K., & D, M. F. M. (2012) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.10.4.413 · Cited by 5
Fan, V. S., & Giardino, N. D. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-673-3_7 · Cited by 5
Cytokine-Induced Sickness Behavior and Depression
Chang, Q., Szegedi, S. S., O’Connor, J. C., Dantzer, R., & Kelley, K. W. (2008) · Springer eBooks · doi:10.1007/978-0-387-84851-8_9 · Cited by 5
Kronfol, Z., Litman, H. J., Back‐Madruga, C., Bieliauskas, L. A., Lindsay, K. L., Lok, A. S.-F., & Fontana, R. J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.010 · Cited by 4
Could the depression of obese patients suffering from chronic hepatitis C be temporarily improved?
Tarantino, G., Basile, V., Conca, P., Ariello, M., Minno, M. N. D. D., Romano, A., Gentile, A., & Capone, D. (2008) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2008.01002.x · Cited by 4
Zincke, M. T., Kurani, A. P., Istafanous, R., & Kellner, C. H. (2007) · Journal of Ect · doi:10.1097/yct.0b013e3181492224 · Cited by 4
Therapie der chronischen Hepatitis C bei Patienten mit psychischen Erkrankungen
Schäfer, M. (2005) · Suchttherapie · doi:10.1055/s-2005-858335 · Cited by 4
A Systematic Review on Interferon Alpha-Induced Cognitive Impairment in Hepatitis C Patients
Khan, M. A., Kaushik, P., Agarwal, N. B., & Garg, A. (2022) · Current Drug Safety · doi:10.2174/1574886317666220428134931 · Cited by 3
Schäfer, M. K.-H. (2002) · Suchttherapie · doi:10.1055/s-2002-32771 · Cited by 3
Elsayed, H., Elsayed, M., Arafa, M., & El‐Bendary, M. (2012) · Middle East Current Psychiatry · doi:10.1097/01.xme.0000407891.12614.d0 · Cited by 2
Co-occurring Depression, Chronic Pain and Substance Use Disorders in People with Hepatitis C
Chereji, E., Kern, S. M., Fuller, B. E., Morasco, B. J., Phelps, A., & Hauser, P. (2016) · Open Medicine Journal · doi:10.2174/1874220301603010079 · Cited by 2
Rondepierre, F., Tauveron-Jalenques, U., Valette, S., Mulliez, A., D'Incan, M., Lauron, S., & Jalenques, I. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282079 · Cited by 2
Innate Immune Signaling and Alcoholism
Vetreno, R. P., & Crews, F. T. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_8 · Cited by 2
Modèles psycho-neuro-immunologiques de la dépression : une revue critique
Guilbaud, O., Corcos, M., Hjalmarsson, L., Loas, G., & Jeammet, P. (2002) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/s0003-4487(02)00149-x · Cited by 2
Chronic C Hepatitis, Interferon and Psychiatric Disorders
Valerio, G., Apicella, E., DAlterio, E., Cecere, A. C., & Bellomo, A. (2013) · InTech eBooks · doi:10.5772/54748
EFFECTS OF A SHORT-TERM MINDFULNESS INTERVENTION ON DEPRESSION AND IMMUNE FUNCTION
Walsh, E. C. (2011) · UKnowledge (University of Kentucky) · Cited by 2
Neuroscience, Molecular Medicine, and New Approaches to the Treatment of Depression and Anxiety
Heninger, G. R. (2005) · Elsevier eBooks · doi:10.1016/b978-012738903-5/50013-8 · Cited by 1
Walker, A. K., Dantzer, R., & Kelley, K. W. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_6 · Cited by 1
Heinze, S. (2009) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-5622 · Cited by 1
Fumaz, R., & del Cármen, M. (2009) · TDX (Tesis Doctorals en Xarxa)
Interferón y depresión. A propósito de un caso
Arroyoa, I. L., & Carriedo, E. R. (2004) · Atención Primaria · doi:10.1016/s0212-6567(04)78931-3
From inflammation to sickness and depression: the cytokine connection
Dantzer, R., & Kelley, K. W. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511780868.014
Un sustrato biológico para los trastornos somatomorfos
Dimsdale, J. E., & Dantzer, R. (2010) · Elsevier eBooks · doi:10.1016/b978-84-458-2037-7.00006-3
Mikhael, V. S., El-Sheikh, H. E., Atta, M. M. E., El-Hamady, M. M., & Abd-Elmaksoud, S. F. (2017) · Middle East Current Psychiatry · doi:10.1097/01.xme.0000457199.25746.9a
(2006) · Elsevier eBooks · doi:10.1016/b0-44-451005-2/00862-7
(2015) · Elsevier eBooks · doi:10.1016/b978-0-444-53717-1.00900-8
ANTIVIRAL DRUGS, INCLUDING IMMUNOGLOBULINS AND INTERFERONS
(2010) · Elsevier eBooks · doi:10.1016/b978-0-444-53272-5.50006-6
Interferon-?? therapy ??? which patients will develop depression?
&NA; (1999) · Reactions Weekly · doi:10.2165/00128415-199907500-00009
CYTOKINES AND CYTOKINE MODULATORS
(2010) · Elsevier eBooks · doi:10.1016/b978-0-444-53267-1.50006-x
Erkrankungen von Leber und Pankreas
Kapfhammer, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65873-4_7
Neurological Impact of Type I Interferon Dysregulation
Mylonas, A. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1006023
Metadata
- Authors
- Capuron, L., & Ravaud, A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-04-29
- Volume
- 340
- Issue
- 17
- Pages
- 1370-1370
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1986891518
- Cited by
- 169
- References
- 4
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 10
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- interferon-alpha therapy, depression, affective states, treatment response prediction, interferon-induced depression
- MeSH terms
- Adult, Affect, Antineoplastic Agents, Depression, Female, Humans, Male, Melanoma, Psychiatric Status Rating Scales, Interferon-alpha
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
