The Role of Leptin in Human Physiology
Abstract
In humans, the relative long-term constancy of body weight, the difficulty of successfully sustaining intentional weight loss, and the metabolic and behavioral alterations that accompany weight change provide strong evidence that body fat is biologically regulated.1 The amount of energy stored as fat affects growth, puberty, fertility, and thyroid function, which suggests that humoral signals reflecting adipose-tissue mass interact with many neuroendocrine systems.1 In mice, the products of the ob and db genes are the main candidates for the ligand and receptor, respectively, for a fat-to-brain signaling system. Mice with the ob mutation (now designated Lepob) have a deficiency . . .
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This mechanism seems to be mediated in part by gut hormonal responses and reductions in the fat-derived hormone leptin, which interact with regulatory regions within the brain to establish a set-point of equilibrium body adiposity.
“This mechanism seems to be mediated in part by gut hormonal responses and reductions in the fat-derived hormone leptin, which interact with regulatory regions within the brain to establish a set-point of equilibrium body adiposity.87,88”
From Definition and diagnostic criteria of clinical obesity (2025) · cites this paper as [88]
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References 7 · Cited by 134
- Authors
- Rosenbaum, M., & Leibel, R. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-09-16
- Volume
- 341
- Issue
- 12
- Pages
- 913-915
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2068462949
- Cited by
- 134
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 1 · 2014: 11 · 2013: 9 · 2012: 7
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, adipose tissue, energy homeostasis, body weight regulation, ob gene, leptin receptor, neuroendocrine regulation, obesity, weight loss
- MeSH terms
- Adipose Tissue, Energy Metabolism, Humans, Metabolism, Inborn Errors, Obesity, Proteins, Leptin
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