The DOI matches its Crossref record.
Use of Placebo Surgery in Controlled Trials of a Cellular-Based Therapy for Parkinson's Disease
Abstract
Surgical procedures are frequently introduced into general practice on the basis of uncontrolled studies that are less rigorous than those required for the approval of medical interventions.1 The standard for the evaluation of surgical therapy is lower because of the complexity of designing and conducting scientifically valid and ethically acceptable clinical trials of surgical procedures.2 As a result, many surgical trials fail to control for investigator bias or placebo effects.3,4 The list of inadequately studied invasive or surgical procedures that became part of standard medical practice only to be abandoned after closer scrutiny includes bloodletting, routine tonsillectomy, routine circumcision, . . .
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Citations
Cited by
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Björklund, A., & Lindvall, O. (2000) · Nature Neuroscience · doi:10.1038/75705 · Cited by 934
A Randomized Study of Endobronchial Valves for Advanced Emphysema
Sciurba, F. C., Ernst, A., Herth, F. J. F., Strange, C., Criner, G. J., Marquette, C. H., Kovitz, K. L., Chiacchierini, R. P., Goldin, J., & McLennan, G. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0900928 · Cited by 832
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Bond, A. E., Shah, B. B., Huss, D. S., Dallapiazza, R. F., Warren, A., Harrison, M. B., Sperling, S. A., Wang, X.-Q., Gwinn, R., Witt, J., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.3098 · Cited by 373
Metadata
- Authors
- Freeman, T. B., Vawter, D. E., Leaverton, P. E., Godbold, J. H., Hauser, R. A., Goetz, C. G., & Olanow, C. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-09-23
- Volume
- 341
- Issue
- 13
- Pages
- 988-992
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2014571087
- Cited by
- 240
- References
- 0
- FWCI
- 16.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Use of Placebo Surgery in Controlled Trials of a Cellular-Based Therapy for Parkinson's Disease. https://app.cochat.ai/papers/10.1056/nejm199909233411311
- The paper
- Freeman, T. B., Vawter, D. E., Leaverton, P. E., Godbold, J. H., Hauser, R. A., Goetz, C. G., & Olanow, C. W. (1999). Use of Placebo Surgery in Controlled Trials of a Cellular-Based Therapy for Parkinson's Disease. New England Journal of Medicine. https://doi.org/10.1056/nejm199909233411311
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
