Cited by 5,204Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesDiet and metabolism studies

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Early Identification of Refractory Epilepsy

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Kwan, Patrick, Brodie, Martin J.·2000·New England Journal of Medicine

DOI 10.1056/nejm200002033420503

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Abstract

BACKGROUND: More than 30 percent of patients with epilepsy have inadequate control of seizures with drug therapy, but why this happens and whether it can be predicted are unknown. We studied the response to antiepileptic drugs in patients with newly diagnosed epilepsy to identify factors associated with subsequent poor control of seizures. METHODS: We prospectively studied 525 patients (age, 9 to 93 years) who were given a diagnosis, treated, and followed up at a single center between 1984 and 1997. Epilepsy was classified as idiopathic (with a presumed genetic basis), symptomatic (resulting from a structural abnormality), or cryptogenic (resulting from an unknown underlying cause). Patients were considered to be seizure-free if they had not had any seizures for at least one year. RESULTS: Among the 525 patients, 333 (63 percent) remained seizure-free during antiepileptic-drug treatment or after treatment was stopped. The prevalence of persistent seizures was higher in patients with symptomatic or cryptogenic epilepsy than in those with idiopathic epilepsy (40 percent vs. 26 percent, P=0.004) and in patients who had had more than 20 seizures before starting treatment than in those who had had fewer (51 percent vs. 29 percent, P<0.001). The seizure-free rate was similar in patients who were treated with a single established drug (67 percent) and patients who were treated with a single new drug (69 percent). Among 470 previously untreated patients, 222 (47 percent) became seizure-free during treatment with their first antiepileptic drug and 67 (14 percent) became seizure-free during treatment with a second or third drug. In 12 patients (3 percent) epilepsy was controlled by treatment with two drugs. Among patients who had no response to the first drug, the percentage who subsequently became seizure-free was smaller (11 percent) when treatment failure was due to lack of efficacy than when it was due to intolerable side effects (41 percent) or an idiosyncratic reaction (55 percent). CONCLUSIONS: Patients who have many seizures before therapy or who have an inadequate response to initial treatment with antiepileptic drugs are likely to have refractory epilepsy.

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Proposal for Revised Classification of Epilepsies and Epileptic Syndromes: Commission on Classification and Terminology of the International League Against Epilepsy
(1989) · Epilepsia · doi:10.1111/j.1528-1157.1989.tb05316.x · Cited by 5,347
Guidelines for Epidemiologic Studies on Epilepsy
(1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb00433.x · Cited by 1,360
Is the underlying cause of epilepsy a major prognostic factor for recurrence?
Semah, F., Picot, M., Adam, C., Broglin, D., Arzimanoglou, A. A., Bazin, B., Cavalcanti, D., & Baulac, M. (1998) · Neurology · doi:10.1212/wnl.51.5.1256 · Cited by 1,105
Surgery for Seizures
Engel, J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603073341008 · Cited by 880
Long-Term Prognosis of Seizures with Onset in Childhood
Sillanpää, M. L., Jalava, M., Kaleva, O., & Shinnar, S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806113382402 · Cited by 725
Remission of Seizures and Relapse in Patients with Epilepsy
Annegers, J. F., Hauser, W. A., & Elveback, L. R. (1979) · Epilepsia · doi:10.1111/j.1528-1157.1979.tb04857.x · Cited by 621
Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy
Brodie, M. J., UK Lamotrigine/Carbamazepine Monotherapy Trial Group, Richens, A., & Yuen, A. W. C. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90581-2 · Cited by 614
Self-citation
MDR1 Gene Expression in Brain of Patients with Medically Intractable Epilepsy
Tishler, D. M., Weinberg, K. I., Hinton, D. R., Barbaro, N. M., Annett, G., & Raffel, C. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb01657.x · Cited by 529
Multidrug resistance: molecular mechanisms and clinical relevance
Ling, V. W. T. (1997) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800051053 · Cited by 525
Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy
Brodie, M. J., Overstall, P. W., & Giorgi, L. (1999) · Epilepsy Research · doi:10.1016/s0920-1211(99)00039-x · Cited by 462
Self-citation

Show all 39 references

Research works printed but not linked: 2

Dreifuss FE. Classification of epileptic seizures. In: Engel J Jr, Pedley TA, eds. Epilepsy: a comprehensive textbook. Vol. 1. Philadelphia: Lippincott-Raven, 1998:517-24.
Wolf P. International classification of the epilepsies. In: Engel J Jr, Pedley TA, eds. Epilepsy: a comprehensive textbook. Vol. 1. Philadelphia: Lippincott-Raven, 1998:773-7.

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Self-citation
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Benbadis, S. R., Geller, E. B., Ryvlin, P., Schachter, S. C., Wheless, J. W., Doyle, W., & Vale, F. Ĺ. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.05.030 · Cited by 76
Epigenetic mechanisms of neurodegenerative diseases and acute brain injury
Bertogliat, M. J., Morris-Blanco, K. C., & Vemuganti, R. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104642 · Cited by 83
Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial
Yang, H., Shi, W., Fan, J., Wang, T., Song, Y., Lian, Y., Shan, W., & Wang, Q. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01353-9 · Cited by 76
“However, approximately one third of the patients are not able to achieve seizure freedom despite appropriate medications and advent of new anti-seizure medications (ASMs), which is known as drug-resistant epilepsy [3].”
Background
Surgical versus medical treatment for refractory epilepsy: Outcomes beyond seizure control
Perry, M. S., & DUCHOWNY, M. S. (2013) · Epilepsia · doi:10.1111/epi.12427 · Cited by 76
No Pharmacokinetic Interaction Between Lacosamide and Carbamazepine in Healthy Volunteers
Cawello, W., Nickel, B., & Eggert‐Formella, A. (2009) · The Journal of Clinical Pharmacology · doi:10.1177/0091270009347675 · Cited by 76
Non-invasive imaging of epileptic seizuresin vivousing photoacoustic tomography
Zhang, Q., Liu, Z., Carney, P. R., Yuan, Z., Chen, H., Roper, S. N., & Jiang, H. (2008) · Physics in Medicine and Biology · doi:10.1088/0031-9155/53/7/008 · Cited by 76
Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model
Łuszczki, J. J., Ratnaraj, N., Patsalos, P. N., & Czuczwar, S. J. (2006) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-006-0055-4 · Cited by 76
Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants
Azam, F., Alkskas, I. A., Khokra, S. L., & Prakash, O. (2008) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2008.02.007 · Cited by 76
Evaluation of Levetiracetam as Adjunctive Treatment for Refractory Canine Epilepsy: A Randomized, Placebo-Controlled, Crossover Trial
Muñana, K. R., Thomas, W., Inzana, K. D., Nettifee, J. A., McLucas, K., Olby, N. J., Mariani, C. L., & Early, P. J. (2012) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2011.00866.x · Cited by 76
Automated Detection of High-Frequency Oscillations in Epilepsy Based on a Convolutional Neural Network
Zuo, R., Jing, W., Li, X., Li, C., Zhao, C., Ren, Z., Liang, Y., Geng, X., Jiang, C., Yang, X., et al. (2019) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2019.00006 · Cited by 79
[11C]UCB-A, a novel PET tracer for synaptic vesicle protein 2A
Estrada, S., Lubberink, M., Thibblin, A., Sprycha, M., Buchanan, T., Mestdagh, N., Kenda, B., Mercier, J., Provins, L., Gillard, M., et al. (2016) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2016.03.004 · Cited by 71
Deep Brain Stimulation: Technology at the Cutting Edge
Shah, R. S., Chang, S.-Y., Min, H.-K. P., Cho, Z., Blaha, C. D., & Lee, K. H. (2010) · Journal of Clinical Neurology · doi:10.3988/jcn.2010.6.4.167 · Cited by 78
The Microbiota–Gut–Brain Axis and Epilepsy
Yue, Q., Cai, M., Xiao, B., Zhan, Q., & Zeng, C. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01130-2 · Cited by 80
Synthesis of isatin semicarbazones as novel anticonvulsants--role of hydrogen bonding.
Pandeya, S. N., Raja, A. S., & Stables, J. P. (2002) · PubMed · Cited by 75
Structural Consequences of Kcna1 Gene Deletion and Transfer in the Mouse Hippocampus
Wenzel, H. J., Vacher, H., Clark, E., Trimmer, J. S., Lee, A. L., Sapolsky, R. M., Tempel, B. L., & Schwartzkroin, P. A. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01189.x · Cited by 75
Treatment Options in Juvenile Myoclonic Epilepsy
Ritter, L. M., & Walker, M. C. (2011) · Current Treatment Options in Neurology · doi:10.1007/s11940-011-0131-z · Cited by 75
Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area
Zaveri, H. P., Pincus, S. M., Goncharova, I. I., Duckrow, R. B., Spencer, D. D., & Spencer, S. S. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832c78e0 · Cited by 75
New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity
Lankau, H., Unverferth, K., Grunwald, C., Hartenhauer, H., Heinecke, K., Bernöster, K., Dost, R., Egerland, U., & Rundfeldt, C. (2007) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2006.12.022 · Cited by 75
Precision medicine in genetic epilepsies: break of dawn?
Reif, P. S., Tsai, M., Helbig, I., Rosenow, F., & Klein, K. M. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1253476 · Cited by 77
Interactions of Lamotrigine with Topiramate and First‐generation Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis
Łuszczki, J. J., Czuczwar, M., Kiś, J., Krysa, J., Pasztelan, I., Świąder, M., & Czuczwar, S. J. (2003) · Epilepsia · doi:10.1046/j.1528-1157.2003.10003.x · Cited by 75
α-[ 11 C]-Methyl- L -Tryptophan PET for Tracer Localization of Epileptogenic Brain Regions: Clinical Studies
Kumar, A., Asano, E., & Chugani, H. T. (2011) · Biomarkers in Medicine · doi:10.2217/bmm.11.68 · Cited by 76
Chromanone-A Prerogative Therapeutic Scaffold: An Overview
Kamboj, S., & Singh, R. (2021) · Arabian Journal for Science and Engineering · doi:10.1007/s13369-021-05858-3 · Cited by 76
Guidelines for Specialized Epilepsy Centers
Lado, F. A., Ahrens, S. M., Riker, E., Muh, C. R., Richardson, R. M., Gray, J. M., Small, B., Lewis, S. Z., Schofield, T. J., Clarke, D., et al. (2024) · Neurology · doi:10.1212/wnl.0000000000208087 · Cited by 74

Authors: Kwan, P., & Brodie, M. J.
Affiliations: Western Infirmary (GB)
ORCID: Kwan, Patrick
Brodie, Martin J.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2000-02-03
Volume: 342
Issue: 5
Pages: 314-319
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm200002033420503
OpenAlex: W1974809694
Cited by: 5,204
References: 39
Citations by year: 2026: 225 · 2025: 241 · 2024: 259 · 2023: 275 · 2022: 269 · 2021: 328 · 2020: 348 · 2019: 253 · 2018: 270 · 2017: 228 · 2016: 249 · 2015: 230 · 2014: 205 · 2013: 233 · 2012: 248
FWCI: 55.69
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
CRC Press eBooks (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Keywords: drug-resistant epilepsy, antiepileptic drugs, seizure control, newly diagnosed epilepsy, idiopathic epilepsy, symptomatic epilepsy, cryptogenic epilepsy, seizure frequency, predictors of treatment failure, adverse drug reactions, polypharmacy
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Anticonvulsants, Child, Epilepsy, Female, Humans, Male, Middle Aged, Prospective Studies, Remission Induction, Treatment Failure

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