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Hypernatremia
Abstract
The serum sodium concentration and thus serum osmolality are closely controlled by water homeostasis, which is mediated by thirst, arginine vasopressin, and the kidneys.1 A disruption in the water balance is manifested as an abnormality in the serum sodium concentration — hypernatremia or hyponatremia.2,3 Hypernatremia, defined as a rise in the serum sodium concentration to a value exceeding 145 mmol per liter, is a common electrolyte disorder. Because sodium is a functionally impermeable solute, it contributes to tonicity and induces the movement of water across cell membranes.4 Therefore, hypernatremia invariably denotes hypertonic hyperosmolality and always causes cellular dehydration, at . . .
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Cited by
Hyponatremia in cirrhosis: Pathogenesis, clinical significance, and management
Ginès, P., & Guevara, M. (2008) · Hepatology · doi:10.1002/hep.22418 · Cited by 323
Assessment of hydration status in a large population
Baron, S., Courbebaisse, M., Lepicard, E. M., & Friedlander, G. (2015) · British Journal of Nutrition · doi:10.1017/s0007114514003213 · Cited by 166
Physiologic basis for understanding quantitative dehydration assessment
Cheuvront, S. N., Kenefick, R. W., Charkoudian, N., & Sawka, M. N. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.044172 · Cited by 154
Diabetes Insipidus after Traumatic Brain Injury
Capatina, C., Paluzzi, A., Mitchell, R., & Karavitaki, N. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4071448 · Cited by 120
Management of hyperosmolar hyperglycaemic state in adults with diabetes
Scott, A. R., Care, T. J. B. D. S. (. F. I., & the JBDS hyperosmolar hyperglycaemic guidelines group (2015) · Diabetic Medicine · doi:10.1111/dme.12757 · Cited by 83
Metadata
- Authors
- Adrogué, H. J., & Madias, N. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-05-18
- Volume
- 342
- Issue
- 20
- Pages
- 1493-1499
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4251948956
- Cited by
- 880
- References
- 0
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Adrogué, H. J., & Madias, N. E. (2000). Hypernatremia. New England Journal of Medicine. https://doi.org/10.1056/nejm200005183422006
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