The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease
Open accessAbstract
BACKGROUND: The acute chest syndrome is the leading cause of death among patients with sickle cell disease. Since its cause is largely unknown, therapy is supportive. Pilot studies with improved diagnostic techniques suggest that infection and fat embolism are underdiagnosed in patients with the syndrome. METHODS: In a 30-center study, we analyzed 671 episodes of the acute chest syndrome in 538 patients with sickle cell disease to determine the cause, outcome, and response to therapy. We evaluated a treatment protocol that included matched transfusions, bronchodilators, and bronchoscopy. Samples of blood and respiratory tract secretions were sent to central laboratories for antibody testing, culture, DNA testing, and histopathological analyses. RESULTS: Nearly half the patients were initially admitted for another reason, mainly pain. When the acute chest syndrome was diagnosed, patients had hypoxia, decreasing hemoglobin values, and progressive multilobar pneumonia. The mean length of hospitalization was 10.5 days. Thirteen percent of patients required mechanical ventilation, and 3 percent died. Patients who were 20 or more years of age had a more severe course than those who were younger. Neurologic events occurred in 11 percent of patients, among whom 46 percent had respiratory failure. Treatment with phenotypically matched transfusions improved oxygenation, with a 1 percent rate of alloimmunization. One fifth of the patients who were treated with bronchodilators had clinical improvement. Eighty-one percent of patients who required mechanical ventilation recovered. A specific cause of the acute chest syndrome was identified in 38 percent of all episodes and 70 percent of episodes with complete data. Among the specific causes were pulmonary fat embolism and 27 different infectious pathogens. Eighteen patients died, and the most common causes of death were pulmonary emboli and infectious bronchopneumonia. Infection was a contributing factor in 56 percent of the deaths. CONCLUSIONS: Among patients with sickle cell disease, the acute chest syndrome is commonly precipitated by fat embolism and infection, especially community-acquired pneumonia. Among older patients and those with neurologic symptoms, the syndrome often progresses to respiratory failure. Treatment with transfusions and bronchodilators improves oxygenation, and with aggressive treatment, most patients who have respiratory failure recover.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Epidemiologically, ACS is a complication of VOC, based on its typical development 2–3 days after the onset of vaso-occlusive pain (111)”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [111]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“it is more common in children and, if untreated, has a high mortality [9% in adults (111)].”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [111]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mortality in sickle cell disease. Life expectancy and risk factors for early death
Platt, O. S., Brambilla, D. J., Rosse, W. F., Milner, P. F., Castro, O., Steinberg, M. H., & Klug, P. P. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406093302303 · Cited by 3,320
Rickinson, A. B. (2002) · PubMed · doi:10.1016/s0168-1702(01)00436-1 · Cited by 2,182
Cerebrovascular accidents in sickle cell disease: rates and risk factors.
(1998) · PubMed · doi:10.1182/blood.v91.1.288 · Cited by 1,694
Incidence of and Risk Factors for Ventilator-Associated Pneumonia in Critically Ill Patients
Cook, D. J., Walter, S. D., Cook, R. J., Griffith, L. E., Guyatt, G. H., Leasa, D., Jaeschke, R. Z., & Brun‐Buisson, C. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-6-199809150-00002 · Cited by 1,108
Castro, O. L., Brambilla, D. J., Thorington, B. D., Reindorf, C. A., Scott, R., GILLETTE, P. N., Vera, J., & Levy, P. S. (1994) · Blood · doi:10.1182/blood.v84.2.643.643 · Cited by 805
Vichinsky, E. P., Haberkern, C. M., Neumayr, L., Earles, A. N., Black, D. M., Koshy, M., Pegelow, C. H., Abboud, M. R., Ohene‐Frempong, K., & Iyer, R. V. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507273330402 · Cited by 644
Self-citationCastro, O. L., Brambilla, D. J., Thorington, B. D., et al. (1994) · Blood · doi:10.1182/blood.v84.2.643.bloodjournal842643 · Cited by 615
Acute Chest Syndrome in Sickle Cell Disease: Clinical Presentation and Course
Vichinsky, E. P., Styles, L. A., Colangelo, L. H., Wright, E. C., Castro, O., Nickerson, B., & Disease, T. C. S. O. S. C. (1997) · Blood · doi:10.1182/blood.v89.5.1787 · Cited by 573
Self-citationSickle cell chronic lung disease: prior morbidity and the risk of pulmonary failure.
Powars, D., WEIDMAN, J. A., Odom‐Maryon, T., Niland, J. C., & Johnson, C. M. (1988) · PubMed · Cited by 329
Sickle Cell Chronic Lung Disease
Powars, D. R., WEIDMAN, J. A., ODOM-MARYON, T., Niland, J. C., & Johnson, C. S. (1988) · Medicine · doi:10.1097/00005792-198801000-00005 · Cited by 283
Research works printed but not linked: 9
- Vichinsky E, 1991, Semin Hematol, 28, 220
- Sprinkle RH, 1986, Am J Pediatr Hematol Oncol, 8, 105
- Landry ML, Hsiung GD. Primary isolation of viruses. In: Specter S, Lancz G, eds. Clinical virology manual. 2nd ed. New York: Elsevier Science Publishing, 1992:43-69.
- Waites KB, Taylor-Robinson D. Mycoplasma and Ureaplasma. In: Murray PR, ed. Manual of clinical microbiology. 7th ed. Washington, D.C.: ASM Press, 1999:782-806.
- Lennette ET, Lennette DA. Immune adherence hemagglutination. In: Specter S, Lancz G, eds. Clinical virology manual. 2nd ed. New York: Elsevier Science Publishing, 1992:251-61.
- Schachter J. Chlamydiae. In: Balows A, Hausler WJ Jr, Hermann KL, Isenberg HD, Shadomy HJ, eds. Manual of clinical microbiology. 5th ed. Washington, D.C.: ASM Press, 1991:1045-53.
- Ohene-Frempong K, 1998, Blood, 91, 288
- Mallouh AA, 1988, Am J Dis Child, 142, 178
- Ibe BO, 1997, Am J Physiol, 272, L597
Cited by
Sorted by citations
Items 801–900 of 1,000
Mawalla, W. F., Nasser, A., Jingu, J. S., Joseph, H., Mmbaga, L. G., Shija, E., Kakumbula, H., Lubuva, N. B., Meda, C., & Chamba, C. C. (2022) · eJHaem · doi:10.1002/jha2.397 · Cited by 3
Haematological Diseases in the Tropics
Thachil, J. V., Mbanya, D., & Bates, I. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-7959-7.00069-5 · Cited by 3
Treating a Patient with Your Hands Tied: Acute Chest Syndrome in a Jehovah’s Witness
Vadehra, D., Davino, T., & Datta, D. (2020) · Cureus · doi:10.7759/cureus.7769 · Cited by 3
Noninvasive ventilation in the pediatric intensive care unit: Is the time now?*
Ackerman, A. D. (2006) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000227020.15630.94 · Cited by 3
Sickle Cell Trait Mimicking Multiple Inflicted Injuries in a 5‐Year‐Old Boy
Kepron, C., Somers, G. R., & Pollanen, M. S. (2009) · Journal of Forensic Sciences · doi:10.1111/j.1556-4029.2009.01098.x · Cited by 3
Acute Chest Syndrome in Sickle Cell Disease
Avila, P. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011023431810 · Cited by 3
Lal, A., & Vichinsky, E. P. (2010) · doi:10.1002/9781444323160.ch7 · Cited by 3
Self-citationAntibiotics for treating community acquired pneumonia in people with sickle cell disease
Martí-Carvajal, A. J., & Conterno, L. D. O. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005598.pub2 · Cited by 3
Cardiopulmonary changes in patients with sickle cell anemia: A systematic review
Lopes, J. S., Viana, Í. G., Santos, M. L. C., de Melo, F. F., Oliveira, M. V., & Souza, C. L. (2022) · World Journal of Hematology · doi:10.5315/wjh.v9.i3.20 · Cited by 2
Vieira, P. P. M. G., Braga, J. A. P., & Regacini, R. (2024) · Hematology Transfusion and Cell Therapy · doi:10.1016/j.htct.2024.07.003 · Cited by 2
Vestibular Dysfunction in Patients With Sickle Cell Disease: A Systematic Review
Laredo, J. A., Torres‐Small, S., Wu, L., Makishima, T., & Richard, C. (2024) · Otology & Neurotology · doi:10.1097/mao.0000000000004327 · Cited by 2
The pattern of lung function tests in children with sickle cell disease: A case-control study
Kannan, A., Sarnaik, G., Agarwal, N., & Jindal, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0329064 · Cited by 2
Dessap, A. M., Habibi, A., Guillaud, C., Kassasseya, C., Larrat, C., Agbakou, M., Tchoubou, T., Candille, C., Carpentier, B., Landais, M., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-104564 · Cited by 2
Goswami, S. G., Gupta, P., Arvinden, V. R., Bhargava, N., Iyer, A. R., Saravanakumar, V., Yadav, P., Jha, S. K., Singh, S., Kumar, A., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04582-1 · Cited by 2
Allali, S., Sbeih, N., Rignault‐Bricard, R., Bruce, J., Gall, M. L., Heilbronner, C., de Cacqueray, N., Angyalosy, S., Taylor, M., Brice, J., et al. (2025) · American Journal of Hematology · doi:10.1002/ajh.70182 · Cited by 2
Long-Term Complications of Sickle Cell Disease
Sánchez, L. M., Lapite, A., Chang, A., & Fasipe, T. (2026) · Pediatrics in Review · doi:10.1542/pir.2024-006446 · Cited by 2
Zantek, N. D., Alquist, C. R., Hofmann, J. C., Klingel, R., Levenbrown, Y., Onwuemene, O. A., Patidar, G. K., Patriquin, C. J., Raval, J. S., Sanchez, A. P., et al. (2026) · Journal of Clinical Apheresis · doi:10.1002/jca.70141 · Cited by 2
Hematology and Oncology in Critical Illness
Brandão, L. R., Howard, S. C., Gow, K. W., Rajasekaran, S., & Tamburro, R. F. (2011) · Springer eBooks · doi:10.1007/978-0-85729-923-9_38 · Cited by 2
Bille, E., Lesage, F., Guiso, N., Quesne, G., Berche, P., & Monnier, A. L. (2010) · Archives de Pédiatrie · doi:10.1016/j.arcped.2010.09.015 · Cited by 2
Therapeutic Cytapheresis, Plasmapheresis, and Plasma Exchange in Neoplastic Diseases of the Blood
Dutcher, J. P. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3764-2_54 · Cited by 2
Pulmonary Complications and Lung Function Abnormalities in Children with Sickle Cell Disease
Greenough, A. (2016) · InTech eBooks · doi:10.5772/64365 · Cited by 2
Alvarez, O. A., & Angélica Wietstruck, P. (2020) · Springer eBooks · doi:10.1007/978-3-030-26961-6_52 · Cited by 2
Prognostic Value of Hyponatremia During Acute Painful Episodes in Sickle Cell Disease
Rech, J., Yao, K., Bachmeyer, C., Bailleul, S., Orlando, J., Grateau, G., Lionnet, F., & Steichen, O. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2020.02.017 · Cited by 2
De, A., Anekwe, C. V., Kattan, M., Yao, Y., Jin, Z., Brittenham, G. M., & Lee, M. T. (2021) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000002164 · Cited by 2
Simonson, J. L., Pandya, D., Kang, J., Talwar, A., & Zaidi, G. Z. (2021) · Pulmonary Circulation · doi:10.1177/20458940211018345 · Cited by 2
Ballas, S. K. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0721-2.00026-x · Cited by 2
Self-citationPowers, J. M., & Brandow, A. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-76174-1.00049-3 · Cited by 2
Pulmonary Complications of Sickle Cell Disease
Cohen, R. T. (2023) · American Academy of PediatricsItasca, IL eBooks · doi:10.1542/9781610026536-51 · Cited by 2
Management of Acute Complications of Sickle Cell Disease
Shamayeva, S., & Morocco, P. C. (2024) · Pediatric Annals · doi:10.3928/19382359-20231205-03 · Cited by 2
Lipid and hemolysis parameters predicting acute chest syndrome in adulthood with sickle cell disease
Feugray, G., Grall, M., Dumesnil, C., Brunel, V., Benhamou, Y., Quillard‐Muraine, M., & Billoir, P. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02135-8 · Cited by 3
Kadam, A., Pantbalekundri, N., Bhagawati, J., Kumar, S., & Acharya, S. (2024) · Cureus · doi:10.7759/cureus.61043 · Cited by 2
Hospital acquired venous thromboembolism in children with sickle cell disease
Agarwal, S., Foster, K. L., Anum, S. J., Shapiro, M. C., Han, H., Scheurer, M. E., Airewele, G. E., & Sartain, S. E. (2024) · Pediatric Hematology and Oncology · doi:10.1080/08880018.2024.2362147 · Cited by 2
Beyond Ischemia: The Rare Occurrence of Hemorrhagic Strokes in Pediatric Sickle Cell Anemia
Mustafa, M., Amawi, M., Altoonisi, M. M., Soliman, W., Kamal, M., Asaad, Z. M., Albalawi, A., Alharbi, J., Awadalla, A. M., Ahmed, M., et al. (2024) · Cureus · doi:10.7759/cureus.70871 · Cited by 2
Abdallah, F., Cerasuolo, D., Brossier, D., Eckart, P., Duroy, E., Delehaye, F., & Faucon, C. (2024) · Archives de Pédiatrie · doi:10.1016/j.arcped.2024.09.002 · Cited by 2
Sowa, A. S., Kudzi, W., Paintsil, V., Kuma, A. B.-A., Segbefia, C. I., Olayemi, E., Adjei, D. N., Bruce, A. K., Gruen, J. R., Owusu‐Dabo, E., et al. (2025) · HemaSphere · doi:10.1002/hem3.70209 · Cited by 2
Delaney, M., & Linenberger, M. L. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2296-9.00030-0 · Cited by 2
New pulmonary infiltrates in a 19 year-old with sickle cell crisis
Islam, T., Usman, M., & Rahman, F. U. (2005) · Primary Care Respiratory Journal · doi:10.1016/j.pcrj.2005.07.002 · Cited by 2
Une crise vaso-occlusive compliquée chez une jeune femme drépanocytaire
Prigent, H., & Carteaux, G. (2006) · Le Praticien en Anesthésie Réanimation · doi:10.1016/s1279-7960(06)75586-3 · Cited by 2
Management of sickle cell disease: acute episodes in the community and in hospital
Telfer, P. T. (2011) · Paediatrics and Child Health · doi:10.1016/j.paed.2011.08.001 · Cited by 2
ATS Core Curriculum 2016: Part III. Pediatric Pulmonary Medicine
Boyer, D. M., Thomson, C. C., Cohen, R. T., Rao, D., Dell, S., Rayment, J. H., Wang, R., Dy, F. J., Wambach, J., Tam‐Williams, J. B., et al. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-097cme · Cited by 2
Elzubeir, A. M., & Mohamed, B. A. (2013) · International Journal of Multidisciplinary and Current Research · Cited by 2
Myers, S. N., Eid, R. C., Myers, J. A., Bertolone, S. J., Panigrahi, A. R., Mullinax, J., & Raj, A. B. (2015) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000461 · Cited by 2
Sichelzellkrankheit in Deutschland
Dickerhoff, R. (2006) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-006-1420-6 · Cited by 2
Non-Cardiac Chest Pain of Non-Esophageal Origin
Almansa, C., & Achem, S. R. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4838-8_2 · Cited by 2
Sickle Cell Crisis and You: A How-to Guide
Raam, R., Mallemat, H. A., Jhun, P., & Herbert, M. (2016) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2016.04.016 · Cited by 2
Anemia and White Blood Cell Disorders
Strong, J., & Rutherford, J. M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-5908-0.00038-7 · Cited by 2
Sickle Cell Disease in Africa and the Arabian Peninsula: Current Management and Challenges
Adekile, A. D., & Makani, J. (2016) · Springer eBooks · doi:10.1007/978-3-319-06713-1_14 · Cited by 2
Pulmonary Hypertension in Sickle Cell Disease
Parent, F., Savale, L., Maître, B., & Simonneau, G. (2012) · Progress in respiratory research/Progress in research in emphysema and chronic bronchitis/Progress in respiration research · doi:10.1159/000335667 · Cited by 2
Simonson, J. L., Rosentsveyg, J., Schwartz, N. G., Agrawal, A., Koenig, S., & Zaidi, G. Z. (2020) · Journal of Intensive Care Medicine · doi:10.1177/0885066620978770 · Cited by 2
Lo, Z. C., & Sobota, A. E. (2021) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000002192 · Cited by 2
Housing Instability and Quality
Stewart, A. M., & Sandel, M. T. (2021) · Springer eBooks · doi:10.1007/978-3-030-65672-0_15 · Cited by 2
Renin-Angiotensin Blockade Reduces Readmission for Acute Chest Syndrome in Sickle Cell Disease
Wamkpah, N. S., Shrestha, A., Salzman, G. A., Simon, S., Suman, S., Poisner, A. M., & Molteni, A. (2022) · Cureus · doi:10.7759/cureus.23567 · Cited by 2
DeBaun, M. R., Frei‐Jones, M. J., & Vichinsky, E. P. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0755-7.00456-5 · Cited by 2
Self-citationManagement of sickle cell disease: management of acute episodes in the community and in hospital
Telfer, P. T. (2019) · Paediatrics and Child Health · doi:10.1016/j.paed.2019.05.004 · Cited by 2
Re‐examining a strong recommendation based on low‐quality evidence in acute chest syndrome
Hemenway, C. S. (2023) · Pediatric Blood & Cancer · doi:10.1002/pbc.30266 · Cited by 2
Managing Acute Complications of Sickle Cell Disease
Avcı, D. N. (2024) · Springer eBooks · doi:10.1007/978-3-031-74081-7_17 · Cited by 2
Acute Pain Management in Sickle Cell Disease Patients
Varadarajan, J. L., & Weisman, S. J. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511576706.035 · Cited by 2
Derivation of a risk assessment tool for emergency department patients with sickle cell disease
Bernard, A. W., Lindsell, C. J., & Venkat, A. (2008) · Emergency Medicine Journal · doi:10.1136/emj.2007.056689 · Cited by 2
Pulmonary infarction without fat or thrombo-embolism in sickle cell anaemia
Rouxel, A. M., Quiot, J.-J., Pasquier, É., & Martin, L. D. S. (2008) · Respiratory Medicine CME · doi:10.1016/j.rmedc.2008.04.009 · Cited by 2
Progress in Pathogenesis and Treatment
Ballas, S. K. (2002) · Cited by 2
Self-citationPulmonary Complications of Hematologic Diseases
Machado, R. F., & Gladwin, M. T. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00094-4 · Cited by 2
An uncommon cause of pneumonia: The golden diagnosis
Fabbri, L., Tonelli, R., Andreani, A., Castaniere, I., Fantini, R., Marchioni, A., & Clini, E. M. (2017) · Respiratory Medicine Case Reports · doi:10.1016/j.rmcr.2017.06.010 · Cited by 2
Risk Factors for Development of Acute Chest Syndrome
(2018) · AAP Grand Rounds · doi:10.1542/gr.39-5-59 · Cited by 2
Hematopoietic Cell Transplantation for Sickle Cell Disease
Walters, M. C. (2003) · Wiley eBooks · doi:10.1002/9780470987070.ch104 · Cited by 2
Roberts, S. W. (2012) · doi:10.1002/9781119963783.ch12 · Cited by 2
The Lung in Sickle Cell Disease
Murphy, T. M., & Knight‐Madden, J. (2006) · Elsevier eBooks · doi:10.1016/b978-0-7216-3695-5.50074-2 · Cited by 2
Acute complications of sickle cell disease in children
BMJ Publishing Group Ltd (2001) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2001.39533 · Cited by 2
Blood transfusions for treating acute chest syndrome in people with sickle cell disease
Alhashimi, D., Alhashimi, F., Dastgiri, S., Fedorowicz, Z., & Nasser, M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007843 · Cited by 2
Antibiotics for treating acute chest syndrome in people with sickle cell disease
Martí-Carvajal, A., Conterno, L., & Knight‐Madden, J. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006110 · Cited by 2
Hypercoagulability and Sickle Cell Disease
Colella, M. P., Paula, E. V. D., Ozelo, M. C., & Traina, F. (2016) · Springer eBooks · doi:10.1007/978-3-319-06713-1_6 · Cited by 1
Williams, S. A., & Wang, M. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139028882.003 · Cited by 1
Acute Chest Syndrome: A narrative review to guide inpatient management
Wang, K. Y., & Das, M. (2022) · American Journal of Hospital Medicine · doi:10.24150/ajhm/2022.004 · Cited by 1
Singh, U. (2023) · Springer eBooks · doi:10.1007/978-981-19-5458-0_15 · Cited by 1
Dubois, G., Virot, E., Marie, M., Poutrel, S., Cannas, G., & Hot, A. (2023) · eJHaem · doi:10.1002/jha2.768 · Cited by 1
Bodla, Z. H., Hashmi, M., Niaz, F., Auyeung, A. B., Oyetoran, A., Khalil, M. J., Faisal, M. S., Khalid, F., Zakieh, A.-R., Bazikian, Y., et al. (2024) · Hematology Reports · doi:10.3390/hematolrep16030041 · Cited by 1
Physician perspectives about the diagnosis and management of acute chest syndrome
Bhasin, N., LeBlanc, D. M., Yates, S. G., Eichbaum, Q. G., Pham, A., Sharma, D., Zhang, L., Vichinsky, E. P., & Sarode, R. (2024) · Transfusion · doi:10.1111/trf.18034 · Cited by 1
Self-citationEmergency care for children with sickle cell disease: a focus on pain and fever
Korman, R., Hatabah, D., & Morris, C. R. (2025) · Expert Review of Hematology · doi:10.1080/17474086.2025.2538537 · Cited by 1
Systematic Review of Extracorporeal Membrane Oxygenation in Adult Sickle Cell Disease
Taitoon, S. A., & Sridharan, K. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14196725 · Cited by 1
Azul, M., & Brandow, A. M. (2025) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2025.08.008 · Cited by 1
Alsaeed, A. A., Al-Eid, R. R., Amin, O. M., Alansari, A., Aleid, H., & Aleid, M. A. (2025) · Pathogens · doi:10.3390/pathogens14111174 · Cited by 1
Diatlov, D., Bohorquez, A., Kirby-Allen, M. A., & Licht, C. P. B. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025016958 · Cited by 1
Moura, M. J., Costa, É., Canelas, M. A., Maia, R., & Ramalheira, S. (2025) · Acta Médica Portuguesa · doi:10.20344/amp.23392 · Cited by 1
Srour, M. L., Landis, D. M., Kim, J., Montgomery, M., & Machado, R. F. (2026) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2026.2622719 · Cited by 1
Clinician Assessment for Acute Chest Syndrome in Febrile Children With Sickle Cell Disease Revisited
Hatabah, D., Alzraikat, N., Malik, Z. M., Lazarus, S. G., Korman, R., Bakshi, N., Rees, C. A., Hagbom, R., & Morris, C. R. (2026) · American Journal of Hematology · doi:10.1002/ajh.70213 · Cited by 1
Patil, U., Pattnaik, S. S., Nayak, S., Das, P., Mohanty, A. P., & Patro, S. (2026) · Cureus · doi:10.7759/cureus.103552 · Cited by 1
Vallelian, F., Schaer, D. J., Lechartier, B., Buehler, P. W., & Irwin, D. C. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106288 · Cited by 2
Acute Chest Syndrome in Children with Sickle Cell Disease: A Narrative Review
Ramirez, V., & Mercier‐Ross, J. (2026) · Children · doi:10.3390/children13050670 · Cited by 1
Bloc auriculoventriculaire complet transitoire chez un africain : la drépanocytose comme cause
Gacon, P.-H., Patrick Jourdain, M., Funck, F., & Amara, W. (2012) · Annales de Cardiologie et d Angéiologie · doi:10.1016/j.ancard.2012.08.035 · Cited by 1
Breathlessness and chest pain in a patient with sickle cell disease
Ranu, H., Buyck, H., Willis, F., & Madden, B. (2011) · BMJ · doi:10.1136/bmj.d3797 · Cited by 1
Enfermedad de células falciformes: papel del pediatra
Solà, S. R. (2013) · Anales de Pediatría Continuada · doi:10.1016/s1696-2818(13)70128-8 · Cited by 1
Coma fébrile et défaillance multiviscérale :suspicion d’hémoglobinopathie SC
Ouédraogo, N. A., Vincenti-Rouquette, I., Niakara, A., Nizou, J.-Y., & Brinquin, L. (2001) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/s0750-7658(01)00363-x · Cited by 1
Le syndrome thoracique aigu de l’adulte drépanocytaire
Quéré, G., Tempescul, A., Couturaud, F., Paleiron, N., Leroyer, C., & Martin, L. D. S. (2011) · Revue de Pneumologie Clinique · doi:10.1016/j.pneumo.2011.07.001 · Cited by 1
Perfluorocarbon Emulsion Therapy Attenuates Pneumococcal Infection in Sickle Cell Mice
Helmi, N. M., Andrew, P. W., & Pandya, H. C. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu653 · Cited by 1
Ajonuma, L. C., Azeez, Y., Bamiro, S. A., Lobo, M. S., Joshua, A. U., Uchechi, A. M., Chioma, E. B., Ogbedeagu, V. M., Lawson, C. C., Adabale, A., et al. (2015) · International Archives of Medicine · doi:10.3823/1784 · Cited by 1
Hypoxic-ischemic encephalopathy following vaso-occlusive crisis in hemoglobin SC disease
Kalp, M. D., Shah, R. R., & Lee‐Iannotti, J. K. (2012) · Neurology Clinical Practice · doi:10.1212/cpj.0b013e31824c6c76 · Cited by 1
Caldas, P. C. P., Boa‐Sorte, N., Amorim, T., Freitas, M., Ribeiro, R. D. A., & da Fonseca, S. F. (2010) · Cited by 1
Difficulty Breathing In Infants And Young Children: An Evidence-Based Approach
Mody, A. P., Mahmoud, G., Avner, J. R., & Cloutier, R. L. (2004) · Cited by 1
Bertholdt, S., Heijmans, C., Huybrechts, S., Dedeken, L., Devalck, C., Schifflers, S., & Ferster, A. (2012) · Cited by 1
Sickle Cell Disease and Acute Chest Syndrome: Mechanisms and Pathogenenesis
Adisa, O. A., Owusu-Ansah, A. T., Abrahams, A. O. D., Ghosh, S., & Ofori-Acquah, S. F. (2016) · Respiratory medicine · doi:10.1007/978-3-319-41912-1_3 · Cited by 1
Therapeutic Apheresis—Applications for Hemorrhagic and Thrombotic Disorders
Connelly‐Smith, L. S., & Delaney, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-46202-0.00029-7 · Cited by 1
Metadata
- Authors
- Vichinsky, E. P., Neumayr, L. D., Earles, A. N., Williams, R., Lennette, E. T., Dean, D., Nickerson, B., Orringer, E., McKie, V., Bellevue, R., Daeschner, C., Abboud, M., Moncino, M., Ballas, S., Ware, R., & Manci, E. A.
- Affiliations
- University of California, San Francisco (US)
- Children's Hospital of Orange County (US)
- University of North Carolina at Chapel Hill (US)
- Augusta University (US)
- NewYork–Presbyterian Brooklyn Methodist Hospital (US)
- East Carolina University (US)
- Duke Medical Center (US)
- University of South Alabama Medical Center (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-06-22
- Volume
- 342
- Issue
- 25
- Pages
- 1855-1865
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2332642667
- Cited by
- 1,234
- References
- 44
- Citations by year
- 2026: 35 · 2025: 55 · 2024: 52 · 2023: 62 · 2022: 59 · 2021: 67 · 2020: 75 · 2019: 44 · 2018: 48 · 2017: 38 · 2016: 63 · 2015: 51 · 2014: 57 · 2013: 59 · 2012: 51
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- University of Southern California
- University of Miami
- Emory University
- University of South Alabama
- National Institutes of Health (5p60hl020985-25)
- National Heart, Lung, and Blood Institute (HL20985, HL 99016)
- National Center for Research Resources (M01 RR 01271)
- Children's Hospital of Pittsburgh
- Topics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Blood transfusion and management
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- acute chest syndrome, sickle cell disease, pulmonary fat embolism, infection, community-acquired pneumonia, bronchodilators, bronchoscopy, mechanical ventilation, respiratory failure, neurological complications, mortality, hypoxia
- MeSH terms
- Acute Disease, Adolescent, Adult, Anemia, Sickle Cell, Blood Transfusion, Bronchodilator Agents, Chest Pain, Child, Child, Preschool, Embolism, Fat, Female, Humans, Infections, Lung Diseases, Male, Prospective Studies, Pulmonary Embolism, Respiration, Artificial, Respiratory Insufficiency, Proportional Hazards Models, Community-Acquired Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
