The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Mutations in Coagulation Factors in Women with Unexplained Late Fetal Loss
Abstract
BACKGROUND: Factor V and prothrombin-gene mutations are independent risk factors for venous thrombosis; it is debated whether a mutation in the gene encoding methylenetetrahydrofolate reductase, an enzyme involved in homocysteine metabolism, also increases the risk of venous thrombosis. Whether any of these mutations is associated with an increased risk of late fetal death is not known. METHODS: We studied 67 women with a first episode of unexplained late fetal loss (fetal death after 20 weeks or more of gestation) and 232 women who had had one or more normal pregnancies and no late fetal losses. All the women were tested for the presence of three gene mutations. Women with other thrombophilic conditions were excluded from the study. RESULTS: Eleven of the 67 women with late fetal loss (16 percent) and 13 of the 232 control women (6 percent) had either the factor V or the prothrombin mutation. The relative risks of late fetal loss in carriers of the factor V and prothrombin mutations were 3.2 (95 percent confidence interval, 1.0 to 10.9) and 3.3 (95 percent confidence interval, 1.1 to 10.3), respectively. Thirteen percent of the women whose fetuses died and 20 percent of the control women were homozygous for the mutation in the methylenetetrahydrofolate reductase gene (relative risk, 0.8; 95 percent confidence interval, 0.5 to 1.2). CONCLUSIONS: Both the factor V and the prothrombin mutations are associated with an approximate tripling of the risk of late fetal loss.
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Mutation in blood coagulation factor V associated with resistance to activated protein C
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Increased Frequency of Genetic Thrombophilia in Women with Complications of Pregnancy
Kupferminc, M. J., Eldor, A., Steinman, N., Many, A., Bar-Am, A., Jaffa, A., Fait, G., & Lessing, J. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400102 · Cited by 956
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Geographic Distribution of the 20210 G to A Prothrombin Variant
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Increased fetal loss in women with heritable thrombophilia
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Cited by
Thrombophilic disorders and fetal loss: a meta-analysis
Rey, E., Kahn, S. R., David, M., & Shrier, I. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12771-7 · Cited by 872
Thrombophilia in pregnancy: a systematic review
Robertson, L., Wu, O., Langhorne, P., Twaddle, S., Clark, P., Lowe, G. D. O., Walker, I. D., Greaves, M., Brenkel, I., Regan, L., et al. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05847.x · Cited by 849
Wu, O., Robertson, L., Twaddle, S., Lowe, G., Clark, P., Greaves, M., Walker, I., Langhorne, P., Brenkel, I., Regan, L., et al. (2006) · Health Technology Assessment · doi:10.3310/hta10110 · Cited by 489
Etiology and prevention of stillbirth
Fretts, R. C. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.03.074 · Cited by 462
Kujovich, J. L. (2011) · Genetics in Medicine · doi:10.1097/gim.0b013e3181faa0f2 · Cited by 419
Metadata
- Authors
- Martinelli, I., Taioli, E., Cetin, I., Marinoni, A., Gerosa, S., Villa, M. V., Bozzo, M., & Mannucci, P. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-10-05
- Volume
- 343
- Issue
- 14
- Pages
- 1015-1018
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2312867046
- Cited by
- 304
- References
- 32
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- closed
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