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Nephropathy and Establishment of a Renal Reservoir of HIV Type 1 during Primary Infection

Open access
Winston, Jonathan A., Bruggeman, Leslie A., Ross, Michael D., Jacobson, Jeffrey, Ross, Leora, D'Agati, Vivette D., Klotman, Paul E., Klotman, Mary E.·2001·New England Journal of Medicine

Abstract

Human immunodeficiency virus type 1 (HIV-1)–associated nephropathy is the chief cause of chronic renal disease in patients with HIV-1 infection and is now the third leading cause of end-stage renal disease in blacks 20 to 64 years of age.1,2 These patients typically have proteinuria followed by a reduction in the glomerular filtration rate that progresses to end-stage renal disease in a few weeks or months. HIV-1–associated nephropathy is characterized morphologically by focal segmental glomerulosclerosis, tubular microcysts, interstitial fibrosis, and inflammation.2–5 The pathogenesis of HIV-1–associated nephropathy is poorly understood, but increasing evidence suggests it is due to HIV-1 infection . . .

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Metadata

Authors
Winston, J. A., Bruggeman, L. A., Ross, M. D., Jacobson, J., Ross, L., D'Agati, V. D., Klotman, P. E., & Klotman, M. E.
Venue
New England Journal of Medicine
Published
2001-06-28
Volume
344
Issue
26
Pages
1979-1984
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2072707986
Cited by
315
References
0
FWCI
11.62
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Nephropathy and Establishment of a Renal Reservoir of HIV Type 1 during Primary Infection. https://app.cochat.ai/papers/10.1056/nejm200106283442604
The paper
Winston, J. A., Bruggeman, L. A., Ross, M. D., Jacobson, J., Ross, L., D'Agati, V. D., Klotman, P. E., & Klotman, M. E. (2001). Nephropathy and Establishment of a Renal Reservoir of HIV Type 1 during Primary Infection. New England Journal of Medicine. https://doi.org/10.1056/nejm200106283442604

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.