The DOI matches its Crossref record.
Emergence of Macrolide Resistance during Treatment of Pneumococcal Pneumonia
Open accessAbstract
Chemotherapy in the ElderlyTo the Editor: Sargent et al. (Oct.11 issue) 1 report that adjuvant chemotherapy with fluorouracil is as effective in older patients with resected colon cancer as it is in younger patients.Their conclusion is based on the absence of a statistically significant interaction between age and treatment effect for both overall and disease-free survival.However, the survival curves for treated and untreated patients who were more than 70 years old seem closer than the curves for treated and untreated younger patients.In our opinion, the absolute gain in survival is the measure that should be discussed with patients when deciding whether to use an adjuvant treatment.We suspect that the absolute differences in the study by Sargent et al. were small, and we would like to know what the absolute gain in survival was at each year of follow-up.
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Cited by
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Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance
Kim, S., Lieberman, T. D., & Kishony, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409800111 · Cited by 264
White, A. R. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh050 · Cited by 198
Metadata
- Authors
- Musher, D. M., Dowell, M. E., Shortridge, V. D., Flamm, R. K., Jorgensen, J. H., Le Magueres, P., & Krause, K. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2002-02-21
- Volume
- 346
- Issue
- 8
- Pages
- 630-631
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1971502282
- Cited by
- 198
- References
- 0
- FWCI
- 22.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Emergence of Macrolide Resistance during Treatment of Pneumococcal Pneumonia. https://app.cochat.ai/papers/10.1056/nejm200202213460820
- The paper
- Musher, D. M., Dowell, M. E., Shortridge, V. D., Flamm, R. K., Jorgensen, J. H., Le Magueres, P., & Krause, K. L. (2002). Emergence of Macrolide Resistance during Treatment of Pneumococcal Pneumonia. New England Journal of Medicine. https://doi.org/10.1056/nejm200202213460820
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
