Visualization of Early Engraftment in Clinical Islet Transplantation by Positron-Emission Tomography
Abstract
To the Editor: Although islet transplantation is an option for patients with type 1 diabetes, even those who become insulin-independent after engraftment have islet-graft function that is estimated...
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It is crucial to reduce the stress response within islets immediately following transplantation to reduce initial cell death, which can result in significant graft loss.
“Specifically, it is crucial to reduce the stress response within islets immediately following transplantation to reduce initial cell death, which can result in significant graft loss.56”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [56]
Early investigation of primary human islet transplants and animal studies demonstrated that 50% or more of the islet graft was lost during the first few days after transplantation.
“Early investigation of primary human islet transplants56 and animal studies122,123 demonstrated that 50% or more of the islet graft was lost during the first few days after transplantation.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [56]
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References 5 · Cited by 198
- Authors
- Eich, T., Eriksson, O., & Lundgren, T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-06-28
- Volume
- 356
- Issue
- 26
- Pages
- 2754-2755
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2071475464
- Cited by
- 198
- References
- 5
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 14 · 2019: 19 · 2018: 12 · 2017: 11 · 2016: 20 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 12
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- islet transplantation, positron emission tomography, type 1 diabetes, islet graft function, insulin independence
- MeSH terms
- Autoradiography, C-Peptide, Diabetes Mellitus, Type 1, Graft Survival, Humans, Liver, Male, Middle Aged, Tomography, X-Ray Computed, Islets of Langerhans Transplantation, Fluorodeoxyglucose F18, Positron-Emission Tomography
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