A PCSK9 Missense Variant Associated with a Reduced Risk of Early-Onset Myocardial Infarction

Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease

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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

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The Rationale for Initiating Treatment of Hypercholesterolemia in Young Adulthood

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Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

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Lipid-Modifying Drugs: Pharmacology and Perspectives

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Positive correlation between plasma PCSK9 and tissue factors levels in patients with angiographically diagnosed coronary artery disease and diabetes mellitus.

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Inhibition of PCSK9

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A Healthy Family of Familial Hypobetalipoproteinemia Caused by a Protein-truncating Variant in the PCSK9 Gene

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Association of Exome Sequences With Cardiovascular Traits Among Blacks in the Jackson Heart Study

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Familial hypobetalipoproteinemia caused by homozygous loss-of-function mutations in PCSK9: A case report

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Human Genomics in Cardiovascular Medicine

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Insights from population-based analyses of plasma lipids across the allele frequency spectrum

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Multilocus Analysis of Genetic Susceptibility to Myocardial Infarction in Russians: Replication Study

Kukava, N. G., Titov, B. V., Osmak, G. J., Matveeva, N. A., Кулакова, О. Г., Favorov, A. V., Shakhnovich, R. M., Ruda, M. Y., & Favorova, O. O. (2017) · Acta Naturae · doi:10.32607/20758251-2017-9-4-74-83 · Cited by 9

Role of SH2B3 R262W gene polymorphism and risk of coronary heart disease

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Disorders of Lipid Metabolism

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Differential Effects of DPP-4 Inhibitors, Anagliptin and Sitagliptin, on PCSK9 Levels in Patients with Type 2 Diabetes Mellitus who are Receiving Statin Therapy

Furuhashi, M., Sakuma, I., Morimoto, T., Higashiura, Y., Sakai, A., Matsumoto, M., Sakuma, M., Shimabukuro, M., Nomiyama, T., Arasaki, O., et al. (2020) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.58396 · Cited by 9

What Can Human Genetics Teach Us About the Causes of Cardiovascular Disease?

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Research Into the Genetic Component of Heart Disease: From Linkage Studies to Genome-Wide Genotyping

Elosúa, R., Lluís-Ganella, C., & Lucas, G. (2009) · Revista Española de Cardiología · Cited by 8

Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo

Schreckenberg, R., Wolf, A., Szabados, T., Gömöri, K., Szabó, I. A., Ágoston, G., Brenner, G. B., Bencsik, P., Ferdinandy, P., Schulz, R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126512 · Cited by 8

Acute Coronary Syndrome: Disparities of Pathophysiology and Mortality with and without Peripheral Artery Disease

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Association study between three polymorphisms and myocardial infarction and ischemic stroke in Chinese Han population

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Deep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS

Rahmouni, M., Clerc, S. L., Spadoni, J.-L., Labib, T., Tison, M., Medina-Santos, R., Bensussan, A., Tamouza, R., Deleuze, J., & Zagury, J. (2025) · BMC Immunology · doi:10.1186/s12865-024-00680-6 · Cited by 6

Application of Genome-Wide Association Studies in Coronary Artery Disease

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Intensive statin therapy for Indians: Part-I. Benefits.

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Opposing Effects of ABCG5/8 Function on Myocardial Infarction and Gallstone Disease

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The evolving therapeutic landscape of PCSK9 inhibition

Mansfield, B. S., Bene-Alhasan, Y. O., Ballantyne, C. M., & Raal, F. J. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.120670 · Cited by 7

Proprotein Convertase Subtilisin Kexin 9 Inhibitors

Pirillo, A., & Catapano, A. L. (2018) · Cardiology Clinics · doi:10.1016/j.ccl.2017.12.006 · Cited by 6

Relationship between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and Estimated Glomerular Filtration Rate in the General Chinese Population

Zhang, H., Zhao, X., Xu, R., Guo, Y., Zhu, C., Wu, N., Cui, C.-J., Dong, Q., & Li, J. (2018) · Cardiorenal Medicine · doi:10.1159/000490766 · Cited by 7

PCSK9 Inhibitors and Cardiovascular Disease: Impact on Cardiovascular Outcomes

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A lipidologist perspective of global lipid guidelines and recommendations, part 1: Lipid treatment targets and risk assessment

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Coronary Vessel Wall Imaging: State of the Art and Future Directions

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Small interfering RNA (siRNA) in dyslipidemia: a systematic review on safety and efficacy of siRNA

Alla, S. S. M., Shah, D. J., Meyur, S., Agarwal, P., Alla, D., Moraboina, S. L., Ghadvaje, G. V., Bayeh, R. G., Malireddi, A., Shajan, T., et al. (2025) · Journal of Experimental Pharmacology · doi:10.2147/jep.s521579 · Cited by 4

The Relationship Between Coronary Artery Disease and Genetic Polymorphisms of Melanoma Inhibitory Activity 3

Zaimkohan, H., Keramatipour, M., Mirhafez, S. R., Tavakkoly‐Bazzaz, J., Tahooni, A., Piryaei, M., Ghayour‐Mobarhan, M., & Ghaderian, S. M. H. (2016) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.31146 · Cited by 4

A lipidologist perspective of global lipid guidelines and recommendations, part 2: Lipid treatment goals

Bays, H. E. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.11.006 · Cited by 4

Evolocumab Treatment in Dyslipidemic Patients Undergoing Coronary Artery Bypass Grafting: One-Year Safety and Efficacy Results

Nasso, G., Vignaroli, W., Amodeo, V., Bartolomucci, F., Larosa, C., Contegiacomo, G., Demola, M. A., Girasoli, C., Valenzano, A., Fiore, F., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102987 · Cited by 4

Associations Between Gene Variants of Lipid‐Lowering Drug Targets and Adverse Outcomes After Ischemic Stroke

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Genetics of Atherosclerotic Cardiovascular Disease

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The pharmacology of cholesterol-lowering drugs: The pharmacology of cholesterol-lowering drugs

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Serum and genetic markers related to rapid clinical progression of coronary artery disease

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Marcadores genéticos y séricos relacionados con una rápida progresión clínica de la arteriosclerosis coronaria

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Metabolomics, Proteomics, and Genomics

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Treatment Targets in the Management of Dyslipidemias: Which Targets in Whom?

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Clinical study FOURIER

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Comment on “Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease: A Mendelian Randomization Analysis”

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SLC30A8: A Complex Road from Association to Function

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A genome-wide polygenic approach to HIV acquisition uncovers link to inflammatory bowel disease and identifies potential novel genetic variantsPreprint

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Development and validation of a next-gen health stratification engine to determine risk for multiple cardiovascular diseasesPreprint

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Review on PCSK9: A Pertinent Therapeutic Target in Cardiovascular Disease

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The Novel Lipid-Based Chronic Disease Model in Lifestyle Medicine: Impact on Prevention of Atherosclerotic Cardiovascular Disease

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Cholesterol-lowering therapy: Old evidence, new guidelines – Which one to follow? A critical appraisal

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Towards Individualized Medicine: Insights Gained from Genomic Studies

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Recommandations diététiques pour prévenir les maladies cardiovasculaires chez les patients hypercholestérolémiques

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Genome-Wide Association Studies of Glaucoma

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Lipoprotein Disorders

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Lipidsenkende Therapie im Alter

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PCSK9 Gene Polymorphisms Associated With the Risk of Myocardial Infarction in Iranian Patients

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The Genetic and Proteomic Detereminants of the Risk of Coronary Artery Disease

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Genome-wide scan and fine-mapping of rare nonsynonymous associations implicates intracellular lipolysis genes in fat distribution and cardio-metabolic riskPreprint

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The Genetics of Coronary Heart Disease

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The Promise of Proprotein Convertase Subtilisin/Kexin 9 Inhibitors for the Treatment of Familial Hypercholesterolemia

Pokharel, Y., Virani, S. S., & Ballantyne, C. M. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0508-7

Clinical Research Regional Distribution and Metabolic Effect of PCSK9 insLEU and R46L Gene Mutations and apoE Genotype

Awan, Z. A., DELVIN, E. E., Levy, E. H., Genest, J. J., Davignon, J., Seidah, N. G., & Baass, A. W. (2013)

Genetics of Cardiovascular Disease and Its Role in Risk Prediction

Musunuru, K., & Kathiresan, S. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1366-4.00004-4

Lipoprotein Disorders

Kathiresan, S., & Rader, D. J. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-369420-1.00055-x

Is LDL apheresis a thing of the past?

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New Agents for Treatment of Dyslipidemia

Simha, V. (2021) · Clinical Dilemmas in Diabetes · doi:10.1002/9781119603207.ch17

Genetics of (Premature) Coronary Artery Disease

Schunkert, H., & Erdmann, J. (2010) · Springer eBooks · doi:10.1007/978-1-84996-471-5_23

MicroRNAs and their role in immunogenetic-dysregulation

Wani, J. A., Ali, S., Khan, I. S., Khan, M. S., Ali, S., Majid, S., & Rehman, M. U. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90053-9.00005-1

Genetics of (Premature) Coronary Artery Disease

Erdmann, J., & Schunkert, H. (2016) · Springer eBooks · doi:10.1007/978-3-319-44203-7_22

Genetics of (Premature) Coronary Artery Disease

Erdmann, J., & Schunkert, H. (2020) · Springer eBooks · doi:10.1007/978-3-030-45457-9_24

Peer Review #2 of "A bibliometric analysis in gene research of myocardial infarction from 2001 to 2015 (v0.1)"

(2018) · PeerJ · doi:10.7287/peerj.4354v0.1/reviews/2

Peer Review #1 of "A bibliometric analysis in gene research of myocardial infarction from 2001 to 2015 (v0.1)"

(2018) · PeerJ · doi:10.7287/peerj.4354v0.1/reviews/1

Peer Review #3 of "A bibliometric analysis in gene research of myocardial infarction from 2001 to 2015 (v0.1)"

(2018) · PeerJ · doi:10.7287/peerj.4354v0.1/reviews/3

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: Efficacy and Safety in the Treatment of Hypercholesterolaemia

Berberoğlu, Z. (2018) · EMJ Diabetes · doi:10.33590/emjdiabet/10311250

Papers that describe genetic association studies

Greenhalgh, T., & Dijkstra, P. (2024) · Wiley eBooks · doi:10.1002/9781394206933.ch15

Deep analysis of the Major Histocompatibility Complex associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDSPreprint

Rahmouni, M., Clerc, S. L., Spadoni, J., Labib, T., Tison, M., Santos, R. M., Bensussan, A., Tamouza, R., Deleuze, J., & Zagury, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.07.625684

Clinical Effect of Evolocumab treatment in coronary artery bypass surgeryPreprint

Nasso, G., Santarpino, G., Vignaroli, W., Calabrese, V., Taverna, G., Rosa, I., Rosa, I., Bartolomucci, F., Montemurro, V., Mastroroberto, P., et al. (2025) · medRxiv · doi:10.1101/2025.03.20.25324358

Additional file 2 of Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms

Frostegård, J., Ahmed, S., Hafström, I., Ajeganova, S., & Rahman, M. (2021) · Figshare · doi:10.6084/m9.figshare.13605367

Additional file 1 of Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms

Frostegård, J., Ahmed, S., Hafström, I., Ajeganova, S., & Rahman, M. (2021) · Figshare · doi:10.6084/m9.figshare.13605364

Clinical effect of proprotein convertase subtilisin/kexin type 9 inhibition in patients undergoing coronary artery bypass surgery

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Modulation pharmacologique et génétique de la fonctionnalité des particules HDL : Conséquences sur le risque cardiovasculaire et le développement de l'athérosclérose

Khoury, P. E. (2014) · theses.fr (ABES) · doi:10.70675/1e05691dz180az4a7cza646z9fa1adb042ac

Genetic causes of cardiovascular disease : special focus on familial hypercholesterolemia and thoracic aortic aneurysms

Elbitar, S. (2018) · theses.fr (ABES) · doi:10.70675/0d164341z4f5cz438cz9edazc7cc446db7a4

Hypercholestérolémie familiale : recherche de nouveaux gènes et étude des formes polygéniques

Ghaleb, Y. (2017) · theses.fr (ABES) · doi:10.70675/ab0b16eez4c40z4cb7zb42fzb7740e0c98ea

Facteurs biologiques et morphologiques prédictifs de récurrences ischémiques et hémorragiques dans l’athéro-thrombose

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A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

Helgadóttir, A., Þorleifsson, G., Manolescu, A. R., Grétarsdóttir, S., Blöndal, T., Jónasdóttir, Á., Jonasdottir, A., Sigurðsson, Á., Baker, A., Pálsson, A., et al. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000279313.65556.85 · Cited by 83

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

Ardissino, D., Berzuini, C., Merlini, P. A., Mannuccio Mannucci, P., Surti, A., Burtt, N., Voight, B., Tubaro, M., Peyvandi, F., Spreafico, M., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.075 · Cited by 80

Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis

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The Common Variant Rs9939609 In The FTO Gene Is Associated With Early-onset Myocardial Infarction (ABSTRACT).

Merlini, P., Berzuini, C., Mannucci, P. M., Peyvandi, F., Tubaro, M., Lina, D., Notarangelo, M. F., Foco, L., Bernardinelli, L., & Ardissino, D. (2008) · Research Explorer (The University of Manchester)

ASSOCIATION BETWEEN GENETIC VARIANTS IN PCSK9/ APOB/ LDLR AND PREMATURE MYOCARDIAL INFARCTION IN HAN CHINESE

Pu, T., Yu, H., Xu, M., & Gao, W. D. (2018) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(18)30655-7