APOE Kyoto Mutation in European Americans with Lipoprotein Glomerulopathy
Abstract
To the Editor: Lipoprotein glomerulopathy is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries.1 It ...
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LPG is more often reported in eastern Asian countries, but cases have also been observed in Europe and America.
“It is more often reported in eastern Asian countries, however cases have also been observed in Europe and America [2–4].”
From Lipoprotein glomerulopathy associated with the Osaka/Kurashiki APOE variant: two cases identified in Latin America (2021) · cites this paper as [3]
APOE Kyoto has been distributed worldwide, not only among Asians in China and Japan, but also among Caucasians in Europe and the USA.
“Furthermore, APOE Kyoto has been distributed worldwide, not only among Asians in China and Japan, but also among Caucasians in Europe and the USA [5, 16, 26].”
From Identification of a founder haplotype of <i>APOE Kyoto</i> variant in lipoprotein glomerulopathy (2025) · cites this paper as [26]
APOE Kyoto carriers in whom the disease develops may have a second defect that reduces clearance of abnormal lipoprotein through pathways independent of the LDL receptor, allowing excessive accumulation of thrombi and the development of clinical kidney disease.
“Rovin et al. [26] reported that the glomerular lipoprotein deposition could be seen in renal biopsy of asymptomatic carrier, which suggested that APOE Kyoto carriers in whom the disease develops may have a second defect that reduces clearance of abnormal lipoprotein through pathways that are independent of the LDL receptor, which allows for excessive accumulation of thrombi and the development of”
From Identification of a founder haplotype of <i>APOE Kyoto</i> variant in lipoprotein glomerulopathy (2025) · cites this paper as [26]
Most reported lipoprotein glomerulopathy cases were sporadic, and some were familial.
“In previous literature reports, most cases were sporadic, and some cases were familial [7, 8, 15, 29–33].”
From A novel apolipoprotein E mutation, ApoE Ganzhou (Arg43Cys), in a Chinese son and his father with lipoprotein glomerulopathy: two case reports (2022) · cites this paper as [15]
Only 10 cases of LPG (including this one) have been reported from North America, and previously only 5 included gene sequencing.
“Only 10 cases of LPG (including this one) have been reported from North America,2,18,21–26 and previously only 5 of these included gene sequencing: 3 APOE Kyoto,18,23 1 APOE Chicago,22 1 APOE Las Vegas.25”
From Lipoprotein Glomerulopathy, First Case Report from Canada (2022) · cites this paper as [23]
Cites
Murano, T., Matsumura, R., Misawa, Y., Ozaki, H., Miyashita, Y., Yoshida, S., Sueioshi, M., Sugiyama, T., & Shirai, K. (2002) · Metabolism · doi:10.1053/meta.2002.29990 · Cited by 27 · see citing works
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APOE gene variants in primary dyslipidemia
Khalil, Y. A., Rabès, J.-P., Boileau, C., & Varret, M. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.05.007 · Cited by 170 · see citing works
Mitani, A., Ishigami, M., Watase, K., Minakata, T., & Yamamura, T. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.7377 · Cited by 24 · see citing works
A founder haplotype of APOE-Sendai mutation associated with lipoprotein glomerulopathy
Toyota, K., Hashimoto, T., Ogino, D., Matsunaga, A., Ito, M., Masakane, I., Degawa, N., Sato, H., Shirai, S., Umetsu, K., et al. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2013.8 · Cited by 19 · see citing works
Clinical and genetic analysis of lipoprotein glomerulopathy patients caused by <i>APOE</i> mutations
Yang, M., Weng, Q., Pan, X., Hussain, H. M. J., Yu, S., Xu, J., Yu, X., Liu, Y., Jin, Y., Zhang, C., et al. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1281 · Cited by 15 · see citing works
Common Apolipoprotein E Gene Mutations Contribute to Lipoprotein Glomerulopathy in China
Han, J., Pan, Y., Chen, Y., Li, X., Xing, G., Shi, J., Hou, P., Zhang, H., & Wang, H. (2010) · Nephron Clinical Practice · doi:10.1159/000276578 · Cited by 13 · see citing works
Lipoprotein Glomerulopathy, First Case Report from Canada
Ting, J. A., McRae, S. A., Schwartz, D., Barbour, S. J., & Riazy, M. (2022) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s364890 · Cited by 7 · see citing works
da Silveira-Neto, J. N., de Oliveira Ahn, G. J., de Menezes Neves, P. D. M., Baptista, V. A. F., de Almeida Araújo, S., Wanderley, D. C., Watanabe, A., Watanabe, E. H., Murai, N. M., Bertollo, E. M. G., et al. (2021) · Diagnostic Pathology · doi:10.1186/s13000-021-01119-x · Cited by 6 · see citing works
Wang, R., Zhao, C., Chen, W., Liu, Z., & Xie, F. (2022) · Journal of Medical Case Reports · doi:10.1186/s13256-022-03302-0 · Cited by 5 · see citing works
Li, Y., Chen, J., Zou, Y., Wang, W., & Li, G. (2022) · Medicine · doi:10.1097/md.0000000000028718 · Cited by 5 · see citing works
Li, M., Li, Y., Jiang, L., Wang, X., Liu, Z., Song, Z., You, R., Chen, Y., Zhou, X., & Zhang, H. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003978
Identification of a founder haplotype of <i>APOE Kyoto</i> variant in lipoprotein glomerulopathy
Wu, H., He, Z., Yang, J., Zhou, Y., Yang, Z., Hu, Z., & Yang, Y. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf234
- Authors
- Rovin, B. H., Roncone, D., McKinley, A., Nadasdy, T., Korbet, S. M., & Schwartz, M. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-12-13
- Volume
- 357
- Issue
- 24
- Pages
- 2522-2524
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2089409921
- Cited by
- 35
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 4 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 6 · 2012: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- lipoprotein glomerulopathy, European Americans, proteinuria, renal failure, glomerular capillaries, genetic susceptibility
- MeSH terms
- Genotype, Glomerulonephritis, Humans, Kidney Glomerulus, Lipoproteins, Male, Mutation, Pedigree, White People, Apolipoprotein E2
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