Reduced cortisol metabolism during critical illness.
Abstract
sponsorship: British Heart Foundation|RG/11/4/28734
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Critically ill patients have paradoxically low ACTH levels and exhibit impaired cortisol clearance, which contributes to the observed hypercortisolism.
“Elevated cortisol concentrations in acute stress have traditionally been attributed to stress-induced activation of the HPA axis with ACTH-driven cortisol secretion, however studies have shown that critically ill patients have paradoxically low ACTH levels and exhibit impaired cortisol clearance which contributes to the observed hypercortisolism.24”
From Adrenal crisis: prevention and management in adult patients (2019) · cites this paper as [24]
Cites
Annane, D. (2000) · JAMA · doi:10.1001/jama.283.8.1038 · Cited by 1,000 · see citing works
Reduced Cortisol Metabolism during Critical Illness
Boonen, E., Vervenne, H., Meersseman, P., Andrew, R., Mortier, L., Declercq, P. E., Vanwijngaerden, Y.-M., Spriet, I., Wouters, P. J., Vander Perre, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214969 · Cited by 477 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Myers, B., McKlveen, J. M., & Herman, J. P. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.12.003 · Cited by 318 · see citing works
Adrenal crisis: prevention and management in adult patients
Dineen, R., Thompson, C. J., & Sherlock, M. (2019) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018819848218 · Cited by 123 · see citing works
Dorin, R. I., Urban, F. K., Perogamvros, I., & Qualls, C. R. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac173 · Cited by 4 · see citing works
- Authors
- Schelling, G., Hauer, D., & Pfob, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2013-08
- Volume
- 369
- Issue
- 5
- Pages
- 479-481
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3149898234
- Cited by
- 23
- References
- 2
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 6 · 2016: 4 · 2014: 1 · 2013: 2
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- New England Journal of Medicine
- Funders
- National Institute for Health and Care Research (NF-SI-0508-10356)
- British Heart Foundation (RG/11/4/28734)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- cortisol metabolism, critical illness, glucocorticoids, stress response, catabolism
- MeSH terms
- Adrenocorticotropic Hormone, Female, Humans, Hydrocortisone, Male, Critical Illness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
