Heparin-Induced Thrombocytopenia Presenting as Bilateral Adrenal Hemorrhages

Temporal Aspects of Heparin-Induced Thrombocytopenia

Warkentin, T. E., & Kelton, J. G. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104263441704 · Cited by 977

Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis

Warkentin, T. E., & Kelton, J. G. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-7-200110020-00009 · Cited by 463

A Comparison of Danaparoid and Lepirudin in Heparin-induced Thrombocytopenia

Farner, B., Eichler, P., Kroll, H., & Greinacher, A. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615946 · Cited by 192

Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder

Warkentin, T. E., Basciano, P. A., Knopman, J., & Bernstein, R. A. (2014) · Blood · doi:10.1182/blood-2014-01-549741 · Cited by 159

Autoimmune heparin‐induced thrombocytopenia

Greinacher, A., Selleng, K., & Warkentin, T. E. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13813 · Cited by 414

Heparin-Induced Thrombocytopenia

Greinacher, A., Bakchoul, T., Cuker, A., & Warkentin, T. E. (1997) · Elsevier eBooks · doi:10.1002/9781118520093.ch30 · Cited by 194

Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management

Hogan, M., & Berger, J. S. (2020) · Vascular Medicine · doi:10.1177/1358863x19898253 · Cited by 183

Assembly of Metal–Phenolic/Catecholamine Networks for Synergistically Anti-Inflammatory, Antimicrobial, and Anticoagulant Coatings

Li, X., Gao, P., Tan, J., Xiong, K., Maitz, M. F., Pan, C., Wu, H., Chen, Y., Yang, Z., & Huang, N. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b14409 · Cited by 172

Heparin-Induced Thrombocytopenia

Arepally, G. M., & Padmanabhan, A. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315445 · Cited by 159

How do we approach thrombocytopenia in critically ill patients?

Thachil, J. V., & Warkentin, T. E. (2016) · British Journal of Haematology · doi:10.1111/bjh.14482 · Cited by 125

COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory Analysis

Bilotta, C., Perrone, G., Adelfio, V., Spatola, G. F., Uzzo, M. L., Argo, A., & Zerbo, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729251 · Cited by 122

Spontaneous HIT syndrome: Knee replacement, infection, and parallels with vaccine-induced immune thrombotic thrombocytopenia

Warkentin, T. E., & Greinacher, A. (2021) · Thrombosis Research · doi:10.1016/j.thromres.2021.05.018 · Cited by 109

Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia

Warkentin, T. E. (2016) · Thrombosis and Haemostasis · doi:10.1160/th16-06-0435 · Cited by 85

The Non-Hemostatic Aspects of Transfused Platelets

Sut, C., Tariket, S., Aubron, C., Aloui, C., Hamzeh‐Cognasse, H., Berthelot, P., Laradi, S., Greinacher, A., Garraud, O., & Cognasse, F. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00042 · Cited by 73

Platelet-activating anti-PF4 disorders: An overview

Warkentin, T. E. (2022) · Seminars in Hematology · doi:10.1053/j.seminhematol.2022.02.005 · Cited by 71

Heparin-Induced Thrombocytopenia

Arepally, G. M., & Padmanabhan, A. (2012) · CRC Press eBooks · doi:10.3109/9781841848617 · Cited by 67

Spontaneous HIT syndrome post-knee replacement surgery with delayed recovery of thrombocytopenia: a case report and literature review

Poudel, D. R., Ghimire, S., Dhital, R., Forman, D. A., & Warkentin, T. E. (2017) · Platelets · doi:10.1080/09537104.2017.1366973 · Cited by 59

Heparin-induced thrombocytopenia

Warkentin, T. E. (2015) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000259 · Cited by 58

Cerebral venous sinus thrombosis associated with spontaneous heparin-induced thrombocytopenia syndrome after total knee arthroplasty

Hwang, S. R., Wang, Y., Weil, E. L., Padmanabhan, A., Warkentin, T. E., & Pruthi, R. K. (2020) · Platelets · doi:10.1080/09537104.2020.1828574 · Cited by 52

Autoimmune Heparin-Induced Thrombocytopenia

Warkentin, T. E. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216921 · Cited by 50

Management of heparin-induced thrombocytopenia

Warkentin, T. E., & Greinacher, A. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000273 · Cited by 50

Use of intravenous immunoglobulin G to treat spontaneous heparin‐induced thrombocytopenia

Irani, M. S., Siegal, E. M., Jella, A., Aster, R. H., & Padmanabhan, A. (2018) · Transfusion · doi:10.1111/trf.15105 · Cited by 49

Investigation of anti-PF4 versus anti-PF4/heparin reactivity using fluid-phase enzyme immunoassay for 4 anti-PF4 disorders: classic heparin-induced thrombocytopenia (HIT), autoimmune HIT, vaccine-induced immune thrombotic thrombocytopenia, and spontaneous HIT

Warkentin, T. E., Arnold, D. M., Sheppard, J. I., Moore, J. C., Kelton, J. G., & Nazy, I. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.04.034 · Cited by 37

Delayed-onset heparin-induced thrombocytopenia without thrombosis in a patient receiving postoperative thromboprophylaxis with rivaroxaban

Tardy-Poncet, B., Piot, M., Montmartin, A., Burdier, A., Chalayer, É., & Tardy, B. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-07-0593 · Cited by 26

Heparin‐induced thrombocytopenia‐associated thrombosis: from arterial to venous to venous limb gangrene

Warkentin, T. E. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14264 · Cited by 23

Temporal presentations of heparin‐induced thrombocytopenia following cardiac surgery: A single‐center, retrospective cohort study

Warkentin, T. E., Sheppard, J. I., & Whitlock, R. P. (2022) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15826 · Cited by 19

Spontaneous heparin-induced thrombocytopenia presenting as bilateral adrenal hemorrhages and pulmonary embolism after total knee arthroplasty

Elshoury, A., Khedr, M., Abousayed, M. M., & Mehdi, S. B. (2015) · Arthroplasty Today · doi:10.1016/j.artd.2015.07.003 · Cited by 19

The Changing Face of Drug-induced Adrenal Insufficiency in the Food and Drug Administration Adverse Event Reporting System

Raschi, E., Fusaroli, M., Massari, F., Mollica, V., Repaci, A., Ardizzoni, A., Poluzzi, E., Pagotto, U., & Di Dalmazi, G. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac359 · Cited by 17

Spontaneous heparin-induced thrombocytopenia syndrome presenting as bilateral adrenal infarction after knee arthroplasty

Vanderveer, E., Torbiak, R. P., Prebtani, A. P. H., & Warkentin, T. E. (2019) · BMJ Case Reports · doi:10.1136/bcr-2019-232769 · Cited by 17

Role of ascorbic acid in dapsone induced methemoglobinemia

Sahu, K. K., & Mishra, A. K. (2019) · Clinical and Experimental Emergency Medicine · doi:10.15441/ceem.18.077 · Cited by 14

Bilateral adrenal haemorrhage: a cause of haemodynamic collapse in heparin-induced thrombocytopaenia

Saleem, N., Khan, M., Parveen, S., & Balavenkataraman, A. (2016) · BMJ Case Reports · doi:10.1136/bcr-2016-214679 · Cited by 11

“Spontaneous” Heparin-Induced Thrombocytopenia and Thrombosis After Total Knee Arthroplasty: A Report of 2 Cases

Olevsky, O. M., & Rosove, M. H. (2021) · Arthroplasty Today · doi:10.1016/j.artd.2021.03.005 · Cited by 9

Prediction of Heparin Induced Thrombocytopenia (HIT) Using a Combination of 4Ts Score and Screening Immune Assays

Thawani, R., Nannapaneni, S., Kumar, V., Oo, P., Simon, M. A., Huang, A., Malhotra, I., & Xu, Y. (2020) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029620962857 · Cited by 6

Heparin-Induced Thrombocytopenia

Warkentin, T. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-46202-0.00026-1 · Cited by 6

Spontaneous heparin-induced thrombocytopaenia with adrenal haemorrhage following orthopaedic surgery: a case report and literature review

Saengboon, S., Chinthammitr, Y., & Kanitsap, N. (2021) · BMJ Case Reports · doi:10.1136/bcr-2021-245385 · Cited by 5

Spontaneous bilateral adrenal hemorrhage following cholecystectomy

Dahan, M., Lim, C., Salloum, C., & Azoulay, D. (2016) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2015.12.09 · Cited by 5

La thrombopénie induite par héparine : mise au point

Camoin‐Jau, L., Mariotti, A., Suchon, P., & Morange, P. (2021) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2021.08.011 · Cited by 4

Anti-platelet Factor 4 Antibody-Mediated Disorders: An Updated Narrative Review

Napolitano, A., Spiezia, L., Biolo, M., Radu, C. M., Toffanin, S., Campello, E., & Simioni, P. (2025) · Seminars in Thrombosis and Hemostasis · doi:10.1055/a-2528-5425 · Cited by 4

Severe Autoimmune LMWH-Induced Thrombocytopenia Presenting with Aortic Thromboses, Adrenal Hemorrhage and Pulmonary Embolism: Response to High-Dose Intravenous Immunoglobulin

Nero, J., Araneta, P., Warkentin, T. E., & Moodley, O. (2018) · Canadian Journal of General Internal Medicine · doi:10.22374/cjgim.v13i3.254 · Cited by 4

Heparin-Induced Thrombocytopenia

Warkentin, T. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35762-3.00133-5 · Cited by 4

Adrenal failure secondary to bilateral adrenal haemorrhage in heparin-induced thrombocytopenia

Tedjaseputra, A., Sawyer, M., Lim, A., Grabek, J., & Low, M. S. Y. (2020) · Annals of Hematology · doi:10.1007/s00277-019-03851-3 · Cited by 3

A 65-Year-Old Man with Bilateral Adrenal Hemorrhage Following Prophylaxis for Postoperative Deep Vein Thrombosis with Rivaroxaban

Al-Rawi, S., Seidahmed, M., Emam, S. S., & Othman, E. S. (2023) · American Journal of Case Reports · doi:10.12659/ajcr.939816 · Cited by 3

Left atrial thrombosis due to heparin-induced thrombocytopenia

Aksu, U., Gülcü, O., & Topçu, S. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.107 · Cited by 3

Bilateral adrenal hemorrhages in a patient with heparin-induced thrombocytopenia

Montealegre-Gallegos, M., & Bose, S. (2019) · Canadian Medical Association Journal · doi:10.1503/cmaj.190379 · Cited by 3

Heparin-induced thrombocytopenia presenting as splenic hemorrhage following cardiac surgery: a case report

Ferry, J. F., Youssef, S., Wu, P., & Hegerova, L. T. (2021) · Thrombosis Journal · doi:10.1186/s12959-021-00257-y · Cited by 2

When a crisis hits: bilateral adrenal haemorrhage – a case report

Windsor, F., & Ralhan, S. (2020) · Clinical Medicine · doi:10.7861/clinmed.20-2-s40 · Cited by 2

A career in solving clinical‐pathological conundrums: Heyde syndrome , anti‐platelet factor 4 disorders, and microvascular limb ischemic necrosis

Warkentin, T. E. (2024) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.14261 · Cited by 2

Spontaneous Heparin-Induced Thrombocytopenia Following Orthopaedic Surgery: Case Report and Review of the Literature

DeBaun, M. R., Spinner, M. A., Genualdi, M. D., Berube, C., & Amanatullah, D. F. (2017) · Open Journal of Orthopedics · doi:10.4236/ojo.2017.712042 · Cited by 1

Bleeding, Heparin-induced thrombocytopenia, and Other adverse reactions

Green, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818781-4.00005-4 · Cited by 1

Suprarenal gland hemorrhage: A bleeding manifestation that may be caused by thrombosis of efferent veins

Girolami, A., Cosi, E., Ferrari, S., Girolami, B., & Randi, M. L. (2018) · Cardiovascular Disorders and Medicine · doi:10.15761/cdm.1000174

Unilateral suprarenal hemorrhage in a teenager: A case of TAFRO

Orrigio, K., Jackson, M. E., Fuller, A. E., Ali, Y., & Avila, L. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.29475

Heparin

(2015) · Reactions Weekly · doi:10.1007/s40278-015-7996-7

Adrenal Gland

Kremer, N., & Squires, J. H. (2015) · Springer eBooks · doi:10.1007/978-3-319-21699-7_14

Generierung von HIT Antikörpern im Rahmen orthopädischer Eingriffe ohne Heparinexposition

Liebig, M. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.71689

Special Populations: Pulmonary Embolism and Heparin-Induced Thrombocytopenia and Thrombosis

Homssi, A. A., & Kreuziger, L. B. (2023) · Springer eBooks · doi:10.1007/978-3-030-70904-4_32-1

Special Populations: Pulmonary Embolism and Heparin-Induced Thrombocytopenia and Thrombosis

Homssi, A. A., & Kreuziger, L. B. (2023) · Springer eBooks · doi:10.1007/978-3-030-70904-4_32-2

Unexplained Bilateral Adrenal Hemorrhage and Adrenal Insufficiency Unveiling Burkitt's Lymphoma

Oweidat, M. H., Rumilah, A. A., Maraqa, M. A., & Natsheh, M. A. (2025) · AACE Endocrinology and Diabetes · doi:10.1016/j.aed.2025.03.007

Heparin-Induced Thrombocytopenia

Warkentin, T. E., Cuker, A. C., & Greinacher, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-96352-0_1

Delayed-onset, persisting autoimmune heparin-induced thrombocytopenia with thrombosis following craniofacial surgery

Will, V., Tritschler, T., & Marx, C. E. (2026) · BMJ Case Reports · doi:10.1136/bcr-2025-269479

Special Populations: Pulmonary Embolism and Heparin-Induced Thrombocytopenia and Thrombosis

Homssi, A. A., & Kreuziger, L. B. (2025) · Springer eBooks · doi:10.1007/978-3-030-70904-4_32-3

Détermination des prédicteurs de sévérité des effets indésirables receveurs au cours des transfusions de concentrés plaquettaires

Sut, C. (2017) · theses.fr (ABES) · doi:10.70675/0985f537z5d88z4470za3dazecd6fc94dc34

Spontaneous Post-Orthopedic HIT-Like Syndrome: A Case Report and Literature Review with a Diagnostic and Therapeutic Guidance

Zermatten, M. G., Friedrich, N., Grandoni, F., Gavillet, M., Aliotta, A., & Alberio, L. (2026) · TH Open · doi:10.1055/a-2978-5120

Severe methemoglobinemia due to topical dapsone misuse in a teenage girl

Yale, S. C., Stefanko, N. S., McCarthy, P. M., McFadden, V. C., & McCarthy, J. J. (2019) · Pediatric Dermatology · doi:10.1111/pde.14080 · Cited by 10

Methemoglobinemia as a Complication of Topical Dapsone Therapy

Callen, J. P. (2015) · Journal watch · doi:10.1056/nejm-jw.na36987

Case Report of Methemoglobinemia in a Toddler Secondary to Topical Dapsone Exposure

Graff, D. M., Bosse, G. M., & Sullivan, J. E. (2016) · PEDIATRICS · doi:10.1542/peds.2015-3186 · Cited by 18

Methemoglobinemia as a Complication of Topical Dapsone

Watton, C., Smith, K., & Carter, E. (2015) · New England Journal of Medicine · doi:10.1056/nejmc1408272 · Cited by 44

Methemoglobinemia from dapsone therapy for suspected dermatitis herpetiformis

Delicou, S., & Andreopoulos, A. (2014) · Aristotle University Medical journal/Aristotle University Medical Journal