The target of metformin in type 2 diabetes
Abstract
Despite the prevalent use of metformin as a first-line treatment of type 2 diabetes, its target has proved elusive. A recent study has uncovered a target.
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It has been hypothesized that pharmacologic strategies effective in preventing diabetes while decreasing insulin resistance may prevent Alzheimer's disease.
“it has been hypothesized that pharmacologic strategies effective in preventing diabetes while decreasing insulin resistance may prevent AD [24].”
From Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial (2016) · cites this paper as [24]
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References 5 · Cited by 136
- Authors
- Ferrannini, E.
- Affiliations
- University of Pisa (IT)
- Corresponding author
- Ferrannini, Ele
- ORCID
- Ferrannini, Ele
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-10-16
- Volume
- 371
- Issue
- 16
- Pages
- 1547-1548
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2324847430
- Cited by
- 136
- References
- 5
- Citations by year
- 2025: 5 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 7 · 2018: 13 · 2017: 16 · 2016: 20 · 2015: 19 · 2014: 1
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- metformin, type 2 diabetes, therapeutic target, first-line therapy, antidiabetic drugs
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Dihydroxyacetone Phosphate, Gluconeogenesis, Glycerolphosphate Dehydrogenase, Humans, Hypoglycemic Agents, Liver, Metformin, Mitochondria, Lactic Acid, Rats
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