Muscling in on cancer
Abstract
Investigators recently described a study of mouse models of cancer, in which they found that contracting muscle fibers synthesize an anticancer myokine, interleukin-6.
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A few mechanistic studies have demonstrated a potential role of other myokines, including Oncostatin M, irisin, and SPARC in the suppression of breast and colon cancer growth.
“A few mechanistic studies have demonstrated a potential role of other myokines, including Oncostatin M, irisin, and SPARC in the suppression of breast and colon cancer growth (41, 224-227).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [226]
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References 6 · Cited by 53
- Authors
- Lucia, A., & Ramírez, M.
- Affiliations
- Research Institute Hospital 12 de Octubre (ES)
- ORCID
- Ramírez, Manuel
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-09
- Volume
- 375
- Issue
- 9
- Pages
- 892-894
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2514199640
- Cited by
- 53
- References
- 6
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 2
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- muscle contraction, myokines, interleukin-6, cancer, mouse tumor model, muscle fibers
- MeSH terms
- Humans, Killer Cells, Natural, Neoplasms, Exercise, Interleukin-6, Muscle, Skeletal
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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