Case 38-2015: A 21-Year-Old Man with Fatigue and Weight Loss
Abstract
A 21-year-old man was admitted to this hospital because of fatigue, weight loss, tender gynecomastia, hyperthyroidism, and lesions in the lungs and liver on radiographic imaging. Diagnostic procedures were performed.
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Patients with testicular choriocarcinoma presenting with overt thyrotoxicosis may have widely metastatic disease at presentation.
“Therefore, patients with testicular choriocarcinoma presenting with overt thyrotoxicosis may have widely metastatic disease at presentation (667,668).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [667]
Patients with choriocarcinoma, including molar pregnancy and testicular cancer, may present with thyrotoxicosis because of the effect of tumor-derived hCG upon the TSH receptor.
“Patients with choriocarcinoma, including molar pregnancy and testicular cancer, may present with thyrotoxicosis because of the effect of tumor-derived hCG upon the TSH receptor (665-668).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [667]
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References 27 · Cited by 9
- Authors
- Pallais, J. C., McInnis, M., Saylor, P. J., & Wu, R. I.
- Affiliations
- Massachusetts General Hospital (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-12-10
- Volume
- 373
- Issue
- 24
- Pages
- 2358-2369
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320384004
- Cited by
- 9
- References
- 27
- Citations by year
- 2024: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Male Breast Health Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Surgery › Medical Case Reports and Studies
- Keywords
- gynecomastia, hyperthyroidism, fatigue, weight loss, lung lesions, liver lesions, young men, differential diagnosis
- MeSH terms
- Choriocarcinoma, Diagnosis, Differential, Fatigue, Chorionic Gonadotropin, Gynecomastia, Humans, Hyperthyroidism, Liver, Liver Neoplasms, Lung, Male, Teratoma, Testicular Neoplasms, Testis, Weight Loss, Young Adult
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