Testosterone Deficiency and Replacement in Older Men
Abstract
It is now clear that men have gradual declines in average serum testosterone levels as they age. These decreases begin by middle age and continue into old age.1,2 Although the decreases are substantial in many men, they are quite variable. Some men, even in old age, maintain serum testosterone levels similar to those of healthy young men.Many of the physical and behavioral changes that occur in men as they age are similar to those that occur in younger men with hypogonadism. These changes include decreases in muscle mass, strength, bone mass, and sexual function and increases in body . . .
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Testosterone has important beneficial effects on muscle mass and strength, adiposity, bone density, and vigor and well-being.
“Testosterone is critical in male sexual behavior and reproduction, but also has important beneficial effects on muscle mass and strength, adiposity, bone density, and vigor and well-being.4”
From Effect of 1 Week of Sleep Restriction on Testosterone Levels in Young Healthy Men (2011) · cites this paper as [4]
Testosterone is critical in male sexual behavior and reproduction.
“Testosterone is critical in male sexual behavior and reproduction, but also has important beneficial effects on muscle mass and strength, adiposity, bone density, and vigor and well-being.4”
From Effect of 1 Week of Sleep Restriction on Testosterone Levels in Young Healthy Men (2011) · cites this paper as [4]
Cites
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954 · see citing works
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861 · see citing works
Self-citationAdverse Events Associated with Testosterone Administration
Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000485 · Cited by 1,494 · see citing works
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Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men
Finkle, W. D., Greenland, S., Ridgeway, G. K., Adams, J. L., Frasco, M. A., Cook, M. B., Fraumeni, J. F., & Hoover, R. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085805 · Cited by 735 · see citing works
Effect of 1 Week of Sleep Restriction on Testosterone Levels in Young Healthy Men
Leproult, R. (2011) · JAMA · doi:10.1001/jama.2011.710 · Cited by 296 · see citing works
- Authors
- Bremner, W. J.
- Affiliations
- University of Washington (US)
- Corresponding author
- Bremner, William J.
- ORCID
- Bremner, William J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-07-08
- Volume
- 363
- Issue
- 2
- Pages
- 189-191
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2039077449
- Cited by
- 41
- References
- 3
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 4 · 2015: 3 · 2014: 6 · 2013: 1 · 2012: 4
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- androgen deficiency, hypogonadism, older men, aging, testosterone replacement therapy, serum testosterone levels, muscle mass, bone mass, sexual function, menopause
- MeSH terms
- Aged, Cardiovascular Diseases, Humans, Hyperlipidemias, Hypertension, Hypogonadism, Male, Testosterone
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