The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Clone wars: the emergence of neoplastic blood-cell clones with aging
Abstract
Blood cells originate from hematopoietic stem cells (HSCs). HSCs are infrequent (<2 per 108 bone marrow cells, or about 11,000 to 22,000 per person) and rarely divide.1,2 Because mutations occur with DNA replication during cell division, HSC quiescence maximizes genomic stability and thus safety.Mutations, however, can and do occur. Most are innocuous and do not substantially alter protein quantities or structure. Some make subtle changes that contribute to cellular diversity and allow HSCs or their offspring to react efficiently to differing environmental stresses. However, if a mutation speeds HSC self-renewal divisions or slows apoptosis, this results in more . . .
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“The selection and expansion of preleukemic-HSPC clones precede the development of AML (Abkowitz 2014; Grove and Vassiliou, 2014; Jan et al., 2012).”
From Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis (2018) · cites this paper as Abkowitz 2014
Citations
Cites
The replication rate of human hematopoietic stem cells in vivo
Catlin, S. N., Busque, L., Gale, R. E., Guttorp, P., & Abkowitz, J. L. (2011) · Blood · doi:10.1182/blood-2010-08-303537 · Cited by 259
Self-citation
Research works printed but not linked: 10
- 10.1182/blood-2002-03-0822 · DOI
- 10.1056/NEJMoa1106968 · DOI
- 10.1056/NEJMoa1301689 · DOI · Paper page
- 10.1182/blood-2013-09-381665 · DOI
- 10.1056/NEJMoa1408617 · DOI · Paper page
- 10.1056/NEJMoa1409405 · DOI · Paper page
- Yoshizoto T, 2014, Blood, 123, 253, 10.1182/blood.V124.21.253.253 · DOI
- 10.3322/caac.21208 · DOI · Paper page
- 10.1056/NEJMoa1408617 · DOI · Paper page
- 10.1056/NEJMoa1409405 · DOI · Paper page
Cited by
Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M. R., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.013 · Cited by 394
Metadata
- Authors
- Abkowitz, J. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-12-25
- Volume
- 371
- Issue
- 26
- Pages
- 2523-2525
- ISSN
- 0028-4793
- 1533-4406
- Cited by
- 18
- References
- 1
- Language
- en
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- Abkowitz, J. L. (2014). Clone wars: the emergence of neoplastic blood-cell clones with aging. New England Journal of Medicine. https://doi.org/10.1056/nejme1412902
