Cited by 815Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Disease Prevention

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Intensive Diabetes Therapy and Carotid Intima–Media Thickness in Type 1 Diabetes Mellitus

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The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group·2003·New England Journal of Medicine

DOI 10.1056/nejmoa022314PMC PMC2701300

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Abstract

BACKGROUND: Cardiovascular disease causes severe morbidity and mortality in type 1 diabetes, although the specific risk factors and whether chronic hyperglycemia has a role are unknown. We examined the progression of carotid intima-media thickness, a measure of atherosclerosis, in a population with type 1 diabetes. METHODS: As part of the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the long-term follow-up of the Diabetes Control and Complications Trial (DCCT), 1229 patients with type 1 diabetes underwent B-mode ultrasonography of the internal and common carotid arteries in 1994-1996 and again in 1998-2000. We assessed the intima-media thickness in 611 subjects who had been randomly assigned to receive conventional diabetes treatment during the DCCT and in 618 who had been assigned to receive intensive diabetes treatment. RESULTS: At year 1 of the EDIC study, the carotid intima-media thickness was similar to that in an age- and sex-matched nondiabetic population. After six years, the intima-media thickness was significantly greater in the diabetic patients than in the controls. The mean progression of the intima-media thickness was significantly less in the group that had received intensive therapy during the DCCT than in the group that had received conventional therapy (progression of the intima-media thickness of the common carotid artery, 0.032 vs. 0.046 mm; P=0.01; and progression of the combined intima-media thickness of the common and internal carotid arteries, -0.155 vs. 0.007; P=0.02) after adjustment for other risk factors. Progression of carotid intima-media thickness was associated with age, and the EDIC base-line systolic blood pressure, smoking, the ratio of low-density lipoprotein to high-density lipoprotein cholesterol, and urinary albumin excretion rate and with the mean glycosylated hemoglobin value during the mean duration (6.5 years) of the DCCT. CONCLUSIONS: Intensive therapy during the DCCT resulted in decreased progression of intima-media thickness six years after the end of the trial.

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Items 301–400 of 813

Oxidative Stress in Diabetes Mellitus: Is There a Role for Hypoglycemic Drugs and/or Antioxidants?
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“Results from the EDIC study, the long-term follow up of the DCCT, suggest a cardiovascular (CV) benefit of tight glycemic control in type 1 diabetes (Nathan et al 2003).”
Method
Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β–dependent vascular endothelial cadherin tyrosine phosphorylation
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“The measurement of IMT in the DCCT/ EDIC cohort has been described in detail (29-30).”
Method
Risk of future microvascular and macrovascular disease in people with Type 1 diabetes of very long duration: a national study with 10‐year follow‐up
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“Benefits of intensive insulin therapy were clearly established in the Diabetes Control and Complications Trial (DCCT) [8] and continue to be observed [9,10].”
Background
Iatrogenic hyperinsulinemia in type 1 diabetes: Its effect on atherogenic risk markers
Wang, M.-Y., Yu, X., Lee, Y., McCorkle, S. K., Clark, G. O., Strowig, S. M., Unger, R. H., & Raskin, P. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.08.008 · Cited by 37
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Result
Targeting the endothelial glycocalyx in acute critical illness as a challenge for clinical and laboratory medicine
Černý, V., Astapenko, D., Brettner, F., Beneš, J., Hyšpler, R., Lehmann, C., & Zadák, Z. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1379943 · Cited by 38
“Last but not the least, EG can be affected by procedures believed to be safe, such as the type and manner of fluid therapy [27–29], therapy for acute and chronic metabolic conditions [30,31], various techniques of organ and metabolic support [32], the use of common drugs [33], and common anesthetic techniques [34].”
Background
Renal Microvascular Injury in Diabetes: RAGE and Redox Signaling
Coughlan, M. T., Cooper, M. E., & Forbes, J. M. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1469 · Cited by 37
Glucosamine-supplementation promotes endoplasmic reticulum stress, hepatic steatosis and accelerated atherogenesis in apoE−/− mice
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“Epidemiological evidence suggests there is an association etween glycemic control and CVD, and hyperglycemia has been dentified as an independent risk factor for CVD [4]; however, the pecific and causal role of glucose in the accelerated development f atherosclerosis remains controversial.”
Background
A New Perspective on Therapeutic Inhibition of Advanced Glycation in Diabetic Microvascular Complications: Common Downstream Endpoints Achieved Through Disparate Therapeutic Approaches?
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Upregulation of the ligand–RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis
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“In conclusion, the results of this study suggest that (1) patient profile is similar in IPII and IIT groups; (2) metabolic results improve with either method, but significantly more so with IIT, for as long as 3 years post-treatment; (3) the price to pay is the more frequent side effects.”
BackgroundResultInfluential
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Shen, X., & Bornfeldt, K. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1394.004 · Cited by 37
Longitudinal Association Between Endothelial Dysfunction, Inflammation, and Clotting Biomarkers With Subclinical Atherosclerosis in Type 1 Diabetes: An Evaluation of the DCCT/EDIC Cohort
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Obesity, Glucose Intolerance and Diabetes and Their Links to Cardiovascular Disease. Implications for Laboratory Medicine
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Protein Kinase Cβ Isoform Inhibitors
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Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients
Cardoso, C. R. L., Marques, C. E. C., Leite, N. C., & Salles, G. F. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328352aba6 · Cited by 35
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Wadwa, R. P. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9016-y · Cited by 36
“Findings from the Epidemiology of Diabetes Interventions and Complications (EDIC) study have shown that glycemic control is also an important factor for the risk of CVD events in adults [26, 27].”
Background
High cumulative insulin exposure: a risk factor of atherosclerosis in type 1 diabetes?
Muis, M. J., Bots, M. L., Bilo, H. J. G., Hoogma, R. P. L. M., Hoekstra, J. B. L., Grobbee, D. E., & Stolk, R. P. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.01.004 · Cited by 36
Advanced glycation end products measured by skin autofluorescence and subclinical cardiovascular disease: the Rotterdam Study
Chen, J., Arshi, B., Waqas, K., Lu, T., Bos, D., Ikram, M. A., Uitterlinden, A. G., Kavousi, M., & Zillikens, M. C. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02052-7 · Cited by 35
“In line with our finding, a study in people with type 1 diabetes showed that, compared to regular glucose management, 6.5 years of intensive glucose management resulted in a lower IMT [13] 6 years after the intervention and the levels of skin AGEs and IMT correlated [12].”
ResultInfluential
SRT1720 counteracts glucosamine-induced endoplasmic reticulum stress and endothelial dysfunction
Fiorentino, T. V., Procopio, T., Mancuso, E., Arcidiacono, G. P., Andreozzi, F., Arturi, F., Sciacqua, A., Perticone, F., Hribal, M. L., & Sesti, G. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv169 · Cited by 35
Islet cell transplantation
McCall, M., & Shapiro, A. M. J. (2014) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2014.03.006 · Cited by 36
Impact of acute hyperglycemia on layer-specific left ventricular strain in asymptomatic diabetic patients: an analysis based on two-dimensional speckle tracking echocardiography
Bogdanović, J. M., Ašanin, M., Krljanać, G., Lalic, N. M., Jotić, A., Stankovic, S. D., Rajkovic, N., Stošić, L., Rasulić, I., Milin-Lazovic, J. S., et al. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0876-3 · Cited by 35
Sugar and Stroke: Cerebrovascular Disease and Blood Glucose Control
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Microalbuminuria: A strong predictor of 3-year adverse prognosis in nondiabetic patients with acute myocardial infarction
Koulouris, S. N., Lekatsas, I., Karabinos, I. K., Georgios Ioannidis, B., Katostaras, T., KRANIDIS, A. J., Triantafyllou, K. A., Thalassinos, N., & Anthopoulos, L. P. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.07.031 · Cited by 35
Management strategies for brittle diabetes
Vantyghem, M., & Press, M. (2006) · Annales d Endocrinologie · doi:10.1016/s0003-4266(06)72600-2 · Cited by 38
Continuous Glucose Monitor, Insulin Pump, and Automated Insulin Delivery Therapies for Type 1 Diabetes: An Update on Potential for Cardiovascular Benefits
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Insulin exhibits short-term anti-inflammatory but long-term proinflammatory effects in vitro
Iwasaki, Y., Nishiyama, M., Taguchi, T., Asai, M., Yoshida, M., Kambayashi, M., Terada, Y., & Hashimoto, K. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.09.030 · Cited by 34
“…level is low nd a spiky increase is observed after each meal, and thus the nti-inflammatory effect of insulin is expected to be dominant. ndeed, a DCCT-EDIC study shows that patients intensely treated ith the basal-bolus insulin regimen are protected from vascular vents (Nathan et al., 2003).”
Background
Atherosclerotic Plaque Imaging
Raggi, P. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.20.2345 · Cited by 34
Impact of Type 2 Diabetes Mellitus on Aortic Elastic Properties in Normotensive Diabetes: Doppler Tissue Imaging Study
Badran, H. M., & Elnoamany, M. F. (2006) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2006.06.004 · Cited by 33
Diabetes Care for Patients with Peripheral Arterial Disease
Heikkinen, M. A., Salmenperä, M., Lepäntalo, A., & Lepäntalo, M. (2007) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2007.01.012 · Cited by 33
Circulating Vitamin D Metabolites and Subclinical Atherosclerosis in Type 1 Diabetes
Sachs, M. C., Brunzell, J. D., Cleary, P. A., Hoofnagle, A. N., Lachin, J. M., Molitch, M. E., Steffes, M. W., Zinman, B., & de Boer, I. H. (2013) · Diabetes Care · doi:10.2337/dc12-2020 · Cited by 34
Diabetes and Cardiovascular Disease
Bloomgarden, Z. T. (2011) · Diabetes Care · doi:10.2337/dc11-0007 · Cited by 32
“In the Diabetes Control and Complications Trial in younger type 1 diabetic patients and in the Kumamoto and UKPDS studies of type 2 diabetic patients, all microvascular end points decreased, while CVD outcomes “were less clear,” although posttrial follow-up of both the DCCT (26,27) and UKPDS (28), despite loss of glyc…”
Background
The early detection of atherosclerosis in type 1 diabetes: why, how and what to do about it
Jenkins, A. J., Januszewski, A. S., & O'Neal, D. N. (2019) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000169 · Cited by 34
Vascular memory: can we broaden the concept of the metabolic memory?
Jermendy, G. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-44 · Cited by 36
Atorvastatin inhibits the expression of RAGE induced by advanced glycation end products on aortas in healthy Sprague–Dawley rats
Xu, L., Zang, P., Feng, B., & Qian, Q. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-102 · Cited by 33
Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE−/− mice
Ganguly, R., Sahu, S., Ohanyan, V. A., Haney, R. M., Chavez, R. J., Shah, S., Yalamanchili, S. P., & Raman, P. (2017) · Scientific Reports · doi:10.1038/srep45279 · Cited by 33
“Risks of atherosclerotic complications are enhanced two-to-four-fold in diabetic patients 1,2 , accounting for > 80% of deaths and hospitalizations in these individuals.”
Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: A prospective study
Basu, A., Jenkins, A. J., Stoner, J. A., Thorpe, S. R., Klein, R. L., Lopes-Virella, M. F., Garvey, W. T., & Lyons, T. J. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.07.001 · Cited by 32
“IMT measurements by B-mode ultrasound, and their reporting in a Central Reading Facility, have previously been described in detail [21].”
Increased arterial stiffness in children and adolescents with type 1 diabetes: no association between arterial stiffness and serum levels of adiponectin
Galler, A., Heitmann, A., Siekmeyer, W., Gelbrich, G., Kapellen, T. M., Kratzsch, J., & Kieß, W. (2009) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2009.00525.x · Cited by 32
Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo
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High glucose promotes vascular smooth muscle cell proliferation by upregulating proto-oncogene serine/threonine-protein kinase Pim-1 expression
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“Vascular remodeling is a common pathological occurrence in diabetes mellitus (DM) that causes complications such as atherosclerosis, leading to enhanced patient morbidity and mortality [1].”
Background
Platelet microparticles contribute to aortic vascular endothelial injury in diabetes via the mTORC1 pathway
Wang, G., Ma, K., Zhang, Y., Hu, Z., Liu, L., Lü, J., Chen, P., Lü, C., Ruan, X. Z., & Liu, B. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0186-4 · Cited by 32
Diabetes Mellitus-Associated Atherosclerosis
Calkin, A. C., & Allen, T. J. (2006) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200606010-00003 · Cited by 31
Strategies in ongoing clinical trials to reduce cardiovascular disease in patients with diabetes mellitus and insulin resistance
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Pharmacological management of vascular endothelial dysfunction in diabetes: TCM and western medicine compared based on biomarkers and biochemical parameters
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The Effectiveness of Intensive Glycemic Control for the Prevention of Vascular Complications in Diabetes Mellitus
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Cerebrovascular disease in diabetes mellitus: The role of carotid intima-media thickness
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Tracking and Prediction of Arterial Blood Pressure From Childhood to Young Adulthood in 868 Patients With Type 1 Diabetes
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Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3This paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.
Blencowe, L. A., Kim, A. J., & Werstuck, G. H. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y05-142 · Cited by 31
Inflammation and Cardiovascular Disease in Patients With Diabetes
Festa, A., & Haffner, S. M. (2005) · Circulation · doi:10.1161/01.cir.0000167558.77793.e8 · Cited by 31
Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D
Basu, A., Bebu, I., Jenkins, A. J., Stoner, J. A., Zhang, Y., Klein, R. L., Lopes-Virella, M. F., Garvey, W. T., Budoff, M. J., Alaupovic, P., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.p090647 · Cited by 30
“In the continuing follow-up phase of DCCT, the Epidemiology of Diabetes Interventions and Complications (EDIC) study, implemented in 1994, HbA1c levels converged and became almost identical between the former DCCT randomization groups, but despite this, over the ensuing years carotid intima-media thickness (IMT) progr…”
Method
Outcomes of pancreas transplantation in older diabetic patients
Montagud‐Marrahí, E., Andújar, A. M., Pané, A., Ramírez-Bajo, M. J., Amor, A. J., Esmatjes, E., Ferrer, J., Musquera, M., Diekmann, F., & Ventura‐Aguiar, P. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000916 · Cited by 30
Autologous adipose mesenchymal stem cell administration in arteriosclerosis and potential for anti-aging application: a retrospective cohort study
Ohta, H., Liu, X., & Maeda, M. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02067-x · Cited by 31
Prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes in Austria
Steigleder‐Schweiger, C., Rami-Merhar, B. M., Waldhoer, T., Fröhlich-Reiterer, E. E., Schwarz, I., Fritsch, M., Borkenstein, M. H., & Schober, E. (2012) · European Journal of Pediatrics · doi:10.1007/s00431-012-1704-x · Cited by 30
Mass spectrometric quantification of amino acid oxidation products identifies oxidative mechanisms of diabetic end-organ damage
Vivekanandan‐Giri, A., Wang, J. H., Byun, J., & Pennathur, S. (2008) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9093-1 · Cited by 30
“During a mean 17 years of follow-up, intensive glucoselowering treatment reduced the risk of any CVD event by 42% suggesting that tight glycemic control lowers macrovascular disease end-points [17, 18].”
Background
Tool to Assess Likelihood of Fasting Glucose ImpairmenT (TAG-IT)
Koopman, R. J., Mainous, A. G., Everett, C. J., & Carter, R. E. (2008) · The Annals of Family Medicine · doi:10.1370/afm.913 · Cited by 35
Below the radar: advanced glycation end products that detour "around the side". Is HbA1c not an accurate enough predictor of long term progression and glycaemic control in diabetes?
Forbes, J. M., Soldatos, G., & Thomas, M. C. (2005) · Europe PMC (PubMed Central) · Cited by 30
Pharmacotherapy of Diabetes: New Developments
Mogensen, C. E. (2007) · Springer eBooks · doi:10.1007/978-0-387-69737-6 · Cited by 30
Pediatric Type 1 Diabetes: Reducing Admission Rates for Diabetes Ketoacidosis
Ilkowitz, J. T., Choi, S. J., Rinke, M. L., Vandervoot, K., & Heptulla, R. A. (2016) · Quality Management in Health Care · doi:10.1097/qmh.0000000000000109 · Cited by 29
“Median length of stay in days, n (range)c 2 (1-47) 2 (1-38) <.”
Background
ATVB In Focus
Hansson, G. K. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000153139.83149.a2 · Cited by 30
Nuclear magnetic resonance-determined lipoprotein subclasses and carotid intima-media thickness in type 1 diabetes
Basu, A., Jenkins, A. J., Zhang, Y., Stoner, J. A., Klein, R. L., Lopes-Virella, M. F., Garvey, W. T., & Lyons, T. J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.106 · Cited by 28
“Our present findings also conform to a previous report of significant associations between IMT progression, examined between EDIC Years 1 and 6, and conventional lipid profiles (ratio of LDL- and HDL-C, although not HDL-C per se): however, in that study, lipoprotein subclasses were not measured [22].”
MethodResult
Assessment of biomarkers of inflammation and premature atherosclerosis in adolescents with type-1 diabetes mellitus
Babar, G., Clements, M. A., Dai, H. D., & Raghuveer, G. (2019) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2018-0192 · Cited by 28
The Role of Surrogate Endpoints in the Evaluation of Efficacy and Safety of Therapeutic Interventions in Diabetes Mellitus
Wieczorek, A., Rys, P., Skrzekowska-Baran, I., & Malecki, M. T. (2008) · The Review of Diabetic Studies · doi:10.1900/rds.2008.5.128 · Cited by 28
“Kawasumi M, Tanaka Y, Uchino H, Shimizu T, Tamura Y, Sato F, Mita T, Watada H, Sakai K, Hirose T, Kawamori R. Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes.”
Background
Serum Levels of Advanced Glycation End Products Are Associated with In-Stent Restenosis in Diabetic Patients
Choi, E., Kwon, H. M., Ahn, C. W., Lee, G. T., Joung, B., Hong, B., Yoon, Y. W., Kim, D., Byun, K.-H., Kang, T. S., et al. (2005) · Yonsei Medical Journal · doi:10.3349/ymj.2005.46.1.78 · Cited by 28
Effects of insulin and other antihyperglycaemic agents on lipid profiles of patients with diabetes
Chaudhuri, A., & Dandona, P. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01423.x · Cited by 28
“In addition, the DCCT/EDIC Research Group compared carotid intima-media thickness, a measure of atherosclerosis, in patients with T1DM treated with insulin therapy [106].”
Method
Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy
Nathan, D. M., Buse, J. B., Davidson, M. B., Ferrannini, E., Holman, R. R., Sherwin, R., & Zinman, B. (2009) · Clinical Diabetes · doi:10.2337/diaclin.27.1.4 · Cited by 29
Ischemia Imaging and Plaque Imaging in Diabetes
Raggi, P., Bellasi, A., & Ratti, C. (2005) · Diabetes Care · doi:10.2337/diacare.28.11.2787 · Cited by 28
Intracoronary ultrasound examinations reveal significantly more advanced coronary atherosclerosis in people with type 1 diabetes than in age- and sex-matched non-diabetic controls
Larsen, J. R., Tsunoda, T., Tuzcu, E. M., Schoenhagen, P., Brekke, M., Arnesen, H., Hanssen, K. F., Nissen, S. E., & Dahl‐Jørgensen, K. (2007) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2007.009 · Cited by 27
The relationship between early atherosclerosis and endothelial dysfunction in type 1 diabetic patients as evidenced by measurement of carotid intima-media thickness and soluble CD146 levels: a cross sectional study
Doğanşen, S. Ç., Helvacı, A., Adaş, M., & Önol, S. D. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-153 · Cited by 26
Morphological Changes in the Carotid Artery Intima after Gastric Bypass for Morbid Obesity
Marchesi, F., Giacosa, R., Reggiani, V., Sario, G. D., Tartamella, F., Melani, E., Mita, M. T., Cinieri, F. G., Cecchini, S., Riccò, M., et al. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2279-9 · Cited by 25
Diabetes in Youth
Kahkoska, A. R., & Dabelea, D. (2021) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.05.007 · Cited by 30
Predictors of first stroke in Type 1 diabetes: The Fremantle Diabetes Study
Davis, T. M. E., Bruce, D. G., & Davis, W. A. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01462.x · Cited by 26
Peripheral Arterial Disease, Foot Ulcers, Lower Extremity Amputations, and Diabetes
Boyko, E. J., Monteiro‐Soares, M., & Wheeler, S. (2018) · Europe PMC (PubMed Central) · Cited by 26
A Novel Transcriptional Mechanism of Cell Type–Specific Regulation of Vascular Gene Expression by Glucose
Raman, P., Harry, C., Weber, M. E., Krukovets, I., & Stenina‐Adognravi, O. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.219675 · Cited by 26
The Potential of Learning Health Care Systems
Maddox, T. M., & Ferguson, T. B. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.05.050 · Cited by 26
Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes Mellitus
Subramanian, S., & Hirsch, I. B. (2017) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.10.012 · Cited by 26
Changes of insulin resistance status and development of complications in type 1 diabetes mellitus: Analysis of DCCT/EDIC study
Mao, Y., & Zhong, W. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.109211 · Cited by 27
Life after pancreas transplantation
Dunn, T. B. (2013) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000045 · Cited by 26
“Intensive insulin therapy has been shown to significantly decrease long-term (>10 years) risk of cardiovascular events and mortality [22,50].”
Background
Vascular disease in the lower limb in type 1 diabetes
EDMONDS, M. E. (2019) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000168 · Cited by 27
Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion
Dan, Q., Wong, R. L. C., Chung, S. K., Chung, S. S. M., & Lam, K. S. L. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.09.010 · Cited by 25
Lipidomics in diabetes
Kim, J. S., Ramachandran, R., & Wierzbicki, A. S. (2021) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000704 · Cited by 25
“In mice with streptozocininduced T1DM ceramide synthesis by desaturase 1, (dihydro)ceramide synthase (CerS)2, serine palmitoyl transferase 1 and mitochondrial CerSs was increased r Health, Inc.”
BackgroundInfluential
Possible involvement of tobacco-derived advanced glycation end products (AGEs) in an increased risk for developing cancers and cardiovascular disease in former smokers
Yamagishi, S., Matsui, T., & Nakamura, K. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.03.020 · Cited by 24
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Inhibition of hyperglycemia-induced angiogenesis and breast cancer tumor growth by systemic injection of microRNA-467 antagonist
Krukovets, I., Legerski, M., Sul, P., & Stenina‐Adognravi, O. (2015) · The FASEB Journal · doi:10.1096/fj.14-267799 · Cited by 24
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Impact of Simultaneous Pancreas-kidney Transplantation on Cardiovascular Risk in Patients With Diabetes
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Background
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Authors: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Corresponding author: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2003-06-05
Volume: 348
Issue: 23
Pages: 2294-2303
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa022314
PMC: PMC2701300
OpenAlex: W1667957779
Cited by: 815
References: 46
Citations by year: 2026: 5 · 2025: 6 · 2024: 15 · 2023: 13 · 2022: 7 · 2021: 22 · 2020: 20 · 2019: 26 · 2018: 21 · 2017: 24 · 2016: 21 · 2015: 41 · 2014: 34 · 2013: 37 · 2012: 41
FWCI: 39.98
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Bristol-Myers Squibb
Eli Lilly and Company
AstraZeneca
GlaxoSmithKline
National Institutes of Health (n01dk062204-003)
Genentech
National Institute of Diabetes and Digestive and Kidney Diseases (N01 DK062204)
National Center for Research Resources
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: type 1 diabetes, intensive diabetes therapy, carotid intima-media thickness, atherosclerosis, cardiovascular risk, glycemic control, HbA1c, Diabetes Control and Complications Trial, carotid artery, LDL/HDL ratio, urinary albumin excretion, smoking, systolic blood pressure
MeSH terms: Adolescent, Adult, Analysis of Variance, Arteriosclerosis, Blood Glucose, Carotid Artery Diseases, Diabetes Mellitus, Type 1, Female, Follow-Up Studies, Humans, Lipids, Male, Risk Factors, Ultrasonography, Linear Models, Least-Squares Analysis, Case-Control Studies, Randomized Controlled Trials as Topic, Carotid Artery, Common, Tunica Intima, Tunica Media, Disease Progression

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Intensive Diabetes Therapy and Carotid Intima–Media Thickness in Type 1 Diabetes Mellitus

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