CoChat
Sign Up
Cited by 1,555Preterm Birth and ChorioamnionitisInfant Development and Preterm CareNeonatal Respiratory Health Research

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Prevention of recurrent preterm delivery by 17 alpha–hydroxyprogesterone caproate

Open access
Meis, Paul J., Klebanoff, Mark, Thom, Elizabeth, Dombrowski, Mitchell P., Sibai, Baha, Moawad, Atef H., Spong, Catherine Y., Hauth, John C., Miodovnik, Menachem, Varner, Michael W., Leveno, Kenneth J., Caritis, Steve N., Iams, Jay D., Wapner, Ronald J., Conway, Deborah, O'Sullivan, Mary J., Carpenter, Marshall, Mercer, Brian, Ramin, Susan M., Thorp, John M., Peaceman, Alan M., Gabbe, Steven·2003·New England Journal of Medicine
DOI 10.1056/nejmoa035140
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk of preterm delivery. METHODS: We conducted a double-blind, placebo-controlled trial involving pregnant women with a documented history of spontaneous preterm delivery. Women were enrolled at 19 clinical centers at 16 to 20 weeks of gestation and randomly assigned by a central data center, in a 2:1 ratio, to receive either weekly injections of 250 mg of 17P or weekly injections of an inert oil placebo; injections were continued until delivery or to 36 weeks of gestation. The primary outcome was preterm delivery before 37 weeks of gestation. Analysis was performed according to the intention-to-treat principle. RESULTS: Base-line characteristics of the 310 women in the progesterone group and the 153 women in the placebo group were similar. Treatment with 17P significantly reduced the risk of delivery at less than 37 weeks of gestation (incidence, 36.3 percent in the progesterone group vs. 54.9 percent in the placebo group; relative risk, 0.66 [95 percent confidence interval, 0.54 to 0.81]), delivery at less than 35 weeks of gestation (incidence, 20.6 percent vs. 30.7 percent; relative risk, 0.67 [95 percent confidence interval, 0.48 to 0.93]), and delivery at less than 32 weeks of gestation (11.4 percent vs. 19.6 percent; relative risk, 0.58 [95 percent confidence interval, 0.37 to 0.91]). Infants of women treated with 17P had significantly lower rates of necrotizing enterocolitis, intraventricular hemorrhage, and need for supplemental oxygen. CONCLUSIONS: Weekly injections of 17P resulted in a substantial reduction in the rate of recurrent preterm delivery among women who were at particularly high risk for preterm delivery and reduced the likelihood of several complications in their infants.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejmoa035140

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 27 references

Research works printed but not linked: 3

  1. LeVine, , L Habitual abortion: a controlled clinical study of pregestational therapy. West J Surg Obstet Gynecol 1964;72:3036-3036
  2. Hauth, , JC , Andrews, , WW , Goldenberg, , RL Infection-related risk factors predictive of spontaneous preterm labor and birth. Prenat Neonat Med 1998;3:86-90
  3. Sondergaard, , F , Ottesen, , B , Detlefsen, , G , Traitement par la progesterone des menaces d'accouchment premature avec taux bas de progesterone plasmatique. Contracept Fertil Sexual 1985;13:1227-1231

Cited by

Sorted by citations

Items 401–500 of 1,000

Related

See all

Metadata

Authors
Meis, P. J., Klebanoff, M., Thom, E., Dombrowski, M. P., Sibai, B., Moawad, A. H., Spong, C. Y., Hauth, J. C., Miodovnik, M., Varner, M. W., Leveno, K. J., Caritis, S. N., Iams, J. D., Wapner, R. J., Conway, D., O'Sullivan, M. J., Carpenter, M., Mercer, B., Ramin, S. M., Thorp, J. M., Peaceman, A. M., & Gabbe, S.
Affiliations
  • Wayne State University (US)
  • National Institutes of Health (US)
  • University of Pittsburgh (US)
  • Thomas Jefferson University (US)
  • From Wake Forest University, Winston-Salem, N.C. (P.J.M.); the National Institute of Child Health and Human Development, Bethesda, Md. (M.K., C.Y.S.); the Biostatistics Center, George Washington University, Rockville, Md. (E.T.); Wayne State University, Detroit (M.P.D.); the University of Tennessee, Memphis (B.S.); the University of Chicago, Chicago (A.H.M.); the University of Alabama, Birmingham (J.C.H.); the University of Cincinnati, Cincinnati,...
  • University of North Carolina at Chapel Hill (US)
  • Northwestern University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2003-06-12
Volume
348
Issue
24
Pages
2379-2385
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa035140
OpenAlex
W2065614074
Cited by
1,555
References
27
Citations by year
2026: 19 · 2025: 29 · 2024: 38 · 2023: 46 · 2022: 50 · 2021: 53 · 2020: 72 · 2019: 56 · 2018: 66 · 2017: 141 · 2016: 94 · 2015: 73 · 2014: 71 · 2013: 85 · 2012: 101
FWCI
38.77
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Center for Research Resources (M01RR000080)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD40512, HD27905, HD27917, U10HD027861, HD-27915, HD34116, HD34136, (HD40500, HD34210, HD-21414, HD 40544, HD-27860, HD40560, HD27861, U10HD027917, U10HD027905, U10HD027860, HD 34208, HD 36801, HD34122, U10HD034210, HD27869, [HD21410, U10HD034122, U10HD034136)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords
17-hydroxyprogesterone caproate, preterm birth prevention, progesterone supplementation, neonatal complications, necrotizing enterocolitis, intraventricular hemorrhage, supplemental oxygen
MeSH terms
17 alpha-Hydroxyprogesterone Caproate, Adult, Birth Weight, Cerebral Hemorrhage, Double-Blind Method, Female, Humans, Hydroxyprogesterones, Infant, Newborn, Infant, Premature, Obstetric Labor, Premature, Oxygen Inhalation Therapy, Pregnancy, Pregnancy Outcome, Risk, Survival Analysis, Enterocolitis, Necrotizing, Progesterone Congeners

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review