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ZAP-70 Compared with Immunoglobulin Heavy-Chain Gene Mutation Status as a Predictor of Disease Progression in Chronic Lymphocytic Leukemia
Abstract
Background The course of chronic lymphocytic leukemia (CLL) is variable. In aggressive disease, the CLL cells usually express an unmutated immunoglobulin heavy-chain variable-region gene (IgV(H)) and the 70-kD zeta-associated protein (ZAP-70), whereas in indolent disease, the CLL cells usually express mutated IgV(H) but lack expression of ZAP-70. Methods We evaluated the CLL B cells from 307 patients with CLL for ZAP-70 and mutations in the rearranged IgV(H) gene. We then investigated the association between the results and the time from diagnosis to initial therapy. Results We found that ZAP-70 was expressed above a defined threshold level in 117 of the 164 patients with an unmutated IgV(H) gene (71 percent), but in only 24 of the 143 patients with a mutated IgV(H) gene (17 percent, P Conclusions Although the presence of an unmutated IgV(H) gene is strongly associated with the expression of ZAP-70, ZAP-70 is a stronger predictor of the need for treatment in B-cell CLL.
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In the citing paper
“The absence of somatic mutations in the immunoglobulin heavy chain variable region (IGHV) genes and expression of the zeta-chain-associated protein kinase 70 (ZAP70) are strongly associated with an aggressive clinical course(2, 3).”
From Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia (2010) · cites this paper as [3]
In the citing paper
“In contrast to normal B-cells, ZAP70 is aberrantly expressed in the malignant cells of CLL with unmutated IGHV status and is associated with poor prognosis(2, 3).”
From Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia (2010) · cites this paper as [3]
In the citing paper
“ZAP70 is expressed in human CLL, is a negative prognostic factor in this disease(2, 3), and regulates BCR signaling in CLL cells(4-6).”
From Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia (2010) · cites this paper as [3]
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Cited by
ZAP-70: an essential kinase in T-cell signaling
Wang, H., Kadlecek, T. A., Au-Yeung, B. B., Goodfellow, H. E. S., Hsu, L. Y., Freedman, T. S., & Weiss, A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002279 · Cited by 395
Self-citationGobessi, S., Laurenti, L., Longo, P. G., Carsetti, L., Berno, V, Sica, S., Leone, G., & Efremov, D. G. (2009) · Leukemia · doi:10.1038/leu.2008.346 · Cited by 200
Badoux, X. C., Keating, M. J., Wen, S., Wierda, W. G., O'Brien, S. M., Faderl, S., Sargent, R., Burger, J. A., & Ferrajoli, A. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.42.8623 · Cited by 158
Self-citationEmerging pathways of non-genomic glucocorticoid (GC) signalling in T cells
Boldizsar, F., Talaber, G., Szabo, M., Bartis, D., Palinkas, L., Nemeth, P., & Berki, T. (2010) · Immunobiology · doi:10.1016/j.imbio.2009.10.003 · Cited by 76
Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia
Sanchez-Aguilera, A., Rattmann, I., Drew, D. Z., Müller, L. U. W., Summey, V, Lucas, D. M., Byrd, J. C., Croce, C. M., Gu, Y., Cancelas, J. A., et al. (2010) · Leukemia · doi:10.1038/leu.2009.217 · Cited by 52
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Metadata
- Authors
- Rassenti, L. Z., Huynh, L., Toy, T. L., Chen, L., Keating, M. J., Gribben, J. G., Neuberg, D. S., Flinn, I. W., Rai, K. R., Byrd, J. C., Kay, N. E., Greaves, A., Weiss, A., & Kipps, T. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2004-08-26
- Volume
- 351
- Issue
- 9
- Pages
- 893-901
- ISSN
- 0028-4793
- 1533-4406
- Cited by
- 745
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: ZAP-70 Compared with Immunoglobulin Heavy-Chain Gene Mutation Status as a Predictor of Disease Progression in Chronic Lymphocytic Leukemia. https://app.cochat.ai/papers/10.1056/nejmoa040857
- The paper
- Rassenti, L. Z., Huynh, L., Toy, T. L., Chen, L., Keating, M. J., Gribben, J. G., Neuberg, D. S., Flinn, I. W., Rai, K. R., Byrd, J. C., Kay, N. E., Greaves, A., Weiss, A., & Kipps, T. J. (2004). ZAP-70 Compared with Immunoglobulin Heavy-Chain Gene Mutation Status as a Predictor of Disease Progression in Chronic Lymphocytic Leukemia. New England Journal of Medicine. https://doi.org/10.1056/nejmoa040857
