Cited by 191Cardiovascular Function and Risk FactorsHeart Failure Treatment and ManagementCardiovascular Health and Risk Factors

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Association of Parental Heart Failure with Risk of Heart Failure in Offspring

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Lee, Douglas S., Pencina, Michael J., Benjamin, Emelia J., Wang, Thomas J., Levy, Daniel, O'Donnell, Christopher J., Nam, Byung-Ho, Larson, Martin G., D'Agostino, Ralph B., Vasan, Ramachandran S.·2006·New England Journal of Medicine

DOI 10.1056/nejmoa052948

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Abstract

BACKGROUND: The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting. METHODS: We examined the cross-sectional association of heart failure in parents with the prevalence of left ventricular systolic dysfunction, as well as left ventricular mass, internal dimensions, and wall thickness, in 1497 participants of the Framingham Offspring Study (mean age, 57 years; 819 women) who underwent routine echocardiography. We also investigated prospectively whether heart failure in parents increased the risk of heart failure in 2214 offspring (mean age, 44 years; 1150 women). RESULTS: As compared with the 1039 participants whose parents did not have heart failure, the 458 participants in the cross-sectional cohort who had at least one parent with heart failure were more likely to have increased left ventricular mass (17.0 percent vs. 26.9 percent), left ventricular internal dimensions (18.6 percent vs. 23.4 percent), and left ventricular systolic dysfunction (3.1 percent vs. 5.7 percent); the multivariable-adjusted odds ratios were 1.35 (95 percent confidence interval, 0.99 to 1.84), 1.29 (95 percent confidence interval, 0.96 to 1.72), and 2.37 (95 percent confidence interval, 1.22 to 4.61), respectively. In the longitudinal cohort, heart failure developed in 90 offspring during follow-up (mean length of follow-up, 20 years). The age- and sex-adjusted 10-year incidence rates of heart failure were 2.72 percent among offspring with a parent with heart failure, as compared with 1.62 percent among those without a parent with heart failure. This increase in risk persisted after multivariable adjustment (hazard ratio, 1.70; 95 percent confidence interval, 1.11 to 2.60). CONCLUSIONS: Heart failure in parents is associated with an increased prevalence of left ventricular systolic dysfunction cross-sectionally and an elevated risk of heart failure longitudinally. Our data emphasize the contribution of familial factors to the heart-failure burden in the community.

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Authors: Lee, D. S., Pencina, M. J., Benjamin, E. J., Wang, T. J., Levy, D., O'Donnell, C. J., Nam, B.-H., Larson, M. G., D'Agostino, R. B., & Vasan, R. S.
Affiliations: National Heart, Lung, and Blood Institute (US)
Boston University (US)
Harvard University (US)
ORCID: Lee, Douglas S.
Pencina, Michael J.
Benjamin, Emelia J.
Wang, Thomas J.
Levy, Daniel
Nam, Byung-Ho
Larson, Martin G.
Vasan, Ramachandran S.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2006-07-13
Volume: 355
Issue: 2
Pages: 138-147
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa052948
OpenAlex: W2145290472
Cited by: 191
References: 35
Citations by year: 2026: 7 · 2025: 11 · 2024: 5 · 2023: 13 · 2022: 6 · 2021: 13 · 2020: 9 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 5 · 2012: 10
FWCI: 5.95
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
University Libraries (University of Maryland) (submittedVersion)
Digital Repository at the University of Maryland (University of Maryland College Park)
Funders: National Institutes of Health (5k23hl074077-03, n01hc25195-41-0-1)
National Heart, Lung, and Blood Institute (U01 HL 66582, K-24-HL-04334, N01‐HC25195, K23-HL-074077, U01HL066582, K24HL004334)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: heart failure, familial risk, left ventricular systolic dysfunction, left ventricular mass, left ventricular dimensions, heart failure incidence, offspring, Framingham Offspring Study
MeSH terms: Aged, Cross-Sectional Studies, Female, Heart Failure, Humans, Longitudinal Studies, Male, Middle Aged, Parents, Risk, Cohort Studies, Incidence, Prevalence, Proportional Hazards Models, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Echocardiography, Doppler, Color, Adult Children

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Association of Parental Heart Failure with Risk of Heart Failure in Offspring

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