The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Colonoscopy in Colorectal-Cancer Screening for Detection of Advanced Neoplasia
Open accessAbstract
BACKGROUND: Recommendations for colorectal-cancer screening are based solely on age and family history of cancer, not sex. METHODS: We performed a cross-sectional analysis of the data from a large colonoscopy-based screening program that included 50,148 participants who were 40 to 66 years of age. People 40 to 49 years of age were eligible only if they had a family history of cancer of any type. Of the 43,042 participants 50 to 66 years of age, 13.3% reported a family history of colorectal cancer, as did 66.3% of the 7106 participants who were 40 to 49 years of age. We defined advanced neoplasia as cancer or adenoma that was at least 10 mm in diameter, had high-grade dysplasia, or had villous or tubulovillous histologic characteristics, or any combination thereof. We used multivariate logistic regression to identify associations between participants' characteristics and advanced neoplasia in a primary (or derivation) data set, and we confirmed the associations in a secondary (or validation) data set. RESULTS: Advanced neoplasia was detected in 2553 (5.9%) participants 50 to 66 years of age and in 243 (3.4%) participants 40 to 49 years of age. The rate of complications during colonoscopy was 0.1%, and no participants died. In the validation set, a logistic-regression model showed that male sex was independently associated with advanced neoplasia (adjusted odds ratio, 1.73; 95% confidence interval, 1.52 to 1.98; P<0.001). In each age group (40 to 49 years, 50 to 54 years, 55 to 59 years, and 60 to 66 years), the number of persons who would have to undergo colorectal-cancer screening in order to detect one advanced neoplasia was significantly lower in men than in women (23 vs. 36, 17 vs. 28, 12 vs. 22, and 10 vs. 18, respectively). CONCLUSIONS: We detected advanced neoplasia at a significantly higher rate in men than in women, which may warrant refinement of the screening recommendations for colorectal cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Applied Linear Statistical Models
(1997) · Technometrics · doi:10.1080/00401706.1997.10485141 · Cited by 7,185
Prevention of Colorectal Cancer by Colonoscopic Polypectomy
Winawer, S. J., Zauber, A. G., Ho, M. N., O'Brien, M. J., Gottlieb, L. S., Sternberg, S. S., Waye, J. D., Schapiro, M., Bond, J. H., Panish, J. F., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292701 · Cited by 4,592
Jemal, A., Murray, T., Samuels, A., Ghafoor, A., Ward, E., & Thun, M. J. (2003) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.53.1.5 · Cited by 3,275
Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood
Mandel, J. S., Bond, J. H., Church, T. R., Snover, D. C., Bradley, G. M., Schuman, L. M., & Ederer, F. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305133281901 · Cited by 3,229
WINAWER, S. (2003) · Gastroenterology · doi:10.1053/gast.2003.50044 · Cited by 2,143
Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer
Lieberman, D. A., Weiss, D. G., Bond, J. H., Ahnen, D. J., Garewal, H., Harford, W. V., Provenzale, D., Sontag, S., Schnell, T., Durbin, T. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007203430301 · Cited by 1,815
Best Subsets Logistic Regression
Hosmer, D. W., Jovanovic, B., & Lemeshow, S. (1989) · Biometrics · doi:10.2307/2531779 · Cited by 1,176
Imperiale, T. F., Wagner, D. R., Lin, C. Y., Larkin, G. N., Rogge, J. D., & Ransohoff, D. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007203430302 · Cited by 1,060
Rex, D. K., Bond, J. H., Winawer, S. J., Levin, T. R., Burt, R. W., Johnson, D. A., Kirk, L. M., Litlin, S., Lieberman, D. A., Waye, J. D., et al. (2002) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(02)04168-0 · Cited by 1,049
Cited by
Rothwell, P. M., Wilson, M., Elwin, C.-E., Norrving, B., Algra, A., Warlow, C. P., & Meade, T. W. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61543-7 · Cited by 1,351
Flossmann, E., & Rothwell, P. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60747-8 · Cited by 820
van Rossum, L. G., van Rijn, A. F., Laheij, R. J., van Oijen, M. G., Fockens, P., van Krieken, H. H., Verbeek, A. L., Jansen, J. B., & Dekker, E. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.040 · Cited by 734
Zhao, S., Wang, S., Pan, P., Xia, T., Chang, X., Yang, X., Guo, L., Meng, Q., Yang, F., Qian, W., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.260 · Cited by 660
Adverse Events After Outpatient Colonoscopy in the Medicare Population
Warren, J. L., Klabunde, C. N., Mariotto, A. B., Meekins, A., Topor, M., Brown, M. L., & Ransohoff, D. F. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-12-200906160-00008 · Cited by 466
Metadata
- Authors
- Regula, J., Rupinski, M., Kraszewska, E., Polkowski, M., Pachlewski, J., Orlowska, J., Nowacki, M. P., & Butruk, E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-11-02
- Volume
- 355
- Issue
- 18
- Pages
- 1863-1872
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2157391819
- Cited by
- 788
- References
- 23
- FWCI
- 24.96
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Colonoscopy in Colorectal-Cancer Screening for Detection of Advanced Neoplasia. https://app.cochat.ai/papers/10.1056/nejmoa054967
- The paper
- Regula, J., Rupinski, M., Kraszewska, E., Polkowski, M., Pachlewski, J., Orlowska, J., Nowacki, M. P., & Butruk, E. (2006). Colonoscopy in Colorectal-Cancer Screening for Detection of Advanced Neoplasia. New England Journal of Medicine. https://doi.org/10.1056/nejmoa054967
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
