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The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer

Open access
Geyer, Charles E., Forster, John, Lindquist, Deborah, Chan, Stephen, Romieu, C. Gilles, Pienkowski, Tadeusz, Jagiello-Gruszfeld, Agnieszka, Crown, John, Chan, Arlene, Kaufman, Bella, Skarlos, Dimosthenis, Campone, Mario, Davidson, Neville, Berger, Mark, Oliva, Cristina, Rubin, Stephen D., Stein, Steven, Cameron, David·2006·New England Journal of Medicine
DOI 10.1056/nejmoa064320
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Abstract

BACKGROUND: Lapatinib, a tyrosine kinase inhibitor of human epidermal growth factor receptor type 2 (HER2, also referred to as HER2/neu) and epidermal growth factor receptor (EGFR), is active in combination with capecitabine in women with HER2-positive metastatic breast cancer that has progressed after trastuzumab-based therapy. In this trial, we compared lapatinib plus capecitabine with capecitabine alone in such patients. METHODS: Women with HER2-positive, locally advanced or metastatic breast cancer that had progressed after treatment with regimens that included an anthracycline, a taxane, and trastuzumab were randomly assigned to receive either combination therapy (lapatinib at a dose of 1250 mg per day continuously plus capecitabine at a dose of 2000 mg per square meter of body-surface area on days 1 through 14 of a 21-day cycle) or monotherapy (capecitabine alone at a dose of 2500 mg per square meter on days 1 through 14 of a 21-day cycle). The primary end point was time to progression, based on an evaluation by independent reviewers under blinded conditions. RESULTS: The interim analysis of time to progression met specified criteria for early reporting on the basis of superiority in the combination-therapy group. The hazard ratio for the independently assessed time to progression was 0.49 (95% confidence interval, 0.34 to 0.71; P<0.001), with 49 events in the combination-therapy group and 72 events in the monotherapy group. The median time to progression was 8.4 months in the combination-therapy group as compared with 4.4 months in the monotherapy group. This improvement was achieved without an increase in serious toxic effects or symptomatic cardiac events. CONCLUSIONS: Lapatinib plus capecitabine is superior to capecitabine alone in women with HER2-positive advanced breast cancer that has progressed after treatment with regimens that included an anthracycline, a taxane, and trastuzumab. (ClinicalTrials.gov number, NCT00078572 [ClinicalTrials.gov].).

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Metadata

Authors
Geyer, C. E., Forster, J., Lindquist, D., Chan, S., Romieu, C. G., Pienkowski, T., Jagiello-Gruszfeld, A., Crown, J., Chan, A., Kaufman, B., Skarlos, D., Campone, M., Davidson, N., Berger, M., Oliva, C., Rubin, S. D., Stein, S., & Cameron, D.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2006-12-28
Volume
355
Issue
26
Pages
2733-2743
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa064320
OpenAlex
W2110444464
Cited by
3,425
References
18
FWCI
95.18
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer. https://app.cochat.ai/papers/10.1056/nejmoa064320
The paper
Geyer, C. E., Forster, J., Lindquist, D., Chan, S., Romieu, C. G., Pienkowski, T., Jagiello-Gruszfeld, A., Crown, J., Chan, A., Kaufman, B., Skarlos, D., Campone, M., Davidson, N., Berger, M., Oliva, C., Rubin, S. D., Stein, S., & Cameron, D. (2006). Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejmoa064320

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.