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Prepubertal Gynecomastia Linked to Lavender and Tea Tree Oils
Abstract
Most cases of male prepubertal gynecomastia are classified as idiopathic. We investigated possible causes of gynecomastia in three prepubertal boys who were otherwise healthy and had normal serum concentrations of endogenous steroids. In all three boys, gynecomastia coincided with the topical application of products that contained lavender and tea tree oils. Gynecomastia resolved in each patient shortly after the use of products containing these oils was discontinued. Furthermore, studies in human cell lines indicated that the two oils had estrogenic and antiandrogenic activities. We conclude that repeated topical exposure to lavender and tea tree oils probably caused prepubertal gynecomastia in these boys.
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Metadata
- Authors
- Henley, D. V., Lipson, N., Korach, K. S., & Bloch, C. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-02
- Volume
- 356
- Issue
- 5
- Pages
- 479-485
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1994982991
- Cited by
- 367
- References
- 0
- FWCI
- 25.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Henley, D. V., Lipson, N., Korach, K. S., & Bloch, C. A. (2007). Prepubertal Gynecomastia Linked to Lavender and Tea Tree Oils. New England Journal of Medicine. https://doi.org/10.1056/nejmoa064725
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
