The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Neurodevelopment and Cognition in Children after Enterovirus 71 Infection
Open accessAbstract
BACKGROUND: Enterovirus 71 is a common cause of hand, foot, and mouth disease and encephalitis in Asia and elsewhere. The long-term neurologic and psychiatric effects of this viral infection on the central nervous system (CNS) are not well understood. METHODS: We conducted long-term follow-up of 142 children after enterovirus 71 infection with CNS involvement - 61 who had aseptic meningitis, 53 who had severe CNS involvement, and 28 who had cardiopulmonary failure after CNS involvement. At a median follow-up of 2.9 years (range, 1.0 to 7.4) after infection, the children received physical and neurologic examinations. We administered the Denver Developmental Screening Test (DDST II) to children 6 years of age or younger and the Wechsler intelligence test to children 4 years of age or older. RESULTS: Nine of the 16 patients with a poliomyelitis-like syndrome (56%) and 1 of the 5 patients with encephalomyelitis (20%) had sequelae involving limb weakness and atrophy. Eighteen of the 28 patients with cardiopulmonary failure after CNS involvement (64%) had limb weakness and atrophy, 17 (61%) required tube feeding, and 16 (57%) required ventilator support. Among patients who underwent DDST II assessment, delayed neurodevelopment was found in only 1 of 20 patients (5%) with severe CNS involvement and in 21 of 28 patients (75%) with cardiopulmonary failure (P<0.001 for the overall comparison). Children with cardiopulmonary failure after CNS involvement scored lower on intelligence tests than did children with CNS involvement alone (P=0.003). CONCLUSIONS: Enterovirus 71 infection with CNS involvement and cardiopulmonary failure may be associated with neurologic sequelae, delayed neurodevelopment, and reduced cognitive functioning. Children with CNS involvement without cardiopulmonary failure did well on neurodevelopment tests. (ClinicalTrials.gov number, NCT00172393 [ClinicalTrials.gov].).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An Epidemic of Enterovirus 71 Infection in Taiwan
Ho, M., Chen, E.-R., Hsu, K.-H., Twu, S.-J., Chen, K.-T., Tsai, S.-F., Wang, J.-R., & Shih, S.-R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909233411301 · Cited by 1,166
The Denver II: A Major Revision and Restandardization of the Denver Developmental Screening Test
Frankenburg, W. K., Dodds, J., Archer, P., Shapiro, H., & Bresnick, B. (1992) · Pediatrics · doi:10.1542/peds.89.1.91 · Cited by 1,111
Neurologic Complications in Children with Enterovirus 71 Infection
Huang, C.-C., Liu, C.-C., Chang, Y.-C., Chen, C.-Y., Wang, S.-T., & Yeh, T.-F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909233411302 · Cited by 718
Chan, L. G., Parashar, U. D., Lye, M. S., Ong, F. G. L., Zaki, S. R., Alexander, J. P., Ho, K. K., Han, L. L., Pallansch, M. A., Suleiman, A. B., et al. (2000) · Clinical Infectious Diseases · doi:10.1086/314032 · Cited by 538
Outcomes of bacterial meningitis in children: a meta-analysis
BARAFF, L. J., LEE, S. I., & SCHRIGER, D. L. (1993) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199305000-00008 · Cited by 495
Chang, L.-Y., Lin, T.-Y., Hsu, K.-H., Huang, Y.-C., Lin, K.-L., Hsueh, C., Shih, S.-R., Ning, H.-C., Hwang, M.-S., Wang, H.-S., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04434-7 · Cited by 402
Self-citationNagy, G., Takátsy, S., Kukán, E., Mihály, I., & Dömök, I. (1982) · Archives of Virology · doi:10.1007/bf01314873 · Cited by 267
The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management
Lin, T.-Y., Chang, L.-Y., Hsia, S.-H., Huang, Y.-C., Chiu, C.-H., Hsueh, C., Shih, S.-R., Liu, C.-C., & Wu, M.-H. (2002) · Clinical Infectious Diseases · doi:10.1086/338819 · Cited by 189
Self-citationShindarov, L., Chumakov, M. P., Voroshilova, M. K., Bojinov, S., Vasilenko, S., Iordanov, I., Kirov, I., Kamenov, E., Leshchinskaia, E. V., Mitov, G., et al. (1979) · PubMed · Cited by 187
Adverse Outcomes of Bacterial Meningitis in School-Age Survivors
Grimwood, K., Anderson, V. A., Bond, L., Catroppa, C., Hore, R. L., Keir, E. H., Nolan, T., & Roberton, D. M. (1995) · Pediatrics · doi:10.1542/peds.95.5.646 · Cited by 180
Cited by
Picornavirus and enterovirus diversity with associated human diseases
Tapparel, C., Siegrist, F., Petty, T. J., & Kaiser, L. (2013) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.10.016 · Cited by 444
The landscape of cognitive function in recovered COVID-19 patients
Zhou, H., Lu, S., Chen, J., Wei, N., Wang, D., Lyu, H., Shi, C., & Hu, S. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.06.022 · Cited by 440
Oliver, S. E., Cloud, G. A., Sánchez, P. J., Demmler, G. J., Dankner, W., Shelton, M., Jacobs, R. F., Vaudry, W., Pass, R. F., Soong, S.-J., et al. (2009) · Journal of Clinical Virology · doi:10.1016/j.jcv.2009.08.012 · Cited by 277
Etiologic classification of attention-deficit/hyperactivity disorder.
Millichap, J. G. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1332 · Cited by 234
Enterovirus and parechovirus infection in children: a brief overview
de Crom, S. C. M., Rossen, J. W. A., van Furth, A. M., & Obihara, C. C. (2016) · European Journal of Pediatrics · doi:10.1007/s00431-016-2725-7 · Cited by 192
Metadata
- Authors
- Chang, L.-Y., Huang, L.-M., Gau, S. S.-F., Wu, Y.-Y., Hsia, S.-H., Fan, T.-Y., Lin, K.-L., Huang, Y.-C., Lu, C.-Y., & Lin, T.-Y.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-03-22
- Volume
- 356
- Issue
- 12
- Pages
- 1226-1234
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1983384565
- Cited by
- 368
- References
- 19
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neurodevelopment and Cognition in Children after Enterovirus 71 Infection. https://app.cochat.ai/papers/10.1056/nejmoa065954
- The paper
- Chang, L.-Y., Huang, L.-M., Gau, S. S.-F., Wu, Y.-Y., Hsia, S.-H., Fan, T.-Y., Lin, K.-L., Huang, Y.-C., Lu, C.-Y., & Lin, T.-Y. (2007). Neurodevelopment and Cognition in Children after Enterovirus 71 Infection. New England Journal of Medicine. https://doi.org/10.1056/nejmoa065954
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
