Cited by 1,924Sepsis Diagnosis and TreatmentHemodynamic Monitoring and TherapyAbdominal Surgery and Complications

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

Open access

Russell, James A., Walley, Keith R., Singer, Joel, Gordon, Anthony C., Hébert, Paul C., Cooper, D. James, Holmes, Cheryl L., Mehta, Sangeeta, Granton, John T., Storms, Michelle M., Cook, Deborah J., Presneill, Jeffrey J., Ayers, Dieter·2008·New England Journal of Medicine

DOI 10.1056/nejmoa067373

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors. METHODS: In this multicenter, randomized, double-blind trial, we assigned patients who had septic shock and were receiving a minimum of 5 microg of norepinephrine per minute to receive either low-dose vasopressin (0.01 to 0.03 U per minute) or norepinephrine (5 to 15 microg per minute) in addition to open-label vasopressors. All vasopressor infusions were titrated and tapered according to protocols to maintain a target blood pressure. The primary end point was the mortality rate 28 days after the start of infusions. RESULTS: A total of 778 patients underwent randomization, were infused with the study drug (396 patients received vasopressin, and 382 norepinephrine), and were included in the analysis. There was no significant difference between the vasopressin and norepinephrine groups in the 28-day mortality rate (35.4% and 39.3%, respectively; P=0.26) or in 90-day mortality (43.9% and 49.6%, respectively; P=0.11). There were no significant differences in the overall rates of serious adverse events (10.3% and 10.5%, respectively; P=1.00). In the prospectively defined stratum of less severe septic shock, the mortality rate was lower in the vasopressin group than in the norepinephrine group at 28 days (26.5% vs. 35.7%, P=0.05); in the stratum of more severe septic shock, there was no significant difference in 28-day mortality (44.0% and 42.5%, respectively; P=0.76). A test for heterogeneity between these two study strata was not significant (P=0.10). CONCLUSIONS: Low-dose vasopressin did not reduce mortality rates as compared with norepinephrine among patients with septic shock who were treated with catecholamine vasopressors. (Current Controlled Trials number, ISRCTN94845869 [controlled-trials.com].).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmoa067373

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

APACHE II
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,518
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,317
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference
(1992) · Critical Care Medicine · doi:10.1097/00003246-199206000-00025 · Cited by 5,134
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Dellinger, R. P., Carlet, J. M., Masur, H., Gerlach, H., Calandra, T., Cohen, J., Gea‐Banacloche, J., Keh, D., Marshall, J. C., Parker, M. M., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2210-z · Cited by 3,309
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Dellinger, R. P., Carlet, J. M., Masur, H., Gerlach, H., Calandra, T., Cohen, J., Gea‐Banacloche, J., Keh, D., Marshall, J. C., Parker, M. M., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000117317.18092.e4 · Cited by 3,038
Discrete sequential boundaries for clinical trials
GORDON LAN, K. K., & DEMETS, D. L. (1983) · Biometrika · doi:10.1093/biomet/70.3.659 · Cited by 2,310
Discrete Sequential Boundaries for Clinical Trials
Lan, K. K. G., & DeMets, D. L. (1983) · Biometrika · doi:10.2307/2336502 · Cited by 2,310

Flagged first, then by citations

Show all 36 references

Research works printed but not linked: 2

Argenziano M, 1997, Circulation, 96, II
Chen JM, 1999, Circulation, 100, II

Sorted by citations

Items 801–900 of 999

Optimum treatment of vasopressor-dependent distributive shock
Vincent, J., & Léone, M. (2016) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2017.1252673 · Cited by 13
Real-Time Temperature Measurements of HMEC-1 Cells During Inflammation Production and Repair Detected by Wireless Thermometry
Li, C., Yan, S. R., He, W., Yang, S., Sun, J., & Gu, N. (2018) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2018.2880740 · Cited by 11
Predicting the Response of Hydroxocobalamin in Postoperative Vasoplegia in Recipients of Cardiopulmonary Bypass
Vollmer, N. J., Wieruszewski, P. M., Martin, N. J., Seelhammer, T. G., Wittwer, E. D., Nabzdyk, C. S., Mara, K. C., & Nei, S. D. (2022) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2022.01.021 · Cited by 11
Oral midodrine does not expedite liberation from protracted vasopressor infusions: A case-control study
Wood, A. J. T., Rauniyar, R., Jacques, A., Palmer, R. N., Wibrow, B. A., & Anstey, M. (2022) · Anaesthesia and Intensive Care · doi:10.1177/0310057x221105297 · Cited by 11
Insights from the evidence evaluation process – Do we have the answers for therapeutic hypothermia?
Nielsen, N., & Friberg, H. (2011) · Resuscitation · doi:10.1016/j.resuscitation.2011.02.041 · Cited by 11
Best vasopressor for advanced vasodilatory shock: should vasopressin be part of the mix?
Maybauer, M. O., & Walley, K. R. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-1942-1 · Cited by 11
Self-citation
Evaluación y tratamiento del paciente cirrótico crítico
Fernández, J., Aracil, C., Solà, E., Soriano, G., Cardona, M. C., Coll, S., Genescà, J., Hombrados, M., Morillas, R. M., Martín–Llahí, M., et al. (2016) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2015.09.019 · Cited by 11
Sepsis in a Panorama: What the Cardiovascular Physician Should Know
Gotur, D. B. (2018) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-14-2-89 · Cited by 13
A current appraisal of evidence for the approach to sepsis and septic shock
Varon, J., & Baron, R. M. (2019) · Therapeutic Advances in Infectious Disease · doi:10.1177/2049936119856517 · Cited by 11
Vasopressin in the pediatric cardiac intensive care unit: Myth or reality
Varma, A., Singh, V., Sharma, R. K., & Agrawal, A. (2009) · Annals of Pediatric Cardiology · doi:10.4103/0974-2069.52814 · Cited by 11
Terlipressin—More than just a prodrug of lysine vasopressin?*
Westphal, M., Rehberg, S. W., Ertmer, C., & Morelli, A. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819b91d5 · Cited by 11
Corticosteroids for Septic Shock
Daley, M. R. (2008) · New England Journal of Medicine · doi:10.1056/nejmc080246 · Cited by 11
Terlipressin or norepinephrine, or both in septic shock?
Mårtensson, J., & Gordon, A. C. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5290-x · Cited by 11
Self-citation
Critical Care Medicine
Felmet, K. A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-06612-9.00039-0 · Cited by 10
Beyond the Surviving Sepsis Campaign Guidelines: a systematic review of interventions affecting mortality in sepsis
Sartini, C., Landoni, G., Belletti, A., Kotani, Y., Maimeri, N., Umbrello, M., Yavorovskiy, A. G., & Jabaudon, M. (2023) · Panminerva Medica · doi:10.23736/s0031-0808.23.04986-8 · Cited by 13
Development of a rectally administrable Dnase1 to treat septic shock by targeting NETs
Kwak, S.-B., Kim, S.-J., Kang, Y. J., Lee, W., Huh, J., & Park, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122526 · Cited by 10
Advancements in Trauma-Induced Acute Kidney Injury: Diagnostic and Therapeutic Innovations
Lassola, S., Cundari, F., Marini, G., Corradi, F., & Rosa, S. D. (2024) · Life · doi:10.3390/life14081005 · Cited by 11
Optimizing intensive care management in paediatric sepsis
Rooney, Z., & Nadel, S. (2009) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328329c493 · Cited by 10
Fármacos vasoactivos en el tratamiento del shock séptico
Andaluz‐Ojeda, D., Cantón‐Bulnes, M. L., Richter, C. P., & Garnacho‐Montero, J. (2022) · Medicina Intensiva · doi:10.1016/j.medin.2022.03.001 · Cited by 12
The pharmacotherapeutic options in patients with catecholamine-resistant vasodilatory shock
Albertson, T. E., Chenoweth, J., Lewis, J., Pugashetti, J. V., Sandrock, C. E., & Morrissey, B. M. (2022) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2110067 · Cited by 11
Incidence, Severity and Clinical Factors Associated with Hypotension in Patients Admitted to an Intensive Care Unit: A Prospective Observational Study
Terwindt, L. E., Schuurmans, J., van der Ster, B. J. P., Wensing, C., Mulder, M. P., Wijnberge, M., Cherpanath, T. G. V., Lagrand, W. K., Karlas, A. A., Verlinde, M. H., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226832 · Cited by 11
Effect of Early Administration of Vasopressin on New-Onset Arrhythmia Development in Patients With Septic Shock: A Retrospective, Observational Cohort Study
McCloskey, M. M., Gibson, G. A., Pope, H. E., Giacomino, B. D., Hampton, N. B., Micek, S. T., Kollef, M. H., & Betthauser, K. D. (2023) · Annals of Pharmacotherapy · doi:10.1177/10600280221095543 · Cited by 10
The Evolution and Future of Intensive Care Management in the Era of Telecritical Care and Artificial Intelligence
Chander, S., Kumari, R., Sadarat, F., & Luhana, S. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.101805 · Cited by 12
Angiotensin II for the Treatment of Refractory Shock: A Matched Analysis*
Smith, L. M., Mentz, G. B., & Engoren, M. (2023) · Critical Care Medicine · doi:10.1097/ccm.0000000000005975 · Cited by 10
The Omics Complexity in Sepsis: The Limits of the Personalized Medicine Approach
Isac, S., Isac, T., Tănăsescu, M. D., Pavel, B., Andreescu, C. V., Badea, A.-G., Ojog, D., Teodorescu, G.-D., Laceanu, A., Trifan, C.-B., et al. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14030225 · Cited by 11
What happens to the fluid balance during and after recovering from septic shock?
Cunha, A. R. L., & Lobo, S. M. (2015) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20150004 · Cited by 10
Essentials of Sepsis Management
Green, J. M. (2014) · Surgical Clinics of North America · doi:10.1016/j.suc.2014.10.006 · Cited by 10
Vasopressors and Inotropes
Zimmerman, J. M., & Cahalan, M. K. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1679-5.00022-3 · Cited by 10
Early-phase Innate Immune Suppression in Murine Severe Sepsis Is Restored with Systemic Interferon-β
Kusakabe, Y., Uchida, K., Yamamura, Y., Hiruma, T., Totsu, T., Tamai, Y., Tsuyuzaki, H., Hasegawa, K., Chang, K., & Yamada, Y. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002185 · Cited by 10
Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT
Gordon, A. C., Santhakumaran, S., Al-Beidh, F., Orme, R., Perkins, G. D., Singer, M., McAuley, D. F., Mason, A. J., Ward, J. K., O'Dea, K. P., et al. (2018) · Efficacy and Mechanism Evaluation · doi:10.3310/eme05060 · Cited by 10
Self-citation
Vasopressin therapy in cardiac surgery
Kunkes, J., Baker, W. L., Hammond, J. A., & Gluck, J. (2018) · Journal of Cardiac Surgery · doi:10.1111/jocs.13968 · Cited by 10
Effect of vasopressin on a porcine model of persistent pulmonary hypertension of the newborn
Amer, R., Elsayed, Y. N., Graham, M. R., Sikarwar, A. S., Hinton, M., & Dakshinamurti, S. (2019) · Pediatric Pulmonology · doi:10.1002/ppul.24248 · Cited by 9
Exogenous vasopressin dose-dependently modulates gastric microcirculatory oxygenation in dogs via V1A receptor
Truse, R., Grewe, S., Herminghaus, A., Schulz, J., Weber, A. P. M., Mettler‐Altmann, T., Bauer, I., Picker, O., & Vollmer, C. (2019) · Critical Care · doi:10.1186/s13054-019-2643-y · Cited by 12
Circulatory shock
Soong, J. T. Y., & Soni, N. (2013) · Medicine · doi:10.1016/j.mpmed.2012.11.012 · Cited by 10
Endovascular Perfusion Augmentation After Resuscitative Endovascular Balloon Occlusion of the Aorta Improves Renal Perfusion and Decreases Vasopressors
Patel, N. T. P., Gaffley, M. W. G., Leblanc, M. J. R., Lane, M. R., Hoareau, G. L., Johnson, M. A., Jordan, J. E., Neff, L. P., & Williams, T. K. (2022) · Journal of Surgical Research · doi:10.1016/j.jss.2022.06.067 · Cited by 10
Subphenotypes of acute kidney injury in adults
Vaara, S. T., Forni, L. G., & Joannidis, M. (2022) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000970 · Cited by 10
Drug use in acute meningococcal disease
Cathie, K., Levin, M., & Faust, S. N. (2008) · Archives of Disease in Childhood Education & Practice · doi:10.1136/adc.2007.127696 · Cited by 10
Potential for overuse of corticosteroids and vasopressin in septic shock
Hsu, J. L., Liu, V. X., Patterson, A. J., Martin, G. S., Nicolls, M. R., & Russell, J. A. (2012) · Critical Care · doi:10.1186/cc11460 · Cited by 10
Self-citation
Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort
Myc, L. A., Stine, J. G., Chakrapani, R., Kadl, A., & Argo, C. K. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i2.106 · Cited by 10
Prescribing of Pressor Agents in Septic Shock: A Survey of Critical Care Pharmacists
Smith, S. E., Sikora, A. N., & Tackett, R. L. (2019) · Journal of Pharmacy Technology · doi:10.1177/8755122519846164 · Cited by 11
SIRS, sepsis and multiorgan failure
Biradar, V., & Moran, J. L. (2011) · University of Adelaide Press eBooks · doi:10.1017/upo9781922064004.018 · Cited by 10
The Etomidate Debate
Jones, A. E. (2010) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2010.07.008 · Cited by 10
Adverse Clinical Effects Associated With Non-catecholamine Pharmacologic Agents for Treatment of Vasoplegic Syndrome in Adult Cardiac Surgery
Hwang, K. Y., Phoon, P. H. Y., & Hwang, N. C. (2023) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2023.12.016 · Cited by 11
Effect of norepinephrine, vasopressin, and dopamine for survivals of the elderly with sepsis and pre-existing heart failure
Zhu, B., Jiang, J., Yu, H., Huang, L. J., & Zhou, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-52514-5 · Cited by 11
Prognostic evaluation of the norepinephrine equivalent score and the vasoactive-inotropic score in patients with sepsis and septic shock: a retrospective cohort study
Li, W., Wang, Y., Abuduaini, B., Li, X., Pan, P., Cui, J., & Yu, X. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1415769 · Cited by 9
Diez aspectos clave sobre el uso de la vasopresina en el paciente crítico
Ferrer, R., Castro, P., Lorencio, C., Monclou, J., Marcos-Neira, P., Ochagavía, A., Ruiz‐Rodríguez, J. C., Trenado, J., Villavicencio, C., Yébenes, J. C., et al. (2024) · Medicina Intensiva · doi:10.1016/j.medin.2024.07.008 · Cited by 9
Angiotensin II for Catecholamine Resistant Vasodilatory Shock in Patients with Acute Kidney Injury: A Post-Hoc Analysis of the ATHOS-3 Trial
Chaba, A., Zarbock, A., Forni, L. G., Hästbacka, J., Korneva, E., Landoni, G., Pickkers, P., & Bellomo, R. (2024) · Shock · doi:10.1097/shk.0000000000002481 · Cited by 10
Management of vasoplegic shock
Mistry, R. N., & Winearls, J. (2024) · BJA Education · doi:10.1016/j.bjae.2024.10.004 · Cited by 12
Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy
Ramsay, S. D., Nenke, M. A., Meyer, E. J., Torpy, D. J., & Young, R. L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1508848 · Cited by 9
The effects of vasopressor choice on renal outcomes in septic shock: a systematic review of randomised trials as a guide for future research
McDonald, R., Burns, M., Wong, A., Smith, C. E., Ostermann, M., & Hutchings, S. (2025) · Critical Care · doi:10.1186/s13054-025-05573-7 · Cited by 9
Adjunctive therapies for severe sepsis
Wittebole, X., Collienne, C., Castanares‐Zapatero, D., & Laterre, P. (2008) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2008.06.005 · Cited by 9
Narrative Review of Controversies Involving Vasopressin Use in Septic Shock and Practical Considerations
Der-Nigoghossian, C. A., Hammond, D. A., & Ammar, M. A. (2020) · Annals of Pharmacotherapy · doi:10.1177/1060028020901521 · Cited by 9
Evaluation of Evidence, Pharmacology, and Interplay of Fluid Resuscitation and Vasoactive Therapy in Sepsis and Septic Shock
Barlow, B., & Bissell, B. D. (2021) · Shock · doi:10.1097/shk.0000000000001783 · Cited by 9
The order of vasopressor discontinuation and incidence of hypotension: a retrospective cohort analysis
Song, X., Liu, X., Evans, K. D., Frank, R. D., Barreto, E. F., Dong, Y., Liu, C., Gao, X., Wang, C., & KASHANI, K. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-96322-7 · Cited by 10
Manejo clínico del shock poscardiotomía en pacientes adultos
Vela, J. L. P., Jorge, C. L., Duerto, J., & Rivera, J. J. J. (2021) · Medicina Intensiva · doi:10.1016/j.medin.2021.08.007 · Cited by 9
Evaluation and management of emergencies in the patient with cirrhosis
Velasco, J. A. V.-R., García-Jiménez, E. S., Aldana-Ledesma, J. M., Tapia-Calderón, D. K., Tornel-Avelar, A. I., Lazcano-Becerra, M., Chávez-Ramírez, R. M., Cano-Contreras, A. D., Remes-Troche, J. M., Colunga‐Lozano, L. E., et al. (2022) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2022.05.001 · Cited by 12
Vasopressin associated hyponatremia in critically ill children: A cross-sectional study
Alakeel, Y. S., Alkahtani, M. M., Hijazi, O., & Algahtani, M. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.06.006 · Cited by 9
A Critical Analysis of the FDA’s Omics-Driven Pharmacodynamic Biomarkers to Establish Biosimilarity
Niazi, S. K. (2023) · Pharmaceuticals · doi:10.3390/ph16111556 · Cited by 10
CAR T-cell therapy: a potential treatment strategy for pediatric midline gliomas
Das, A. K., Sinha, M., Singh, S. K., Chaudhary, A., Boro, A. K., Agrawal, M., Bhardwaj, S., Kishore, S., & Kumari, K. (2024) · Acta Neurologica Belgica · doi:10.1007/s13760-024-02519-8 · Cited by 9
Current controversies in the support of sepsis
Chawla, S., & DeMuro, J. P. (2014) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000154 · Cited by 9
Management of Complications of End-Stage Liver Disease in the Intensive Care Unit
DellaVolpe, J. D., Garavaglia, J. M., & Huang, D. T. (2014) · Journal of Intensive Care Medicine · doi:10.1177/0885066614551144 · Cited by 9
Understanding patient-centredness: contrasting expert versus patient perspectives on vasopressor therapy for shock
Lamontagne, F., Cohen, D., & Herridge, M. S. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4518-x · Cited by 9
Risk of Hyponatremia in Patients with Aneurysmal Subarachnoid Hemorrhage Treated with Exogenous Vasopressin Infusion
Marr, N., Yu, J., Kutsogiannis, D. J., & Mahmoud, S. H. (2016) · Neurocritical Care · doi:10.1007/s12028-016-0300-8 · Cited by 9
Effect of non-adrenergic vasopressors on macro- and microvascular coupling in distributive shock
Heßler, M., Kampmeier, T., & Rehberg, S. W. (2016) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2016.10.010 · Cited by 9
Evaluating the impact of obesity on safety and efficacy of weight-based norepinephrine dosing in septic shock: A single-center, retrospective study
Wong, P. J., Pandya, K. A., & Flannery, A. H. (2017) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2017.02.003 · Cited by 9
Postoperative complications in cirrhotic pediatric deceased donor liver transplantation: Focus on transfusion therapy
Nacoti, M., Cazzaniga, S., Colombo, G., Corbella, D., Fazzi, F., Fochi, O., Gattoni, C., Zambelli, M. F., Colledan, M., & Bonanomi, E. (2017) · Pediatric Transplantation · doi:10.1111/petr.13020 · Cited by 9
Inclusion and definition of acute renal dysfunction in critically ill patients in randomized controlled trials: a systematic review
Passos, R. D. H., Ramos, J. G. R., Gobatto, A. L. N., Caldas, J. R., Macedo, E. M., & Batista, P. B. P. (2018) · Critical Care · doi:10.1186/s13054-018-2009-x · Cited by 8
Hämodynamische Stabilisierung des septischen Patienten in der Notaufnahme
Schmoch, T., Bernhard, M. H., Siegler, B. H., Brenner, T., & Weigand, M. A. (2018) · Notfall + Rettungsmedizin · doi:10.1007/s10049-018-0515-7 · Cited by 9
Efficacy and Safety of Vasopressin as First-Line Treatment of Distributive and Hemorrhagic Shock States
Haan, B. J., Cadiz, M. L., & Natavio, A. M. (2019) · Annals of Pharmacotherapy · doi:10.1177/1060028019882035 · Cited by 9
Vasopressin Loading for Refractory Septic Shock: A Preliminary Analysis of a Case Series
Nakamura, K., Nakano, H., Naraba, H., Mochizuki, M., Takahashi, Y., Sonoo, T., Hashimoto, H., Abe, T., Hayakawa, M., & Yamakawa, K. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.644195 · Cited by 9
Arterial Pressure Waveforms
Chambers, D. J., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.038 · Cited by 9
Circulatory shock in adults in emergency department
Pannu, A. K. (2023) · Turkish Journal of Emergency Medicine · doi:10.4103/2452-2473.367400 · Cited by 19
Nitric oxide in enteric nervous system mediated the inhibitory effect of vasopressin on the contraction of circular muscle strips from colon in male rats
Jing, H., Qin, J., Feng, M., Wang, T., Zhu, J., Wang, C.-L., Wang, F., Liu, K., Li, J., & Liu, C. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01646.x · Cited by 9
San Antonio Vasopressin in Shock Symposium Report
Cohn, S. M., Blackbourne, L. H., Landry, D. W., Proctor, K. G., Walley, K. R., & Wenzel, V. (2010) · Resuscitation · doi:10.1016/j.resuscitation.2010.06.005 · Cited by 9
Self-citation
Predictors of prolonged vasopressin infusion for the treatment of septic shock
Personett, H. A., Stollings, J. L., Cha, S. S., & Oyen, L. J. (2012) · Journal of Critical Care · doi:10.1016/j.jcrc.2011.11.015 · Cited by 9
Septic shock: new pharmacotherapy options or better trial design?
Vincent, J., & Nuffelen, M. V. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.777429 · Cited by 9
Management of Acute Kidney Injury and Acid-Base Balance in the Septic Patient
Weyker, P. D., Pérez-Fernández, X. L., & Liu, K. D. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.01.012 · Cited by 10
New Consensus Definitions for Sepsis and Septic Shock: Implications for Treatment Strategies and Drug Development?
Berry, M. T., Patel, B. V., & Brett, S. J. (2017) · Drugs · doi:10.1007/s40265-017-0698-0 · Cited by 9
Clinical management of sepsis
Lam, S., Lau, A. C., Lam, R. P. K., & Yan, W. (2017) · Hong Kong Medical Journal · doi:10.12809/hkmj165057 · Cited by 11
Evaluation of Vasopressin for Septic Shock in Patients on Chronic Renin-Angiotensin-Aldosterone System Inhibitors
Erwin, B. L., Denaburg, M., Barker, A. B., McArdle, P. J., Windham, S. T., & Morgan, C. J. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002729 · Cited by 9
Vasopressor and inotrope treatment for septic shock: An umbrella review of reviews
Einav, S., Helviz, Y., Ippolito, M., & Cortegiani, A. (2021) · Journal of Critical Care · doi:10.1016/j.jcrc.2021.05.017 · Cited by 9
Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial
Li, X., Wang, R., Kang, Y. M., Liu, J., Zuo, Y.-X., Zeng, X.-F., & Cheng, G. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/3948795 · Cited by 10
Vasopressin, Norepinephrine, and Vasodilatory Shock after Cardiac Surgery
Russell, J. A. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001435 · Cited by 9
Self-citation
Vasopressin infusion in COVID-19 critical illness is not associated with impaired viral clearance: a pilot study
Leisman, D. E., Mehta, A., Li, Y., Kays, K. R., Li, J. Z., Filbin, M. R., & Goldberg, M. B. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.07.005 · Cited by 9
Endocrine pharmacology
Keegan, M. T. (2019) · Pharmacology and Physiology for Anesthesia · doi:10.1016/b978-0-323-48110-6.00036-3 · Cited by 11
Arterial Pressure Response to an Increase in Norepinephrine Varies Depending on the Baseline Norepinephrine Dose in Patients With Septic Shock
Bosch, N. A., Teja, B. J., Law, A. C., Wunsch, H., & Walkey, A. J. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.05.008 · Cited by 8
Intraoperative Vasoactive Medications and Perioperative Outcomes in Liver Transplantation: A Systematic Review and Network Meta-analyses
Carrier, F. M., Girard, M., Zuo, R. M., Ziegler, D., Trottier, H., & Chassé, M. (2023) · Transplantation · doi:10.1097/tp.0000000000004744 · Cited by 8
Impact on fluid balance of an optimized restrictive strategy targeting non-resuscitative fluids in intensive care patients with septic shock: a single-blind, multicenter, randomized, controlled, pilot study
Boulet, N., Quenot, J., Serrand, C., Antier, N., Garnier, S., Buzançais, A., Müller, L., Roger, C., Lefrant, J., & Barbar, S. D. (2024) · Critical Care · doi:10.1186/s13054-024-05155-z · Cited by 8
Vasopressin Initiation Timing and In-Hospital Mortality in Septic Shock: An Observational Study of Large Public Databases
Sacha, G. L., Duggal, A., Reddy, A. J., Wang, L., & Bauer, S. R. (2025) · Critical Care Explorations · doi:10.1097/cce.0000000000001284 · Cited by 9
Management of Sepsis in Hospitalized Patients
Palakshappa, J. A., & Taylor, S. P. (2025) · Annals of Internal Medicine · doi:10.7326/annals-25-02685 · Cited by 8
Vasopressor Therapy and the Brain: Dark Side of the Moon
Heming, N., Mazeraud, A., Azabou, É., Moine, P., & Annane, D. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2019.00317 · Cited by 9
DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis
Gupta, S., Amatullah, H., Tsoporis, J. N., Wei, K., Monteiro, A. P. T., Ektesabi, A. M., Varkouhi, A. K., Vaswani, C. M., Formosa, A., Fabro, A. T., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00993-2 · Cited by 8
Self-citation
Norepinephrine dose, lactate or heart rate: what impacts prognosis in sepsis and septic shock? Results from a prospective, monocentric registry
Schupp, T., Weidner, K., Rusnak, J., Jawhar, S., Forner, J., Dulatahu, F., Brück, L. M., Hoffmann, U., Bertsch, T., Akın, İ., et al. (2023) · Current Medical Research and Opinion · doi:10.1080/03007995.2023.2194777 · Cited by 8
Management of Sepsis in the First 24 Hours: Bundles of Care and Individualized Approach
Coloretti, I., Tosi, M., Biagioni, E., Busani, S., & Girardis, M. (2024) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0044-1789185 · Cited by 8
Septic shock: The initial moments and beyond
Lam, S. W., Bauer, S. R., & Guzmán, J. A. (2013) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.80a.12002 · Cited by 8
Residual rates of mortality in patients with severe sepsis: a fatality or a new challenge?
Asfar, P., Claessens, Y.-É., Duranteau, J., Kipnis, É., Léone, M., Lévy, B., & Mira, J. P. (2013) · Annals of Intensive Care · doi:10.1186/2110-5820-3-27 · Cited by 8
Preventive strategies and potential therapeutic interventions for delirium in sepsis
de Souza-Dantas, V. C., Póvoa, P. M. S. R., Bozza, F. A., Soares, M., & Salluh, J. I. (2016) · Hospital Practice · doi:10.1080/21548331.2016.1192453 · Cited by 8
Postoperative Cardiac Ischemia Detection by Continuous 12-Lead Electrocardiographic Monitoring in Vascular Surgery Patients: A Prospective, Observational Study
Ollila, A., Virolainen, J., Vanhatalo, J., Vikatmaa, P., Tikkanen, I. T., Venermo, M. A., Salmenperä, M., Pettilä, V., & Vikatmaa, L. (2016) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2016.09.027 · Cited by 8
Cardiovascular Responsiveness to Vasopressin and α1-Adrenergic Receptor Agonists After Burn Injury
Evans, A. E., Vana, P. G., LaPorte, H. M., Kennedy, R. H., Gamelli, R. L., & Majetschak, M. (2016) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000374 · Cited by 8
Renal autoregulation in experimental septic shock and its response to vasopressin and norepinephrine administration
Post, E. H., Su, F., Shinotsuka, C. R., Taccone, F. S., Créteur, J., Backer, D. D., & Vincent, J. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00783.2017 · Cited by 8

Authors: Russell, J. A., Walley, K. R., Singer, J., Gordon, A. C., Hébert, P. C., Cooper, D. J., Holmes, C. L., Mehta, S., Granton, J. T., Storms, M. M., Cook, D. J., Presneill, J. J., & Ayers, D.
Affiliations: St. Paul's Hospital (CA)
University of Ottawa (CA)
The Alfred Hospital (AU)
University of British Columbia (CA)
Mount Sinai Hospital (CA)
University of Toronto (CA)
McMaster University (CA)
The Royal Melbourne Hospital (AU)
ORCID: Russell, James A.
Walley, Keith R.
Singer, Joel
Gordon, Anthony C.
Hébert, Paul C.
Cooper, D. James
Holmes, Cheryl L.
Mehta, Sangeeta
Granton, John T.
Presneill, Jeffrey J.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2008-02-28
Volume: 358
Issue: 9
Pages: 877-887
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa067373
OpenAlex: W2108153775
Cited by: 1,924
References: 36
Citations by year: 2026: 106 · 2025: 119 · 2024: 101 · 2023: 91 · 2022: 88 · 2021: 85 · 2020: 104 · 2019: 205 · 2018: 114 · 2017: 104 · 2016: 100 · 2015: 83 · 2014: 91 · 2013: 84 · 2012: 89
FWCI: 88.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Health Sciences › Medicine › Surgery › Abdominal Surgery and Complications
Keywords: septic shock, vasopressin, norepinephrine, vasopressor therapy, catecholamines, mortality, 28-day mortality, 90-day mortality, sepsis treatment, blood pressure support, adverse events, subgroup analysis
MeSH terms: Adult, Aged, Blood Pressure, Catecholamines, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Norepinephrine, Severity of Illness Index, Shock, Septic, Vasoconstrictor Agents, Vasopressins, Treatment Failure, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks