Cited by 1,065Glioma Diagnosis and TreatmentNeurobiology of Language and BilingualismIntraoperative Neuromonitoring and Anesthetic Effects

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Functional Outcome after Language Mapping for Glioma Resection

Open access

Sanai, Nader, Mirzadeh, Zaman, Berger, Mitchel S.·2008·New England Journal of Medicine

DOI 10.1056/nejmoa067819

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Language sites in the cortex of the brain vary among patients. Language mapping while the patient is awake is an intraoperative technique designed to minimize language deficits associated with brain-tumor resection. METHODS: To study language function after brain-tumor resection with language mapping, we examined 250 consecutive patients with gliomas. Positive language sites (i.e., language regions in the cortex of the brain, 1 cm by 1 cm, which were temporarily inactivated by means of a bipolar electrode) were identified and categorized into cortical language maps. The tumors were resected up to 1 cm from the cortical areas where intraoperative stimulation produced a disturbance in language. Our resection strategy did not require identification of the stimulation-induced language sites within the field of exposure. RESULTS: A total of 145 of the 250 patients (58.0%) had at least one site with an intraoperative stimulation-induced speech arrest, 82 patients had anomia, and 23 patients had alexia. Overall, 3094 of 3281 cortical sites (94.3%) were not associated with stimulation-induced language deficits. A total of 159 patients (63.6%) had intact speech preoperatively. One week after surgery, baseline language function remained in 194 patients (77.6%), it worsened in 21 patients (8.4%), and 35 patients (14.0%) had new speech deficits. However, 6 months after surgery, only 4 of 243 surviving patients (1.6%) had a persistent language deficit. Cortical maps generated with intraoperative language data also showed surprising variability in language localization within the dominant hemisphere. CONCLUSIONS: Craniotomies tailored to limit cortical exposure, even without localization of positive language sites, permit most gliomas to be aggressively resected without language deficits. The composite language maps generated in our study suggest that our current models of human language organization insufficiently account for observed language function.

Integrity signals

Registry

Crossref · 10.1056/nejmoa067819

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cortical language localization in left, dominant hemisphere
Ojemann, G. A., Ojemann, J. G., Lettich, E., & Berger, M. S. (1989) · Journal of neurosurgery · doi:10.3171/jns.1989.71.3.0316 · Cited by 1,487
Self-citation
The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography
Chollet, F., Piero, V. D., Wise, R. J. S., Brooks, D. J., Dolan, R. J., & Frackowiak, R. S. J. (1991) · Annals of Neurology · doi:10.1002/ana.410290112 · Cited by 1,096
Neurosurgical Outcomes in a Modern Series of 400 Craniotomies for Treatment of Parenchymal Tumors
Sawaya, R. A., Hammoud, M. A., Schoppa, D., Hess, K. R., Wu, S. Z., Shi, W. M., & WiIdrick, D. M. (1998) · Neurosurgery · doi:10.1097/00006123-199805000-00054 · Cited by 645
Cortical organization of language
Ojemann, G. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-08-02281.1991 · Cited by 500
Neurosurgical Outcomes in a Modern Series of 400 Craniotomies for Treatment of Parenchymal Tumors
Ebersold, M. J. (1998) · Neurosurgery · doi:10.1097/00006123-199805000-00058 · Cited by 490
Cortical Localization of Temporal Lobe Language Sites in Patients with Gliomas
Haglund, M. M., Berger, M. S., Shamseldin, M., Lettich, E., & Ojemann, G. A. (1994) · Neurosurgery · doi:10.1227/00006123-199404000-00001 · Cited by 455
Self-citation
Awake craniotomy with brain mapping as the routine surgical approach to treating patients with supratentorial intraaxial tumors: a prospective trial of 200 cases
Taylor, M. D., & Bernstein, M. (1999) · Journal of neurosurgery · doi:10.3171/jns.1999.90.1.0035 · Cited by 442
Individual variability in cortical localization of language
Ojemann, G. A. (1979) · Journal of neurosurgery · doi:10.3171/jns.1979.50.2.0164 · Cited by 419
Supratentorial low-grade glioma in adults: an analysis of prognostic factors and timing of radiation.
Leighton, C. E., Fisher, B., Bauman, G. S., Depiero, S., Stitt, L., Macdonald, D., & Cairncross, G. J. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.4.1294 · Cited by 365
Resection, biopsy, and survival in malignant glial neoplasms
Devaux, B. C., O'Fallon, J. R., & Kelly, P. J. (1993) · Journal of neurosurgery · doi:10.3171/jns.1993.78.5.0767 · Cited by 354

Flagged first, then by citations

Show all 37 references

Research works printed but not linked: 4

10.1097/00006123-199404000-00001 · DOI
Ojemann GA, 1990, Semin Neurosci, 2, 297
Tomaszewki Farias S, 2005, AJNR Am J Neuroradiol, 26, 2492
10.1097/00006123-199304000-00010 · DOI

Sorted by citations

Items 601–700 of 1,000

Pediatric Applications of fMRI
Altman, N. R., & Bernal, B. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0345-7_28 · Cited by 10
Resection of glioma in an fMRI-defined “split” Broca’s area
Kim, J. H., Amankulor, N. M., Peck, K. K., Brennan, N. M. P., Gutin, P. H., & Holodny, A. I. (2013) · Neurocase · doi:10.1080/13554794.2013.826678 · Cited by 10
Resection of gliomas around language areas
Junck, L., Hervey‐Jumper, S. L., & Sagher, O. (2015) · Neurology · doi:10.1212/wnl.0000000000001241 · Cited by 10
Intracranial Electrophysiology in Language Research
Flinker, A., Piai, V., & Knight, R. T. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780198786825.013.43 · Cited by 10
Speech and lexico-semantic errors during direct cortical stimulation mapping of the language-dominant hemisphere: effects of object and action naming.
Rofes, A., D'Agata, F., Guerrini, F., & Spena, G. (2024) · Journal of Neurosurgery · doi:10.3171/2023.10.jns231493 · Cited by 7
The Case for Neurosurgical Intervention in Cancer Neuroscience
Bernstock, J. D., Gerstl, J. V. E., Chen, J., Johnston, B. R., Nonnenbroich, L. F., Spanehl, L., Gessler, F. A., Valdes, P. A., Lu, Y., Srinivasan, S. S., et al. (2024) · Neurosurgery · doi:10.1227/neu.0000000000003039 · Cited by 9
Predictive Value of Transcranial Evoked Potential Monitoring for Intramedullary Spinal Cord Tumors
Ille, S., Wagner, A., Joerger, A.-K., Wostrack, M., Meyer, B., & Shiban, E. (2021) · Journal of Neurological Surgery Part A Central European Neurosurgery · doi:10.1055/s-0040-1710504 · Cited by 9
A Review on the Surgical Management of Insular Gliomas
Renfrow, J. J., Julian, B.-Q., Brown, D. A., Tatter, S. B., Laxton, A. W., Lesser, G. J., Strowd, R. E., III, & Parney, I. F. (2021) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2021.248 · Cited by 9
Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging for Language Mapping in Brain Tumor Surgery: Validation With Direct Cortical Stimulation and Cortico–Cortical Evoked Potential
Kang, K. M., Kim, K., Kim, I. S., Kim, J. H., Kang, H. J., Ji, S. Y., Dho, Y., Oh, H., Park, H., Seo, H. G., et al. (2023) · Korean Journal of Radiology · doi:10.3348/kjr.2022.1001 · Cited by 9
Live Image-Based Neurosurgical Guidance and Roadmap Generation Using Unsupervised Embedding
Sarwin, G., Carretta, A., Staartjes, V. E., Zoli, M., Mazzatenta, D., Regli, L., Serra, C., & Konukoğlu, E. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-34048-2_9 · Cited by 9
Impact of White Matter Dissection in Microneurosurgical Procedures
Güngör, A., Gurses, M. E., Demirtaş, O. K., Rahmanov, S., & Türe, U. (2023) · Springer eBooks · doi:10.1007/978-981-99-3412-6_3 · Cited by 9
Surgical management of high-grade glioma: a standard of care
Watts, C. (2012) · CNS Oncology · doi:10.2217/cns.12.26 · Cited by 9
Patient Preparation and Paradigm Design in fMRI
Gene, M. N., Brennan, N. M. P., & Holodny, A. I. (2020) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2020.09.007 · Cited by 9
Awake craniotomy in brain tumors - Technique systematization and the state of the art
KRAMBEK, M. C., Araújo, J. L. V., Lovato, R. M., & Veiga, J. C. E. (2021) · Revista do Colégio Brasileiro de Cirurgiões · doi:10.1590/0100-6991e-20202722 · Cited by 9
Neurosurgical Clinical Trials for Glioblastoma: Current and Future Directions
Shah, A. H., & Heiss, J. D. (2022) · Brain Sciences · doi:10.3390/brainsci12060787 · Cited by 9
The role of surgery in grade II/III oligodendroglial tumors
Thon, N., Kreth, F.-W., & Tonn, J. (2015) · CNS Oncology · doi:10.2217/cns.15.26 · Cited by 9
Training stem cells for treatment of malignant brain tumors
Li, S. C. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i4.432 · Cited by 9
Towards a Speech BCI Using ECoG
Leuthardt, E. C., Cunningham, J. P., & Barbour, D. L. (2013) · Springer briefs in electrical and computer engineering · doi:10.1007/978-3-642-36083-1_10 · Cited by 9
Awake craniotomy: analysis of complicated cases
Kulikov, A. S., Kobyakov, G. L., Гаврилов, А. Г., & Lubnin, А. Y. (2015) · Burdenko s Journal of Neurosurgery · doi:10.17116/neiro201579615-21 · Cited by 9
Common Disconnections in Glioma Surgery: An Anatomic Description
Glenn, C. A., Conner, A. K., Rahimi, M., Briggs, R. G., Baker, C. M., & Sughrue, M. E. (2017) · Cureus · doi:10.7759/cureus.1778 · Cited by 9
Identification of risk factors for poor language outcome in surgical resection of glioma involving the arcuate fasciculus: an observational study
Li, F., Liu, H.-Y., Zhang, J., Sun, Z.-H., Zhang, J., Sun, Z., Yu, X.-G., Chen, X., & Xu, B.-N. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.290901 · Cited by 9
Integrated datasets of normalized brain with functional localization using intra-operative electrical stimulation
Tamura, M., Sato, I., Maruyama, T., Ohshima, K., Mangin, J., Nitta, M., Saito, T., Yamada, H., Minami, S., Masamune, K., et al. (2019) · International Journal of Computer Assisted Radiology and Surgery · doi:10.1007/s11548-019-01957-7 · Cited by 9
Is electrocorticography-based language mapping ready to replace stimulation?
Asano, E., & Gotman, J. (2016) · Neurology · doi:10.1212/wnl.0000000000002533 · Cited by 9
Naming impairments evoked by focal cortical electrical stimulation in the ventral temporal cortex correlate with increased functional connectivity
Aron, O., Krieg, J., Brissart, H., Abdallah, C., Colnat‐Coulbois, S., Jonas, J., & Maillard, L. G. (2022) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2022.06.002 · Cited by 8
Development of an educational method to rethink and learn oncological brain surgery in an “a la carte” connectome-based perspective
Valdes, P. A., Ng, S., Bernstock, J., & Duffau, H. (2023) · Acta Neurochirurgica · doi:10.1007/s00701-023-05626-2 · Cited by 6
Evoking artificial speech perception through invasive brain stimulation for brain-computer interfaces: current challenges and future perspectives
Hong, Y., Ryun, S., & Chung, C. K. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1428256 · Cited by 9
Navigated repetitive Transcranial Magnetic Stimulation (TMS) for language mapping: a new tool for surgical planning
Espadaler, J. M., & Conesa, G. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0723-2_19 · Cited by 8
Characterizing and predicting cortical evoked responses to direct electrical stimulation of the human brain
Steinhardt, C. R., Sacré, P., Sheehan, T. C., Wittig, J. H., Inati, S. K., Sarma, S. V., & Zaghloul, K. A. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.05.001 · Cited by 8
Monitoring Cortico-cortical Evoked Potentials Using Only Two 6-strand Strip Electrodes for Gliomas Extending to the Dominant Side of Frontal Operculum During One-step Tumor Removal Surgery
Saito, T., Muragaki, Y., Tamura, M., Maruyama, T., Nitta, M., Tsuzuki, S., Fukui, A., Koriyama, S., & Kawamata, T. (2022) · World Neurosurgery · doi:10.1016/j.wneu.2022.06.141 · Cited by 8
What surgical approach for left-sided eloquent glioblastoma: biopsy, resection under general anesthesia or awake craniotomy?
Gallet, C., Clavreul, A., Morandi, X., Delion, M., Madec, N., Meneï, P., & D, J.-M. L. M. (2022) · Journal of Neuro-Oncology · doi:10.1007/s11060-022-04163-9 · Cited by 8
Preoperative individual-target transcranial magnetic stimulation demonstrates an effect comparable to intraoperative direct electrical stimulation in language-eloquent glioma mapping and improves postsurgical outcome: A retrospective fiber-tracking and electromagnetic simulation study
Li, S., Mu, Y., Rao, Y., Sun, C., Li, X., Liu, H., Xun, Y., Yan, X. J., Ding, Y., Wang, Y., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1089787 · Cited by 8
Deformable Anatomic Templates Improve Analysis of Gliomas With Minimal Mass Effect in Eloquent Areas
Kumar, V. A., Hamilton, J. D., Hayman, L. A., Kumar, A. J., Rao, G., Weinberg, J. S., Sawaya, R. A., & Prabhu, S. S. (2013) · Neurosurgery · doi:10.1227/01.neu.0000431479.87160.e2 · Cited by 8
Does right-sided language lateralization on bold-fmri affect postoperative language outcome for avm patients?
Liu, Z., Deng, X., Cao, Y. B., Zhao, Y., Zhao, J., & Wang, S. (2016) · Turkish Neurosurgery · doi:10.5137/1019-5149.jtn.17105-16.0 · Cited by 8
Keyhole transsylvian resection of infiltrative insular gliomas: technique and anatomic results
Sughrue, M. E., Othman, J., Mills, S. A., Bonney, P. A., Maurer, A. J., & Teo, C. (2015) · Turkish Neurosurgery · doi:10.5137/1019-5149.jtn.14534-15.0 · Cited by 8
Reduced Expression of Jumonji AT-Rich Interactive Domain 2 (JARID2) in Glioma Inhibits Tumor Growth In Vitro and In Vivo
Li, Z., Xu, C., Gao, M., Ding, B., Wei, X., & Ji, N. (2016) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504016x14738135889976 · Cited by 8
Awake craniotomy in developing countries: review of hurdles
Shafiq, F., Khan, S. A., Nathani, K. R., & Enam, S. (2017) · IJS Short Reports · doi:10.4103/2468-7332.200557 · Cited by 8
Intraoperative motor speech mapping under general anesthesia using long-latency response from laryngeal muscles
Aydınlar, E. I., Dikmen, P. Y., Kocak, M., Sahillioğlu, E., & Pamir, M. N. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.105672 · Cited by 8
Cytologic control of the resection margins of hemispheric gliomas and metastases
Ermolaev, A., Kravets, L. Y., Smetanina, S. V., Kolpakova, A. A., Сергеевич, Я. К., Морев, А. В., Smetatina, O. V., Klyuev, E. A., & Medyanik, I. A. (2020) · Burdenko s Journal of Neurosurgery · doi:10.17116/neiro20208401133 · Cited by 8
A Super-selective Wada Test Successfully Detected an Artery That Supplied Broca’s Area in a Case of Left Frontal Lobe Glioblastoma: Technical Case Report
Yamashita, S., Saito, R., Osawa, S.-I., Niizuma, K., Ukishiro, K., Kanamori, M., Kakinuma, K., Suzuki, K., & Tominaga, T. (2021) · Neurologia medico-chirurgica · doi:10.2176/nmc.tn.2021-0054 · Cited by 8
Summary of 15 Years Experience of Awake Surgeries for Neuroepithelial Tumors in Tohoku University
Kumabe, T., Sato, K., Iwasaki, M., Shibahara, I., Kawaguchi, T., Saito, R., Kanamori, M., Yamashita, Y., Sonoda, Y., Iizuka, O., et al. (2013) · Neurologia medico-chirurgica · doi:10.2176/nmc.53.455 · Cited by 8
Neurosurgical Treatment Planning
Bi, W. L., Olubiyi, O. I., Tharin, S. A., & Golby, A. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800945-1.00023-9 · Cited by 8
A comprehensive framework for glioma surgery by the PIONEER Consortium and RANO resect group, part 2: perioperative recommendations for neurological, language, functional, and quality-of-life assessment
Gerritsen, J. K. W., Karschnia, P., Bello, L., Hervey‐Jumper, S. L., Young, J. S., Seidel, K., Satoer, D., Schnell, O., Parsons, M., Nahed, B. V., et al. (2025) · The Lancet Oncology · doi:10.1016/s1470-2045(25)00532-7 · Cited by 7
Self-citation
Does white matter structure relate to hemispheric language lateralization? A systematic review
Andrulyte, I., Demirkan, E., Branzi, F. M., Bonnett, L. J., & Keller, S. S. (2026) · Brain Communications · doi:10.1093/braincomms/fcag009 · Cited by 7
Functionally tailored transcortical approach of deep-seated lesions: An alternative to the transulcal approach? A technical case report
Bresson, D., Madadaki, C., Poisson, I., Habas, C., & Mandonnet, E. (2013) · Neurochirurgie · doi:10.1016/j.neuchi.2013.08.002 · Cited by 7
Organizing Variables Affecting fMRI Estimates of Language Dominance in Patients with Brain Tumors
Połczyńska, M. M. (2021) · Brain Sciences · doi:10.3390/brainsci11060694 · Cited by 7
Cortical and white matter anatomy relevant for the lateral and superior approaches to resect intraaxial lesions within the frontal lobe
Dziedzic, T. A., Bala, A., Balasa, A., Olejnik, A., & Marchel, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-25375-z · Cited by 7
Inhibitory control of speech production in the human premotor frontal cortex
Zhao, L., Silva, A. B., Kurteff, G., & Chang, E. F. (2025) · Nature Human Behaviour · doi:10.1038/s41562-025-02118-4 · Cited by 8
Information‐Guided Surgery of Intracranial Gliomas: Overview of an Advanced Intraoperative Technology
Muragaki, Y., Chernov, M., Yoshimitsu, K., Suzuki, T., Iseki, H., Maruyama, T., Tamura, M., Ikuta, S., Nitta, M., Watanabe, A., et al. (2012) · Journal of Healthcare Engineering · doi:10.1260/2040-2295.3.4.551 · Cited by 7
Neuropsychology of Chemotherapy in Brain Tumor Patients
Loughan, A. R., Allen, D., Ah, D. M. V., & Braun, S. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812100-9.00062-0 · Cited by 7
The auditory and association cortex and language evaluation methods
Papanicolaou, A. C., Rezaie, R., & Simos, P. G. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64032-1.00031-x · Cited by 7
A Novel Language Paradigm for Intraoperative Language Mapping: Feasibility and Evaluation
Rosengarth, K., Pai, D., Dodoo‐Schittko, F., Hense, K., Tamm, T., Ott, C., Lürding, R., Bumes, E., Greenlee, M. W., Schebesch, K.-M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040655 · Cited by 7
Preoperative Repetitive Navigated TMS and Functional White Matter Tractography in a Bilingual Patient with a Brain Tumor in Wernike Area
Baro, V., Caliri, S. L., Sartori, L., Facchini, S., Guarrera, B., Zangrossi, P., Anglani, M., Denaro, L., D’Avella, D., Ferreri, F., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11050557 · Cited by 7
Contralesional Cortical and Network Features Associated with Preoperative Language Deficit in Glioma Patients
Zhou, C., Fang, S., Weng, S., Zhang, Z., Jiang, T., Wang, Y., Wang, L., & Tang, K. (2022) · Cancers · doi:10.3390/cancers14184469 · Cited by 7
Wide Dissection Trans-Sulcal Approach for Resection of Deep Intra-Axial Lesions in Eloquent Brain Areas
Kaye, B., Santiago, R. B., MacKinnon, G., Dabecco, R. M., Ibrahim, B., Ali, A. M., Santos, R. C., Johansen, P. M., Ranjan, S., Obrzut, M., et al. (2022) · Current Oncology · doi:10.3390/curroncol29100581 · Cited by 7
Chirurgie éveillée des gliomes cérébraux : plaidoyer pour un investissement accru des anesthésistes
Duffau, H. (2012) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2012.04.009 · Cited by 7
Reorganization and Stability for Motor and Language Areas Using Cortical Stimulation: Case Example and Review of the Literature
Serafini, S., Komisarow, J. M., Gallentine, W. B., Mikati, M. A., Bonner, M., Kranz, P. G., Haglund, M. M., & Grant, G. A. (2013) · Brain Sciences · doi:10.3390/brainsci3041597 · Cited by 7
The Stony Brook awake craniotomy protocol: A technical note
Shen, E., Calandra, C., Geralemou, S., Page, C. R., Davis, R. P., Andraous, W., & Mikell, C. B. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.06.042 · Cited by 7
Resting State Functional MR Imaging of Language Function
Lee, J. J., Luckett, P. H., Fakhri, M., Leuthardt, E. C., & Shimony, J. S. (2020) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2020.09.005 · Cited by 8
Clinical outcome assessments of motor status in patients undergoing brain tumor surgery
Correia, M. P. S. G., Neville, I. S., de Almeida, C. C., Hayashi, C. Y., Ferreira, L. T. D., Quadros, D. G., dos Santos, A. G., Solla, D. J. F., Marta, G. N., Teixeira, M. J., et al. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.106420 · Cited by 7
Correlation of natural language assessment results with health-related quality of life in adult glioma patients
Ammanuel, S. G., Almeida, N. C., Kurteff, G., Kakaizada, S., Molinaro, A. M., Berger, M. S., Chang, E. F., & Hervey-Jumper, S. L. (2021) · Journal of neurosurgery · doi:10.3171/2021.1.jns203387 · Cited by 7
Self-citation
Language Areas Involving the Inferior Temporal Cortex on Intraoperative Mapping in a Bilingual Patient With Glioblastoma
Kin, H., Ishikawa, E., Takano, S., Ayuzawa, S., MATSUSHITA, A., Muragaki, Y., Aiyama, H., Sakamoto, N., Yamamoto, T., & Matsumura, A. (2013) · Neurologia medico-chirurgica · doi:10.2176/nmc.53.256 · Cited by 7
Bioimaging and surgery of brain tumors
Widhalm, G., Traub‐Weidinger, T., Hainfellner, J. A., Bieńkowski, M., Wolfsberger, S., & Czech, T. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802395-2.00033-x · Cited by 7
The First Awake Craniotomy for Eloquent Glioblastoma in Southern Thailand
Kaewborisutsakul, A., Sae-heng, S., Kitsiripant, C., & Benjhawaleemas, P. (2019) · Journal of Health Science and Medical Research · doi:10.31584/jhsmr.202077 · Cited by 7
Effects of low‐dose remifentanil infusion on analgesic or antiemetic requirement during brain function mapping: A retrospective cohort study
Shiraki, A., Goto, W., Fukagawa, H., Arakawa, Y., Kikuchi, T., Mineharu, Y., Yamao, Y., Yasuda, T., Hattori, E., Fukui, A., et al. (2020) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13554 · Cited by 7
Low-Grade Astrocytomas
Sanai, N., & Berger, M. S. (2010) · Springer eBooks · doi:10.1007/978-3-642-02874-8_5 · Cited by 7
Self-citation
Normalized fluorescence lifetime imaging for tumor identification and margin delineation
Sherman, A. J., Papour, A., Bhargava, S., John, M. S., Yong, W. H., Taylor, Z. D., Grundfest, W. S., & Stafsudd, O. M. (2013) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2013414 · Cited by 7
Establishment of Different Intraoperative Monitoring and Mapping Techniques and Their Impact on Survival, Extent of Resection, and Clinical Outcome in Patients with High-Grade Gliomas—A Series of 631 Patients in 14 Years
Staub‐Bartelt, F., Babu, M. P. S., Szelényi, A., Rapp, M., & Sabel, M. (2024) · Cancers · doi:10.3390/cancers16050926 · Cited by 6
Endoscopic Approach of the Insula Through the Anterior Middle Temporal Gyrus: A Feasibility Study in the Laboratory
Corrivetti, F., Froelich, S. C., & Mandonnet, E. (2017) · Operative Neurosurgery · doi:10.1093/ons/opx128 · Cited by 6
Outcomes of tumour related epilepsy in a specialised epilepsy surgery unit
Kim, J., Radjadurai, S., Rahman, Z., Hitos, K., Ghattas, S., Gomes, L., Wong, C., Bleasel, A., & Dexter, M. A. J. (2018) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2018.01.062 · Cited by 6
Resting state fMRI in pre-surgical brain mapping. Literature review
Смирнов, А. С., Sharaev, M., Melnikova-Pitskhelauri, T. V., Zhukov, V. Y., Bikanov, A. E., Sharova, E. V., Pogosbekyan, E. L., Turkin, A. M., Fadeeva, L. M., Pitskhelauri, D. V., et al. (2018) · Medical Visualization · doi:10.24835/1607-0763-2018-5-6-13 · Cited by 6
Development and implementation of a novel child life protocol to enhance psychosocial support for pediatric awake craniotomies: technical note
McDowell, M. M., Peraza, D. O., & Abel, T. J. (2020) · Neurosurgical FOCUS · doi:10.3171/2019.11.focus19774 · Cited by 6
The Efficacy of Intraoperative Passive Language Mapping for Glioma Surgery: A Case Report
Kanaya, K., Mitsuhashi, T., Kiuchi, T., & Kobayashi, S. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.652401 · Cited by 6
What is the cognitive footprint of insular glioma?
Nichols, N., Ezzat, B., Waters, A. C., Panov, F. E., Yong, R. L. M., & Germano, I. M. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1382380 · Cited by 6
Effects of tasks on BOLD signal responses to sentence contrasts: Review and commentary
Caplan, D. N., & Gow, D. W. (2010) · Brain and Language · doi:10.1016/j.bandl.2010.08.002 · Cited by 6
Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation
Sato, K., Fukuda, M., Sato, Y., Hiraishi, T., Takao, T., & Fujii, Y. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.07.037 · Cited by 6
Language recovery after epilepsy surgery of the Broca's area
Mnatsakanyan, L., Vadera, S., Ingalls, C. W., Zheng, J., Sazgar, M., Hsu, F. P. K., & Lin, J. J. (2017) · Epilepsy & Behavior Case Reports · doi:10.1016/j.ebcr.2017.06.002 · Cited by 7
Impact of connectivity between the pars triangularis and orbitalis on identifying the frontal language area in patients with dominant frontal gliomas
Saito, T., Muragaki, Y., Tamura, M., Maruyama, T., Nitta, M., Tsuzuki, S., & Kawamata, T. (2018) · Neurosurgical Review · doi:10.1007/s10143-018-1052-z · Cited by 6
Leptomeningeal dissemination of low-grade neuroepithelial CNS tumors in adults: a 15-year experience
Karschnia, P., Barbiero, F. J., Schwaiblmair, M. H., Kaulen, L. D., Piepmeier, J. M., Huttner, A. J., Becker, K. P., Fulbright, R. K., & Baehring, J. M. (2019) · Neuro-Oncology Practice · doi:10.1093/nop/npz020 · Cited by 6
Dexmedetomidine as adjunct in awake craniotomy – improvement or not?
Raimann, F. J., Adam, E., Strouhal, U., Zacharowski, K. D., Seifert, V., & Forster, M.-T. (2020) · Anaesthesiology Intensive Therapy · doi:10.5114/ait.2020.93043 · Cited by 6
Electrical Cortical Stimulation
Alarcón, G., Nawoor, L., & Valentı́n, A. (2020) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2020.03.013 · Cited by 6
Accurate Preoperative Identification of Motor Speech Area as Termination of Arcuate Fasciculus Depicted by Q-Ball Imaging Tractography
Koike, T., Tanaka, S., Kin, T., Suzuki, Y., Takayanagi, S., Takami, H., Kugasawa, K., Nambu, S., Omura, T., Yamazawa, E., et al. (2022) · World Neurosurgery · doi:10.1016/j.wneu.2022.05.041 · Cited by 6
A unique case of Chinese language and music dissociation with tumor located in Broca's area: Multimodal mapping for tumor resection and functional preservation
Zhang, J., Lu, J., Wu, J., Yao, C., Zhuang, D., Qiu, T., Mao, Y. Q., & Zhou, L. (2013) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2013.07.011 · Cited by 6
Impact of Extent of Resection on Outcomes in Patients with High-Grade Gliomas
Mukherjee, D. R., & Quiñones‐Hinojosa, A. (2011) · Springer eBooks · doi:10.1007/978-94-007-0618-7_19 · Cited by 6
Perioperative functional neuroimaging of gliomas in eloquent brain areas
Mellerio, C., Charron, S., Lion, S., Roca, P., Kuchcinski, G., Legrand, L., Edjlali, M., Naggara, O. N., Méder, J.-F., Pallud, J., et al. (2017) · Neurochirurgie · doi:10.1016/j.neuchi.2016.10.012 · Cited by 6
Awake Motor Examination During Intracranial Aneurysm Surgery
Abla, A. A., & Lawton, M. T. (2013) · World Neurosurgery · doi:10.1016/j.wneu.2013.09.032 · Cited by 6
‘Moderate global aphasia’: A generalized decline of language processing caused by glioma surgery but not stroke
Zyryanov, A., Stupina, E., Gordeyeva, E., Buivolova, O. V., Novozhilova, E., Akinina, Y. S., Бронов, О., Эдуардовна, Г. Н., Gunenko, G., Вячеславовна, И. Е., et al. (2021) · Brain and Language · doi:10.1016/j.bandl.2021.105057 · Cited by 6
The impact of intraoperative mapping during re-resection in recurrent gliomas: a systematic review
van Opijnen, M. P., Sadigh, Y., Dijkstra, M. E., Young, J. S., Krieg, S. M., Ille, S., Sanai, N., Rincón-Torroella, J., Maruyama, T., Schucht, P., et al. (2024) · Journal of Neuro-Oncology · doi:10.1007/s11060-024-04874-1 · Cited by 6
Self-citation
nTMS, MEG, and fMRI: Comparing and Contrasting Three Functional Mapping Techniques
Tarapore, P. E., & Nagarajan, S. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-54918-7_2 · Cited by 5
Trajectories of memory, language, and visuoperceptual problems in people with stroke during the first year and controls in Colombia
Olabarrieta‐Landa, L., Pugh, M., Chagualá, A. C., Perrin, P. B., & Arango‐Lasprilla, J. C. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2019.1622799 · Cited by 5
The biological and clinical basis for early referral of low grade glioma patients to a surgical neuro-oncologist
Dimou, J., & Kelly, J. J. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.04.119 · Cited by 5
Relation Between Reading Performance and White-Matter Alteration and Reorganization in Neurosurgical Patients
Cargnelutti, E., Maieron, M., Ius, T., Škrap, M., & Tomasino, B. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.563259 · Cited by 5
National medicare trends in the utilization of fMRI
Karambelkar, A., Gandhi, A. V., Trunz, L. M., Talekar, K. S., Faro, S. H., Gorniak, R., & Flanders, A. E. (2021) · Neuroscience Informatics · doi:10.1016/j.neuri.2021.100031 · Cited by 5
Prediction of Early Postoperative Language Function by Quantitative Evaluation with Visual and Auditory Naming Tasks during Awake Craniotomy for Brain Tumor Resection: Significance of Auditory Naming Task
Wakamatsu, K., Ishiai, S., Aihara, N., Kurokawa, S., Kimura, Y., & Mikuni, N. (2023) · Neurologia medico-chirurgica · doi:10.2176/jns-nmc.2022-0319 · Cited by 5
Mapping of cortical speech zones and arcuate tract in patients with gliomas of temporal lobe of left hemisphere (analysis of a series of 27 observations)
Zhukov, V. Y., Goryainov, S. A., Буклина, С. Б., Afandiev, R. M., Vologdina, Y. O., Maryashev, S. A., Ogurtsova, A. A., & Kobyakov, G. L. (2023) · Russian journal of neurosurgery · doi:10.17650/1683-3295-2023-25-1-53-61 · Cited by 5
The Association Between Task Complexity and Cortical Language Mapping Accuracy
Semonche, A. M., Lee, A., Negussie, M. B., Ambati, V. S., Aabedi, A. A., Kaur, J., Mehari, M., Berger, M. S., & Hervey‐Jumper, S. L. (2024) · Neurosurgery · doi:10.1227/neu.0000000000002981 · Cited by 5
Self-citation
Awake surgery for a deaf patient using sign language: A case report
Yamamoto, A., Kijima, N., Utsugi, R., Mrakami, K., Kuroda, H., Tachi, T., Hirayama, R., Okita, Y., Kagawa, N., & Kishima, H. (2024) · Surgical Neurology International · doi:10.25259/sni_52_2024 · Cited by 5
Changing the Paradigm for Tractography Segmentation in Neurosurgery: Validation of a Streamline-Based Approach
Sarubbo, S., Vavassori, L., Zigiotto, L., Corsini, F., Annicchiarico, L., Rozzanigo, U., & Avesani, P. (2024) · Brain Science · doi:10.3390/brainsci14121232 · Cited by 4
Efficacy and safety of anesthetic agents in awake craniotomy using monitored anesthesia care protocol: a systematic review and meta-analysis
Aghajanian, S., Naeimi, A., Mohammadifard, F., Mohammadi, I., Firouzabadi, S. R., Bagheri, A. B., Khorasanizadeh, M., & Elsamadicy, A. A. (2025) · Neurosurgical Review · doi:10.1007/s10143-025-03176-y · Cited by 5
Surgery for Diffuse Low-Grade Gliomas (DLGG) Oncological Considerations
Duffau, H. (2013) · Springer eBooks · doi:10.1007/978-1-4471-2213-5_23 · Cited by 5
A Wake “Anesthesia” for Intraoperative Language Testing During Temporary Clip Application in a Patient With Giant Intracranial Aneurysm
Bilotta, F., Santoro, A., & Rosa, G. (2010) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0b013e3181e416c7 · Cited by 5

Authors: Sanai, N., Mirzadeh, Z., & Berger, M. S.
Affiliations: University of California, San Francisco (US)
ORCID: Sanai, Nader
Mirzadeh, Zaman
Berger, Mitchel S.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2008-01-03
Volume: 358
Issue: 1
Pages: 18-27
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa067819
OpenAlex: W1989413447
Cited by: 1,065
References: 37
Citations by year: 2026: 28 · 2025: 44 · 2024: 50 · 2023: 64 · 2022: 62 · 2021: 73 · 2020: 69 · 2019: 62 · 2018: 67 · 2017: 84 · 2016: 70 · 2015: 74 · 2014: 63 · 2013: 61 · 2012: 50
FWCI: 21.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Health Sciences › Medicine › Surgery › Intraoperative Neuromonitoring and Anesthetic Effects
Keywords: glioma, intraoperative language mapping, awake craniotomy, language localization, language deficits, speech arrest, anomia, alexia, tumor resection
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Anomia, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Dominance, Cerebral, Dyslexia, Female, Glioma, Humans, Language, Language Tests, Male, Middle Aged, Postoperative Complications, Monitoring, Intraoperative

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Functional Outcome after Language Mapping for Glioma Resection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks