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Cited by 1,449Cardiac electrophysiology and arrhythmiasCardiovascular Effects of ExerciseCardiac pacing and defibrillation studies

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Sudden Cardiac Arrest Associated with Early Repolarization

Open access
Haïssaguerre, Michel, Derval, Nicolas, Sacher, Frederic, Jesel, Laurence, Deisenhofer, Isabel, de Roy, Luc, Pasquié, Jean-Luc, Nogami, Akihiko, Babuty, Dominique, Yli-Mayry, Sinikka, De Chillou, Christian, Scanu, Patrice, Mabo, Philippe, Matsuo, Seiichiro, Probst, Vincent, Le Scouarnec, Solena, Defaye, Pascal, Schlaepfer, Juerg, Rostock, Thomas, Lacroix, Dominique, Lamaison, Dominique, Lavergne, Thomas, Aizawa, Yoshifusa, Englund, Anders, Anselme, Frederic, O'Neill, Mark, Hocini, Meleze, Lim, Kang Teng, Knecht, Sebastien, Veenhuyzen, George D., Bordachar, Pierre, Chauvin, Michel, Jais, Pierre, Coureau, Gaelle, Chene, Genevieve, Klein, George J., Clémenty, Jacques·2008·New England Journal of Medicine
DOI 10.1056/nejmoa071968
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Abstract

BACKGROUND: Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a clinical association with sudden cardiac arrest. METHODS: We reviewed data from 206 case subjects at 22 centers who were resuscitated after cardiac arrest due to idiopathic ventricular fibrillation and assessed the prevalence of electrocardiographic early repolarization. The latter was defined as an elevation of the QRS-ST junction of at least 0.1 mV from baseline in the inferior or lateral lead, manifested as QRS slurring or notching. The control group comprised 412 subjects without heart disease who were matched for age, sex, race, and level of physical activity. Follow-up data that included the results of monitoring with an implantable defibrillator were obtained for all case subjects. RESULTS: Early repolarization was more frequent in case subjects with idiopathic ventricular fibrillation than in control subjects (31% vs. 5%, P<0.001). Among case subjects, those with early repolarization were more likely to be male and to have a history of syncope or sudden cardiac arrest during sleep than those without early repolarization. In eight subjects, the origin of ectopy that initiated ventricular arrhythmias was mapped to sites concordant with the localization of repolarization abnormalities. During a mean (+/-SD) follow-up of 61+/-50 months, defibrillator monitoring showed a higher incidence of recurrent ventricular fibrillation in case subjects with a repolarization abnormality than in those without such an abnormality (hazard ratio, 2.1; 95% confidence interval, 1.2 to 3.5; P=0.008). CONCLUSIONS: Among patients with a history of idiopathic ventricular fibrillation, there is an increased prevalence of early repolarization.

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  1. Wellens HJJ, 1992, Circulation, 85, I
  2. Loire R, 1996, Arch Mal Coeur Vaiss, 89, 13

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Metadata

Authors
Haïssaguerre, M., Derval, N., Sacher, F., Jesel, L., Deisenhofer, I., de Roy, L., Pasquié, J.-L., Nogami, A., Babuty, D., Yli-Mayry, S., De Chillou, C., Scanu, P., Mabo, P., Matsuo, S., Probst, V., Le Scouarnec, S., Defaye, P., Schlaepfer, J., Rostock, T., Lacroix, D., Lamaison, D., Lavergne, T., Aizawa, Y., Englund, A., Anselme, F., O'Neill, M., Hocini, M., Lim, K. T., Knecht, S., Veenhuyzen, G. D., Bordachar, P., Chauvin, M., Jais, P., Coureau, G., Chene, G., Klein, G. J., & Clémenty, J.
Affiliations
Université de Bordeaux (FR)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2008-05-08
Volume
358
Issue
19
Pages
2016-2023
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa071968
OpenAlex
W2168574959
Cited by
1,449
References
28
Citations by year
2026: 26 · 2025: 36 · 2024: 42 · 2023: 47 · 2022: 49 · 2021: 61 · 2020: 72 · 2019: 74 · 2018: 69 · 2017: 113 · 2016: 123 · 2015: 106 · 2014: 109 · 2013: 141 · 2012: 130
FWCI
60.38
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • DIAL (Catholic University of Leuven) (submittedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
  • IRIS (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
early repolarization, sudden cardiac arrest, idiopathic ventricular fibrillation, QRS notching, recurrent ventricular fibrillation, syncope, ventricular arrhythmias
MeSH terms
Actuarial Analysis, Adult, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Recurrence, Ventricular Fibrillation, Prevalence, Case-Control Studies, Death, Sudden, Cardiac, Catheter Ablation, Defibrillators, Implantable, Statistics, Nonparametric, Cardiac Electrophysiology

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