A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure

Mead, Simon, Whitfield, Jerome, Poulter, Mark, Shah, Paresh, Uphill, James, Campbell, Tracy, Al-Dujaily, Huda, Hummerich, Holger +6 more·2009·New England Journal of Medicine

Cited by (205)

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  2. Discriminant analysis of prion sequences for prediction of susceptibility
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  9. Frequency distribution of PRNP polymorphisms in the Pakistani population
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  10. Genome wide association studies and prion disease
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  15. Prion diseases: Lessons from historical outbreaks and potential emerging ones
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  17. Human prion diseases: current issues
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  18. Evolution of Transmissible Spongiform Encephalopathies and the Prion Protein Gene (PRNP) in Mammals
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  19. First report of a novel polymorphism and genetic characteristics of the leporine prion protein (PRNP) gene
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  20. Neuropathologically directed profiling of PRNP somatic and germline variants in sporadic human prion disease
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  27. Atomic insight into prion disorder: An intricate detail gained by 0.5 μs molecular dynamics simulation of preventive G127V and deleterious D178V mutation in prion protein
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  28. Evolved protection against human prions
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  29. Inherited Prion Disease May Manifest as Chronic Diarrhea Years Prior to Neurological Symptoms
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  32. 1H, 13C, 15N backbone and side‐chain resonance assignments of the pathogenic G131V mutant of human prion protein (91–231)
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  34. Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy
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  35. Novel Prion Protein Variant Found Protective Against Exposure to Kuru
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  39. A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model
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  40. Cofactor Involvement in Prion Propagation
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  41. Carphology by A Fo Ben
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  42. Human prion diseases
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  43. SimOutbreakSelection: a simulation-based tool to optimise sampling design and analysis strategies for detecting epidemic-driven selection
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  44. Kuru, the first prion disease: a travel back in time from Papua New Guinea to Neanderthals extinction
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  45. Biophysical characterization of oligomerization and fibrillization of the G131V pathogenic mutant of human prion protein
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  46. The first step towards the development of an electrophoretic prion detector
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  47. Transmissible Spongiform Encephalopathies of Humans and Animals
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  57. A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure
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  58. Kuru Susceptibility Genetics
    Michael D. Geschwind · 2010 · Journal watch
  59. Anthropological Methods Used in Kuru Research
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  60. Kuru: Introduction to Prion Diseases
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  61. The Prion Diseases
    Patrick Alfryn Lewis, Jennifer E. Spillane · 2018 · Elsevier eBooks
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  63. Genetic mutation blocks prion disease
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  64. Síndrome de Alpers uma variante da Doença de Creutzfeldt-Jakob?
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  70. Transgenic Mouse Models of Prion Diseases
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  72. Kuru
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  73. Volume 41 Number 4
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  75. Prions of Vertebrates
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  82. A gene–culture co-evolutionary perspective on the puzzle of human twinship
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  83. Prion Diseases of Animals and Humans
    Benjamin S. Steadman, Jason C. Bartz · 2024 · Springer eBooks
  84. Transmissible Spongiform Encephalopathies (Creutzfeldt-Jakob Disease, Gerstmann-Sträussler-Scheinker Disease, Kuru, Fatal Familial Insomnia, New Variant Creutzfeldt-Jakob Disease, Sporadic Fatal Insomnia, Variably Protease Sensitive Prionopathy)
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  85. Preparing for therapeutic trials in human prion disease: clinical and laboratory approaches to improve early diagnosis and monitoring of disease progression
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  86. Additional file 1 of Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods
    Jan Langeveld, Laura Pirisinu, Jorg G Jacobs et al. · 2020 · Figshare
  87. Additional file 3 of Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein
    Jan Langeveld, Anne Balkema‐Buschmann, Becher, Dieter et al. · 2021 · Figshare
  88. Additional file 5 of Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods
    Jan Langeveld, Laura Pirisinu, Jorg G Jacobs et al. · 2020 · Figshare
  89. Additional file 6 of Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods
    Jan Langeveld, Laura Pirisinu, Jorg G Jacobs et al. · 2020 · Figshare
  90. Additional file 2 of Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods
    Jan Langeveld, Laura Pirisinu, Jorg G Jacobs et al. · 2020 · Figshare
  91. Additional file 1 of Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein
    Jan Langeveld, Anne Balkema‐Buschmann, Becher, Dieter et al. · 2021 · Figshare
  92. Additional file 3 of Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods
    Jan Langeveld, Laura Pirisinu, Jorg G Jacobs et al. · 2020 · Figshare
  93. Additional file 4 of Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods
    Jan Langeveld, Laura Pirisinu, Jorg G Jacobs et al. · 2020 · Figshare
  94. Additional file 2 of Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein
    Jan Langeveld, Anne Balkema‐Buschmann, Becher, Dieter et al. · 2021 · Figshare
  95. Rôle de la protéine prion cellulaire (PRPC) dans la différenciation neuronale : Infection par les prions (PRPSC) et bases moléculaires de la neurodégénérescence
    Caroline Dakowski · 2012 · theses.fr (ABES)
  96. Evaluation expérimentale du risque prion lié aux porteurs asymptomatiques chez l'Homme et le macaque
    Jessica Rontard · 2018 · theses.fr (ABES)
  97. La protéine prion cellulaire : un relai de neurotoxicité commun aux protéines amyloïdes et aux nanoparticules
    François Boudet-Devaud · 2018 · theses.fr (ABES)
  98. De la fonction physiologique de la protéine prion cellulaire aux maladies neurodégénératives amyloïdes
    Hélène Arnould · 2019 · theses.fr (ABES)
  99. Du rôle physiologique de la protéine prion cellulaire à l'infection par les prions : régulation/dérégulation du module de signalisation PDK1/TACE α-secrétase
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  100. La protéine prion cellulaire : rôles physiologiques et implications croisées dans les maladies neurodégénératives amyloïdes
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