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Cited by 554

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Adjuvant Chemotherapy in Older Women with Early-Stage Breast Cancer

Open access
Muss, Hyman B., Berry, Donald A., Cirrincione, Constance T., Theodoulou, Maria, Mauer, Ann M., Kornblith, Alice B., Partridge, Ann H., Dressler, Lynn G., Cohen, Harvey J., Becker, Heather P., Kartcheske, Patricia A., Wheeler, Judith D., Perez, Edith A., Wolff, Antonio C., Gralow, Julie R., Burstein, Harold J., Mahmood, Ahmad A., Magrinat, Gustav, Parker, Barbara A., Hart, Ronald D., Grenier, Debjani, Norton, Larry, Hudis, Clifford A., Winer, Eric P.·2009·New England Journal of Medicine
DOI 10.1056/nejmoa0810266
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Abstract

BACKGROUND: Older women with breast cancer are underrepresented in clinical trials, and data on the effects of adjuvant chemotherapy in such patients are scant. We tested for the noninferiority of capecitabine as compared with standard chemotherapy in women with breast cancer who were 65 years of age or older. METHODS: We randomly assigned patients with stage I, II, IIIA, or IIIB breast cancer to standard chemotherapy (either cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide plus doxorubicin) or capecitabine. Endocrine therapy was recommended after chemotherapy in patients with hormone-receptor-positive tumors. A Bayesian statistical design was used with a range in sample size from 600 to 1800 patients. The primary end point was relapse-free survival. RESULTS: When the 600th patient was enrolled, the probability that, with longer follow-up, capecitabine therapy was highly likely to be inferior to standard chemotherapy met a prescribed level, and enrollment was discontinued. After an additional year of follow-up, the hazard ratio for disease recurrence or death in the capecitabine group was 2.09 (95% confidence interval, 1.38 to 3.17; P<0.001). Patients who were randomly assigned to capecitabine were twice as likely to have a relapse and almost twice as likely to die as patients who were randomly assigned to standard chemotherapy (P=0.02). At 3 years, the rate of relapse-free survival was 68% in the capecitabine group versus 85% in the standard-chemotherapy group, and the overall survival rate was 86% versus 91%. Two patients in the capecitabine group died of treatment-related complications; as compared with patients receiving capecitabine, twice as many patients receiving standard chemotherapy had moderate-to-severe toxic effects (64% vs. 33%). CONCLUSIONS: Standard adjuvant chemotherapy is superior to capecitabine in patients with early-stage breast cancer who are 65 years of age or older. (ClinicalTrials.gov number, NCT00024102.)

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Metadata

Authors
Muss, H. B., Berry, D. A., Cirrincione, C. T., Theodoulou, M., Mauer, A. M., Kornblith, A. B., Partridge, A. H., Dressler, L. G., Cohen, H. J., Becker, H. P., Kartcheske, P. A., Wheeler, J. D., Perez, E. A., Wolff, A. C., Gralow, J. R., Burstein, H. J., Mahmood, A. A., Magrinat, G., Parker, B. A., Hart, R. D., Grenier, D., Norton, L., Hudis, C. A., & Winer, E. P.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2009-05-14
Volume
360
Issue
20
Pages
2055-2065
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa0810266
OpenAlex
W2013600972
Cited by
554
References
33
FWCI
16.61
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Adjuvant Chemotherapy in Older Women with Early-Stage Breast Cancer. https://app.cochat.ai/papers/10.1056/nejmoa0810266
The paper
Muss, H. B., Berry, D. A., Cirrincione, C. T., Theodoulou, M., Mauer, A. M., Kornblith, A. B., Partridge, A. H., Dressler, L. G., Cohen, H. J., Becker, H. P., Kartcheske, P. A., Wheeler, J. D., Perez, E. A., Wolff, A. C., Gralow, J. R., Burstein, H. J., Mahmood, A. A., Magrinat, G., Parker, B. A., . . . Winer, E. P. (2009). Adjuvant Chemotherapy in Older Women with Early-Stage Breast Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejmoa0810266

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.