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Perioperative Safety in the Longitudinal Assessment of Bariatric Surgery
Open accessAbstract
BACKGROUND: To improve decision making in the treatment of extreme obesity, the risks of bariatric surgical procedures require further characterization. METHODS: We performed a prospective, multicenter, observational study of 30-day outcomes in consecutive patients undergoing bariatric surgical procedures at 10 clinical sites in the United States from 2005 through 2007. A composite end point of 30-day major adverse outcomes (including death; venous thromboembolism; percutaneous, endoscopic, or operative reintervention; and failure to be discharged from the hospital) was evaluated among patients undergoing first-time bariatric surgery. RESULTS: There were 4776 patients who had a first-time bariatric procedure (mean age, 44.5 years; 21.1% men; 10.9% nonwhite; median body-mass index [the weight in kilograms divided by the square of the height in meters], 46.5). More than half had at least two coexisting conditions. A Roux-en-Y gastric bypass was performed in 3412 patients (with 87.2% of the procedures performed laparoscopically), and laparoscopic adjustable gastric banding was performed in 1198 patients; 166 patients underwent other procedures and were not included in the analysis. The 30-day rate of death among patients who underwent a Roux-en-Y gastric bypass or laparoscopic adjustable gastric banding was 0.3%; a total of 4.3% of patients had at least one major adverse outcome. A history of deep-vein thrombosis or pulmonary embolus, a diagnosis of obstructive sleep apnea, and impaired functional status were each independently associated with an increased risk of the composite end point. Extreme values of body-mass index were significantly associated with an increased risk of the composite end point, whereas age, sex, race, ethnic group, and other coexisting conditions were not. CONCLUSIONS: The overall risk of death and other adverse outcomes after bariatric surgery was low and varied considerably according to patient characteristics. In helping patients make appropriate choices, short-term safety should be considered in conjunction with both the long-term effects of bariatric surgery and the risks associated with being extremely obese. (ClinicalTrials.gov number, NCT00433810.)
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“The complication evidence base included those studies from the efficacy and predictors searches that included complication data,141,156 as well as those studies that met the expanded search criteria.139,143,145,146,152,153,160,170,171”
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“Relative to other major surgical procedures, the operative mortality rate after bariatric surgery is low and it ranges from 0.28% to 0.4% [110-113].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [111]
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“19”
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“this type of procedure is performed on an outpatient basis in most certain centers and was therefore excluded from our analysis [7].”
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EARLY COMPLICATIONS IN BARIATRIC SURGERY:
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“The first proposal was by DeMaria et al. 3 in 2007, which was initially limited to estimating the mortality rate and was validated in this area by the author himself 4 and others 5,6 and then was extended to predicting morbidity in 2011 by Sarela et al. 7 Other proposals have followed Flum et al. 18 based on the result…”
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“Our study’s favorable outcomes occurred despite our exclusion of adjustable gastric band patients, as this procedure is usually associated with lower complication and mortality rates.(26) Therefore, we believe that incorporating IV acetaminophen into the perioperative management of bariatric patients, using a clinical…”
BackgroundComplications of bariatric surgery in adolescents
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The coming of age of metabolic surgery
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BackgroundMedical Malpractice in Bariatric Surgery: a Review of 140 Medicolegal Claims
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Tracheotomy Outcomes in Super Obese Patients
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“failed to find age as a risk factor in a large cohort of patients undergoing bariatric surgery [30].”
BackgroundResultCOMPLICATIONS REQUIRING HOSPITAL MANAGEMENT AFTER BARIATRIC SURGERY
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Severe Chronic Kidney Disease Is Associated with a Lower Efficiency of Bariatric Surgery
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“In our study, this led to an underestimation of comorbidity burden compared to specific, prospective databases used in other studies.(11,12)”
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“A composite 30-day end point was defined as death, postbariatric surgical operations, or unplanned postdischarge anticoagulation therapy for suspected venous thromboembolism and failure to be discharged after 30-days postsurgery.(19)”
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Is Laparoscopic Bariatric Surgery a Safe Option in Extremely High-Risk Morbidly Obese Patients?
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“7,8 The center-dependent comparison of surgical outcomes has also been made in several population-level studies.”
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Prevalence of obstructive sleep apnea in an Asian bariatric population: an underdiagnosed dilemma
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Chirurgie de l’obésité et ses complications
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Surgical treatment of type 2 diabetes: the surgeon perspective
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Ethnic Considerations for Metabolic Surgery
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Endobarrier as a Pre Bariatric Surgical Intervention in High-Risk Patients: a Feasibility Study
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“Impaired functional status has also been known as a factor for post-operative morbidity or mortality [35].”
BackgroundChanges in Smoking Behavior Before and After Gastric Bypass
King, W. C., White, G. E., Belle, S. H., Yanovski, S. Z., Pomp, A., Pories, W. J., Wolfe, B. M., Ahmed, B., & Courcoulas, A. P. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000003828 · Cited by 22
“Smoking prevalence 1 year before surgery (ie, 14%) in the current LABS-2 RYGB sample matches the past-year smoking prevalence reported among 4775 consecutive pre-surgical patients in the LABS-1 study.(30) Thus, both the LABS-1 and LABS-2 studies indicate smoking is slightly less common among adults the year before bar…”
ResultSchiesser, M., Kressig, P., Bueter, M., Nocito, A., Bauerfeind, P., & Gubler, C. (2014) · Digestive Surgery · doi:10.1159/000358849 · Cited by 22
Caiazzo, R. J., & Pattou, F. N. (2013) · Journal of Visceral Surgery · doi:10.1016/j.jviscsurg.2013.03.011 · Cited by 21
Strategies for Weight Reduction Prior to Total Joint Arthroplasty
Chen, M. J., Bhowmick, S., Beseler, L., Schneider, K. L., Kahan, S. I., Morton, J. M., Goodman, S. B., & Amanatullah, D. F. (2018) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.18.00020 · Cited by 21
Russian Consensus “Hyperammonemia in Adults” (Version 2021)
Lazebnik, L. B., Голованова, Е. В., Alekseenko, S. A., Bueverov, A. O., Plotnikova, E. Y., Dolgushina, A. I., Ilchenko, L. Y., Ермолова, Т. В., Тарасова, Л. В., Lee, E. D., et al. (2021) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-187-3-97-118 · Cited by 21
Neff, R. T., Havrilesky, L. J., Chino, J., O’Malley, D. M., & Cohn, D. E. (2015) · Gynecologic Oncology · doi:10.1016/j.ygyno.2015.07.002 · Cited by 21
G Protein-Coupled Receptors as Regulators of Energy Homeostasis
Tao, Y., Yuan, Z., & Xie, J. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386933-3.00001-7 · Cited by 21
Perioperative outcome of laparoscopic sleeve gastrectomy for high-risk patients
Borbély, Y., Juilland, O., Altmeier, J., Kröll, D., & Nett, P. C. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.08.492 · Cited by 21
“Although these patients could profit most from a bariatric procedure, they carry the highest perioperative risk and are therefore often refrained from surgery [5,6].”
BackgroundGan, J., Wang, Y., & Zhou, X. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3475-6 · Cited by 21
Ruíz-Tóvar, J., Zubiaga, L., Muñoz, J. L. B., & Llavero, C. (2018) · International Journal of Surgery · doi:10.1016/j.ijsu.2018.09.010 · Cited by 21
Citation classics: Top 50 cited articles in bariatric and metabolic surgery
Aminian, A., Daigle, C. R., Brethauer, S. A., & Schauer, P. R. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.12.021 · Cited by 21
“(LABS Consortium) [54] Perioperative safety in the longitudinal assessment of bariatric surgery New Engl.”
BackgroundKeshava, H. B., Mowla, A., Heinberg, L. J., Schauer, P. R., Brethauer, S. A., & Aminian, A. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.05.002 · Cited by 22
Bariatric Surgery in Septuagenarians: a Comparison with <60 Year Olds
Parmar, C. D., Mahawar, K. K., Carr, W. R. J., Schroeder, N., Balupuri, S., & Small, P. K. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2739-x · Cited by 21
Ansari, W. E., El-Menyar, A. A., El-Ansari, K., Al-Ansari, A. A., & Lock, M. (2024) · Obesity Surgery · doi:10.1007/s11695-024-07184-7 · Cited by 20
Dang, J. T., Tavakoli, I., Switzer, N. J., Mocanu, V., Shi, X., de Gara, C., Birch, D. W., & Karmali, S. (2020) · Canadian Journal of Surgery · doi:10.1503/cjs.014918 · Cited by 20
Surve, A., Potts, J., Cottam, D. R., Roslin, M. S., Medlin, W., Uchal, M., Richards, C., & Belnap, L. P. (2022) · Obesity Surgery · doi:10.1007/s11695-022-06051-7 · Cited by 20
Systematic Review of Same-Day Laparoscopic Adjustable Gastric Band Surgery
Thomas, H., & Agrawal, S. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0384-3 · Cited by 20
Varban, O. A., Reames, B. N., Finks, J. F., Thumma, J. R., & Dimick, J. B. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.09.030 · Cited by 20
“Prior studies evaluating the effect of volume on outcomes after bariatric surgery reported a strong relationship between low-volume hospitals and high rates of adverse events compared with high-volume hospitals [1– 3,5,16,17].”
ResultMorgan, D. J. R., & Ho, K. M. (2015) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2015.01.005 · Cited by 20
Fuller, A., RAZVI, H. A., Denstedt, J. D., Nott, L., Hendrikx, A. J. M., Luke, M., & de la Rosette, J. J. M. C. H. (2014) · Canadian Urological Association Journal · doi:10.5489/cuaj.2258 · Cited by 20
Eikermann, M., Garzon-Serrano, J., Kwo, J., Grosse-Sundrup, M., Schmidt, U. H., & Bigatello, L. M. (2010) · The Open Respiratory Medicine Journal · doi:10.2174/1874306401004010058 · Cited by 20
de Moura, E. G. H., Neto, A. M. D. P., Tsakmaki, A., Aiello, V. D., Bewick, G. A., & Brunaldi, V. (2019) · Endoscopy International Open · doi:10.1055/a-0862-0263 · Cited by 20
“However, bariatric surgery is associated with severe adverse events, rendering it unappealing for many patients [5 – 7].”
BackgroundGabriel, R. A., Burton, B. N., Ingrande, J., Joshi, G. P., Waterman, R. S., Spurr, K., & Urman, R. D. (2019) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2019.06.012 · Cited by 20
Is bariatric surgery safe in patients who refuse blood transfusion?
Kitahama, S., Smith, M. D., Rosencrantz, D. R., & Patterson, E. J. (2012) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.02.008 · Cited by 20
“Although the number of patients in the present study was ow, the complication rates were acceptable and in keeping ith other published data [8,11].”
BackgroundResultFollowing Bariatric Surgery: an Exploration of the Couples’ Experience
Pories, M. L., Hodgson, J. L., Rose, M. A., Pender, J. R., Sira, N., & Swanson, M. S. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1720-9 · Cited by 20
Nutrition Delivery for Obese ICU Patients
Martindale, R. G., DeLegge, M. H., McClave, S. A., Monroe, C., Smith, V. L., & Kiraly, L. N. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111415532 · Cited by 19
Hasley, R. B., Aly, S., Carter, C. O., Carmine, B. J., Hess, D. T., McAneny, D. B., & Pernar, L. I. M. (2022) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-021-05214-8 · Cited by 19
Ross, R. C., Akinde, Y. M., Schauer, P. R., le Roux, C. W., Brennan, D. J., Jernigan, A. M., Bueter, M., & Albaugh, V. L. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.943544 · Cited by 20
King, W. C., Hinerman, A. S., & White, G. E. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.31593 · Cited by 19
Provision of nutritional support to those experiencing complications following bariatric surgery
Segaran, E. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001965 · Cited by 19
Metabolic effects of sleeve gastrectomy in female rat model of diet-induced obesity
Brinckerhoff, T. Z., Bondada, S., Lewis, C. E., French, S. W., & DeUgarte, D. A. (2011) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2011.09.025 · Cited by 19
“025 in the treatment of morbid obesity, because it leads to significant long-term weight loss and a rapid resolution of co-morbidities and is associated with increased life expectancy [2–5].”
Metadata
- Authors
- The Longitudinal Assessment of Bariatric Surgery (LABS) Consortium
- Affiliations
- University of Washington (US)
- Corresponding author
- The Longitudinal Assessment of Bariatric Surgery (LABS) Consortium
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-07-30
- Volume
- 361
- Issue
- 5
- Pages
- 445-454
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC2854565
- OpenAlex
- W1558000543
- Cited by
- 1,392
- References
- 21
- Citations by year
- 2026: 17 · 2025: 30 · 2024: 34 · 2023: 44 · 2022: 64 · 2021: 52 · 2020: 73 · 2019: 82 · 2018: 79 · 2017: 88 · 2016: 115 · 2015: 122 · 2014: 136 · 2013: 107 · 2012: 121
- FWCI
- 116.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK066471, U01DK066557, U01DK066526, U01DK066568, U01DK066555, U01DK066667, U01DK066585)
- National Center for Research Resources (M01RR000037)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Surgery › Body Contouring and Surgery
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
- Keywords
- bariatric surgery, perioperative safety, morbid obesity, Roux-en-Y gastric bypass, laparoscopic adjustable gastric banding, postoperative mortality, venous thromboembolism, obstructive sleep apnea, body mass index, risk factors, patient decision-making
- MeSH terms
- Adult, Aged, Female, Humans, Length of Stay, Male, Middle Aged, Obesity, Postoperative Complications, Prospective Studies, Reoperation, Risk Factors, Thromboembolism, Comorbidity, Body Mass Index, Outcome Assessment, Health Care, Observation, Sleep Apnea, Obstructive, Venous Thrombosis, Bariatric Surgery
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