Two randomized trials of linaclotide for chronic constipation

Lembo, Anthony J., Schneier, Harvey A., Shiff, Steven J., Kurtz, Caroline B., MacDougall, James E., Jia, Xinwei D., Shao, James Z., Lavins, Bernard J. +6 more·2011·New England Journal of Medicine
DOI 10.1056/nejmoa1010863

Cited by (372)

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  15. Irritable Bowel Syndrome: Pathophysiology and Current Therapeutic Approaches
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