The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4
Open accessAbstract
An outbreak caused by Shiga-toxin–producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic analysis of an isolate from one member of the family. This analysis involved the use of rapid, bench-top DNA sequencing technology, open-source data release, and prompt crowd-sourced analyses. In less than a week, these studies revealed that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.
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Epidemic Profile of Shiga-Toxin–Producing Escherichia coli O104:H4 Outbreak in Germany
Frank, C., Werber, D., Cramer, J. P., Askar, M., Faber, M., an der Heiden, M., Bernard, H., Fruth, A., Prager, R., Spode, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106483 · Cited by 1,139
Cited by
Comparison of Next-Generation Sequencing Systems
Liu, L., Li, Y., Li, S., Hu, N., He, Y., Pong, R., Lin, D., Lu, L., & Law, M. (2012) · Journal of Biomedicine and Biotechnology · doi:10.1155/2012/251364 · Cited by 1,533
Self-citationEpidemic Profile of Shiga-Toxin–Producing Escherichia coli O104:H4 Outbreak in Germany
Frank, C., Werber, D., Cramer, J. P., Askar, M., Faber, M., an der Heiden, M., Bernard, H., Fruth, A., Prager, R., Spode, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106483 · Cited by 1,139
The human microbiome: Our second genome
Grice, E. A., & Segre, J. A. (2012) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090711-163814 · Cited by 759
E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity
Leimbach, A., Hacker, J., & Dobrindt, U. (2013) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2012_303 · Cited by 366
Current and Emerging Legionella Diagnostics for Laboratory and Outbreak Investigations
Mercante, J. W., & Winchell, J. M. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-14 · Cited by 339
Metadata
- Authors
- Rohde, H., Qin, J., Cui, Y., Li, D., Loman, N. J., Hentschke, M., Chen, W., Pu, F., Peng, Y., Li, J., Xi, F., Li, S., Li, Y., Zhang, Z., Yang, X., Zhao, M., Wang, P., Guan, Y., Cen, Z., Zhao, X., Christner, M., Kobbe, R., Loos, S., Oh, J., Yang, L., Danchin, A., Gao, G. F., Song, Y., Li, Y., Yang, H., Wang, J., Xu, J., Pallen, M. J., Wang, J., Aepfelbacher, M., & Yang, R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-08-25
- Volume
- 365
- Issue
- 8
- Pages
- 718-724
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2142898494
- Cited by
- 412
- References
- 1
- FWCI
- 41.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rohde, H., Qin, J., Cui, Y., Li, D., Loman, N. J., Hentschke, M., Chen, W., Pu, F., Peng, Y., Li, J., Xi, F., Li, S., Li, Y., Zhang, Z., Yang, X., Zhao, M., Wang, P., Guan, Y., Cen, Z., . . . Yang, R. (2011). Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1107643
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
