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Cited by 1,982

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Glioma Groups Based on 1p/19q,IDH, and TERT Promoter Mutations in Tumors

Open access
Eckel-Passow, Jeanette E., Lachance, Daniel H., Molinaro, Annette M., Walsh, Kyle M., Decker, Paul A., Sicotte, Hugues, Pekmezci, Melike, Rice, Terri, Kosel, Matt L., Smirnov, Ivan V., Sarkar, Gobinda, Caron, Alissa A., Kollmeyer, Thomas M., Praska, Corinne E., Chada, Anisha R., Halder, Chandralekha, Hansen, Helen M., McCoy, Lucie S., Bracci, Paige M., Marshall, Roxanne, Zheng, Shichun, Reis, Gerald F., Pico, Alexander R., O’Neill, Brian P., Buckner, Jan C., Giannini, Caterina, Huse, Jason T., Perry, Arie, Tihan, Tarik, Berger, Mitchell S., Chang, Susan M., Prados, Michael D., Wiemels, Joseph, Wiencke, John K., Wrensch, Margaret R., Jenkins, Robert B.·2015·New England Journal of Medicine
DOI 10.1056/nejmoa1407279
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Abstract

BACKGROUND: The prediction of clinical behavior, response to therapy, and outcome of infiltrative glioma is challenging. On the basis of previous studies of tumor biology, we defined five glioma molecular groups with the use of three alterations: mutations in the TERT promoter, mutations in IDH, and codeletion of chromosome arms 1p and 19q (1p/19q codeletion). We tested the hypothesis that within groups based on these features, tumors would have similar clinical variables, acquired somatic alterations, and germline variants. METHODS: We scored tumors as negative or positive for each of these markers in 1087 gliomas and compared acquired alterations and patient characteristics among the five primary molecular groups. Using 11,590 controls, we assessed associations between these groups and known glioma germline variants. RESULTS: Among 615 grade II or III gliomas, 29% had all three alterations (i.e., were triple-positive), 5% had TERT and IDH mutations, 45% had only IDH mutations, 7% were triple-negative, and 10% had only TERT mutations; 5% had other combinations. Among 472 grade IV gliomas, less than 1% were triple-positive, 2% had TERT and IDH mutations, 7% had only IDH mutations, 17% were triple-negative, and 74% had only TERT mutations. The mean age at diagnosis was lowest (37 years) among patients who had gliomas with only IDH mutations and was highest (59 years) among patients who had gliomas with only TERT mutations. The molecular groups were independently associated with overall survival among patients with grade II or III gliomas but not among patients with grade IV gliomas. The molecular groups were associated with specific germline variants. CONCLUSIONS: Gliomas were classified into five principal groups on the basis of three tumor markers. The groups had different ages at onset, overall survival, and associations with germline variants, which implies that they are characterized by distinct mechanisms of pathogenesis. (Funded by the National Institutes of Health and others.).

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Authors
Eckel-Passow, J. E., Lachance, D. H., Molinaro, A. M., Walsh, K. M., Decker, P. A., Sicotte, H., Pekmezci, M., Rice, T., Kosel, M. L., Smirnov, I. V., Sarkar, G., Caron, A. A., Kollmeyer, T. M., Praska, C. E., Chada, A. R., Halder, C., Hansen, H. M., McCoy, L. S., Bracci, P. M., Marshall, R., Zheng, S., Reis, G. F., Pico, A. R., O’Neill, B. P., Buckner, J. C., Giannini, C., Huse, J. T., Perry, A., Tihan, T., Berger, M. S., Chang, S. M., Prados, M. D., Wiemels, J., Wiencke, J. K., Wrensch, M. R., & Jenkins, R. B.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2015-06-25
Volume
372
Issue
26
Pages
2499-2508
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1407279
OpenAlex
W571060166
Cited by
1,982
References
3
FWCI
91.47
Type
journal article
Language
en
Open access
bronze

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