The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery
Open accessAbstract
BACKGROUND: Atrial fibrillation after cardiac surgery is associated with increased rates of death, complications, and hospitalizations. In patients with postoperative atrial fibrillation who are in stable condition, the best initial treatment strategy--heart-rate control or rhythm control--remains controversial. METHODS: Patients with new-onset postoperative atrial fibrillation were randomly assigned to undergo either rate control or rhythm control. The primary end point was the total number of days of hospitalization within 60 days after randomization, as assessed by the Wilcoxon rank-sum test. RESULTS: Postoperative atrial fibrillation occurred in 695 of the 2109 patients (33.0%) who were enrolled preoperatively; of these patients, 523 underwent randomization. The total numbers of hospital days in the rate-control group and the rhythm-control group were similar (median, 5.1 days and 5.0 days, respectively; P=0.76). There were no significant between-group differences in the rates of death (P=0.64) or overall serious adverse events (24.8 per 100 patient-months in the rate-control group and 26.4 per 100 patient-months in the rhythm-control group, P=0.61), including thromboembolic and bleeding events. About 25% of the patients in each group deviated from the assigned therapy, mainly because of drug ineffectiveness (in the rate-control group) or amiodarone side effects or adverse drug reactions (in the rhythm-control group). At 60 days, 93.8% of the patients in the rate-control group and 97.9% of those in the rhythm-control group had had a stable heart rhythm without atrial fibrillation for the previous 30 days (P=0.02), and 84.2% and 86.9%, respectively, had been free from atrial fibrillation from discharge to 60 days (P=0.41). CONCLUSIONS: Strategies for rate control and rhythm control to treat postoperative atrial fibrillation were associated with equal numbers of days of hospitalization, similar complication rates, and similarly low rates of persistent atrial fibrillation 60 days after onset. Neither treatment strategy showed a net clinical advantage over the other. (Funded by the National Institutes of Health and the Canadian Institutes of Health Research; ClinicalTrials.gov number, NCT02132767.).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A recent medium-sized trial randomizing patients with postoperative AF to either rhythm control therapy with amiodarone or to rate control did not find a difference in hospital admissions during a 60day follow-up, 962”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [962]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,145
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596
A comparison of rate control and rhythm control in patients with atrial fibrillation
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa021328 · Cited by 4,405
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805
Wann, L. S., Curtis, A. B., January, C. T., Ellenbogen, K. A., Lowe, J. E., Estes, N. A. M., Page, R. L., Ezekowitz, M. D., Slotwiner, D. J., Jackman, W. M., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181fa3cf4 · Cited by 1,338
A multicenter risk index for atrial fibrillation after cardiac surgery
Mathew, J. P. (2004) · JAMA · doi:10.1001/jama.291.14.1720 · Cited by 1,234
Predictors of Atrial Fibrillation After Coronary Artery Surgery
Aranki, S. F., Shaw, D. P., Adams, D. H., Rizzo, R. J., Couper, G. S., VanderVliet, M., Collins, J. J., Cohn, L. H., & Burstin, H. R. (1996) · Circulation · doi:10.1161/01.cir.94.3.390 · Cited by 1,180
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Huezey, J.-Y. L., Lowe, J. E., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.013 · Cited by 928
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Le Huezey, J.-Y., Lowe, J. E., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318214876d · Cited by 859
Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery
Mathew, J. P. (1996) · JAMA · doi:10.1001/jama.276.4.300 · Cited by 806
Mechanisms, Prevention, and Treatment of Atrial Fibrillation After Cardiac Surgery
Echahidi, N., Pîbarot, P., O’Hara, G. E., & Mathieu, P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.043 · Cited by 678
Management Practices and Major Infections After Cardiac Surgery
Gelijns, A. C., Moskowitz, A. J., Acker, M. A., Argenziano, M., Geller, N. L., Puskas, J. D., Perrault, L. P., Smith, P. K., Kron, I. L., Michler, R. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.04.052 · Cited by 184
Self-citationPostoperative Atrial Fibrillation
Chelazzi, C., Villa, G., & Gaudio, A. R. D. (2011) · ISRN Cardiology · doi:10.5402/2011/203179 · Cited by 110
Lee, J. K., Klein, G. J., Krahn, A. D., Yee, R. K., Zarnke, K. B., Simpson, C. S., Skanes, A. C., & Spindler, B. (2000) · American Heart Journal · doi:10.1067/mhj.2000.111104 · Cited by 81
The Changing Face of Postoperative Atrial Fibrillation Prevention
Mayson, S. E., Greenspon, A. J., Adams, S., DeCaro, M. V., Sheth, M. P., Weitz, H. H., & Whellan, D. J. (2007) · Cardiology in Review · doi:10.1097/crd.0b013e31813e62bb · Cited by 75
Atrial fibrillation after cardiac surgery
Nair, S. (2010) · Annals of Cardiac Anaesthesia · doi:10.4103/0971-9784.69047 · Cited by 68
Özaydın, M., Icli, A., Yücel, H., Akçay, S., Peker, O., Erdoğan, D., Varol, E., Doğan, A. F., & Okutan, H. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs423 · Cited by 67
Atrial fibrillation following cardiac surgery.
Mitchell, L. B., Crystal, E., Heilbron, B., & Pagé, P. (1996) · PubMed · Cited by 59
Al‐Khatib, S. M., Hafley, G. E., Harrington, R. A., Mack, M. J., Ferguson, T. B., Peterson, E. D., Califf, R. M., Kouchoukos, N. T., & Alexander, J. H. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.09.003 · Cited by 46
Self-citationPostoperative Atrial Fibrillation
Jongnarangsin, K., & Oral, H. (2008) · Cardiology Clinics · doi:10.1016/j.ccl.2008.09.011 · Cited by 37
Lee, J. K., Klein, G. J., Krahn, A. D., Yee, R. K., Zarnke, K. B., Simpson, C. S., & Skanes, A. C. (2003) · Cardiac Electrophysiology Review · doi:10.1023/a:1027428003609 · Cited by 30
Imazio, M., Belli, R., Brucato, A. L., Ferrazzi, P., Patrini, D., Martinelli, L., Polizzi, V., Cemin, R., Leggieri, A., Caforio, A. L. P., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.03.025 · Cited by 25
Cited by
Sorted by citations
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castella, M., Dan, G.-A., Dilaveris, P., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 10,550
2018 ESC/EACTS guidelines on myocardial revascularization
Neumann, F.-J., Sousa-Uva, M., Ahlsson, A., Alfonso, F., Banning, A. P., Benedetto, U., Byrne, R. A., Collet, J.-P., Falk, V., Head, S. J., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy394 · Cited by 7,167
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
Gelder, I. C. V., Rienstra, M., Bunting, K. V., Casado-Arroyo, R., Caso, V., Crijns, H. J. G. M., Potter, T. J. R. D., Dwight, J., Guasti, L., Hanke, T., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae176 · Cited by 3,594
Metadata
- Authors
- Gillinov, A. M., Bagiella, E., Moskowitz, A. J., Raiten, J. M., Groh, M. A., Bowdish, M. E., Ailawadi, G., Kirkwood, K. A., Perrault, L. P., Parides, M. K., Smith, R. L., Kern, J. A., Dussault, G., Hackmann, A. E., Jeffries, N. O., Miller, M. A., Taddei-Peters, W. C., Rose, E. A., Weisel, R. D., Williams, D. L., Mangusan, R. F., Argenziano, M., Moquete, E. G., O’Sullivan, K. L., Pellerin, M., Shah, K. J., Gammie, J. S., Mayer, M. L., Voisine, P., Gelijns, A. C., O’Gara, P. T., & Mack, M. J.
- Affiliations
- Cleveland Clinic (US)
- Mission Health (US)
- University of Southern California (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of Maryland Medical Center (US)
- Brigham and Women's Hospital (US)
- ORCID
- Gillinov, A. Marc
- Bagiella, Emilia
- Moskowitz, Alan J.
- Bowdish, Michael E.
- Ailawadi, Gorav
- Kirkwood, Katherine A.
- Perrault, Louis P.
- Parides, Michael K.
- Smith, Robert L.
- Kern, John A.
- Miller, Marissa A.
- Williams, Deborah L.
- Mangusan, Ralph F.
- Argenziano, Michael
- Gammie, James S.
- Voisine, Pierre
- Gelijns, Annetine C.
- O’Gara, Patrick T.
- Mack, Michael J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-05-19
- Volume
- 374
- Issue
- 20
- Pages
- 1911-1921
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4908812
- OpenAlex
- W2328315835
- Cited by
- 398
- References
- 22
- Citations by year
- 2026: 25 · 2025: 35 · 2024: 32 · 2023: 44 · 2022: 42 · 2021: 39 · 2020: 43 · 2019: 39 · 2018: 34 · 2017: 45 · 2016: 20
- FWCI
- 37.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Brigham and Women's Hospital
- University of Southern California
- University of Pennsylvania
- University of Toronto
- Université de Montréal
- Institut de Cardiologie de Montréal
- National Institutes of Health (5u01hl088953-05)
- Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval
- Canadian Institutes of Health Research
- National Heart, Lung, and Blood Institute (UM1HL117922, UM1HL118007, R01HL102121, UM1HL088963, UM1HL088953, UM1HL088939, UM1HL088955, UM1HL117924, U01HL088942, UM1HL088925, U01-HL088953)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
- Keywords
- postoperative atrial fibrillation, cardiac surgery, rate control, rhythm control, amiodarone, hospitalization, persistent atrial fibrillation, anticoagulation, thromboembolism, bleeding events, adverse drug reactions
- MeSH terms
- Adrenergic beta-Antagonists, Aged, Amiodarone, Angiotensin-Converting Enzyme Inhibitors, Anti-Arrhythmia Agents, Atrial Fibrillation, Combined Modality Therapy, Electric Countershock, Female, Heart Rate, Cardiac Surgical Procedures, Humans, Male, Middle Aged, Postoperative Complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
