Cited by 916Sepsis Diagnosis and TreatmentHemodynamic Monitoring and TherapyTrauma, Hemostasis, Coagulopathy, Resuscitation

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Angiotensin II for the Treatment of Vasodilatory Shock

Open access

Khanna, Ashish, English, Shane W., Wang, Xueyuan S., Ham, Kealy, Tumlin, James, Szerlip, Harold, Busse, Laurence W., Altaweel, Laith, Albertson, Timothy E., Mackey, Caleb, McCurdy, Michael T., Boldt, David W., Chock, Stefan, Young, Paul J., Krell, Kenneth, Wunderink, Richard G., Ostermann, Marlies, Murugan, Raghavan, Gong, Michelle N., Panwar, Rakshit, Hästbacka, Johanna, Favory, Raphael, Venkatesh, Balasubramanian, Thompson, B. Taylor, Bellomo, Rinaldo, Jensen, Jeffrey, Kroll, Stew, Chawla, Lakhmir S., Tidmarsh, George F., Deane, Adam M.·2017·New England Journal of Medicine

DOI 10.1056/nejmoa1704154

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Vasodilatory shock that does not respond to high-dose vasopressors is associated with high mortality. We investigated the effectiveness of angiotensin II for the treatment of patients with this condition. METHODS: We randomly assigned patients with vasodilatory shock who were receiving more than 0.2 μg of norepinephrine per kilogram of body weight per minute or the equivalent dose of another vasopressor to receive infusions of either angiotensin II or placebo. The primary end point was a response with respect to mean arterial pressure at hour 3 after the start of infusion, with response defined as an increase from baseline of at least 10 mm Hg or an increase to at least 75 mm Hg, without an increase in the dose of background vasopressors. RESULTS: A total of 344 patients were assigned to one of the two regimens; 321 received a study intervention (163 received angiotensin II, and 158 received placebo) and were included in the analysis. The primary end point was reached by more patients in the angiotensin II group (114 of 163 patients, 69.9%) than in the placebo group (37 of 158 patients, 23.4%) (odds ratio, 7.95; 95% confidence interval [CI], 4.76 to 13.3; P<0.001). At 48 hours, the mean improvement in the cardiovascular Sequential Organ Failure Assessment (SOFA) score (scores range from 0 to 4, with higher scores indicating more severe dysfunction) was greater in the angiotensin II group than in the placebo group (-1.75 vs. -1.28, P=0.01). Serious adverse events were reported in 60.7% of the patients in the angiotensin II group and in 67.1% in the placebo group. Death by day 28 occurred in 75 of 163 patients (46%) in the angiotensin II group and in 85 of 158 patients (54%) in the placebo group (hazard ratio, 0.78; 95% CI, 0.57 to 1.07; P=0.12). CONCLUSIONS: Angiotensin II effectively increased blood pressure in patients with vasodilatory shock that did not respond to high doses of conventional vasopressors. (Funded by La Jolla Pharmaceutical Company; ATHOS-3 ClinicalTrials.gov number, NCT02338843 .).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmoa1704154

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

APACHE II
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,518
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine (see contributors to the project in the appendix)
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,371
Comparison of Dopamine and Norepinephrine in the Treatment of Shock
De Backer, D., Biston, P., Devriendt, J., Madl, C., Chochrad, D., Aldecoa, C., Brasseur, A., Defrance, P., Gottignies, P., & Vincent, J.-L. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907118 · Cited by 1,940
Epidemiology of severe sepsis
Mayr, F., Yende, S. P., & Angus, D. C. (2013) · Virulence · doi:10.4161/viru.27372 · Cited by 1,298
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock*
López, A., Lorente, J. A., Steingrub, J. S., Bakker, J., McLuckie, A., Willatts, S. M., Brockway, M., Anzueto, A., Holzapfel, L., Breen, D. P., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000105581.01815.c6 · Cited by 917
Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock
Morelli, A., Ertmer, C., Westphal, M., Rehberg, S. W., Kampmeier, T., Ligges, S., Orecchioni, A., D’Egidio, A., D''Ippoliti, F., Raffone, C., et al. (2013) · JAMA · doi:10.1001/jama.2013.278477 · Cited by 739
History about the discovery of the renin-angiotensin system.
Basso, N., & Terragno, N. (2001) · HYPERTENSION · doi:10.1161/hy1201.101214 · Cited by 236
Survival After Shock Requiring High-Dose Vasopressor Therapy
Brown, S. M., Lanspa, M. J., Jones, J. P., Kuttler, K. G., Li, Y., Carlson, R., Miller, R. R., Hirshberg, E. L., Grissom, C. K., & Morris, A. H. (2013) · CHEST Journal · doi:10.1378/chest.12-1106 · Cited by 211

Flagged first, then by citations

Show all 24 references

Research works printed but not linked: 2

Chawla LS, 2017, Crit Care Resusc, 19, 43
Bassi E, 2013, Crit Care Res Pract, 2013, 654708

Sorted by citations

Items 601–700 of 916

Proline, a privileged fragment in drug design: advances and future perspectives
Li, T.-T., Liu, L.-R., Ge, G., Guo, S., Zhang, X., Zhou, X., Liu, J.-Y., Liang, J.-W., Fan-hao, M., & Zhang, T. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118685 · Cited by 2
Animal models of critical illness in the Asia–Pacific region: current practices, shared challenges, and future directions
Fujinami, Y., Liu, S., Bassi, G. L., Osuchowski, M. F., Yao, Y., Fraser, J. F., & Inoue, S. (2026) · Intensive Care Medicine Experimental · doi:10.1186/s40635-026-00874-9 · Cited by 2
The Weight of the Situation: The Case for Standardizing Vasopressor Dosing Units
Rudoni, M. A., Sacha, G. L., Dugar, S. P., Motayar, N., & Wieruszewski, P. M. (2026) · Critical Care Medicine · doi:10.1097/ccm.0000000000007141 · Cited by 2
Pre intubation vasopressor infusions and the risk of haemodynamic instability following emergency intubation in the ICU
Brown, A., Cuthbertson, G., Boer, M., Walker, H. G. M., & Faltys, M. (2026) · Trends in Anaesthesia and Critical Care · doi:10.1016/j.tacc.2026.101658 · Cited by 2
Targeting the Renin-Angiotensin-Aldosterone System: Preclinical and Clinical Developments
Steckelings, U. M., Rossitto, G., & Bäder, M. (2026) · Circulation Research · doi:10.1161/circresaha.126.327681 · Cited by 2
Early multimodal vasopressor strategy in septic shock: results of the TRICYCLE randomized controlled trial
Kalamar, Ž., Landoni, G., Gorenjak, M., Cestar, I., Fluher, J., Horvat, M., Jerenec, K., Kit, B., Marinšek, M., Puklavec, N., et al. (2026) · Critical Care · doi:10.1186/s13054-026-06323-z · Cited by 2
Sudden cardiac arrest in hypertrophic cardiomyopathy with dynamic cavity obstruction: The case for a decatecholaminisation strategy
Balan, C. I., & Wong, A. V.-K. (2017) · Journal of the Intensive Care Society · doi:10.1177/1751143717732729 · Cited by 2
Too Much Pressure at the Bedside...*
Beale, R. J. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003333 · Cited by 2
Lessons from the ICU: Choosing the Right Vasopressor
Fiorini, F., Antcliffe, D. B., & Gordon, A. C. (2019) · Lessons from the ICU · doi:10.1007/978-3-319-69269-2_30 · Cited by 2
Prise en charge de la nécrose tubulaire aiguë en 2020
Lafargue, M.-C., Aubert, S., Rabemiarason, N., Vilaine, É., Ébel, A., Dargelos, M., Couturier, A., Massy, Z. A., & Essig, M. (2021) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2020.11.002 · Cited by 2
Update in Critical Care 2020
Khemani, R. G., Lee, J. T., Wu, D., Schenck, E. J., Hayes, M. M., Kritek, P., Mutlu, G. M., Gershengorn, H. B., & Coudroy, R. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202102-0336up · Cited by 2
Principles of Resuscitation
Kupchik, N. (2021) · Critical Care Nursing Clinics of North America · doi:10.1016/j.cnc.2021.05.001 · Cited by 2
Evaluation of High-Frequency Oscillatory Ventilation as a Rescue Strategy in Respiratory Failure
Thind, G. S., Hatipoglu, U. S., Chatburn, R. L., Krishnan, S., Duggal, A., & Mireles‐Cabodevila, E. (2021) · Respiratory Care · doi:10.4187/respcare.08936 · Cited by 2
Incidence of Hypotension Associated With Two Different Vasopressin Discontinuation Strategies in the Recovery Phase of Septic Shock
Murata, J., Buckley, M. S., Lehn, J. M., Agarwal, S., Stevenson, B., Martinez, B. K., & MacLaren, R. (2022) · Journal of Pharmacy Practice · doi:10.1177/08971900221078270 · Cited by 2
Agentes vasoactivos en sepsis: revisión crítica de la literatura
Correa, J. E. B., Carrillo, V. P., Rondón-Carvajal, J., & Laserna, A. (2023) · Universitas Médica · doi:10.11144/javeriana.umed64-2.seps · Cited by 2
Adoption of a Novel Vasopressor Agent in Critically Ill Adults
Vail, E. A., Bosch, N. A., Law, A. C., Gershengorn, H. B., Wunsch, H., & Walkey, A. J. (2023) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202306-540rl · Cited by 2
BENEFIT OF HIGHER BLOOD PRESSURE TARGET IN SEVERE ACUTE KIDNEY INJURY TREATED BY CONTINUOUS RENAL REPLACEMENT THERAPY
Matsuura, R., Komaru, Y., Hamasaki, Y., Nangaku, M., & Doi, K. (2023) · Shock · doi:10.1097/shk.0000000000002207 · Cited by 2
Prior Use of Angiotensin-converting Enzyme Inhibitors or Angiotensin II Receptor Blockers and Clinical Outcomes of Sepsis and Septic Shock: A Systematic Review and Meta-analysis
Shrestha, D. B., Sedhai, Y. R., Oli, P. R., Proskuriakova, E., Adelkhanova, A., Shtembari, J., Khan, T. M. A., Singh, K., Ahmed, M. A., Waheed, I., et al. (2023) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001491 · Cited by 2
The Dubious Ethics of Patient-Level Cost Containment in the ICU
Kellum, J. A. (2024) · Critical Care Medicine · doi:10.1097/ccm.0000000000006373 · Cited by 2
Kidney Blood Flow and Renin-Angiotensin-Aldosterone System Measurements Associated With Kidney and Cardiovascular Dysfunction in Pediatric Shock
Fisler, G. M., Murphy, K., Mastroianni, F., Schneider, J. B., Deutschman, C. S., Leisman, D. E., & Taylor, M. D. (2024) · Critical Care Explorations · doi:10.1097/cce.0000000000001134 · Cited by 2
Dexmedetomidine Improves Microcirculatory Alterations in Patients With Initial Resuscitated Septic Shock
Xu, J., Wang, Y., Shu, C., Chang, W., & Guo, F. (2024) · Journal of Intensive Care Medicine · doi:10.1177/08850666241267860 · Cited by 2
Renal dysfunction in surgical patients
Booke, H., Zarbock, A., & Meersch, M. (2024) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001203 · Cited by 2
Fluids, Vasopressors, and Inotropes to Restore Heart–Vessel Coupling in Sepsis: Treatment Options and Perspectives
Innocenti, F., Palmieri, V., Grossi, G., Maddaluni, L., Scardia, A., & Pini, R. (2024) · Anesthesia Research · doi:10.3390/anesthres1020013 · Cited by 2
Rapid uptake of adjunctive corticosteroids for critically ill adults with septic shock following publication of ADRENAL trial. A multicenter, retrospective analysis of prescribing practices in Queensland Intensive Care Units
White, K. C., Chaba, A., Meyer, J., Ramanan, M., Tabah, A., Attokaran, A. G., Kumar, A., McCullough, J., Shekar, K., Garrett, P., et al. (2024) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2024.101435 · Cited by 2
Angiotensin II in Vasoplegia: Expanding Frontiers in Hemodynamic Therapy
Siddiqui, N., Sanders, J., & Krishnan, S. K. (2025) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2025.02.023 · Cited by 2
The Role of Angiotensin‐II Infusion in an Infant With Autosomal Recessive Polycystic Kidney Disease Postbilateral Nephrectomies and Refractory Hypotension in the Neonatal Period
Gilbert, A. N., Bischoff, A. R., & Merrill, K. A. (2025) · Case Reports in Nephrology · doi:10.1155/crin/1431773 · Cited by 2
ATS Core Curriculum 2020. Adult Critical Care Medicine
Çoruh, B., Pasnick, S., Acho, M., Bass, G. D., Baston, C. M., Card, M. E., de Moraes, A. G., Griffeth, V. E. M., Kanj, A., Leveno, M. J., et al. (2020) · ATS Scholar · doi:10.34197/ats-scholar.2020-0015re · Cited by 2
Successful treatment of intravenous drug abuser with refractory vasoplegic syndrome after mitral valve repair for infective endocarditis
Lambert, J., Hayanga, J. W. A., Turley, S., McCarthy, P. J., Salman, M. M. A., Kabulski, G. M., Henrickson, R. E., Cook, C., & Hayanga, H. K. (2021) · SAGE Open Medical Case Reports · doi:10.1177/2050313x211019788 · Cited by 2
How Effective is Angiotensin II in Decreasing Mortality of Vasodilatory Shock? A Systematic Review
Semedi, B. P., Rehatta, N. M., Soetjipto, S., Nugraha, J., Mahyuddin, M. H., Arnindita, J. N., & Wairooy, N. A. P. (2023) · Open Access Emergency Medicine · doi:10.2147/oaem.s391167 · Cited by 2
Use of Aerosolized Prostacyclins in Critically Ill Patients and Association With Clinical Outcomes
Hussain, S. T., Jaliawala, H. A., Zhao, D. Y., Ijaz, S. H., Tsui, J., Chasteen, B., Brown, B. R., & Bernardo, R. J. (2023) · Critical Care Explorations · doi:10.1097/cce.0000000000000845 · Cited by 2
Fármacos vasoactivos en el tratamiento del shock séptico
Andaluz‐Ojeda, D., Cantón‐Bulnes, M. L., Richter, C. P., & Garnacho‐Montero, J. (2022) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2022.03.007 · Cited by 2
The Time Course of Catecholamine Dose Reduction in Septic Shock as a Predictor of Bacterial Susceptibility to Empiric Antimicrobial Therapy: A Retrospective Observational Study
Kuwana, T., Kinoshita, K., Yamaya, Y., Takahashi, K., Yamaguchi, J., Sakurai, A., & Imai, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13216618 · Cited by 2
Vasoaktive Substanzen im septischen Schock – individualisierte Strategien
Lehner, G. F., Mayerhöfer, T., Perschinka, F., Benda, B., & Joannidis, M. (2025) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-025-01272-x · Cited by 2
Hydroxocobalamin Dosing Strategies for Vasoplegic Syndrome Post-cardiac Surgery: A Retrospective Cohort Study
Behlers, Q. B., Buenger, B., Peitz, G. J., Shostrom, V., & Brannan, S. (2025) · Cureus · doi:10.7759/cureus.85596 · Cited by 2
Methylene Blue in Septic Shock: Emerging Evidence, Clinical Applications, and Future Directions
Maheshwari, N., Malkania, B., & Mudiyanselage, R. (2025) · Cureus · doi:10.7759/cureus.86701 · Cited by 3
Intensivmedizinische Studien aus 2017/2018
Reuß, C. J., Bernhard, M. H., Beynon, C., Hecker, A., Jungk, C., Nußhag, C., Weigand, M. A., Michalski, D., & Brenner, T. (2018) · Der Anaesthesist · doi:10.1007/s00101-018-0474-x · Cited by 2
Inotropes and Vasoactive Agents: Differences Between Europe and the United States
Beersel, D. V., & Rex, S. (2019) · Current anesthesiology reports · doi:10.1007/s40140-019-00323-2 · Cited by 2
Choc septique réfractaire à la noradrénaline
Meresse, Z., Medam, S., Mathieu, C., & Léone, M. (2019) · Anesthésie & Réanimation · doi:10.1016/j.anrea.2019.03.002 · Cited by 3
Perioperative management in cardiovascular surgery
Rivera, J. J. J., Jorge, C. L., Gude, M. J. L., & Vela, J. L. P. (2021) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2020.10.005 · Cited by 2
24th International Symposium on Infections in the Critically Ill Patient
Artigas, A., Carlet, J. M., Garnacho, J., Niederman, M. S., & Torres, A. (2019) · Medical Sciences · doi:10.3390/medsci7020023 · Cited by 2
Shock: causes, assessment and investigation
Dockrell, L., & Gantner, D. C. (2023) · Anaesthesia & intensive care medicine · doi:10.1016/j.mpaic.2022.12.010 · Cited by 2
Acute Kidney Injury and Renal Replacement Therapy
Tam, C. W., Kumar, S. R., & Chow, J. (2023) · Anesthesiology Clinics · doi:10.1016/j.anclin.2022.10.004 · Cited by 2
Characterizing the Stability of Angiotensin II in 0.9% Sodium Chloride Using High Performance Liquid Chromatography and Liquid Chromatography Tandem Mass Spectrometry
Belcher, R. M., Mashhad, S., Dahlquist, A., Johnson, J. J., Dangi, B., Benedetti, E., Benken, J. J., & Benken, S. T. (2023) · Hospital Pharmacy · doi:10.1177/00185787231206525 · Cited by 2
Angiotensin II and Thromboembolism—Reading the Fine Print*
Kotani, Y., & Khanna, A. K. (2024) · Critical Care Medicine · doi:10.1097/ccm.0000000000006468 · Cited by 2
Self-citation
The Birth of Angiotensin: An International Compromise
Smulyan, H., & Villarreal, D. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2018.08.017 · Cited by 2
États de choc : grands cadres étiologiques, prise en charge initiale
Durand, A., Cartier, L., Duburcq, T., Onimus, T., Favory, R., & Préau, S. (2019) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2019.08.006 · Cited by 2
Self-citation
Angiotensin II for the emergency physician
Wallis, M., Chow, J. H., Winters, M. E., & McCurdy, M. T. (2020) · Emergency Medicine Journal · doi:10.1136/emermed-2019-209062 · Cited by 2
Self-citation
Angiotensin II for the treatment of septic shock in a neutropenic patient with T-cell acute lymphoblastic leukaemia
Bui, A., Helgeson, S. A., Guru, P. K., & Sanghavi, D. (2020) · BMJ Case Reports · doi:10.1136/bcr-2019-233432 · Cited by 2
Two-component vasopressor therapy for septic shock
Kochkin, А. А., Likhvantsev, V. V., & Kadantseva, K. (2021) · Messenger of Anesthesiology and Resuscitation · doi:10.21292/2078-5658-2021-18-1-57-64 · Cited by 2
ATHOS-3 and the knights of the round table—the search for the holy grail of vasopressors
Heßler, M., Arnemann, P., Seidel, L., Kampmeier, T., Rehberg, S. W., & Ertmer, C. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.08.29 · Cited by 2
Treatment with angiotensin II in COVID-19 patients may not be beneficial
Rysz, S., Jalde, F. C., Oldner, A., Eriksson, L. I., Lundberg, J., & Fagerlund, M. J. (2020) · Critical Care · doi:10.1186/s13054-020-03233-6 · Cited by 2
Vasoplegia in cardiac surgery: Know your enemy and attack early
Slomovits, M., Neuburger, P. J., & Rong, L. Q. (2021) · Journal of Cardiac Surgery · doi:10.1111/jocs.15670 · Cited by 2
Hydroxocobalamin Versus Methylene Blue: Still Unanswered and Needing a Change in Approach
Kumar, N., Falkson, S. R., Lu, S., & Dalia, A. A. (2023) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2023.08.134 · Cited by 2
Vasopressor use in septic shock: separating evidence, practice, and future directions
Fage, N., Chew, M. S., & Asfar, P. (2026) · Intensive Care Medicine · doi:10.1007/s00134-026-08337-1 · Cited by 2
Septic shock patients with adequate tissue perfusion parameters still need the recommended minimal Mean Arterial Pressure: Not really
Gazmuri, R. J., & de Gomez, C. A. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.01.009 · Cited by 1
Optimal Inotropic Support Strategy in Low Cardiac Output Syndrome
Miles, T. J., Blackburn, K. W., Moon, M. R., & Chatterjee, S. (2025) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2025.04.002 · Cited by 1
Vasopressin Is Not Associated With Severe Kidney Injury in Liver Transplantation: A Propensity Score-adjusted Analysis
Antonucci, E., Bokoch, M. P., Adelmann, D., Kolodzie, K., Roll, G. R., Sun, E., Legrand, M. M., & Kothari, R. P. (2025) · Transplantation Direct · doi:10.1097/txd.0000000000001814 · Cited by 1
Emerging Paradigms in Sepsis Management: Critical Insights from Contemporary Clinical Trials
Sasidharan, S., & Dhillon, H. S. (2025) · APIK Journal of Internal Medicine · doi:10.4103/ajim.ajim_32_25 · Cited by 1
A Novel Digital Phenotype for Burn Sepsis: Leveraging Electronic Health Record Data and Natural Language Processing to Improve Case Definition
Soulakis, N. D., Li, L., Peters, A. A., & Kubasiak, J. (2026) · Applied Clinical Informatics · doi:10.1055/a-2885-7810 · Cited by 1
Causes, Predictors, and Treatment of Vasoplegia in Cardiac Surgery: A Narrative Review
Awad, A. S., Mangold, A. S., Ainechi, A., & Mitrev, L. V. (2026) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000008086 · Cited by 1
Current and future strategies aiming at reducing catecholamine exposure in septic shock
Dubech, A., Picod, A., Pierre, A., Préau, S., Favory, R., & Garcia, B. (2026) · Critical Care · doi:10.1186/s13054-026-06109-3 · Cited by 1
Self-citation
Cardiogenic Shock Supported With VA-ECMO: Association Between cDPP3 Concentrations and Outcomes in a Post Hoc Analysis of the ADRECMO Cohort
Bruno, J., Durand, M., Azibani, F., Louis, H., Sadoune, M., Duarte, K., Girerd, N., Santos, K. F., Hartmann, O., Lévy, B., et al. (2026) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2026.07.030 · Cited by 1
Early hemodynamic response to angiotensin II defines a prognostic phenotype in bloodstream infection–associated septic shock
Khattar, G., Ham, K., Danley, S., Cartin‐Ceba, R., Skolnik, A., Sen, A., & Pulsipher, A. M. (2026) · Journal of Critical Care · doi:10.1016/j.jcrc.2026.155708 · Cited by 1
Self-citation
Strategies for the Management of Sepsis
Gilbert, B. W., Reichert, M., & Fletcher, S. (2019) · AACN Advanced Critical Care · doi:10.4037/aacnacc2019526 · Cited by 1
Vasopressor Drugs
Singhal, V., Chopra, P., & Sikri, V. (2024) · Springer eBooks · doi:10.1007/978-981-99-8059-8_23 · Cited by 1
Development of an improved Scientific Registry of Transplant Recipients deceased donor heart yield model using donor critical care data from the Donor Management Goal Registry cohort
Swanson, E. A., Kian, S., Noreen, S. M., Shivega, W. G., McBride, V., Lange, P., Sally, M. B., & Malinoski, D. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.07.001 · Cited by 1
Apelin-13 administration allows for norepinephrine sparing in a rat model of cecal ligation and puncture-induced septic shock
Salvail, W., Salvail, D., Chagnon, F., & Lesur, O. (2024) · Intensive Care Medicine Experimental · doi:10.1186/s40635-024-00650-7 · Cited by 1
Management of AKI: Vasopressors
Persona, P., & Pettenuzzo, T. (2024) · Springer eBooks · doi:10.1007/978-3-031-66541-7_32 · Cited by 1
Recent Advances in Nephrology: The Research Gaps and the Need for Greater Emphasis on Incorporating Hard Clinical Endpoints
Okafor, E., Ebede, S. O., & Agbo, E. (2025) · Nigerian Journal of Clinical Practice · doi:10.4103/njcp.njcp_867_23 · Cited by 1
Angiotensin II Use in Postcardiac Surgery Vasoplegic Syndrome Patients: A Single‐Center Descriptive Experience
Auerbach, J. S., Gershengorn, H. B., Cabrera, J. L., Lamelas, J., Patel, S. S., Ferreira, T., Perez, D., & Jain, P. (2025) · Journal of Cardiac Surgery · doi:10.1155/jocs/8801912 · Cited by 1
Insights Into the Pathophysiology of Catecholamine-Refractory Shock: A Narrative Review
Gonçalves, A., Pereira, F. G., Fernandes, S. M., & Gonçalves-Pereira, J. (2025) · Cureus · doi:10.7759/cureus.86224 · Cited by 1
Prevalence and characteristics of metaraminol usage in a large intensive care patient cohort. A multicentre, retrospective, observational study
Zimsen, T., Quick, L., White, G., Costa‐Pinto, R., Whebell, S. F., Meyer, J., McCullough, J., Shekar, K., Laupland, K. B., Ramanan, M., et al. (2025) · Critical Care and Resuscitation · doi:10.1016/j.ccrj.2025.100112 · Cited by 1
Refractory septic shock: our updated pragmatic approach
Palmesino, F., Woodman-Bailey, A., Hanks, F., Khoo, S., Ostermann, M., Ioannou, N., Meadows, C. I. S., & Wyncoll, D. L. A. (2026) · Journal of Anesthesia Analgesia and Critical Care · doi:10.1186/s44158-025-00336-w · Cited by 1
Self-citation
Suicide left ventricle after aortic valve intervention: Mechanisms, risk phenotypes, and clinical considerations
Tang, D. C. Y., Salter, R., Chatfield, A., Young, P. J., & Ch’ng, S. L. T. (2026) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2026.03.005 · Cited by 1
Self-citation
Renin-Angiotensin-Aldosterone Medication Use and Outcomes in Injured Patients Receiving Blood
Werenski, H. E., Diz, D. I., Chappell, M. C., Hoth, J. J., Avery, M. D., Nunn, A. M., & Stettler, G. R. (2026) · Journal of Surgical Research · doi:10.1016/j.jss.2026.03.045 · Cited by 1
Advances in Cardiovascular Pharmacotherapy. VIII. Angiotensin II in Vasodilatory Shock
Pagel, P. S., Hang, D., Freed, J. K., & Crystal, G. J. (2026) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2026.04.027 · Cited by 1
Protocolized Evaluation of Permissive Blood Pressure Targets Versus Usual Care (PRESSURE): Statistical Analysis Plan for the PRESSURE Trial
Viola, T., Broomhall, J. M., Sadique, Z., Mouncey, P., Harrison, D. A., Inwald, D. P., & for the Protocolized Evaluation of Permissive Blood Pressure Targets vs. Usual Care (PRESSURE) trial investigators on behalf of the Paediatric Critical Care Society Study Group (PCCS-SG) (2026) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000003961 · Cited by 1
Management Algorithm for Vasoplegic Shock After Cardiac Surgery: An Interdisciplinary Collaboration
Chatterjee, S., Ortoleva, J. P., Arora, R. C., Dalton, K., Engelman, D. T., Girardi, L. N., Grant, M. C., Miles, T. J., Moon, M. R., Suero, O. R., et al. (2026) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2026.06.013 · Cited by 1
Beyond the Pump: Unravelling Immunometabolic Crosstalk and Organelle Dynamics in Sepsis-Induced Cardiomyopathy
Liu, G., Hao, L., Zhang, J., Guo, Y., Lv, G., Liu, J., Cheng, C., Yi, H., Zhou, J., & Liu, Z. (2026) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-026-10826-z · Cited by 1
The Postcardiac Arrest Inflammatory Response: Mechanisms and Therapeutic Targets
Batchelor, R., Stub, D. A., Donner, D. G., Burrell, A. J. C., Nehme, Z., Bloom, J. E., & Kaye, D. M. (2026) · Circulation · doi:10.1161/circulationaha.126.080096 · Cited by 1
Elevated Serum Renin Before Liver Transplantation Is Associated With Increased Intraoperative Vasopressor Requirements and Posttransplant Acute Kidney Injury
Hilaire, L. S., Tran, A. T., Kothari, R. P., Adelmann, D., Hellman, J., & Bokoch, M. P. (2026) · Transplantation · doi:10.1097/tp.0000000000005877 · Cited by 1
Angiotensin II — a new tool in vasodilatory shock
Fernández-Ruíz, I. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.90 · Cited by 1
Vasopressor hormones in shock—noradrenaline, vasopressin or angiotensin II: which one will make the race?
Dünser, M. W., & Meier, J. M. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.06.127 · Cited by 1
Vasopressors in Sepsis
Ortiz, J. A., & Backer, D. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-73506-1_9 · Cited by 1
Differenzierter Einsatz kardiovaskulär wirksamer Substanzen
Rehberg, S. W. (2018) · Intensivmedizin up2date · doi:10.1055/s-0043-121074 · Cited by 1
Noteworthy Literature in 2018 for Cardiovascular Anesthesiologists and Intensivists
Flynn, B. C., Shen, L., Littlejohn, J., Shirak, M. O., & Ivascu, N. S. (2019) · Seminars in Cardiothoracic and Vascular Anesthesia · doi:10.1177/1089253219842659 · Cited by 1
Special Considerations for ICU Management of Patients Receiving CAR Therapy
Mahadeo, K. M., Tambaro, F. P., & Gutiérrez, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-66181-2.00006-8 · Cited by 1
Terlipressin for refractory septic shock: a study protocol of a single center, placebo-controlled double-blind phase III RCT (The TERESEP study).
Aritajati, T., Chayakul, C., & Tongyoo, S. (2022) · Clinical Critical Care · doi:10.54205/ccc.v30.254966 · Cited by 1
Angiotensin in Critical Care
Hall, A., Busse, L. W., & Ostermann, M. (2018) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-319-73670-9_10 · Cited by 1
Self-citation
Circulatory Failure/Shock
Pfeiffer, S., & Wong, H. R. (2021) · Springer eBooks · doi:10.1007/978-3-030-53363-2_17 · Cited by 2
Angiotensin in shock
See, E. J., Lankadeva, Y. R., Bellomo, R., & May, C. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99618-1.00024-6 · Cited by 1
Self-citation
A Rare Cause of Refractory Vasodilatory Shock Due to Calcium Channel Blocker Toxicity from Drug-Drug Interaction Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) And Manidipine
Sathaporn, N., Khwannimit, B., Wisaratapong, T., & Wongpraphairot, S. (2023) · Journal of Health Science and Medical Research · doi:10.31584/jhsmr.2023962 · Cited by 1
Early and mid-term outcome of inhaled versus intravenous milrinone in patients with rheumatic mitral stenosis and pulmonary hypertension undergoing mitral valve surgery
Patel, J., Garg, P., Madkaiker, A., Lakhia, K., & Patel, K. G. (2024) · Heart Vessels and Transplantation · doi:10.24969/hvt.2024.484 · Cited by 1
Thrombotic Safety of Angiotensin II for Distributive Shock in the Cardiothoracic Intensive Care Unit
Cunningham, C., Pawlowski, A. E., & Schaidle, S. B. (2024) · Journal of Pharmacy Practice · doi:10.1177/08971900241287614 · Cited by 1
The Argument for Clinician Autonomy, Individualized Care, and the Use of Adjunctive Vasopressors
See, E. J., Chaba, A., & Bellomo, R. (2024) · Critical Care Medicine · doi:10.1097/ccm.0000000000006409 · Cited by 1
Self-citation
Septic Shock: Pathophysiology to Patient Care
Saboohi, E., Mallick, A. H., & Shahid, Y. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1007410 · Cited by 1
Systemic and Pulmonary Microcirculation, Double Microcirculation: From Basic Concepts to Treatment Key Points
Wang, G., Deng, Q., Wang, J., Zhang, Q., Lian, H., & Wang, X. (2025) · Journal of Intensive Care Medicine · doi:10.1177/08850666251321786 · Cited by 1
Self-citation
Effectiveness of Corticosteroids on Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Patients with Septic Shock: A Retrospective Claims Database Study
Takano, H., Kanda, N., Ohbe, H., Yoshida, M., & Nakamura, K. (2025) · Journal of Intensive Care Medicine · doi:10.1177/08850666251353723 · Cited by 1
Angiotensin II for septic shock treatment
Griffiths, C. L., Jackson, M., Hoke, T. J., & Hertel, K. A. (2018) · Nursing Critical Care · doi:10.1097/01.ccn.0000546307.15415.e6 · Cited by 1
Angiotensin in Clinical Practice
Ahmadnia, E., Hall, A., & Ostermann, M. (2019) · Journal of Translational Critical Care Medicine · doi:10.4103/jtccm.jtccm_1_18 · Cited by 1
Self-citation

Authors: Khanna, A., English, S. W., Wang, X. S., Ham, K., Tumlin, J., Szerlip, H., Busse, L. W., Altaweel, L., Albertson, T. E., Mackey, C., McCurdy, M. T., Boldt, D. W., Chock, S., Young, P. J., Krell, K., Wunderink, R. G., Ostermann, M., Murugan, R., Gong, M. N., Panwar, R., Hästbacka, J., Favory, R., Venkatesh, B., Thompson, B. T., Bellomo, R., Jensen, J., Kroll, S., Chawla, L. S., Tidmarsh, G. F., & Deane, A. M.
Affiliations: Cleveland Clinic (US)
Regions Hospital (US)
Inova Health System (US)
Albert Einstein College of Medicine (US)
University of Maryland, Baltimore (US)
Northwestern University (US)
ORCID: Khanna, Ashish
English, Shane W.
Ham, Kealy
Szerlip, Harold
Busse, Laurence W.
Albertson, Timothy E.
McCurdy, Michael T.
Young, Paul J.
Wunderink, Richard G.
Ostermann, Marlies
Murugan, Raghavan
Gong, Michelle N.
Panwar, Rakshit
Hästbacka, Johanna
Venkatesh, Balasubramanian
Thompson, B. Taylor
Bellomo, Rinaldo
Chawla, Lakhmir S.
Deane, Adam M.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2017-08-03
Volume: 377
Issue: 5
Pages: 419-430
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1704154
OpenAlex: W2614578436
Cited by: 916
References: 24
Citations by year: 2026: 100 · 2025: 103 · 2024: 121 · 2023: 103 · 2022: 90 · 2021: 95 · 2020: 123 · 2019: 80 · 2018: 75 · 2017: 25
FWCI: 64.87
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Figshare (submittedVersion)
Työväentutkimus Vuosikirja (submittedVersion)
Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
NOVA (University of Newcastle Australia) (submittedVersion)
Funders: Bristol-Myers Squibb
GlaxoSmithKline
La Jolla Pharmaceutical Company
Alexion Pharmaceuticals
Regeneron Pharmaceuticals
Genentech
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords: angiotensin II, vasodilatory shock, septic shock, vasopressors, norepinephrine, mean arterial pressure, SOFA score, mortality, blood pressure response, adverse events, sepsis treatment, vasopressor-refractory shock, fluid resuscitation, vasopressor dose reduction, organ dysfunction, 28-day mortality
MeSH terms: Aged, Angiotensin II, Blood Pressure, Catecholamines, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Hypotension, Male, Middle Aged, Shock, Vasoconstrictor Agents, Organ Dysfunction Scores

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Angiotensin II for the Treatment of Vasodilatory Shock

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks