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Transfer of Fresh versus Frozen Embryos in Ovulatory Women
Open accessAbstract
BACKGROUND: Elective frozen-embryo transfer has been shown to result in a higher live-birth rate than fresh-embryo transfer among anovulatory women with the polycystic ovary syndrome. It is uncertain whether frozen-embryo transfer increases live-birth rates among ovulatory women with infertility. METHODS: In this multicenter, randomized trial, we randomly assigned 2157 women who were undergoing their first in vitro fertilization cycle to undergo either fresh-embryo transfer or embryo cryopreservation followed by frozen-embryo transfer. Up to two cleavage-stage embryos were transferred in each participant. The primary outcome was a live birth after the first embryo transfer. RESULTS: The live-birth rate did not differ significantly between the frozen-embryo group and the fresh-embryo group (48.7% and 50.2%, respectively; relative risk, 0.97; 95% confidence interval [CI], 0.89 to 1.06; P=0.50). There were also no significant between-group differences in the rates of implantation, clinical pregnancy, overall pregnancy loss, and ongoing pregnancy. Frozen-embryo transfer resulted in a significantly lower risk of the ovarian hyperstimulation syndrome than fresh-embryo transfer (0.6% vs. 2.0%; relative risk, 0.32; 95% CI, 0.14 to 0.74; P=0.005). The risks of obstetrical and neonatal complications and other adverse outcomes did not differ significantly between the two groups. CONCLUSIONS: The live-birth rate did not differ significantly between fresh-embryo transfer and frozen-embryo transfer among ovulatory women with infertility, but frozen-embryo transfer resulted in a lower risk of the ovarian hyperstimulation syndrome. (Funded by the National Key Research and Development Program of China and the National Natural Science Foundation of China; Chinese Clinical Trial Registry number, ChiCTR-IOR-14005406 .).
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Cited by
Neonatal and maternal outcome after frozen embryo transfer: Increased risks in programmed cycles
Ginström Ernstad, E., Wennerholm, U.-B., Khatibi, A., Petzold, M., & Bergh, C. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.03.010 · Cited by 330
Bourdon, M., Raad, J., Dahan, Y., Marcellin, L., Maignien, C., Even, M., Pocate-Cheriet, K., Lamau, M. C., Santulli, P., & Chapron, C. (2018) · PLOS ONE · doi:10.1371/journal.pone.0202399 · Cited by 42
Lee, J. C., Badell, M. L., & Kawwass, J. F. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00869-z · Cited by 41
Dyer, S., Archary, P., de Mouzon, J., Fiadjoe, M., & Ashiru, O. (2019) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.11.001 · Cited by 25
Wei, Q., Chen, H., Zou, H., Zhang, H., Liu, S., Zheng, J., Zhang, S., & Hu, L. (2024) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-024-03066-0 · Cited by 16
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Metadata
- Authors
- Shi, Y., Sun, Y., Hao, C., Zhang, H., Wei, D., Zhang, Y., Zhu, Y., Deng, X., Qi, X., Li, H., Ma, X., Ren, H., Wang, Y., Zhang, D., Wang, B., Liu, F., Wu, Q., Wang, Z., Bai, H., Li, Y., Zhou, Y., Sun, M., Liu, H., Li, J., Zhang, L., Chen, X., Zhang, S., Sun, X., Legro, R. S., & Chen, Z.-J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2018-01-11
- Volume
- 378
- Issue
- 2
- Pages
- 126-136
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2783637675
- Cited by
- 511
- References
- 0
- FWCI
- 57.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shi, Y., Sun, Y., Hao, C., Zhang, H., Wei, D., Zhang, Y., Zhu, Y., Deng, X., Qi, X., Li, H., Ma, X., Ren, H., Wang, Y., Zhang, D., Wang, B., Liu, F., Wu, Q., Wang, Z., Bai, H., . . . Chen, Z.-J. (2018). Transfer of Fresh versus Frozen Embryos in Ovulatory Women. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1705334
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