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PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock
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BACKGROUND: In patients who have acute myocardial infarction with cardiogenic shock, early revascularization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes. However, the majority of patients with cardiogenic shock have multivessel disease, and whether PCI should be performed immediately for stenoses in nonculprit arteries is controversial. METHODS: In this multicenter trial, we randomly assigned 706 patients who had multivessel disease, acute myocardial infarction, and cardiogenic shock to one of two initial revascularization strategies: either PCI of the culprit lesion only, with the option of staged revascularization of nonculprit lesions, or immediate multivessel PCI. The primary end point was a composite of death or severe renal failure leading to renal-replacement therapy within 30 days after randomization. Safety end points included bleeding and stroke. RESULTS: At 30 days, the composite primary end point of death or renal-replacement therapy had occurred in 158 of the 344 patients (45.9%) in the culprit-lesion-only PCI group and in 189 of the 341 patients (55.4%) in the multivessel PCI group (relative risk, 0.83; 95% confidence interval [CI], 0.71 to 0.96; P=0.01). The relative risk of death in the culprit-lesion-only PCI group as compared with the multivessel PCI group was 0.84 (95% CI, 0.72 to 0.98; P=0.03), and the relative risk of renal-replacement therapy was 0.71 (95% CI, 0.49 to 1.03; P=0.07). The time to hemodynamic stabilization, the risk of catecholamine therapy and the duration of such therapy, the levels of troponin T and creatine kinase, and the rates of bleeding and stroke did not differ significantly between the two groups. CONCLUSIONS: Among patients who had multivessel coronary artery disease and acute myocardial infarction with cardiogenic shock, the 30-day risk of a composite of death or severe renal failure leading to renal-replacement therapy was lower among those who initially underwent PCI of the culprit lesion only than among those who underwent immediate multivessel PCI. (Funded by the European Union 7th Framework Program and others; CULPRIT-SHOCK ClinicalTrials.gov number, NCT01927549 .).
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“Among patients presenting with ST-elevation myocardial infarction (STEMI), ∼25% have a history of diabetes and more than 40% show a previously undiagnosed T2DM or pre-diabetes.410”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [410]
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Metadata
- Authors
- Thiele, H., Akin, I., Sandri, M., Fuernau, G., de Waha, S., Meyer-Saraei, R., Nordbeck, P., Geisler, T., Landmesser, U., Skurk, C., Fach, A., Lapp, H., Piek, J. J., Noc, M., Goslar, T., Felix, S. B., Maier, L. S., Stepinska, J., Oldroyd, K., Serpytis, P., Montalescot, G., Barthelemy, O., Huber, K., Windecker, S., Savonitto, S., Torremante, P., Vrints, C., Schneider, S., Desch, S., & Zeymer, U.
- Affiliations
- University Hospital Leipzig (DE)
- Universitätsklinikum Tübingen (DE)
- Amsterdam UMC Location University of Amsterdam (NL)
- Ljubljana University Medical Centre (SI)
- Universität Greifswald (DE)
- University Hospital Regensburg (DE)
- Sorbonne Université (FR)
- Sigmund Freud Privatuniversität Wien (AT)
- University of Bern (CH)
- Alessandro Manzoni Hospital (IT)
- Antwerp University Hospital (BE)
- Stiftung Institut für Herzinfarktforschung (DE)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-12-21
- Volume
- 377
- Issue
- 25
- Pages
- 2419-2432
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2766152280
- Cited by
- 1,209
- References
- 21
- Citations by year
- 2026: 99 · 2025: 152 · 2024: 175 · 2023: 141 · 2022: 125 · 2021: 138 · 2020: 136 · 2019: 113 · 2018: 111 · 2017: 14
- FWCI
- 78.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion)
- BORIS (University Library Bern) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- GRO (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Open Access CRIS of the University of Bern
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
- Keywords
- acute myocardial infarction, cardiogenic shock, percutaneous coronary intervention, multivessel coronary artery disease, staged revascularization, early revascularization, renal replacement therapy, mortality, bleeding complications, stroke, hemodynamic stabilization, catecholamine therapy, troponin T, creatine kinase, 30-day outcomes
- MeSH terms
- Aged, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Myocardial Infarction, Risk, Shock, Cardiogenic, Renal Replacement Therapy, Renal Insufficiency, Kaplan-Meier Estimate, Time-to-Treatment, Percutaneous Coronary Intervention
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