The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
. Effects of serelaxin in patients with acute heart failure
Open accessAbstract
BACKGROUND: Serelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in better outcomes in patients with acute heart failure. METHODS: In this multicenter, double-blind, placebo-controlled, event-driven trial, we enrolled patients who were hospitalized for acute heart failure and had dyspnea, vascular congestion on chest radiography, increased plasma concentrations of natriuretic peptides, mild-to-moderate renal insufficiency, and a systolic blood pressure of at least 125 mm Hg, and we randomly assigned them within 16 hours after presentation to receive either a 48-hour intravenous infusion of serelaxin (30 μg per kilogram of body weight per day) or placebo, in addition to standard care. The two primary end points were death from cardiovascular causes at 180 days and worsening heart failure at 5 days. RESULTS: A total of 6545 patients were included in the intention-to-treat analysis. At day 180, death from cardiovascular causes had occurred in 285 of the 3274 patients (8.7%) in the serelaxin group and in 290 of the 3271 patients (8.9%) in the placebo group (hazard ratio, 0.98; 95% confidence interval [CI], 0.83 to 1.15; P = 0.77). At day 5, worsening heart failure had occurred in 227 patients (6.9%) in the serelaxin group and in 252 (7.7%) in the placebo group (hazard ratio, 0.89; 95% CI, 0.75 to 1.07; P = 0.19). There were no significant differences between the groups in the incidence of death from any cause at 180 days, the incidence of death from cardiovascular causes or rehospitalization for heart failure or renal failure at 180 days, or the length of the index hospital stay. The incidence of adverse events was similar in the two groups. CONCLUSIONS: In this trial involving patients who were hospitalized for acute heart failure, an infusion of serelaxin did not result in a lower incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days than placebo. (Funded by Novartis Pharma; RELAX-AHF-2 ClinicalTrials.gov number, NCT01870778.).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, the RELAX -AHF phase-III clinical trial failed in achieving the primary end -points of lowering the 6-month total and cardiovascular adverse events, 3”
From Revivifying research on relaxin receptor-targeted therapy for cardiovascular diseases (2025) · cites this paper as [3]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Effect of Nesiritide in Patients with Acute Decompensated Heart Failure
O'Connor, C. M., Starling, R. C., Hernandez, A. F., Armstrong, P. W., Dickstein, K., Hasselblad, V., Heizer, G., Michel Komajda, N., Massie, B. M., McMurray, J. J. V., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100171 · Cited by 1,249
Self-citationTeerlink, J. R., Cotter, G., Davison, B. A., Felker, G. M., Filippatos, G. S., Greenberg, B., Ponikowski, P. P., Unemori, E., Voors, A. A., Adams, K. F., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61855-8 · Cited by 926
Self-citationRehospitalization for Heart Failure
Gheorghiade, M., Vaduganathan, M., Fonarow, G. C., & Bonow, R. O. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.09.038 · Cited by 769
Solomon, S. D., Dobson, J., Pocock, S., Skali, H., McMurray, J. J. V., Granger, C. B., Yusuf, S., Swedberg, K., Young, J. B., Michelson, E. L., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.696906 · Cited by 681
Relaxin family peptides and their receptors
Bathgate, R. A. D., Halls, M. L., van der Westhuizen, E. T., Callander, G. E., Kocan, M., & Summers, R. J. (2013) · Physiological Reviews · doi:10.1152/physrev.00001.2012 · Cited by 534
Packer, M., Colucci, W. S., Fisher, L. D., Massie, B. M., Teerlink, J. R., Young, J. B., Padley, R. J., Thakkar, R. B., Delgado‐Herrera, L., Salon, J. E., et al. (2013) · JACC Heart Failure · doi:10.1016/j.jchf.2012.12.004 · Cited by 443
Self-citationHarjola, V., Müllens, W., Banaszewski, M., Bauersachs, J. K., Rocca, H. B., Chioncel, O., Collins, S. P., Doehner, W., Filippatos, G. S., Flammer, A. J., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.872 · Cited by 435
Self-citationMetra, M., Cotter, G., Davison, B. A., Felker, G. M., Filippatos, G. S., Greenberg, B., Ponikowski, P. P., Unemori, E., Voors, A. A., Adams, K. F., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.005 · Cited by 427
Self-citationTeerlink, J. R., Metra, M., Felker, G. M., Ponikowski, P. P., Voors, A. A., Davison, B. A., Marmor, A. T., Katz, A., Grzybowski, J., Unemori, E., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60622-x · Cited by 422
Self-citationA graphical approach to sequentially rejective multiple test procedures
Bretz, F., Maurer, W., Brannath, W., & Posch, M. (2009) · Statistics in Medicine · doi:10.1002/sim.3495 · Cited by 420
Cited by
Sorted by citations
Voors, A. A., Angermann, C. E., Teerlink, J. R., Collins, S. P., Kosiborod, M., Biegus, J., Ferreira, J. P., Nassif, M. E., Psotka, M. A., Tromp, J., et al. (2022) · Nature Medicine · doi:10.1038/s41591-021-01659-1 · Cited by 951
Self-citationKittleson, M. M., Panjrath, G. S., Amancherla, K., Davis, L. L., Deswal, A., Dixon, D. L., Januzzi, J. L., & Yancy, C. W. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.03.393 · Cited by 554
Damman, K., Beusekamp, J. C., Boorsma, E. M., Swart, H. P., Smilde, T. D. J., Elvan, A., van Eck, J. W. M., Heerspink, H. J. L., & Voors, A. A. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1713 · Cited by 480
Self-citationMüllens, W., Damman, K., Testani, J. M., Martens, P., Mueller, C. E., Lassus, J. P. E., Tang, W. H. W., Skouri, H. N., Verbrugge, F. H., Orso, F., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1697 · Cited by 432
Self-citationTomasoni, D., Adamo, M., Lombardi, C., & Metra, M. (2019) · ESC Heart Failure · doi:10.1002/ehf2.12555 · Cited by 286
Self-citationSchulze, P. C., Bogoviku, J., Westphal, J. G., Aftanski, P., Haertel, F., Grund, S., von Haehling, S., Schumacher, U., Möbius‐Winkler, S., & Busch, M. (2022) · Circulation · doi:10.1161/circulationaha.122.059038 · Cited by 230
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure
Njoroge, J. N., & Teerlink, J. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318186 · Cited by 240
Self-citationJCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure
Kitai, T., Kohsaka, S., Kato, T., Kato, E. T., Sato, K., TERAMOTO, K., Yaku, H., Akiyama, E., Ando, M., Izumi, C., et al. (2025) · Circulation Journal · doi:10.1253/circj.cj-25-0002 · Cited by 275
Tsutsui, H., Albert, N. M., Coats, A. J. S., Anker, S. D., Bayés‐Genís, A., Butler, J., Chioncel, O. D., deFilippi, C. R., Drazner, M. H., Felker, G. M., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.2848 · Cited by 200
Self-citationTrial of an Intervention to Improve Acute Heart Failure Outcomes
Lee, D. S., Straus, S. E., Farkouh, M. E., Austin, P. C., Taljaard, M., Chong, A. S., Fahim, C., Poon, S., Cram, P. M., Smith, S. J., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2211680 · Cited by 148
Kozhuharov, N., Goudev, A., Flores, D., Maeder, M. T., Walter, J. E., Shrestha, S., Gualandro, D. M., de Oliveira, M. T., Sabti, Z., Müller, B., et al. (2019) · JAMA · doi:10.1001/jama.2019.18598 · Cited by 148
Self-citation‘Time is Prognosis’ in Heart Failure: Time-to-Treatment Initiation as a Modifiable Risk Factor
Abdin, A., Anker, S. D., Butler, J., Coats, A. J. S., Kindermann, I., Lainščak, M., Lund, L. H., Metra, M., Müllens, W., Rosano, G. M. C., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13646 · Cited by 137
Self-citationTsutsui, H., Albert, N. M., Coats, A. J. S., Anker, S. D., Bayés‐Genís, A., Butler, J., Chioncel, O. D., deFilippi, C. R., Drazner, M. H., Felker, G. M., et al. (2023) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2023.02.009 · Cited by 127
Self-citationKimmoun, A., Takagi, K., Gall, E., Ishihara, S., Hammoum, P., Bèze, N. E., Bourgeois, A., Chassard, G., Pegorer-Sfes, H., Gayat, É., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2103 · Cited by 112
Tromp, J., Ponikowski, P. P., Salsali, A., Angermann, C. E., Biegus, J., Blatchford, J., Collins, S. P., Ferreira, J. P., Grauer, C., Kosiborod, M., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2137 · Cited by 102
Self-citationButt, J. H., Fosbøl, E. L., Gerds, T. A., Andersson, C., McMurray, J. J. V., Petrie, M. C., Gustafsson, F., Madelaire, C., Kristensen, S. L., Gislason, G., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1800 · Cited by 90
Self-citationWorsening renal function in acute heart failure in the context of diuretic response
Emmens, J. E., ter Maaten, J. M., Matsue, Y., Figarska, S. M., Sama, I. E., Cotter, G., Cleland, J. G. F., Davison, B. A., Felker, G. M., Givertz, M. M., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2384 · Cited by 91
Self-citationTargeting Fibrosis: From Molecular Mechanisms to Advanced Therapies
Di, X., Li, Y., Wei, J., Li, T., & Liao, B. (2024) · Advanced Science · doi:10.1002/advs.202410416 · Cited by 92
Immune regulation of cardiac fibrosis post myocardial infarction
Zaidi, Y., Aguilar, E. G., Troncoso, M., Ilatovskaya, D. V., & DeLeon‐Pennell, K. Y. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109837 · Cited by 77
Heart Failure in the Last Year: Progress and Perspective
Tomasoni, D., Adamo, M., Anker, M. S., von Haehling, S., Coats, A. J. S., & Metra, M. (2020) · ESC Heart Failure · doi:10.1002/ehf2.13124 · Cited by 84
Self-citationAcute heart failure: More questions than answers
Tomasoni, D., Lombardi, C., Sbolli, M., Cotter, G., & Metra, M. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.04.007 · Cited by 74
Self-citationLung Ultrasound–Guided Emergency Department Management of Acute Heart Failure (BLUSHED-AHF)
Pang, P. S., Russell, F. M., Ehrman, R. R., Ferre, R. M., Gargani, L., Levy, P. D., Noble, V. E., Lane, K. A., Li, X., & Collins, S. P. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.05.008 · Cited by 68
Self-citationMechanisms and Models in Heart Failure
Mann, D. L., & Felker, G. M. (2021) · Circulation Research · doi:10.1161/circresaha.121.318158 · Cited by 68
Self-citationEndothelial Dysfunction in Heart Failure: What Is Its Role?
Drera, A., Rodella, L., Brangi, E., Riccardi, M., & Vizzardi, E. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13092534 · Cited by 68
2026 ESC Guidelines for the management of heart failure
Køber, L., Adamo, M., Ruwald, A., Tomasoni, D., Anderson, L., Andersson, C., Brugts, J. J., Chioncel, O. D., Donal, E., Ferdinandy, P., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag100 · Cited by 109
Self-citationStrategies to enhance monoclonal antibody uptake and distribution in solid tumors
Bordeau, B. M., & Balthasar, J. P. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0704 · Cited by 56
Scalise, R. F. M., Sarro, R. D., Caracciolo, A., Lauro, R., Squadrito, F., Carerj, S., Bitto, A., Micari, A., Bella, G. D., Costa, F., et al. (2021) · Medical Sciences · doi:10.3390/medsci9010016 · Cited by 52
JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure
Kitai, T., Kohsaka, S., Kato, T., Kato, E. T., Sato, K., TERAMOTO, K., Yaku, H., Akiyama, E., Ando, M., Izumi, C., et al. (2025) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2025.02.014 · Cited by 58
Arrigo, M., Biegus, J., Asakage, A., Mebazaa, A., Davison, B. A., Edwards, C., Adamo, M., Barros, M., Čelutkienė, J., Čerlinskaitė‐Bajorė, K., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.2920 · Cited by 45
Self-citationMiró, Ò., Rosselló, X., Platz, E., Masip, J., Gualandro, D. M., Peacock, W. F., Price, S., Cullen, L., DiSomma, S., de Oliveira, M. T., et al. (2020) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872620930889 · Cited by 43
Self-citationAsakura, M., Ito, S., Yamada, T., Saito, Y., Kimura, K., Yamashina, A., Hirayama, A., Kobayashi, Y., Hanatani, A., Tsujimoto, M., et al. (2020) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvaa132 · Cited by 42
Adrenergic Downregulation in Critical Care: Molecular Mechanisms and Therapeutic Evidence
Belletti, A., Landoni, G., Ломиворотов, В. В., Oriani, A., & Ajello, S. (2019) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2019.10.017 · Cited by 43
Effects of serelaxin in patients admitted for acute heart failure: a meta-analysis
Teerlink, J. R., Davison, B. A., Cotter, G., Maggioni, A. P., Sato, N., Chioncel, O., Ertl, G., Felker, G. M., Filippatos, G., Greenberg, B. H., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1692 · Cited by 41
Self-citationPragmatic Design of Randomized Clinical Trials for Heart Failure
Greene, S. J., Velazquez, E. J., Anstrom, K. J., Eisenstein, E. L., Sapp, S. K., Morgan, S., Harding, T. M., Sachdev, V., Ketema, F., Kim, D., et al. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.01.013 · Cited by 40
Self-citationKu, J. C., Raiten, J., & Li, Y. (2024) · Biomedical Engineering Advances · doi:10.1016/j.bea.2024.100118 · Cited by 44
Janwanishstaporn, S., Feng, S., Teerlink, J. R., Metra, M., Cotter, G., Davison, B. A., Felker, G. M., Filippatos, G. S., Pang, P. S., Ponikowski, P. P., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1772 · Cited by 39
Self-citationZymliński, R., Sierpiński, R., Metra, M., Cotter, G., Sokolski, M., Siwołowski, P., Garus, M., Gajewski, P., Tryba, J., Samorek, M., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.13064 · Cited by 35
Self-citationAcute Heart Failure Is a Malignant Process: But We Can Induce Remission
Cotter, G., Davison, B. A., Lam, C. S. P., Metra, M., Ponikowski, P. P., Teerlink, J. R., & Mebazaa, A. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.031745 · Cited by 33
Self-citationGenomics of Human Fibrotic Diseases: Disordered Wound Healing Response
Stone, R. C., Chen, V., Burgess, J. L., Pannu, S., & Tomic‐Canic, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228590 · Cited by 35
Engineering Three-Dimensional Vascularized Cardiac Tissues
Williams, M. A. C., Mair, D. B., Lee, W., Lee, E., & Kim, D. (2021) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2020.0343 · Cited by 36
Martens, P., Chen, H. H., Verbrugge, F. H., Testani, J., Müllens, W., & Tang, W. H. W. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2662 · Cited by 34
Decongestion and Outcomes in Patients Hospitalized for Acute Heart Failure
Pagnesi, M., Staal, L., ter Maaten, J. M., Beldhuis, I. E., Cotter, G., Davison, B. A., Jongs, N., Felker, G. M., Filippatos, G., Greenberg, B., et al. (2024) · JACC Heart Failure · doi:10.1016/j.jchf.2024.09.013 · Cited by 33
Self-citationRecent and Upcoming Drug Therapies for Pediatric Heart Failure
Loss, K. L., Shaddy, R. E., & Kantor, P. F. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.681224 · Cited by 34
Standardized Definitions for Evaluation of Acute Decompensated Heart Failure Therapies
Lala, A., HAMO, C. E., Bozkurt, B., Fiuzat, M., Blumer, V. L., Bukhoff, D., Butler, J., Costanzo, M. R., Felker, G. M., Filippatos, G. S., et al. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2023.09.030 · Cited by 33
Self-citationThe year in cardiology: heart failure
Cleland, J. G. F., Lyon, A. R., McDonagh, T. A., & McMurray, J. J. V. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz949 · Cited by 34
Self-citationCongestion and Diuretic Resistance in Acute or Worsening Heart Failure
Kristjánsdóttir, I., Thorvaldsen, T., & Lund, L. H. (2020) · Cardiac failure review · doi:10.15420/cfr.2019.18 · Cited by 31
Development of a long‐acting relaxin analogue, LY3540378, for treatment of chronic heart failure
Verdino, P., Lee, S. L., Cooper, F. N., Cottle, S. R., Grealish, P. F., Hu, C. C., Meyer, C. M., Lin, J., Copeland, V., Porter, G., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16055 · Cited by 31
Time-Sensitive Approach in the Management of Acute Heart Failure
Shiraishi, Y., Kawana, M., Nakata, J., Sato, N., Fukuda, K., & Kohsaka, S. (2020) · ESC Heart Failure · doi:10.1002/ehf2.13139 · Cited by 29
Relaxin as an anti-fibrotic treatment: Perspectives, challenges and future directions
Samuel, C. S., & Bennett, R. G. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114884 · Cited by 31
Bundgaard, H., Raja, A. A., Iversen, K. K., Valeur, N., Tønder, N., Schou, M., Christensen, A. H., Bruun, N. E., Søholm, H., Ghanizada, M., et al. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.121.009120 · Cited by 30
Self-citationMallart, S., Ingenito, R., Bianchi, E., Bresciani, A., Esposito, S., Gallo, M., Magotti, P., Monteagudo, E., Orsatti, L., Roversi, D., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01533 · Cited by 29
Current RNA strategies in treating cardiovascular diseases
Chia, S. P. S., Pang, J. K. S., & Soh, B.-S. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.028 · Cited by 32
Recombinant human H2 relaxin (serelaxin) as a cardiovascular drug: aiming at the right target
Bani, D. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.04.014 · Cited by 29
Biomarkers and Their Relation to Cardiac Function Late After Peripartum Cardiomyopathy
Ersbøll, A. S., Goetze, J. P., Johansen, M., Hauge, M. G., Sliwa, K. S., Vejlstrup, N. G., Gustafsson, F., & Damm, P. (2021) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2021.01.002 · Cited by 29
Single‐Shot Solid‐Phase Synthesis of Full‐Length H2 Relaxin Disulfide Surrogates
Zhao, R. J., Shi, P., Cui, J., Shi, C., Wei, X., Luo, J., Xia, Z., Shi, W., Zhou, Y., Tang, J., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202216365 · Cited by 26
Effects of a Novel Nitroxyl Donor in Acute Heart Failure
Felker, G. M., McMurray, J. J. V., Cleland, J. G. F., O’Connor, C. M., Teerlink, J. R., Voors, A. A., Bělohlávek, J., Böhm, M., Borentain, M., Bueno, H., et al. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.10.012 · Cited by 25
Self-citationCowger, J. A., Basir, M. B., Baran, D. A., Hayward, C., Rangaswami, J., Walton, A., Tita, C., Minear, S. C., Hakemi, E. U., Klein, L., et al. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2023.06.018 · Cited by 25
Chioncel, O. D., Mebazaa, A., Farmakis, D. T., Abdelhamid, M., Lund, L. H., Harjola, V., Anker, S. D., Filippatos, G., Gal, T. B., Damman, K., et al. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.3673 · Cited by 26
Self-citationFu, K., Hu, Y., Zhang, H., Wang, C., Lin, Z., Lu, H., & Ji, X. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.760152 · Cited by 24
Relaxin-2 as a Potential Biomarker in Cardiovascular Diseases
Aragón‐Herrera, A., Feijóo‐Bandín, S., Anido‐Varela, L., Moraña‐Fernández, S., Roselló‐Lletí, E., Portolés, M., Tarazón, E., Gualillo, O., González‐Juanatey, J. R., & Lago, F. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071021 · Cited by 24
Matsue, Y., Sama, I. E., Postmus, D., Metra, M., Greenberg, B., Cotter, G., Davison, B. A., Felker, G. M., Filippatos, G. S., Pang, P. S., et al. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.07.001 · Cited by 23
Self-citationSodium Nitroprusside in Acute Heart Failure: A Multicenter Historic Cohort Study
Garatti, L., Frea, S., Bocchino, P. P., Angelini, F., Cingolani, M. M., Sacco, A., Rondinara, G. M., Bagnardi, V., Sala, I., Kapur, N. K., et al. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.08.009 · Cited by 23
Cause of Death in Patients With Acute Heart Failure
Loungani, R. S., Teerlink, J. R., Metra, M., Allen, L. A., Butler, J., Carson, P. E., Chen, C., Cotter, G., Davison, B. A., Eapen, Z. J., et al. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.09.010 · Cited by 23
Self-citationDistinct Comorbidity Clusters in Patients With Acute Heart Failure
Gomez, K. F. A., Tromp, J., Figarska, S. M., Beldhuis, I. E., Cotter, G., Davison, B. A., Felker, G. M., Gimpelewicz, C. R., Greenberg, B., Lam, C. S. P., et al. (2024) · JACC Heart Failure · doi:10.1016/j.jchf.2024.04.028 · Cited by 22
Self-citationPollesello, P., Gal, T. B., Béttex, D., Černý, V., Colet, J. C., Eremenko, A. A., Farmakis, D. T., Fedele, F., Fonseca, C., Harjola, V., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111834 · Cited by 21
Neues zur Diagnostik und Therapie der Herzinsuffizienz
Wintrich, J., Berger, A.-K., Bewarder, Y., Emrich, I. E., Slawik, J., & Böhm, M. (2021) · Herz · doi:10.1007/s00059-021-05062-x · Cited by 28
Self-citationUltrafiltration for acute heart failure
Srivastava, M., Harrison, N. E., Caetano, A. F. S., Tan, A. R., & Law, M. M. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013593.pub2 · Cited by 21
Diagnosis and Management of Heart Failure
Gladysheva, I. P., & Sullivan, R. D. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-4153-2 · Cited by 21
Endpoints in Heart Failure Drug Development
Hussain, A., Misra, A., & Bozkurt, B. (2022) · Cardiac failure review · doi:10.15420/cfr.2021.13 · Cited by 21
Müllens, W., Schulze, P. C., Westphal, J. G., Bogoviku, J., & Bauersachs, J. K. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad266 · Cited by 21
Devarakonda, T., Mauro, A. G., Guzman, G., Hovsepian, S., Cain, C. K., Das, A., Praveen, P., Hossain, M. A., & Salloum, F. N. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015748 · Cited by 20
Ceelen, D. C. H., ter Maaten, J. M., Voordes, G. H. D., Cotter, G., Davison, B. A., Filippatos, G. S., Pang, P. S., Gimpelewicz, C. R., Cleland, J. G. F., Felker, G. M., et al. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.70091 · Cited by 19
Self-citationCardiovascular effects of relaxin-2: therapeutic potential and future perspectives
Almeida-Pinto, N., Dschietzig, T. B., Brás‐Silva, C., & Adão, R. (2023) · Clinical Research in Cardiology · doi:10.1007/s00392-023-02305-1 · Cited by 19
Illiano, S., Poirier, B., Minoletti, C., Pasquier, O., Riva, L., Chénedé, X., Menguy, I., Guillotel, M., Prigent, P., Claire, S. L., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-24716-2 · Cited by 19
Pellicori, P., Cleland, J. G. F., Borentain, M., Taubel, J., Graham, F. J., Khan, J., Bruzzese, D., Kessler, P., McMurray, J. J. V., Voors, A. A., et al. (2024) · European Journal of Heart Failure · doi:10.1002/ejhf.3077 · Cited by 18
Self-citationVasodilators for Acute Heart Failure — A Systematic Review with Meta-Analysis
Lukoschewitz, J. D., Miger, K. C., Olesen, A. S. O., Caidi, N. O. E., Kamp, C. B., Nielsen, O. W., Hassager, C., Hove, J. D., Seven, E., Møller, J. E., et al. (2024) · NEJM Evidence · doi:10.1056/evidoa2300335 · Cited by 20
Miró, Ò., Sánchez, C., Gil, V., Repullo, D., García‐Lamberechts, E. J., del Castillo, J. M. G., & Llorens, P. (2024) · Emergencias · doi:10.55633/s3me/e082.2022 · Cited by 17
Grand, J., Miger, K. C., Sajadieh, A., Køber, L., Torp-Pedersen, C. T., Ertl, G., Lopez-Sendon, J. L., Maggioni, A. P., Teerlink, J. R., Sato, N., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022288 · Cited by 17
Self-citationJha, N., & Jha, A. K. (2021) · Heart Failure Reviews · doi:10.1007/s10741-020-10060-y · Cited by 20
Cherbi, M., Lairez, O., Baudry, G., Gautier, P., Roubille, F., & Delmas, C. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039105 · Cited by 18
Martens, P., Burkhoff, D., Cowger, J. A., Jorde, U. P., Kapur, N. K., & Tang, W. H. W. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2023.06.021 · Cited by 16
Blanco, R., Ambrosio, G., Belziti, C. A., Lucas, L. O., Arias, A., D’Antonio, A., OBERTI, P. F., Carluccio, E., & Pizarro, R. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.04.044 · Cited by 16
Zamfirescu, M.-B., Ghilencea, L. N., Popescu, M. R., Bejan, G. C., Ghiordanescu, I. M., Popescu, A.-C., Myerson, S. G., & Dorobanţu, M. (2021) · Diagnostics · doi:10.3390/diagnostics11020198 · Cited by 16
Borlaug, B. A., Testani, J. M., Petrie, M. C., Wang, Z., Cunningham, J. W., Adams, K. F., Amir, O., Bělohlávek, J., Bocchi, E. A., Freitas, A. F., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03939-6 · Cited by 18
Self-citationShiraishi, Y., Kohsaka, S., Abe, T., Nagai, T., Goda, A., Nishihata, Y., Nagatomo, Y., Saji, M., Toyosaki, Y., Takei, M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113394 · Cited by 15
Cardiac and Renal Fibrosis, the Silent Killer in the Cardiovascular Continuum: An Up-to-Date
Chiuariu, T., Șalaru, D. L., Ureche, C., Tapoi, L. C., Lupu, A., Lupu, V. V., Șerban, A. M., Zăvoi, A., Benchea, L.-C., Clément, A., et al. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11020062 · Cited by 18
Wang, C., Gaspari, T. A., Ferens, D. M., Spizzo, I., Kemp‐Harper, B. K., & Samuel, C. S. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15428 · Cited by 15
Alam, F., Gaspari, T. A., Kemp‐Harper, B. K., Low, E., Aw, A., Ferens, D. M., Spizzo, I., Jefferis, A., Praveen, P., Widdop, R. E., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114370 · Cited by 15
Relaxin-2 May Suppress Endometriosis by Reducing Fibrosis, Scar Formation, and Inflammation
Yoshino, O., Ono, Y., Honda, M., Hattori, K., Sato, E., Hiraoka, T., Ito, M., Kobayashi, M., Arai, K., Katayama, H., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8110467 · Cited by 14
An Academic Clinician’s Road Map to Hypertension Genomics
Magavern, E. F., Warren, H. R., Ng, F. L., Cabrera, C., Munroe, P. B., & Caulfield, M. J. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14535 · Cited by 15
Bozkurt, B. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2022.12.001 · Cited by 14
Jakubauskiene, L., Jakubauskas, M., Leber, B., Strupas, K., Stiegler, P., & Schemmer, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020631 · Cited by 14
Horiuchi, Y., Wettersten, N. W., van Veldhuisen, D. J., Mueller, C. E., Filippatos, G. S., Nowak, R. M., Hogan, C. J., Kontos, M. C., Cannon, C. M., Muller, G. A., et al. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.01.040 · Cited by 14
Self-citationChen, Y., Voors, A. A., Jaarsma, T., Lang, C. C., Sama, I. E., Akkerhuis, K. M., Boersma, E. H., Hillege, H. L., & Postmus, D. (2021) · BMC Medicine · doi:10.1186/s12916-020-01894-2 · Cited by 14
Self-citationConnolly, K., George, R., Omar, S., Matsson, E., Åstrand, M., Althage, M., Pettersen, D., Mohamed, E., Fang, K., Lima, J. A. C., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.034067 · Cited by 13
Kaushal, N., Attarwala, H. Z., Iqbal, M. J., Saini, R., Van, L. M., & Liang, M. (2024) · Clinical and Translational Science · doi:10.1111/cts.13894 · Cited by 14
Shiraishi, Y., Kohsaka, S., Katsuki, T., Harada, K., Miyazaki, T., Miyamoto, T., Matsushita, K., Iida, K., Takei, M., Yamamoto, Y., et al. (2020) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872619891075 · Cited by 13
Feng, S., Janwanishstaporn, S., Teerlink, J. R., Metra, M., Cotter, G., Davison, B. A., Felker, G. M., Filippatos, G. S., Pang, P. S., Ponikowski, P. P., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.2012 · Cited by 13
Self-citationBlood Pressure Reduction in Hypertensive Acute Heart Failure
Harrison, N. E., Pang, P. S., Collins, S. P., & Levy, P. D. (2021) · Current Hypertension Reports · doi:10.1007/s11906-021-01127-8 · Cited by 13
Self-citationNovel and emerging therapies in pulmonary arterial hypertension
Cassady, S. J., Soldin, D., & Ramani, G. V. (2022) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2022.1022971 · Cited by 14
Metadata
- Authors
- Metra, M., Teerlink, J. R., Cotter, G., Davison, B. A., Felker, G. M., Filippatos, G., Greenberg, B. H., Pang, P. S., Ponikowski, P., Voors, A. A., Adams, K. F., Anker, S. D., Arias-Mendoza, A., Avendaño, P., Bacal, F., Böhm, M., Bortman, G., Cleland, J. G. F., Cohen-Solal, A., Crespo-Leiro, M. G., Dorobantu, M., Echeverría, L. E., Ferrari, R., Goland, S., Goncalvesová, E., Goudev, A., Køber, L., Lema-Osores, J., Levy, P. D., McDonald, K., Manga, P., Merkely, B., Mueller, C., Pieske, B., Silva-Cardoso, J., Špinar, J., Squire, I., Stępińska, J., Van Mieghem, W., von Lewinski, D., Wikström, G., Yilmaz, M. B., Hagner, N., Holbro, T., Hua, T. A., Sabarwal, S. V., Severin, T., Szecsödy, P., & Gimpelewicz, C.
- Affiliations
- San Francisco VA Medical Center (US)
- University of North Carolina at Chapel Hill (US)
- From Cardiology, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia (M.M.), Centro Cardiologico Universitario di Ferrara, University of Ferrara, Ferrara (R.F.), and Maria Cecilia Hospital, GVM Care and Research, Cotignola (R.F.) — all in Italy; the Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, San Francisco (J.R.T.), and the Division of...
- University of Copenhagen (DK)
- University College Dublin (IE)
- Semmelweis University (HU)
- Uppsala University (SE)
- ORCID
- Metra, Marco
- Teerlink, John R.
- Cotter, Gad
- Davison, Beth A.
- Felker, G. Michael
- Filippatos, Gerasimos
- Greenberg, Barry H.
- Pang, Peter S.
- Ponikowski, Piotr
- Voors, Adriaan A.
- Anker, Stefan D.
- Bacal, Fernando
- Böhm, Michael
- Bortman, Guillermo
- Cleland, John G.F.
- Echeverría, Luis E.
- Ferrari, Roberto
- Goland, Sorel
- Goudev, Assen
- Køber, Lars
- Levy, Phillip D.
- McDonald, Kenneth
- Manga, Pravin
- Merkely, Béla
- Mueller, Christian
- Pieske, Burkert
- Špinar, Jindřich
- Squire, Iain
- Stępińska, Janina
- Wikström, Gerhard
- Gimpelewicz, Claudio
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2019-08-22
- Volume
- 381
- Issue
- 8
- Pages
- 716-726
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2969766757
- Cited by
- 282
- References
- 32
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 45 · 2023: 42 · 2022: 41 · 2021: 47 · 2020: 38 · 2019: 13
- FWCI
- 25.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- New England Journal of Medicine (publishedVersion, other-oa)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- HAL (submittedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- Document Server@UHasselt (UHasselt) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, other-oa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion, other-oa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, other-oa)
- Funders
- Novartis Pharma AG
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- serelaxin, relaxin-2, acute heart failure, cardiovascular mortality, worsening heart failure, vasodilator therapy, natriuretic peptides, renal failure, dyspnea, hospital readmission, adverse events, heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, length of hospital stay
- MeSH terms
- Acute Disease, Aged, Blood Pressure, Cardiovascular Diseases, Double-Blind Method, Female, Heart Failure, Hospitalization, Humans, Infusions, Intravenous, Male, Recombinant Proteins, Relaxin, Vasodilator Agents, Incidence, Treatment Failure, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
