Cited by 1,281Clostridium difficile and Clostridium perfringens researchGut microbiota and healthAntibiotic Resistance in Bacteria

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Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

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DeFilipp, Zachariah, Bloom, Patricia P., Torres Soto, Mariam, Mansour, Michael K., Sater, Mohamad R.A., Huntley, Miriam H., Turbett, Sarah, Chung, Raymond T., Chen, Yi-Bin, Hohmann, Elizabeth L.·2019·New England Journal of Medicine

DOI 10.1056/nejmoa1910437

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Abstract

bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor by means of genomic sequencing. One of the patients died. Enhanced donor screening to limit the transmission of microorganisms that could lead to adverse infectious events and continued vigilance to define the benefits and risks of FMT across different patient populations are warranted.

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Authors: DeFilipp, Z., Bloom, P. P., Torres Soto, M., Mansour, M. K., Sater, M. R. A., Huntley, M. H., Turbett, S., Chung, R. T., Chen, Y.-B., & Hohmann, E. L.
Affiliations: Harvard University (US)
From the Blood and Marrow Transplant Program (Z.D., Y.-B.C.), the Liver Center, Division of Gastroenterology (P.P.B., R.T.C.), and the Division of Infectious Diseases (M.T.S., M.K.M., S.T., E.L.H.), Massachusetts General Hospital, Harvard Medical School (Z.D., P.P.B., M.T.S., M.K.M., S.T., R.T.C., Y.-B.C., E.L.H.), and Day Zero Diagnostics (M.R.A.S., M.H.H.) — all in Boston.
ORCID: DeFilipp, Zachariah
Bloom, Patricia P.
Torres Soto, Mariam
Mansour, Michael K.
Sater, Mohamad R.A.
Huntley, Miriam H.
Turbett, Sarah
Chung, Raymond T.
Chen, Yi-Bin
Hohmann, Elizabeth L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2019-11-21
Volume: 381
Issue: 21
Pages: 2043-2050
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1910437
OpenAlex: W2982566732
Cited by: 1,281
References: 26
Citations by year: 2026: 202 · 2025: 160 · 2024: 158 · 2023: 175 · 2022: 169 · 2021: 184 · 2020: 222 · 2019: 10
FWCI: 112.06
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Massachusetts General Hospital
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: drug-resistant Escherichia coli, bacteremia, fecal microbiota transplantation, donor screening, genome sequencing
MeSH terms: Fecal Microbiota Transplantation, Aged, beta-Lactamases, Escherichia coli, Feces, Hepatic Encephalopathy, Humans, Male, Myelodysplastic Syndromes, Bacteremia, Fatal Outcome, Drug Resistance, Bacterial, Dysbiosis

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Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

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