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Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination
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Abstract
BACKGROUND: Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1 nCov-19, AstraZeneca). More data were needed on the pathogenesis of this unusual clotting disorder. METHODS: We assessed the clinical and laboratory features of 11 patients in Germany and Austria in whom thrombosis or thrombocytopenia had developed after vaccination with ChAdOx1 nCov-19. We used a standard enzyme-linked immunosorbent assay to detect platelet factor 4 (PF4)-heparin antibodies and a modified (PF4-enhanced) platelet-activation test to detect platelet-activating antibodies under various reaction conditions. Included in this testing were samples from patients who had blood samples referred for investigation of vaccine-associated thrombotic events, with 28 testing positive on a screening PF4-heparin immunoassay. RESULTS: Of the 11 original patients, 9 were women, with a median age of 36 years (range, 22 to 49). Beginning 5 to 16 days after vaccination, the patients presented with one or more thrombotic events, with the exception of 1 patient, who presented with fatal intracranial hemorrhage. Of the patients with one or more thrombotic events, 9 had cerebral venous thrombosis, 3 had splanchnic-vein thrombosis, 3 had pulmonary embolism, and 4 had other thromboses; of these patients, 6 died. Five patients had disseminated intravascular coagulation. None of the patients had received heparin before symptom onset. All 28 patients who tested positive for antibodies against PF4-heparin tested positive on the platelet-activation assay in the presence of PF4 independent of heparin. Platelet activation was inhibited by high levels of heparin, Fc receptor-blocking monoclonal antibody, and immune globulin (10 mg per milliliter). Additional studies with PF4 or PF4-heparin affinity purified antibodies in 2 patients confirmed PF4-dependent platelet activation. CONCLUSIONS: Vaccination with ChAdOx1 nCov-19 can result in the rare development of immune thrombotic thrombocytopenia mediated by platelet-activating antibodies against PF4, which clinically mimics autoimmune heparin-induced thrombocytopenia. (Funded by the German Research Foundation.).
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“Thrombocytopenia and immune thrombocytopenia (ITP) were also included due to their association with TTS and reports of ITP as an independent safety signal [7,19,20].”
From COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals (2024) · cites this paper as [19]
Experimental — accuracy not yet measuredIn the citing paper
“These adverse events, which primarily affect young women, have been linked with the ChAdOx1 nCoV-1932 and Ad26.COV2.S (Johnson & Johnson–Janssen) Covid-19 vaccines,33 both of which are adenoviral vector vaccines.”
From Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting (2021) · cites this paper as [32]
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Cuker, A. C., Arepally, G. M., Chong, B. H., Cines, D. B., Greinacher, A., Gruel, Y., Linkins, L. A., Rodner, S. B., Selleng, S., Warkentin, T. E., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018024489 · Cited by 755
Self-citationCLINICAL PRACTICE. Heparin-Induced Thrombocytopenia.
Greinacher, A. (2015) · PubMed · doi:10.1056/nejmcp1411910 · Cited by 612
Self-citationDelayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis
Warkentin, T. E., & Kelton, J. G. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-7-200110020-00009 · Cited by 463
Self-citationAutoimmune heparin‐induced thrombocytopenia
Greinacher, A., Selleng, K., & Warkentin, T. E. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13813 · Cited by 414
Self-citationDelayed-Onset Heparin-Induced Thrombocytopenia
Rice, L., Attisha, W. K., Drexler, A. J., & Francis, J. L. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-3-200202050-00009 · Cited by 268
Othman, M., Labelle, A., Mazzetti, I., Elbatarny, H. S., & Lillicrap, D. (2006) · Blood · doi:10.1182/blood-2006-06-032524 · Cited by 220
Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review
Warkentin, T. E., Pai, M., & Linkins, L. (2017) · Blood · doi:10.1182/blood-2017-04-778993 · Cited by 210
Self-citationWarkentin, T. E. (2019) · Expert Review of Hematology · doi:10.1080/17474086.2019.1636645 · Cited by 180
Self-citationA Spontaneous Prothrombotic Disorder Resembling Heparin-induced Thrombocytopenia
Warkentin, T. E., Makris, M., Jay, R. M., & Kelton, J. G. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.03.012 · Cited by 170
Self-citationJuhl, D., Eichler, P., Lübenow, N., Strobel, U., Wessel, A., & Greinacher, A. (2006) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2005.00621.x · Cited by 170
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Dupuy, A., Liu, X., Kong, Y. X., Qi, M., Perdomo, J., Fenwick, J., Tieng, J., Johnston, B., Shi, Q. S., Larance, M., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024014165 · Cited by 11
Lesgards, J., Cerdan, D., & Perronne, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167879 · Cited by 13
Amini, A., Garner, L. C., Shaw, R. H., Kelly, N. E. W., Adele, S., Skelly, D., Dejnirattisai, W., Greenland, M., Liu, X., Heslington, A., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adu3337 · Cited by 12
Geeraerts, T., Montastruc, F., Bonneville, F., Mémier, V., Raposo, N., Darcourt, J., Pommier, M., Bounes, F. V., Alvarez, M., Izopet, J., et al. (2021) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2021.100889 · Cited by 11
Nappi, F., Iervolino, A., & Singh, S. (2021) · Metabolites · doi:10.3390/metabo11060341 · Cited by 11
Centonze, L., Lauterio, A., Carlis, R. D., Ferla, F., & Carlis, L. G. D. (2021) · Transplantation · doi:10.1097/tp.0000000000003875 · Cited by 11
Heparin-induced thrombocytopenia: An update for the COVID-19 era
Bailly, J., Haupt, L., Joubert, J., Loebenberg, P., Jacobson, B. F., Louw, V. J., Wessels, P., & Opie, J. (2021) · South African Medical Journal · doi:10.7196/samj.2021.v111i9.15909 · Cited by 11
Lucchese, G., Jahantigh, H. R., Benedictis, L. D., Lovreglio, P., & Stufano, A. (2021) · Viruses · doi:10.3390/v13081461 · Cited by 10
SARS-CoV-2 and Autoimmune Cytopenia
Quinn, R., & Murakhovskaya, I. (2021) · Hemato · doi:10.3390/hemato2030029 · Cited by 11
Urban, N., Weber, B., Deinsberger, J., Gschwandtner, M. E., Bauer, W. M., & Handisurya, A. (2021) · Case Reports in Dermatology · doi:10.1159/000519147 · Cited by 11
Haimei, M. (2021) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296211040110 · Cited by 11
Challenges to Vaccination against SARS-CoV-2 in Patients with Immune-Mediated Diseases
Ramirez, G. A., Asperti, C., Cucca, V., & Yacoub, M. (2021) · Vaccines · doi:10.3390/vaccines9101147 · Cited by 11
Thrombosis formation after COVID-19 vaccination Immunological Aspects: Review article
Waggiallah, H. A. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.09.065 · Cited by 11
COVID-lateral damage: cardiovascular manifestations of SARS-CoV-2 infection
Al-Kindi, S. G., & Zidar, D. A. (2021) · Translational research · doi:10.1016/j.trsl.2021.11.005 · Cited by 10
Murthy, S. K., Kuenzig, M. E., Windsor, J. W., Ghia, J., Griffiths, A. M., Panaccione, R., Seow, C. H., Benchimol, E. I., Bernstein, C. N., Bitton, A., et al. (2021) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwab033 · Cited by 13
COVID-19 vaccines and herpes infection
Cifuentes, F. T., Callejo, Á. L., & Peláez, M. J. T. (2021) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2021.05.005 · Cited by 11
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Krasilnikov, I. V., Kudriavtsev, A. V., Vakhrusheva, A., Frolova, M. E., Ivanov, A. V., Stukova, M., Romanovskaya-Romanko, E., Vasilyev, K., Mushenkova, N. V., & Isaev, A. A. (2022) · Vaccines · doi:10.3390/vaccines10010069 · Cited by 11
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Schönborn, L., Seck, S. N., Thiele, T., Warkentin, T. E., & Greinacher, A. (2022) · New England Journal of Medicine · doi:10.1056/nejmc2206601 · Cited by 11
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Nashwan, A. J., Yassin, M. A., Soliman, A. T., Sanctis, V. D., & Ibrahim, M. (2022) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v93i3.13103 · Cited by 11
Mele, F., Tafuri, S., Stefanizzi, P., d’Amati, A., Calvano, M., Leonardelli, M., Macorano, E., Duma, S. M., Gabriele, G. D., Introna, F., et al. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2095166 · Cited by 11
Acute Ischemic Stroke in the Context of SARS-CoV-2 Vaccination: A Systematic Review
Rahmig, J., Altarsha, E., Siepmann, T., & Barlinn, K. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s374549 · Cited by 13
Chao, C.-H., Cheng, D., Huang, S., Chuang, Y., Yeh, T., & Wang, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1023943 · Cited by 11
Baek, Y. J., Kim, W., Ko, J., Lee, Y.-J., Ahn, J. Y., Kim, J. H., Jang, H. C., Jeong, H. W., Kim, Y. C., Park, Y. S., et al. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.01.063 · Cited by 11
Thrombotic and Thromboembolic Complications After Vaccination Against COVID-19: A Systematic Review
Favas, T. T., Lall, N., Joshi, D., Singh, V. K., Pathak, A., Chakravarty, K., Mishra, V. N., Chaurasia, R. N., & Kumar, A. (2023) · Cureus · doi:10.7759/cureus.37275 · Cited by 11
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Bae, E., Bae, S., Vays, M., Abdelwahed, M. S., Sarkar, K., & Bae, S. (2023) · Cureus · doi:10.7759/cureus.37612 · Cited by 14
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Gerhard, A., Raeder, V., Pernice, H. F., Boesl, F., Schroeder, M., Richter, J., Endres, M., Prüß, H., Hahn, K., Audebert, H. J., et al. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11895-9 · Cited by 11
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Romano, E., Pascolo, S., & Ott, P. A. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002932 · Cited by 11
Ruggeri, Z. M., & Ruf, W. (2021) · Nature Immunology · doi:10.1038/s41590-021-01042-9 · Cited by 11
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Lehmann, K. J. (2021) · doi:10.31219/osf.io/gh9u2 · Cited by 11
Charidimou, A., Samudrala, S., Cervantes-Arslanian, A. M., Sloan, J. M., Dasenbrock, H. H., & Daneshmand, A. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.106113 · Cited by 10
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Abrams, S. T., Du, M., Shaw, R., Johnson, C., McGuinness, D., Schofield, J., Yong, J., Turtle, L. C. W., Nicolson, P. L. R., Moxon, C. A., et al. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.12.008 · Cited by 10
Vayne, C., Rollin, J., Clare, R., Daka, M., Atsouawe, M., Guéry, E., Cauchie, P., Cordonnier, C., Cuisenier, P., de Maistre, E., et al. (2024) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2024.05.005 · Cited by 10
Arlt, F. A., Breuer, A., Trampenau, E., Boesl, F., Kirchner, M., Mertins, P., Sánchez-Sendín, E., Nasouti, M., Mayrhofer, M., Blüthner, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1404800 · Cited by 10
Designing an integrated sustainable-resilient mix-and-match vaccine supply chain network
Jahed, A., Molana, S. M. H., Tavakkoli-Moghaddam, R. R., & Valizadeh, V. (2024) · Annals of Operations Research · doi:10.1007/s10479-024-06211-1 · Cited by 12
Benemei, S., Gatto, F., Marcucci, R., & Gresele, P. (2024) · Thrombosis and Haemostasis · doi:10.1055/a-2413-4345 · Cited by 10
Yong, S. J., Kenny, T., Halim, A., Munipalli, B., Alhashem, Y. N., AlSaihati, H., Al‐Subaie, M. F., Kaabi, N. A., Fares, M. A. A., Garout, M. A., et al. (2025) · Reviews in Medical Virology · doi:10.1002/rmv.70070 · Cited by 13
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McDonnell, T., Thornber, M., Cooksley, T., Jain, S., & McGlynn, S. J. (2021) · QJM · doi:10.1093/qjmed/hcab124 · Cited by 10
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Warkentin, T. E. (2021) · Thrombosis and Haemostasis · doi:10.1055/a-1585-6264 · Cited by 10
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Zazzeron, L., Rosovsky, R. P. G., Bittner, E. A., & Chang, M. G. (2021) · Critical Care Explorations · doi:10.1097/cce.0000000000000519 · Cited by 10
Chiang, C., Chen, C., Yu, W., Kan, W., & Feng, Y. (2021) · Cureus · doi:10.7759/cureus.18390 · Cited by 10
Perrotta, A., Biondi‐Zoccai, G., Saade, W., Miraldi, F., Morelli, A., Marullo, A. G. M., Cavarretta, E., Carnevale, R., FALCO, E. D., Chimenti, I., et al. (2021) · Panminerva Medica · doi:10.23736/s0031-0808.21.04435-9 · Cited by 10
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Duan, R., Goldmann, L., Li, Y., Weber, C., Siess, W., & von Hundelshausen, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010076 · Cited by 10
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Khajavirad, N., Salehi, M., Ghadery, A. H., Khalili, H., Ahmadi, M. A., Manshadi, S. A. D., & Dehnavi, A. Z. (2022) · Clinical Case Reports · doi:10.1002/ccr3.5390 · Cited by 10
Lonati, P. A., Bodio, C., Scavone, M., Martini, G., Pesce, E., Bandera, A., Lombardi, A., Gerosa, M., Franceschini, F., Tincani, A., et al. (2022) · RMD Open · doi:10.1136/rmdopen-2021-001902 · Cited by 10
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Kaimori, R., Nishida, H., Uchida, T., Tamura, M., Kuroki, K., Murata, K., Hatakeyama, K., Ikeda, Y., Amemiya, K., Nishizono, A., et al. (2022) · Thrombosis Journal · doi:10.1186/s12959-022-00418-7 · Cited by 10
Zheng, X., Gao, F., Wang, L., Meng, Y., Ageno, W., & Qi, X. (2022) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-022-02732-3 · Cited by 10
Geeraerts, T., Guilbeau‐Frugier, C., Garcia, C., Mémier, V., Raposo, N., Bonneville, F., Galès, C., Darcourt, J., Voisin, S., Ribes, A. M., et al. (2023) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200127 · Cited by 12
Procter, T. D., Ogasawara, H., Spruin, S., Wijayasri, S., Abraham, N., Blaser, C., Hutchings, K., Shaw, A. K., & Ogunnaike-Cooke, S. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.09.062 · Cited by 10
Lien, L.-M., Lu, W., Lin, K., Kang, L.-H., Chen, T.-Y., Lin, B.-J., Lu, Y., Huang, C., Shih, C., Chen, H., et al. (2021) · Molecules · doi:10.3390/molecules26175340 · Cited by 10
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Firinu, D., Perra, A., Campagna, M., Littera, R., Meloni, F., Sedda, F., Conti, M., Costanzo, G. A. M. L., Erbi, M., Usai, G., et al. (2021) · Vaccines · doi:10.3390/vaccines9121478 · Cited by 10
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Higgins, H., Andrews, N. J., Stowe, J., Amirthalingam, G., Ramsay, M. E., Bahra, G., Hackett, A., Breen, K. A., Desborough, M., Khan, D., et al. (2022) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12698 · Cited by 11
Markewitz, R. D. H., Juhl, D., Pauli, D., Görg, S., Junker, R., Rupp, J., Engel, S., Steinhagen, K., Herbst, V., Zapf, D., et al. (2022) · Vaccines · doi:10.3390/vaccines10050649 · Cited by 10
Simón‐Fuentes, M., Sánchez‐Ramón, S., Fernández-Paredes, L., Alonso, B., Guevara‐Hoyer, K., Vega, M. A., Corbí, A. L., & Domínguez‐Soto, Á. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01277-7 · Cited by 11
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Yang, S., Tong, Y., Chen, L., & Yu, W. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00077-0 · Cited by 10
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Müller, L., Dabbiru, V. A. S., Rutten, L., Bos, R., Zahn, R. C., Handtke, S., Thiele, T., Palicio, M., Esteban, O., Broto, M., et al. (2024) · Vaccines · doi:10.3390/vaccines13010003 · Cited by 9
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Metadata
- Authors
- Greinacher, A., Thiele, T., Warkentin, T. E., Weisser, K., Kyrle, P. A., & Eichinger, S.
- Affiliations
- Universitätsmedizin Greifswald (DE)
- Corresponding author
- Greinacher, Andreas
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-06-03
- Volume
- 384
- Issue
- 22
- Pages
- 2092-2101
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8095372
- OpenAlex
- W3140226555
- Cited by
- 2,259
- References
- 27
- Citations by year
- 2026: 77 · 2025: 139 · 2024: 171 · 2023: 297 · 2022: 725 · 2021: 848
- FWCI
- 479.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (Projektnummer 374031971 – TRR 240)
- Topics
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- ChAdOx1 nCoV-19 vaccine, AstraZeneca COVID-19 vaccine, vaccine-associated thrombosis, platelet factor 4, PF4/heparin antibodies, platelet-activating antibodies, cerebral venous thrombosis, pulmonary embolism, splanchnic vein thrombosis, disseminated intravascular coagulation, heparin, Fc receptor blockade, gamma globulin
- MeSH terms
- COVID-19 Vaccines, ChAdOx1 nCoV-19, Adult, Autoantibodies, Autoimmune Diseases, Blood Chemical Analysis, Disseminated Intravascular Coagulation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Platelet Factor 4, Thrombocytopenia, Thrombosis, Platelet Activation, Fatal Outcome, Intracranial Hemorrhages, Young Adult
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