The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels
Open accessAbstract
BACKGROUND: Endovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect of EVT for occlusion of medium or distal vessels is unclear. METHODS: We randomly assigned participants with an isolated occlusion of medium or distal vessels (occlusion of the nondominant or codominant M2 segment of the middle cerebral artery [MCA]; the M3 or M4 segment of the MCA; the A1, A2, or A3 segment of the anterior cerebral artery; or the P1, P2, or P3 segment of the posterior cerebral artery) to receive EVT plus best medical treatment or best medical treatment alone within 24 hours after the participant was last seen to be well. The primary outcome was the level of disability at 90 days, as assessed with the modified Rankin scale score. RESULTS: A total of 543 participants (women, 44%; median age, 77 years) were included in the analysis: 271 were assigned to receive EVT plus best medical treatment and 272 to receive best medical treatment alone. The median score on the National Institutes of Health Stroke Scale (range, 0 to 42, with higher scores indicating more severe symptoms) at admission was 6 (interquartile range, 5 to 9). Intravenous thrombolysis was given to 65.4% of the participants. The predominant occlusion locations were the M2 segment (in 44.0% of the participants), M3 segment (in 26.9%), P2 segment (in 13.4%), and P1 segment (in 5.5%). In the comparison between EVT plus best medical treatment and best medical treatment alone, no significant difference in the distribution of modified Rankin scale scores was observed at 90 days (common odds ratio for improvement in the score, 0.90; 95% confidence interval, 0.67 to 1.22; P = 0.50). All-cause mortality was similar in the two groups (15.5% with EVT plus best medical treatment and 14.0% with best medical treatment alone), as was the incidence of symptomatic intracranial hemorrhage (5.9% and 2.6%, respectively). CONCLUSIONS: In persons with stroke with occlusion of medium or distal vessels, EVT did not result in a lower level of disability or a lower incidence of death than best medical treatment alone. (Funded by the Swiss National Science Foundation and others; DISTAL ClinicalTrials.gov number, NCT05029414.).
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Goyal, M., Menon, B. K., van Zwam, W. H., Dippel, D. W. J., Mitchell, P. J., Demchuk, A. M., Dávalos, A., Majoie, C. B. L. M., van der Lugt, A., de Miquel, M. A., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00163-x · Cited by 7,815
Self-citationPowers, W. J., Rabinstein, A. A., Ackerson, T., Adeoye, O. M., Bambakidis, N. C., Becker, K., Biller, J., Brown, M., Demaerschalk, B. M., Hoh, B., et al. (2019) · Stroke · doi:10.1161/str.0000000000000211 · Cited by 7,468
Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis
Saver, J. L., Goyal, M., van der Lugt, A., Menon, B. K., Majoie, C. B. L. M., Dippel, D. W., Campbell, B. C., Nogueira, R. G., Demchuk, A. M., Tomasello, A., et al. (2016) · JAMA · doi:10.1001/jama.2016.13647 · Cited by 2,180
Self-citationEuropean Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke
Berge, E., Whiteley, W., Audebert, H., De Marchis, G., Fonseca, A. C., Padiglioni, C., Pérez de la Ossa, N., Strbian, D., Tsivgoulis, G., & Turc, G. (2021) · European Stroke Journal · doi:10.1177/2396987321989865 · Cited by 1,355
Self-citationTrial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion
Jovin, T. G., Li, C., Wu, L., Wu, C., Chen, J., Jiang, C., Shi, Z., Gao, Z., Song, C., Chen, W., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2207576 · Cited by 725
Self-citationTrial of Endovascular Treatment of Acute Basilar-Artery Occlusion
Tao, C., Nogueira, R. G., Zhu, Y., Sun, J., Han, H., Yuan, G., Wen, C., Zhou, P., Chen, W., Zeng, G., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2206317 · Cited by 699
Mazya, M., Egido, J. A., Ford, G. A., Lees, K. R., Mikulik, R., Toni, D., Wahlgren, N., & Ahmed, N. (2012) · Stroke · doi:10.1161/strokeaha.111.644815 · Cited by 383
Saver, J. L., Chaisinanunkul, N., Campbell, B. C. V., Grotta, J. C., Hill, M. D., Khatri, P., Landen, J., Lansberg, M. G., Venkatasubramanian, C., Albers, G. W., et al. (2021) · Stroke · doi:10.1161/strokeaha.121.034480 · Cited by 323
Self-citationTrial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size
Costalat, V., Jovin, T. G., Albucher, J. F., Cognard, C., Henon, H., Nouri, N., Gory, B., Richard, S., Marnat, G., Sibon, I., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2314063 · Cited by 294
Self-citationFischer, U., Kaesmacher, J., Strbian, D., Eker, O., Cognard, C., Plattner, P. S., Bütikofer, L., Mordasini, P., Deppeler, S., Pereira, V. M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00537-2 · Cited by 291
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Metadata
- Authors
- Psychogios, M., Brehm, A., Ribo, M., Rizzo, F., Strbian, D., Räty, S., Arenillas, J. F., Martínez-Galdámez, M., Hajdu, S. D., Michel, P., Gralla, J., Piechowiak, E. I., Kaiser, D. P. O., Puetz, V., Van den Bergh, F., De Raedt, S., Bellante, F., Dusart, A., Hellstern, V., Khanafer, A., Parrilla, G., Morales, A., Kirschke, J. S., Wunderlich, S., Fiehler, J., Thomalla, G., Lemmens, R., Peluso, J. P., Bolognese, M., von Hessling, A., van Es, A., Kruyt, N. D., Coutinho, J. M., Castaño, C., Minnerup, J., van Zwam, W., Dhondt, E., Nolte, C. H., Machi, P., Loehr, C., Mattle, H. P., Buhk, J.-H., Kaesmacher, J., Dobrocky, T., Papanagiotou, P., Alonso, A., Holtmannspoetter, M., Zini, A., Renieri, L., Keil, F., van den Wijngaard, I., Kägi, G., Terceño, M., Wiesmann, M., Amaro, S., Rommers, N., Balmer, L., Fragata, I., Katan, M., Leker, R. R., Saver, J. L., Staals, J., & Fischer, U.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2025-04-10
- Volume
- 392
- Issue
- 14
- Pages
- 1374-1384
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4407172754
- Cited by
- 270
- References
- 12
- FWCI
- 162.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Psychogios, M., Brehm, A., Ribo, M., Rizzo, F., Strbian, D., Räty, S., Arenillas, J. F., Martínez-Galdámez, M., Hajdu, S. D., Michel, P., Gralla, J., Piechowiak, E. I., Kaiser, D. P. O., Puetz, V., Van den Bergh, F., De Raedt, S., Bellante, F., Dusart, A., Hellstern, V., . . . Fischer, U. (2025). Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels. New England Journal of Medicine. https://doi.org/10.1056/nejmoa2408954
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