The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
ADHD Drugs and Cardiovascular Risk
Abstract
On February 9, the Drug Safety and Risk Management Advisory Committee of the FDA voted to recommend a “black-box” warning describing the cardiovascular risks of stimulant drugs used to treat ADHD. Dr. Steven Nissen explains why the advisory committee took decisive action.
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Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The median of these published sudden death rates in children is at 1.2–1.3/100,000/year.”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
In the citing paper
“Sudden death rates range from 0.8 to 8.5/100,000 patient-years [20, 30, 98, 99, 159].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
In the citing paper
“In contrast to adults, sudden death occurs only rarely in the general paediatric population.”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
In the citing paper
“the frequency of reported sudden death per year of ADHD therapy with methylphenidate, atomoxetine or amfetamines among children was 0.2–0.5/100,000 patient-years [99].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
In the citing paper
“QTc prolongation (and sudden death and increased heart rate) have been reported with methylphenidate and dexamfetamine [99] and atomoxetine [34].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
Citations
Cites
Phenylpropanolamine and the Risk of Hemorrhagic Stroke
Kernan, W. N., Viscoli, C. M., Brass, L. M., Broderick, J. P., Brott, T. G., Feldmann, E. G., Morgenstern, L. B., Wilterdink, J. L., & Horwitz, R. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432501 · Cited by 746
Contraindicated Use of Cisapride
Smalley, W. E., Shatin, D., Wysowski, D. K., Gurwitz, J. H., Andrade, S. E., Goodman, M. J., Chan, K. A., Platt, R. G., Schech, S. D., & Ray, W. A. (2000) · JAMA · doi:10.1001/jama.284.23.3036 · Cited by 253
Wilens, T. E., Hammerness, P. G., Biederman, J., Kwon, A., Spencer, T. J., Clark, S., Scott, M., Podolski, A., Ditterline, J., Morris, M. C., et al. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0215 · Cited by 149
Postmarketing Surveillance of Suicidal Adverse Events with Pediatric Use of Antidepressants
Mosholder, A. D., & Pamer, C. A. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.33 · Cited by 25
Report From the Cardiovascular and Renal Drugs Advisory Committee
Nissen, S. E. (2005) · Circulation · doi:10.1161/circulationaha.105.573105 · Cited by 20
Self-citationThe Relative Safety of Ephedra Compared with Other Herbal Products
Kingston, R. L., & Borron, S. W. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-5_part_1-200309020-00017 · Cited by 6
Cited by
Sorted by citations
Pliszka, S. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318054e724 · Cited by 1,765
Conrad, P. (2007) · Johns Hopkins University Press eBooks · doi:10.56021/9780801885846 · Cited by 1,448
Sharma, A., & Couture, J. (2014) · Annals of Pharmacotherapy · doi:10.1177/1060028013510699 · Cited by 516
Effectiveness of manual therapies: the UK evidence report
Bronfort, G., Haas, M., Evans, R., Leininger, B., & Triano, J. (2010) · Chiropractic & Osteopathy · doi:10.1186/1746-1340-18-3 · Cited by 434
ADHD Drugs and Serious Cardiovascular Events in Children and Young Adults
Cooper, W. O., Habel, L. A., Sox, C. M., Chan, K. A., Arbogast, P. G., Cheetham, T. C., Murray, K. T., Quinn, V. P., Stein, C. M., Callahan, S. T., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1110212 · Cited by 411
Metadata
- Authors
- Nissen, S. E.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Nissen, Steven E.
- ORCID
- Nissen, Steven E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-04-06
- Volume
- 354
- Issue
- 14
- Pages
- 1445-1448
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2032285255
- Cited by
- 331
- References
- 6
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 14 · 2014: 19 · 2013: 25 · 2012: 28
- FWCI
- 26.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- attention deficit hyperactivity disorder, stimulants, cardiovascular risk, black box warning, drug safety, cardiovascular adverse events
- MeSH terms
- Adult, Central Nervous System Stimulants, Appetite Depressants, Attention Deficit Disorder with Hyperactivity, Cardiovascular Diseases, Child, Death, Sudden, Drug and Narcotic Control, Female, Humans, Male, Phenylpropanolamine, Sympathomimetics, United States, United States Food and Drug Administration, Ephedra
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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