Hereditary Hemochromatosis — A New Look at an Old Disease

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168

Mutation nomenclature extensions and suggestions to describe complex mutations: A discussion

den Dunnen, J. T., & Antonarakis, S. E. (2000) · Human Mutation · doi:10.1002/(sici)1098-1004(200001)15:1 · Cited by 1,757

A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697

Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

Ganz, T. (2003) · Blood · doi:10.1182/blood-2003-03-0672 · Cited by 1,544

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324

Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis

Niederau, C., Fischer, R., Sonnenberg, A., Stremmel, W., Trampisch, H. J., & Strohmeyer, G. W. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511143132004 · Cited by 1,063

Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D., & Camaschella, C. (2003) · Nature Genetics · doi:10.1038/ng1053 · Cited by 860

Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders

Shahandeh, A., Bui, B. V., Finkelstein, D. I., & Nguyen, C. T. O. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.794809 · Cited by 21

Meta-analyses of HFE variants in coronary heart disease

Lian, J., Xu, L., Huang, Y., Le, Y., Jiang, D., Yang, X., Xu, W., Huang, X., Dong, C., Ye, M., et al. (2013) · Gene · doi:10.1016/j.gene.2013.06.034 · Cited by 21

Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: The HEmochromatosis FAmily Study

Jacobs, E. M. G., Hendriks, J. C. M., van Deursen, C. T. B. M., Kreeftenberg, H. G., de Vries, R. A., Marx, J. J. M., Stalenhoef, A. F. H., Verbeek, A. L. M., & Swinkels, D. W. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.08.014 · Cited by 21

A Q312X Mutation in the Hemojuvelin Gene is Associated with Cardiomyopathy Due to Juvenile Haemochromatosis

Nagayoshi, Y., Nakayama, M., Suzuki, S., Hokamaki, J., Shimomura, H., Tsujita, K., Fukuda, M., Yamashita, T., Nakamura, Y., Sugiyama, S., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.07.012 · Cited by 21

Erythrocytic Pyruvate Kinase Mutations Causing Hemolytic Anemia, Osteosclerosis, and Secondary Hemochromatosis in Dogs

Gültekin, G. İ., Raj, K., Foureman, P. A., Lehman, S., Manhart, K., Abdulmalik, O. Y., & Giger, U. (2012) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2012.00958.x · Cited by 21

Laboratory Tests in Liver Disease

Vuppalanchi, R., & Chalasani, N. (2011) · Elsevier eBooks · doi:10.1016/b978-0-443-06803-4.00005-8 · Cited by 22

Use of nitrous oxide and oxygen for conscious sedation to manage pain and anxiety.

Ryding, H. A., & Murphy, H. J. (2007) · PubMed · Cited by 21

A novel ferroportin mutation in a Canadian family with autosomal dominant hemochromatosis

Morris, T. J., Litvinova, M. M., Ralston, D., Mattman, A., Holmes, D. T., & Lockitch, G. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.07.007 · Cited by 22

Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects

Kontoghiorghes, G. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054970 · Cited by 20

Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure

Ye, Q., & Kim, J. (2016) · Metallomics · doi:10.1039/c6mt00080k · Cited by 20

Hereditary hyperferritinaemia???cataract syndrome: a challenging diagnosis for the hepatogastroenterologist

Ferrante, M., Geubel, A., Fevery, J., Marogy, G., Horsmans, Y., & Nevens, F. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200511000-00016 · Cited by 20

Anxiolytic-like action in mice treated with nitrous oxide and oral triazolam or diazepam

Gries, D. A., Condouris, G. A., Shey, Z., & Houpt, M. I. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.07.028 · Cited by 20

The Puzzle of Aspirin and Iron Deficiency: The Vital Missing Link of the Iron-Chelating Metabolites

Kontoghiorghes, G. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105150 · Cited by 22

Terephthalamide-containing ligands: fast removal of iron from transferrin

Abergel, R. J., & Raymond, K. N. (2007) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-007-0314-y · Cited by 19

Hereditary Hemochromatosis: Missed Diagnosis or Misdiagnosis?

Cherfane, C. E., Hollenbeck, R. D., Go, J. T., & Brown, K. E. (2013) · The American Journal of Medicine · doi:10.1016/j.amjmed.2013.07.013 · Cited by 19

Serum Transferrin Saturation Increase Is Associated With Decrease of Antibacterial Activity of Serum in Patients With HFE-Related Genetic Hemochromatosis

Jolivet‐Gougeon, A., Loréal, O., Ingels, A., Danic, B., Ropert, M., Bardou‐Jacquet, E., Aqodad, N., Aussant-Bertel, F., Férec, C., & Brissot, P. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.02036.x · Cited by 19

Diabetes mellitus Typ 3c – Prävalenz, Diagnose, Besonderheiten der Therapie

Bojunga, J., & Schlereth, F. (2018) · Der Diabetologe · doi:10.1007/s11428-018-0346-7 · Cited by 19

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

Adris, N., Chua, A. C. G., Knuiman, M. W., Divitini, M., Trinder, D., & Olynyk, J. K. (2018) · BMC Cancer · doi:10.1186/s12885-018-4775-x · Cited by 19

HFE C282Y Homozygosity Is Associated with an Increased Risk of Total Hip Replacement for Osteoarthritis

Wang, Y., Gurrin, L. C., Wluka, A. E., Bertalli, N. A., Osborne, N. J., Delatycki, M. B., Giles, G. G., English, D. R., Hopper, J. L., Simpson, J. A., et al. (2011) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2011.11.003 · Cited by 19

Does the SLC40A1 gene modify HFE-related haemochromatosis phenotypes?

Altés, A., Bach, V., Ruiz, A., Esteve, A., Remacha, A. F., Sardà, M. P., Félez, J., & Baiget, M. (2008) · Annals of Hematology · doi:10.1007/s00277-008-0590-9 · Cited by 18

Reversibility of hypogonadotropic hypogonadism in a patient with the juvenile form of hemochromatosis

Angelopoulos, N., Goula, A., Dimitriou, E., & Tolis, G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.05.070 · Cited by 19

Effects of Iron Overload on Cardiac Calcium Regulation: Translational Insights Into Mechanisms and Management of a Global Epidemic

Khamseekaew, J., Kumfu, S., Chattipakorn, S. C., & Chattipakorn, N. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.10.012 · Cited by 19

A Diagnostic Approach to Hemochromatosis

Tavill, A. S., & Adams, P. C. (2006) · Canadian Journal of Gastroenterology · doi:10.1155/2006/934098 · Cited by 19

Reduced exercise capacity in genetic haemochromatosis

Davidsen, E. S., Liseth, K., Omvik, P., Hervig, T. A., & Gerdts, E. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3280ac151c · Cited by 19

Sistemática diagnóstica en la hiperferritinemia

Altés, A., Pérez-Lucena, M. J., & Bruguera, M. (2013) · Medicina Clínica · doi:10.1016/j.medcli.2013.06.010 · Cited by 20

Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice

Krijt, J., Niederkofler, V., Salie, R., Šefc, L., Pelichovská, T., Vokurka, M., & Nečas, E. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.02.004 · Cited by 18

Iron

Ponka, P., Tenenbein, M., & Eaton, J. W. (2007) · Elsevier eBooks · doi:10.1016/b978-012369413-3/50085-9 · Cited by 19

Serum Ferritin, Insulin Resistance, and Metabolic Syndrome: Clinical and Laboratory Associations in 769 Non-Hispanic Whites Without Diabetes Mellitus in the HEIRS Study

Acton, R. T., Barton, J. C., & Barton, J. C. (2014) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2014.0106 · Cited by 19

Iron

Ponka, P., Tenenbein, M., & Eaton, J. W. (2014) · Elsevier eBooks · doi:10.1016/b978-0-444-59453-2.00041-x · Cited by 20

Juvenile hemochromatosis

Pietrangelo, A. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.09.003 · Cited by 19

Mutations in HAMP and HJV genes and their impact on expression of clinical hemochromatosis in a cohort of 100 Spanish patients homozygous for the C282Y mutation of HFE gene

Altés, A., Bach, V., Ruiz, A., Esteve, A., Félez, J., Remacha, A. F., Sardà, M. P., & Baiget, M. (2009) · Annals of Hematology · doi:10.1007/s00277-009-0705-y · Cited by 18

Asymptomatic individuals at genetic risk of haemochromatosis take appropriate steps to prevent disease related to iron overload

Allen, K. J., Nisselle, A. E., Collins, V., Williamson, R., & Delatycki, M. B. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01661.x · Cited by 18

Iron-independent specific protein expression pattern in the liver of HFE-deficient mice

Petrák, J., Myslivcová, D., Halada, P., Čmejla, R., Čmejlová, J., Vyoral, D., & Vulpe, C. D. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.021 · Cited by 17

An open population screening study for HFE gene major mutations proves the low prevalence of C282Y mutation in Central Italy

Floreani, A., Rizzotto, E. R., Basso, D., Navaglia, F., Zaninotto, M., Petridis, I., Andrea, O. D., Testa, R., Marra, M., Baldo, V., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03401.x · Cited by 17

Quantification of Hepatic Fat and Iron with Magnetic Resonance Imaging

Wells, S. A. (2014) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2014.04.010 · Cited by 18

Total Mortality by Elevated Transferrin Saturation in Patients With Diabetes

Ellervik, C., Andersen, H. U., Tybjærg‐Hansen, A., Frandsen, M., Birgens, H., Nordestgaard, B. G., & Mandrup-Poulsen, T. R. (2013) · Diabetes Care · doi:10.2337/dc12-2032 · Cited by 17

Liver Toxicity of Thioacetamide is Increased by Hepatocellular Iron Overload

Ackerman, Z., Pappo, O., Link, G., Glazer, M., & Grozovski, M. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-0110-9 · Cited by 17

Prevalence of C282Y and H63D mutations in the HFE gene of Brazilian individuals with clinical suspicion of hereditary hemochromatosis

Ferreira, A. C. D. S., Oliveira, V. C., Caxito, F. A., Gomes, K. B., de Castro, A. M., & Pardini, V. C. (2008) · Revista Brasileira de Hematologia e Hemoterapia · doi:10.1590/s1516-84842008000500010 · Cited by 17

Study of total stimulated saliva flow and hyperpigmentation in the oral mucosa of patients diagnosed with hereditary hemochromatosis. Series of 25 cases.

Sanchez-Pablo, M., Gonzalez-Garcia, V., & Rueda, A. D. C. (2012) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.17206 · Cited by 17

Acute Free-Iron Exposure Does Not Explain the Impaired Haemorheology Associated with Haemochromatosis

McNamee, A. P., Sabapathy, S., Singh, I., Horobin, J. T., Guerrero, J., & Simmonds, M. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146448 · Cited by 18

Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy

Das, S. K., Zhabyeyev, P., Basu, R., Patel, V. B., Dyck, J. R. B., Kassiri, Z., & Oudit, G. Y. (2017) · Bioscience Reports · doi:10.1042/bsr20171302 · Cited by 18

The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein

Ka, C., Gac, G. L., Dupradeau, F., Rochette, J., & Férec, C. (2005) · Human Genetics · doi:10.1007/s00439-005-1307-y · Cited by 17

Heritability of serum iron measures in the hemochromatosis and iron overload screening (HEIRS) family study

McLaren, C. E., Barton, J. C., Eckfeldt, J. H., McLaren, G. D., Acton, R. T., Adams, P. C., Henkin, L. F., Gordeuk, V. R., Vulpe, C. D., Harris, E. L., et al. (2009) · American Journal of Hematology · doi:10.1002/ajh.21585 · Cited by 17

Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes

Andriopoulos, B., & Pantopoulos, K. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.025 · Cited by 18

Increase in type II collagen turnover after iron depletion in patients with hereditary haemochromatosis

Richette, P., Eymard, C., Deberg, M. A., Vidaud, D., de Kerguenec, C., Valla, D. C., Vicaut, É., Bardin, T., & Henrotin, Y. E. (2010) · Rheumatology · doi:10.1093/rheumatology/kep429 · Cited by 17

Case 33-2006

Chung, R. T., Misdraji, J., & Sahani, D. V. (2006) · New England Journal of Medicine · doi:10.1056/nejmcpc069024 · Cited by 17

Hereditary Hemochromatosis

Ferrara, F., Corradini, E., & Pietrangelo, A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_54 · Cited by 17

Inherited metabolic liver disease

Schilsky, M. L., & Fink, S. A. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000218957.63311.0e · Cited by 17

HFE mutations in α-1-antitrypsin deficiency: an examination of cirrhotic explants

Lam, M. M., Torbenson, M. S., Yeh, M. M., Vivekanandan, P., & Ferrell, L. D. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.42 · Cited by 16

Ferroptosis inhibitor improves cardiac function more effectively than inhibitors of apoptosis and necroptosis through cardiac mitochondrial protection in rats with iron-overloaded cardiomyopathy

Kumfu, S., Sripetchwandee, J., Thonusin, C., Sumneang, N., Maneechote, C., Arunsak, B., Chunchai, T., Oo, T. T., Kongkaew, A., Chattipakorn, S. C., et al. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116727 · Cited by 16

Hemochromatosis: Niche Construction and the Genetic Domino Effect in the European Neolithic

McCullough, Heath, & Smith (2015) · Human Biology · doi:10.13110/humanbiology.87.1.0039 · Cited by 16

Iron

Wessling‐Resnick, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802168-2.00014-2 · Cited by 18

Whole genome sequencing of one complex pedigree illustrates challenges with genomic medicine

Fang, H., Wu, Y., Yang, H., Yoon, M. S., Jiménez-Barrón, L. T., Mittelman, D., Robison, R. J., Wang, K., & Lyon, G. J. (2017) · BMC Medical Genomics · doi:10.1186/s12920-017-0246-5 · Cited by 17

Biomarkers in the clinical management of patients with atrial fibrillation and heart failure.

Koniari, I. C., Artopoulou, E., Velissaris, D., Ainslie, M., Mplani, V., Karavasili, G., Kounis, N. G., & Tsigkas, G. (2021) · PubMed Central · doi:10.11909/j.issn.1671-5411.2021.11.010 · Cited by 16

Active transport nanochelators for the reduction of liver iron burden in iron overload

Abbina, S., Abbasi, U., Gill, A., Leitch, H. A., & Kizhakkedathu, J. N. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.056 · Cited by 16

Molecularly Imprinted Ion-Exchange Resin for Fe3+

Owens, G. S., Southard, G. E., Houten, K. A. V., & Murray, G. M. (2005) · Separation Science and Technology · doi:10.1080/01496390500201177 · Cited by 16

Alterations in sympathetic nerve traffic in genetic haemochromatosis before and after iron depletion therapy: a microneurographic study

Seravalle, G., Piperno, A., Mariani, R., Pelloni, I., Facchetti, R., Dell’Oro, R., Cuspidi, C., Mancia, G., & Grassi, G. M. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv696 · Cited by 16

HFE Gene Mutations and Iron Status in 100 Healthy Polish Children

Kaczorowska-Hać, B., Łuszczyk, M., Antosiewicz, J., Ziółkowski, W., Adamkiewicz‐Drożyńska, E., Myśliwiec, M., Miłosz, E., & Kaczor, J. J. (2017) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000826 · Cited by 16

Expression of iron transport proteins divalent metal transporter‐1, Ferroportin‐1, HFE and transferrin receptor‐1 in human monocyte‐derived dendritic cells

Brinkmann, M., Teuffel, R., Laham-Karam, N., Ehrlich, R. L., Decker, P., Lemonnier, F. A., & Pascolo, S. (2006) · Cell Biochemistry and Function · doi:10.1002/cbf.1363 · Cited by 16

Estudo das mutações C282Y, H63D e S65C do gene HFE em doentes brasileiros com sobrecarga de ferro

Cançado, R. D., Guglielmi, A. C. D. O., Vergueiro, C. S. V., Rolim, E. G., Figueiredo, M. S., & CHIATTONE, C. S. (2007) · Revista Brasileira de Hematologia e Hemoterapia · doi:10.1590/s1516-84842007000400007 · Cited by 16

Hereditary hemochromatosis

Franchini, M., & Veneri, D. (2005) · Hematology · doi:10.1080/10245330500065771 · Cited by 16

New Mutations in HFE2 and TFR2 Genes Causing Non HFE-Related Hereditary Hemochromatosis

Hernández, G., Ferrer-Cortés, X., Venturi, V., Musri, M. M., Pilquil, M. F., Muñoz-Torres, P., Hernández‐Rodríguez, I., Mínguez, M. Á. R., Kelleher, N. J., Pelucchi, S., et al. (2021) · Genes · doi:10.3390/genes12121980 · Cited by 17

Analysis of HFE Genes C282Y, H63D, and S65D in Patients With Hyperferritinemia From Northeastern Brazil

Leão, G. D. R., Freire, J. M., Fernandes, A. L. A. D. C., de Oliveira, T. M. M., Costa, N. D. L., Gil, E. A., de Vasconcelos, R. C., Azevedo, J. P. D. S., Sales, V. S. D. F., Lemos, T. M. A. M., et al. (2014) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21663 · Cited by 15

HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases

Evangelista, A. S., Nakhle, M. C., de Araújo, T. F., Abrantes‐Lemos, C. P., Deguti, M. M., Carrilho, F. J., & Cançado, E. L. R. (2015) · BioMed Research International · doi:10.1155/2015/164671 · Cited by 15

Iron deficiency anemia from iron malabsorption caused by proton pump inhibitors

Boxer, M. A. (2020) · eJHaem · doi:10.1002/jha2.96 · Cited by 17

Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate?*

Olsson, K. S., Konar, J., Dufva, I. H., Ricksten, A., & Raha‐Chowdhury, R. (2010) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2010.01536.x · Cited by 15

Neuromuscular manifestations in hereditary haemochromatosis

Wouthuis, S. F., van Deursen, C. T. B. M., Lintelo, M. P. T., Rozeman, C. A. M., & Beekman, R. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5548-x · Cited by 15

Facilitation of blood donation amongst haemochromatosis patients

Marrow, B., Clarkson, J., Chapman, C., & Masson, S. (2015) · Transfusion Medicine · doi:10.1111/tme.12182 · Cited by 15

The medical complications of alcohol use: understanding mechanisms to improve management

Chase, V., Neild, R., Sadler, C., & Batey, R. G. (2005) · Drug and Alcohol Review · doi:10.1080/09595230500167510 · Cited by 15

Disturbances of Copper and Iron Metabolism

Lefkowitch, J. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-7020-7584-1.00014-0 · Cited by 15

Elevated serum ferritin level associated with hepatic steatosis and fibrosis in hepatitis C virus–infected patients

Batsaikhan, B., Gantumur, G., Huang, C., Yeh, M., Huang, C., Lin, Z., Chen, S., Huang, J., Yu, M., Chuang, W., et al. (2019) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000009 · Cited by 15

Lebertransplantation zwischen Indikation und Spenderallokation

Strassburg, C. P., Becker, T., Klempnauer, J. L., & Manns, M. P. (2004) · Der Internist · doi:10.1007/s00108-004-1295-3 · Cited by 15

Heredity hemochromatosis: Temporal trends, sociodemographic characteristics, and independent risk factor of hepatocellular cancer – nationwide population-based study

Haider, M. B., Sbihi, A. A., Chaudhary, A. J., Haider, S. M., & Edhi, A. I. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i9.1804 · Cited by 14

Regulatory and Sensing Iron–Sulfur Clusters: New Insights and Unanswered Questions

SantaMaria, A. M., & Rouault, T. A. (2024) · Inorganics · doi:10.3390/inorganics12040101 · Cited by 17

Role of HFE gene mutations on developing iron overload in beta thalassaemia carriers in Egypt

Madani, H. A., Afify, R. A. A., Aal, A. A. A., Salama, N., & Ramy, N. (2011) · Eastern Mediterranean Health Journal · doi:10.26719/2011.17.6.546 · Cited by 14

Cottonseed Oil in Diets for Broilers in the Pre-Starter and Starter Phases

Lima, V. B. D. S., Dourado, L. R. B., Machado, L. P., Biagiotti, D., de Lima, S. B. P., Ferreira, G. J. B. D. C., Farias, L. A., de Sousa, F. A., Acácio, R. M., & Silva, D. R. S. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147695 · Cited by 14

ESAT-6 Protein of Mycobacterium tuberculosis Increases Holotransferrin-Mediated Iron Uptake in Macrophages by Downregulating Surface Hemochromatosis Protein HFE

Jha, V., Pal, R. K., Kumar, D., & Mukhopadhyay, S. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1801357 · Cited by 14

Genetic polymorphisms in bovine transferrin receptor 2 (TFR2) and solute carrier family 40 (iron‐regulated transporter), member 1 (SLC40A1) genes and their association with beef iron content

Duan, Q., Tait, R. G., Mayes, M. S., Garrick, D. J., Liu, Q., Eenennaam, A. L. V., Mateescu, R. G., Overbeke, D. L. V., Garmyn, A. J., Beitz, D. C., et al. (2011) · Animal Genetics · doi:10.1111/j.1365-2052.2011.02224.x · Cited by 14

Total and Cause-Specific Mortality by Elevated Transferrin Saturation and Hemochromatosis Genotype in Individuals With Diabetes: Two General Population Studies

Ellervik, C., Mandrup-Poulsen, T. R., Tybjærg‐Hansen, A., & Nordestgaard, B. G. (2013) · Diabetes Care · doi:10.2337/dc13-1198 · Cited by 14

Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis

Huang, J. (2015) · World Journal of Experimental Medicine · doi:10.5493/wjem.v5.i4.232 · Cited by 14

The soluble transferrin receptor as a marker of iron homeostasis in normal subjects and in HFE-related hemochromatosis.

Brandão, M., Oliveira, J. C., Bravo, F., Reis, J., Garrido, I., & Porto, G. (2005) · PubMed · Cited by 14

The relationship between iron overload and clinical characteristics in a Spanish cohort of 100 C282Y homozygous hemochromatosis patients

Altés, A., Ruiz, A., Martinez, C., Esteve, A., Vela, M. D., Remacha, A. F., Sardà, M. P., Bach, V., & Baiget, M. (2007) · Annals of Hematology · doi:10.1007/s00277-007-0336-0 · Cited by 14

Laboratory Tests in Liver Disease

Vuppalanchi, R., & Chalasani, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-42873-6.00003-2 · Cited by 13

Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin

Varghese, J., Varghese, J., John, N. M., Deschemin, J., Vaulont, S., McKie, A. T., & Jacob, M. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109175 · Cited by 13

Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-α and macrophage migration inhibitory factor concentrations in African children

Kasvosve, I., Debebe, Z., Nekhai, S. A., & Gordeuk, V. R. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.04.031 · Cited by 12

Increased Redox-Sensitive Green Fluorescent Protein Reduction Potential in the Endoplasmic Reticulum following Glutathione-Mediated Dimerization

Sarkar, D. D., Edwards, S. K., Mauser, J., Suarez, A. M., Serowoky, M. A., Hudok, N. L., Hudok, P. L., Nuñez, M., Weber, C. S., Lynch, R. M., et al. (2013) · Biochemistry · doi:10.1021/bi400052u · Cited by 13

MRI Appearance of Focal Lesions in Liver Iron Overload

Pecorelli, A., Franceschi, P., Braccischi, L., Izzo, F., Renzulli, M., & Golfieri, R. (2022) · Diagnostics · doi:10.3390/diagnostics12040891 · Cited by 13

HLA‐A3‐B14 and the origin of the haemochromatosis C282Y mutation: founder effects and recombination events during 12 generations in a Scandinavian family with major iron overload

Olsson, K. S., Ritter, B., & Raha‐Chowdhury, R. (2009) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2009.01376.x · Cited by 13

Hemochromatosis: As a conformational disorder

Gray, S. G., Crowe, J., & Lawless, M. W. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.04.006 · Cited by 13

Two novel mutations in the SLC40A1 and HFE genes implicated in iron overload in a Spanish man

Rueda, A. D. C., Moreno‐Carralero, M., Álvarez-Sala, J. L., Cuadrado‐Grande, N., de Salamanca, R. E., Méndez, M., & Morán‐Jiménez, M. (2010) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2010.01565.x · Cited by 13

Hereditary hemochromatosis, iron, hepcidin, and coronary heart disease

Mascitelli, L., & Goldstein, M. R. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.12.013 · Cited by 13

The impact of H63D HFE gene carriage on hemoglobin and iron status in children

Kaczorowska-Hać, B., Łuszczyk, M., Antosiewicz, J., Ziółkowski, W., Adamkiewicz-Drożyńska, E., Malgorzata, M., Miłosz, E., & Jacek, K. J. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2792-x · Cited by 13

HLA haplotype map of river valley populations with hemochromatosis traced through five centuries in Central Sweden

Olsson, K. S., Ritter, B., Hansson, N., & Chowdhury, R. R. (2008) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2008.01078.x · Cited by 13

Les hémochromatoses. Nouvelle compréhension, nouveaux traitements

Brissot, P. (2009) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2009.04.004 · Cited by 13

The HLA‐A1‐B8 haplotype hitchhiking with the hemochromatosis mutation: does it affect the phenotype?

Olsson, K. S., Ritter, B., & Hansson, N. (2007) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2007.00953.x · Cited by 13

External quality assurance of molecular analysis of haemochromatosis gene mutations

Hertzberg, M., Neville, S., & McDonald, D. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.026005 · Cited by 13

Hemochromatosis (HFE) genotype and atherosclerosis: Increased susceptibility to iron-induced vascular damage in C282Y carriers?

Engberink, M. F., Povel, C. M., Durga, J., Swinkels, D. W., de Kort, W. L. A. M., Schouten, E. G., Verhoef, P., & Geleijnse, J. M. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.03.018 · Cited by 13

Phenotype and HFE genotype in a population with abnormal iron markers recruited from an Endocrinology Department

Vantyghem, M., Fajardy, I., Dhondt, F., Girardot, C., d’Herbomez, M., Danzé, P. M., Rousseaux, J., & Wémeau, J.-L. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02152 · Cited by 13

Iron and the Reticuloendothelial System

Weiß, G. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_11 · Cited by 13

Dietary and Sentinel Factors Leading to Hemochromatosis

Oh, C.-K., & Moon, Y. (2019) · Nutrients · doi:10.3390/nu11051047 · Cited by 12

Revisiting Hereditary Hemochromatosis: Current Concepts and Progress

Yen, A. W., Fancher, T. L., & Bowlus, C. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.041 · Cited by 58

Advances in pathophysiology, diagnosis and management of hereditary hemochromatosis

Zhang, Z. (2012) · Shengming kexue

HEMOCHROMATOSIS

Powell, L. W., & Yapp, T. R. (2000) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70104-5 · Cited by 28

Molecular insights into the pathogenesis of hereditary haemochromatosis

Pietrangelo, A. (2006) · Gut · doi:10.1136/gut.2005.078063 · Cited by 53

[Hereditary hemochromatosis].

Cojocariu, C., Trifan, A. V., & Stanciu, C. (2007) · PubMed