Cited by 432Genetic Associations and EpidemiologyCardiovascular Health and Risk FactorsCardiac electrophysiology and arrhythmias

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Cardiovascular Disease

Open access

Nabel, Elizabeth G.·2003·New England Journal of Medicine

DOI 10.1056/nejmra035098

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Abstract

ardiovascular disease, including stroke, is the leading cause of illness and death in the United States.There are an estimated 62 million people with cardiovascular disease and 50 million people with hypertension in this country.1 In 2000, approximately 946,000 deaths were attributable to cardiovascular disease, accounting for 39 percent of all deaths in the United States. 2 Epidemiologic studies and randomized clinical trials have provided compelling evidence that coronary heart disease is largely preventable.3 However, there is also reason to believe that there is a heritable component to the disease.In this review, I highlight what we know now about genetic factors in cardiovascular disease.As future genomic discoveries are translated to the care of patients with cardiovascular disease, it is likely that what we can do will change.c lessons learned from monogenic cardiovascular disorders

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Authors: Nabel, E. G.
Affiliations: National Institutes of Health (US)
Corresponding author: Nabel, Elizabeth G.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2003-07-03
Volume: 349
Issue: 1
Pages: 60-72
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra035098
OpenAlex: W4245959283
Cited by: 431
References: 86
Citations by year: 2026: 11 · 2025: 22 · 2024: 45 · 2023: 37 · 2022: 26 · 2021: 20 · 2020: 9 · 2019: 9 · 2018: 14 · 2017: 10 · 2016: 17 · 2015: 15 · 2014: 19 · 2013: 14 · 2012: 14
FWCI: 2.11
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: cardiovascular disease, genetic factors, heritability, coronary artery disease, hypertension, stroke, cardiovascular mortality, cardiovascular disease prevention, genomics
MeSH terms: Arrhythmias, Cardiac, Cardiovascular Diseases, Coronary Disease, Genetic Testing, Humans, Hypercholesterolemia, Hypertension, Cholesterol, LDL, Mutation, Cardiomyopathies, Polymorphism, Genetic, Thrombosis, Gene Expression Profiling

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