Effectiveness of Antimalarial Drugs
Abstract
A global resurgence of malaria has taken place as a result of a lapse in preventive efforts and the emergence of resistance to standard antimalarial drugs. New therapies are available, but because of social, economic, and clinical factors, the use of older drugs persists. This review considers current approaches to the prevention and treatment of malaria.
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Killing parasites in RBCs requires prolonged treatment with high doses, which results in toxicities, potential for missed doses and development of resistance.
“Killing parasites in the RBCs requires prolonged treatment with high doses, which results in toxicities, potential for missed doses and development of resistance 104 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [104]
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References 117 · Cited by 375
- Authors
- Baird, J. K.
- Corresponding author
- Baird, J. Kevin
- ORCID
- Baird, J. Kevin
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-04-14
- Volume
- 352
- Issue
- 15
- Pages
- 1565-1577
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2169812632
- Cited by
- 375
- References
- 117
- Citations by year
- 2025: 7 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 8 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 7 · 2016: 15 · 2015: 18 · 2014: 26 · 2013: 19 · 2012: 27
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Keywords
- malaria, antimalarial drugs, drug resistance, malaria prevention, malaria treatment
- MeSH terms
- Animals, Antimalarials, Chloroquine, Drug Combinations, Drug Resistance, Drug Therapy, Combination, Humans, Life Cycle Stages, Malaria, Patient Compliance, Plasmodium, Primaquine, Pyrimethamine, Quinine, Sulfadoxine, Mefloquine, Treatment Failure, Secondary Prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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