Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
Abstract
This review of oncogene-induced cell senescence describes a physiological mechanism that provides protection against cancer. The mechanisms underlying the arrest of growth in benign or premalignant neoplasms have considerable clinical implications.
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Expression of certain oncogenes accelerates the de-repression of the CDKN2a locus, a phenomenon called oncogene-induced senescence.
“the expression of certain oncogenes accelerated the de-repression of the CDKN2a locus, a phenomenon that was called 'oncogene-induced senescence' 5, 6”
From The common biology of cancer and ageing (2007) · cites this paper as [5]
There are abundant senescent cells within tumours.
“recent data have shown that there are abundant senescent cells within tumours”
From The common biology of cancer and ageing (2007) · cites this paper as [5]
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References 83 · Cited by 371
- Authors
- Mooi, W. J., & Peeper, D. S.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- The Netherlands Cancer Institute (NL)
- ORCID
- Peeper, D.S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-09-07
- Volume
- 355
- Issue
- 10
- Pages
- 1037-1046
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2071113489
- Cited by
- 371
- References
- 83
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 3 · 2023: 18 · 2022: 10 · 2021: 11 · 2020: 17 · 2019: 18 · 2018: 14 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 25 · 2013: 22 · 2012: 31
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- oncogene-induced senescence, cellular senescence, cancer prevention, growth arrest, tumor suppression
- MeSH terms
- Cell Transformation, Neoplastic, DNA Damage, Humans, Melanoma, Neoplasms, Oncogenes, Telomere, Cellular Senescence, Apoptosis
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