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Guillain–Barré Syndrome
Abstract
Sera from patients with Guillain-Barré syndrome (GBS) following Campylobacter jejuni infection have autoantibody to GM1 ganglioside in the acute phase of the illness. There is a strong association between GBS and Penner's serotype 19 (PEN 19) of C. jejuni. The terminal structure of the bacterial lipopolysaccharide is identical to the terminal tetrasaccharide of GM1 ganglioside. Anti-GM1 antibody inhibits motoneuron excitability. Molecular mimicry between infectious agents and nerve tissue components may function in the development of GBS.
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Citations
Cited by
Schnaar, R. L., Gerardy-Schahn, R., & Hildebrandt, H. (2014) · Physiological Reviews · doi:10.1152/physrev.00033.2013 · Cited by 745
Intravenous immunoglobulin for Guillain-Barré syndrome
Hughes, R. A., Swan, A. V., & van Doorn, P. A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002063.pub6 · Cited by 721
Guillain-Barre syndrome and influenza vaccines: a meta-analysis.
Martín Arias, L. H., Sanz, R., Sáinz, M., Treceño, C., & Carvajal, A. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.05.013 · Cited by 132
Guillain-Barré syndrome and anti-ganglioside antibodies: A clinician-scientist’s journey
YUKI, N. (2012) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.88.299 · Cited by 109
Self-citationModulation of Glycan Recognition by Clustered Saccharide Patches
(2014) · International Review of Cell and Molecular Biology · doi:10.1016/b978-0-12-800097-7.00003-8 · Cited by 84
Metadata
- Authors
- Yuki, N., & Hartung, H.-P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-06-14
- Volume
- 366
- Issue
- 24
- Pages
- 2294-2304
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2068751098
- Cited by
- 1,260
- References
- 0
- FWCI
- 42.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
